DK352086A - Steroide aromatase-inhibitorer - Google Patents

Steroide aromatase-inhibitorer Download PDF

Info

Publication number: DK352086A
Authority: DK; Denmark
Prior art keywords: group; alkyl; unsubstituted; chem; aromatase inhibitors
Prior art date: 1985-08-01

Application number

DK352086A

Other languages

English (en)

Other versions

DK164173B (da

DK164173C (da

DK352086D0 (da

Inventor

Franco Faustini

Alessio Roberto D

Vittorio Villa

Salle Enrico Di

Paolo Lombardi

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-01

Filing date

1986-07-24

Publication date

1987-02-02

1986-07-24 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1986-07-24 Publication of DK352086D0 publication Critical patent/DK352086D0/da

1987-02-02 Publication of DK352086A publication Critical patent/DK352086A/da

1992-05-18 Publication of DK164173B publication Critical patent/DK164173B/da

1992-10-12 Application granted granted Critical

1992-10-12 Publication of DK164173C publication Critical patent/DK164173C/da

Links

239000003886 aromatase inhibitor Substances 0.000 title abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
LUJVUUWNAPIQQI-QAGGRKNESA-N androsta-1,4-diene-3,17-dione Chemical class O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 LUJVUUWNAPIQQI-QAGGRKNESA-N 0.000 abstract 1
229940046844 aromatase inhibitors Drugs 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D63/00—Flexible elongated elements, e.g. straps, for bundling or supporting articles
- B65D63/10—Non-metallic straps, tapes, or bands; Filamentary elements, e.g. strings, threads or wires; Joints between ends thereof
- B65D63/12—Joints produced by deformation or tying of ends of elements
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0027—Azides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S383/00—Flexible bags
- Y10S383/905—Dead fold, ductile, closure element
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T24/00—Buckles, buttons, clasps, etc.
- Y10T24/15—Bag fasteners
- Y10T24/153—Plastic band bag tie
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T24/00—Buckles, buttons, clasps, etc.
- Y10T24/15—Bag fasteners
- Y10T24/157—Twist-to-close bag tie
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24008—Structurally defined web or sheet [e.g., overall dimension, etc.] including fastener for attaching to external surface
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31786—Of polyester [e.g., alkyd, etc.]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Mechanical Engineering (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Oncology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Package Frames And Binding Bands (AREA)
Manufacture Of Macromolecular Shaped Articles (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK352086A 1985-08-01 1986-07-24 6-substituerede androsta-1,4-dien-3,17-dionderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende saadanne forbindelser DK164173C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB858519398A GB8519398D0 (en)	1985-08-01	1985-08-01	Steroidic aromatase inhibitors
GB8519398		1985-08-01

Publications (4)

Publication Number	Publication Date
DK352086D0 DK352086D0 (da)	1986-07-24
DK352086A true DK352086A (da)	1987-02-02
DK164173B DK164173B (da)	1992-05-18
DK164173C DK164173C (da)	1992-10-12

Family

ID=10583186

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK352086A DK164173C (da)	1985-08-01	1986-07-24	6-substituerede androsta-1,4-dien-3,17-dionderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende saadanne forbindelser

Country Status (20)

Country	Link
US (1)	US4771043A (da)
EP (1)	EP0210832B1 (da)
JP (1)	JPH07635B2 (da)
KR (1)	KR870002049A (da)
AT (1)	ATE40140T1 (da)
AU (1)	AU584225B2 (da)
CA (1)	CA1252085A (da)
DE (1)	DE3661833D1 (da)
DK (1)	DK164173C (da)
ES (1)	ES2001476A6 (da)
FI (1)	FI84273C (da)
GB (1)	GB8519398D0 (da)
GR (1)	GR861951B (da)
HU (1)	HU197028B (da)
IE (1)	IE60754B1 (da)
IL (1)	IL79465A0 (da)
NZ (1)	NZ216922A (da)
PT (1)	PT83061B (da)
SU (1)	SU1540656A3 (da)
ZA (1)	ZA865525B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8615092D0 (en) *	1986-06-20	1986-07-23	Erba Farmitalia	Androst-4-ene-317-diones
GB8624251D0 (en) *	1986-10-09	1986-11-12	Erba Farmitalia	"1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives
JPH0655982A (ja) *	1992-08-07	1994-03-01	Ikeda Bussan Co Ltd	加飾部材付内装材
JPH0672255A (ja) *	1992-08-31	1994-03-15	Ikeda Bussan Co Ltd	加飾部材付内装材
US20040082557A1 (en) *	2001-01-26	2004-04-29	Wajszczuk Charles Paul	Methods for treating estrogen-dependent disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB892620A (en) *	1957-07-20	1962-03-28	Syntex Sa	Cyclopentanophenanthrene derivatives
GB1042291A (en) *	1961-11-08	1966-09-14	Organon Labor Ltd	í¸-6ª‡-amino steroids and the preparation thereof
GB992998A (en) *	1962-07-17	1965-05-26	Shionogi & Co	Process for preparing 5ª-hydroxy-6ª-aminosteroids of the pregnane series
US3320291A (en) *	1962-10-23	1967-05-16	Du Pont	5-fluoro-6-nitrimino-and 6-keto steroids and their preparation
US3239510A (en) *	1963-03-30	1966-03-08	Shionogi & Co	6-dialkylamino-4-pregnene-3, 20-diones
US3781276A (en) *	1972-07-11	1973-12-25	Schering Corp	6-azido-6-dehydro steroids of the progesterone series,methods for their manufacture and intermediates produced therby
US4028348A (en) *	1976-02-17	1977-06-07	Richter Gedeon Vegyeszeti Gyar Rt	6-Amino-5β,19-cycloandrostane derivatives
AU577677B2 (en) *	1986-02-25	1988-09-29	Development Finance Corporation Of New Zealand, The	Cutting apparatus

1985
- 1985-08-01 GB GB858519398A patent/GB8519398D0/en active Pending
1986
- 1986-07-18 HU HU862969A patent/HU197028B/hu not_active IP Right Cessation
- 1986-07-21 ES ES8600446A patent/ES2001476A6/es not_active Expired
- 1986-07-21 IL IL79465A patent/IL79465A0/xx not_active IP Right Cessation
- 1986-07-21 US US06/887,438 patent/US4771043A/en not_active Expired - Fee Related
- 1986-07-21 AU AU60381/86A patent/AU584225B2/en not_active Ceased
- 1986-07-22 NZ NZ216922A patent/NZ216922A/xx unknown
- 1986-07-23 DE DE8686305647T patent/DE3661833D1/de not_active Expired
- 1986-07-23 EP EP86305647A patent/EP0210832B1/en not_active Expired
- 1986-07-23 AT AT86305647T patent/ATE40140T1/de not_active IP Right Cessation
- 1986-07-24 JP JP61172925A patent/JPH07635B2/ja not_active Expired - Lifetime
- 1986-07-24 ZA ZA865525A patent/ZA865525B/xx unknown
- 1986-07-24 DK DK352086A patent/DK164173C/da not_active IP Right Cessation
- 1986-07-24 GR GR861951A patent/GR861951B/el unknown
- 1986-07-25 CA CA000514647A patent/CA1252085A/en not_active Expired
- 1986-07-25 PT PT83061A patent/PT83061B/pt not_active IP Right Cessation
- 1986-07-25 IE IE197086A patent/IE60754B1/en not_active IP Right Cessation
- 1986-07-25 SU SU864027926A patent/SU1540656A3/ru active
- 1986-07-25 FI FI863068A patent/FI84273C/fi not_active IP Right Cessation
- 1986-07-26 KR KR1019860006111A patent/KR870002049A/ko not_active Ceased

Also Published As

Publication number	Publication date
NZ216922A (en)	1989-07-27
DK164173B (da)	1992-05-18
ES2001476A6 (es)	1988-06-01
GR861951B (en)	1986-11-25
CA1252085A (en)	1989-04-04
FI84273C (fi)	1991-11-11
IE861970L (en)	1987-02-01
PT83061A (en)	1986-08-01
FI863068A0 (fi)	1986-07-25
HUT42783A (en)	1987-08-28
IE60754B1 (en)	1994-08-10
GB8519398D0 (en)	1985-09-04
KR870002049A (ko)	1987-03-28
PT83061B (pt)	1989-02-28
AU584225B2 (en)	1989-05-18
IL79465A0 (en)	1986-10-31
ATE40140T1 (de)	1989-02-15
EP0210832B1 (en)	1989-01-18
JPS6270393A (ja)	1987-03-31
JPH07635B2 (ja)	1995-01-11
US4771043A (en)	1988-09-13
HU197028B (en)	1989-02-28
DE3661833D1 (de)	1989-02-23
FI863068L (fi)	1987-02-02
DK164173C (da)	1992-10-12
ZA865525B (en)	1987-03-25
EP0210832A1 (en)	1987-02-04
AU6038186A (en)	1987-02-05
FI84273B (fi)	1991-07-31
SU1540656A3 (ru)	1990-01-30
DK352086D0 (da)	1986-07-24

Legal Events

Date	Code	Title	Description
1996-03-25	PBP	Patent lapsed
2006-11-27	PUP	Patent expired

Publication	Publication Date	Title
ES8802429A1 (es)	1988-06-01	Un procedimiento para la preparacion de androsta-1,4-dien-3,17-dionas
DK396284D0 (da)	1984-08-17	17beta-methoxycarbonylderivater af androstan-raekken samt deres fremstiling og anvendelse
FI884087A0 (fi)	1988-09-06	Foerfarande foer framstaellning av metylenderivat av androsta-1,4-dien-3,17-dion.
FI91070B (fi)	1994-01-31	Parannus androsta-1,4-dieeni-3,17-dionin 6-metyleenijohdannaisten synteesissä
AU584225B2 (en)	1989-05-18	Steroidic aromatase inhibitors
DE3760277D1 (en)	1989-08-03	New 6- or 7-methylenandrosta-1, 4-diene-3,17-dione derivatives and process for their preparation
FI865259A0 (fi)	1986-12-22	Foerfarande foer framstaellning av 10 -alkynylestrenderivat.
AU2636988A (en)	1989-06-01	New 2-(piperazinyl)-2-substituted flavonoid derivatives, processes for preparing them and pharmaceutical compositions containing them
FI88393C (fi)	1993-05-10	Foerfarande foer framstaellning av 17-substituerade androsta-1,4-dien-3-onderivat
GB1033920A (en)	1966-06-22	Novel derivatives of triphenylethanols
FI932446A0 (fi)	1993-05-28	2b,19-metylaminobrosteroider som aromatasinhibitorer
ES456639A1 (es)	1978-02-01	Un procedimiento de preparacion de los derivados del ciclo- penta (b) tiofeno.