DK355088A - Fremgangsmaade til dehydrogenering af en steroidforbindelse - Google Patents

Fremgangsmaade til dehydrogenering af en steroidforbindelse

Info

Publication number: DK355088A
Authority: DK; Denmark
Prior art keywords: chem; dehydrogenation; steroid; procedure; connection
Prior art date: 1987-06-29

Application number

DK355088A

Other languages

English (en)

Other versions

DK172531B1 (da

DK355088D0 (da

Inventor

Apurba Bhattacharya

Alan W Douglas

Edward J Grabowski

Ulf H Dolling

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-29

Filing date

1988-06-28

Publication date

1989-02-24

1988-06-28 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1988-06-28 Publication of DK355088D0 publication Critical patent/DK355088D0/da

1989-02-24 Publication of DK355088A publication Critical patent/DK355088A/da

1998-04-28 Priority to DK199800580A priority Critical patent/DK175240B1/da

1999-06-21 Application granted granted Critical

1999-06-21 Publication of DK172531B1 publication Critical patent/DK172531B1/da

Links

238000000034 method Methods 0.000 title abstract 2
238000006356 dehydrogenation reaction Methods 0.000 title 1
150000003431 steroids Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)

DK198803550A 1987-06-29 1988-06-28 Fremgangsmåde til fremstilling af et delta1-4-azasteroid DK172531B1 (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK199800580A DK175240B1 (da)	1987-06-29	1998-04-28	Krystallinsk 17beta-(N-tert-butylcarbamoyl)-4-aza-5alfa-androst-1-en-3-on og fremgangsmåde til fremstilling deraf, farmaceutisk præparat indeholdende forbindelsen og anvendelse af forbindelsen til fremstilling af et medikament til behandling

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US6757287A	1987-06-29	1987-06-29
US6756887A	1987-06-29	1987-06-29
US6756887		1987-06-29
US6757287		1987-06-29

Publications (3)

Publication Number	Publication Date
DK355088D0 DK355088D0 (da)	1988-06-28
DK355088A true DK355088A (da)	1989-02-24
DK172531B1 DK172531B1 (da)	1999-06-21

Family

ID=26748021

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198803550A DK172531B1 (da)	1987-06-29	1988-06-28	Fremgangsmåde til fremstilling af et delta1-4-azasteroid

Country Status (16)

Country	Link
EP (1)	EP0298652B1 (da)
JP (1)	JPH0725791B2 (da)
KR (1)	KR960015038B1 (da)
AT (1)	ATE117317T1 (da)
AU (1)	AU608860B2 (da)
CA (1)	CA1331601C (da)
CY (1)	CY1871A (da)
DE (1)	DE3852790T2 (da)
DK (1)	DK172531B1 (da)
ES (1)	ES2066786T3 (da)
GR (1)	GR3015690T3 (da)
HK (1)	HK116695A (da)
IE (1)	IE64996B1 (da)
IL (1)	IL86821A (da)
NZ (1)	NZ225100A (da)
PT (1)	PT87777B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5049562A (en) *	1984-02-27	1991-09-17	Merck & Co., Inc.	17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US5084574A (en) *	1988-04-18	1992-01-28	Merck & Co., Inc.	Dehydrogenation process
US5237061A (en) *	1988-10-31	1993-08-17	Merck & Co., Inc.	Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5021575A (en) *	1989-11-13	1991-06-04	Merck & Co., Inc.	Method for introducing a 1,2 double bond into azasteroids
GB9002922D0 (en) *	1990-02-09	1990-04-04	Erba Carlo Spa	17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
US5091534A (en) *	1990-08-27	1992-02-25	Merck & Co., Inc.	Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
US5187278A (en) *	1990-08-27	1993-02-16	Merck & Co., Inc.	Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-aza-5α-androstan-3-one steroids
US5120847A (en) *	1990-08-27	1992-06-09	Merck & Co., Inc.	Process for iodinating or brominating the α-methylenic carbon of a secondary amide
AU676478B2 (en) *	1992-05-20	1997-03-13	Merck & Co., Inc.	New delta-17 and delta-20 olefinic and saturated 17beta- substituted-4-aza-5alpha-androstan-3-ones as 5alpha- reductase inhibitors
JPH07506575A (ja) *	1992-05-21	1995-07-20	アンドルシェルシュ・インコーポレイテッド	テストステロン５α−レダクターゼ活性の阻害剤
US5468860A (en) *	1992-11-19	1995-11-21	Merck & Co., Inc.	New finasteride processes
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
WO1997015564A1 (en) *	1995-10-26	1997-05-01	Merck & Co., Inc.	4-oxa and 4-thia steroids
JP2004508380A (ja) *	2000-09-07	2004-03-18	ドクター・レディーズ・ラボラトリーズ・リミテッド	１７−β−（Ｎ−ｔｅｒ−ブチルカルバモイル）−４−アザ−５−α−アンドロスト−１−エン−３−オンの新規の多形体及びその調製方法
SK2732003A3 (en) *	2000-09-07	2004-01-08	Reddys Lab Ltd Dr	Novel polymorphic form of 17-beta-(N-ter.butyl carbamoyl)-4-aza- 5-alpha-androst-1-en-3-one and a process for preparing it
KR20030029947A (ko)	2000-09-07	2003-04-16	닥터 레디스 레보러터리즈 리미티드	17-β-(엔-티-부틸카르바모일)-4-아자-5-α-안드로스트-1-엔-3-온의 신규의다형태 및 그 제조방법
US6645974B2 (en)	2001-07-31	2003-11-11	Merck & Co., Inc.	Androgen receptor modulators and methods for use thereof
ES2185503B1 (es) *	2001-09-29	2004-08-01	Ragactives, S.L.	Procedimiento para la obtencion de 17beta-(sustituido)-3-oxoalfa1,2-4-azaesteroides e intermedios.
HU227117B1 (en)	2002-05-10	2010-07-28	Richter Gedeon Nyrt	Process for dehydrogenation of aza-androstane compounds
CN1319985C (zh)	2002-07-16	2007-06-06	西格弗里德杰耐克斯国际两合公司	3－氧代－4－氮杂甾族化合物引入1,2－双键的方法
ES2206065B1 (es)	2002-10-31	2005-08-16	Ragactives, S.L.	Procedimiento para la obtencion de la forma polimorfica i de finasterida.
KR100508019B1 (ko)	2003-07-19	2005-08-17	한미약품 주식회사	고순도 1-안드로스텐 유도체의 제조 방법
DE502004007503D1 (de) *	2003-07-21	2008-08-14	Siegfried Generics Int Ag	Verfahren zur herstellung von alpha, beta-ungesattigten ami dverbindungen
EP2070943A1 (en) *	2007-12-14	2009-06-17	Crystal Pharma, S.A.	Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
DE102010024714C5 (de)	2010-06-23	2018-10-18	Bwg Bergwerk- Und Walzwerk-Maschinenbau Gmbh	Verfahren zum Streckbiegerichten von Metallbändern und Streckbiegerichtanlage
KR102234106B1 (ko) *	2019-07-16	2021-04-01	한국에너지기술연구원	NOx 및 SOx 동시 제거를 위한 흡수제, 조성물 및 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS54109958A (en) *	1978-02-16	1979-08-29	Patpharma Ets	Steroid compound and its manufacture
AU527030B2 (en) *	1978-04-13	1983-02-10	Merck & Co., Inc.	4-aza-17-substituted-5a-androstan-3-ones
ZA802452B (en) *	1979-05-02	1981-04-29	Richardson Merrell Inc	Novel steroid 5 alpha-reductase inhibitors
IL74365A (en) *	1984-02-27	1990-07-26	Merck & Co Inc	17beta-(n-t.-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one and pharmaceutical compositions containing it

1988
- 1988-06-20 NZ NZ225100A patent/NZ225100A/xx unknown
- 1988-06-21 PT PT87777A patent/PT87777B/pt not_active IP Right Cessation
- 1988-06-21 IL IL86821A patent/IL86821A/xx not_active IP Right Cessation
- 1988-06-23 CA CA000570228A patent/CA1331601C/en not_active Expired - Lifetime
- 1988-06-27 ES ES88305926T patent/ES2066786T3/es not_active Expired - Lifetime
- 1988-06-27 AU AU18457/88A patent/AU608860B2/en not_active Expired
- 1988-06-27 EP EP88305926A patent/EP0298652B1/en not_active Expired - Lifetime
- 1988-06-27 DE DE3852790T patent/DE3852790T2/de not_active Expired - Lifetime
- 1988-06-27 AT AT88305926T patent/ATE117317T1/de not_active IP Right Cessation
- 1988-06-28 KR KR1019880007814A patent/KR960015038B1/ko not_active Expired - Fee Related
- 1988-06-28 IE IE195888A patent/IE64996B1/en not_active IP Right Cessation
- 1988-06-28 DK DK198803550A patent/DK172531B1/da not_active IP Right Cessation
- 1988-06-29 JP JP63159579A patent/JPH0725791B2/ja not_active Expired - Fee Related
1995
- 1995-04-04 GR GR950400837T patent/GR3015690T3/el unknown
- 1995-07-13 HK HK116695A patent/HK116695A/en not_active IP Right Cessation
1996
- 1996-04-05 CY CY187196A patent/CY1871A/xx unknown

Also Published As

Publication number	Publication date
DK172531B1 (da)	1999-06-21
EP0298652A3 (en)	1990-03-07
ES2066786T3 (es)	1995-03-16
DK355088D0 (da)	1988-06-28
IL86821A0 (en)	1988-11-30
NZ225100A (en)	1991-09-25
IE64996B1 (en)	1995-10-04
DE3852790D1 (de)	1995-03-02
HK116695A (en)	1995-07-21
KR890000512A (ko)	1989-03-15
AU1845788A (en)	1989-01-05
CY1871A (en)	1996-04-05
PT87777A (pt)	1989-05-31
EP0298652B1 (en)	1995-01-18
KR960015038B1 (ko)	1996-10-24
DE3852790T2 (de)	1995-08-17
CA1331601C (en)	1994-08-23
ATE117317T1 (de)	1995-02-15
EP0298652A2 (en)	1989-01-11
AU608860B2 (en)	1991-04-18
IL86821A (en)	1993-05-13
JPH0725791B2 (ja)	1995-03-22
JPS6479198A (en)	1989-03-24
IE881958L (en)	1988-12-29
PT87777B (pt)	1992-10-30
GR3015690T3 (en)	1995-07-31

Legal Events

Date	Code	Title	Description
1999-06-21	B1	Patent granted (law 1993)
2008-07-14	PUP	Patent expired

Publication	Publication Date	Title
DK355088A (da)	1989-02-24	Fremgangsmaade til dehydrogenering af en steroidforbindelse
IE781234L (en)	1978-12-20	Isoxazolopyridines
PT85025A (en)	1987-07-01	Process for the preparation 2-benzoyl-1,3,5-cyclohexanetriones as well as of intermediates
DK466786D0 (da)	1986-09-30	Fremgangsmaade til fremstilling af n-substituerede dihydrolysergsyre-derivater
NO179408C (no)	1996-10-02	Flytende krystallblanding
NZ233196A (en)	1991-09-25	Process for preparing glutaric acid derivatives and 2-alkoxycarbonylalkyl cyclohexanone derivatives
AU2124892A (en)	1993-02-25	A method and intermediates for the preparation of 6-fluorobenzisothiazoles
DK460585D0 (da)	1985-10-08	Mellemprodukter til fremstilling af prostatriensyrederivater
DK0501369T3 (da)	1995-05-29	Fremgangsmåde til fremstilling af sulfonylisocyanater
CA2095495A1 (en)	1993-12-02	Assay for serum cholinesterase
WO1994008948A3 (en)	1994-06-23	Process for the preparation of oxime derivatives, certain intermediates and the use of the oxime derivatives as fungicides
DE3778088D1 (de)	1992-05-14	Substituierte pyrimidochinoxaline.
NO894191L (no)	1990-06-22	Nye mellomprodukter.