ATE117317T1 - Dehydrierungsverfahren und zwischenprodukte. - Google Patents

Dehydrierungsverfahren und zwischenprodukte.

Info

Publication number: ATE117317T1
Authority: AT; Austria
Prior art keywords: chem; intermediate products; dehydration process; straight; compound
Prior art date: 1987-06-29

Application number

AT88305926T

Other languages

English (en)

Inventor

Apurba Bhattacharya

Alan W Douglas

Edward J Grabowski

Ulf H Dolling

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-29

Filing date

1988-06-27

Publication date

1995-02-15

1988-06-27 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1995-02-15 Application granted granted Critical

1995-02-15 Publication of ATE117317T1 publication Critical patent/ATE117317T1/de

Links

238000000034 method Methods 0.000 title abstract 2
230000018044 dehydration Effects 0.000 title 1
238000006297 dehydration reaction Methods 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Catalysts (AREA)

AT88305926T 1987-06-29 1988-06-27 Dehydrierungsverfahren und zwischenprodukte. ATE117317T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6757287A	1987-06-29	1987-06-29
US6756887A	1987-06-29	1987-06-29

Publications (1)

Publication Number	Publication Date
ATE117317T1 true ATE117317T1 (de)	1995-02-15

Family

ID=26748021

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88305926T ATE117317T1 (de)	1987-06-29	1988-06-27	Dehydrierungsverfahren und zwischenprodukte.

Country Status (16)

Country	Link
EP (1)	EP0298652B1 (de)
JP (1)	JPH0725791B2 (de)
KR (1)	KR960015038B1 (de)
AT (1)	ATE117317T1 (de)
AU (1)	AU608860B2 (de)
CA (1)	CA1331601C (de)
CY (1)	CY1871A (de)
DE (1)	DE3852790T2 (de)
DK (1)	DK172531B1 (de)
ES (1)	ES2066786T3 (de)
GR (1)	GR3015690T3 (de)
HK (1)	HK116695A (de)
IE (1)	IE64996B1 (de)
IL (1)	IL86821A (de)
NZ (1)	NZ225100A (de)
PT (1)	PT87777B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5049562A (en) *	1984-02-27	1991-09-17	Merck & Co., Inc.	17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US5084574A (en) *	1988-04-18	1992-01-28	Merck & Co., Inc.	Dehydrogenation process
US5237061A (en) *	1988-10-31	1993-08-17	Merck & Co., Inc.	Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5021575A (en) *	1989-11-13	1991-06-04	Merck & Co., Inc.	Method for introducing a 1,2 double bond into azasteroids
GB9002922D0 (en) *	1990-02-09	1990-04-04	Erba Carlo Spa	17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
US5091534A (en) *	1990-08-27	1992-02-25	Merck & Co., Inc.	Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
US5120847A (en) *	1990-08-27	1992-06-09	Merck & Co., Inc.	Process for iodinating or brominating the α-methylenic carbon of a secondary amide
US5187278A (en) *	1990-08-27	1993-02-16	Merck & Co., Inc.	Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-aza-5α-androstan-3-one steroids
DE69313114T2 (de) *	1992-05-20	1998-03-19	Merck & Co Inc	NEUE DELTA-17 UND DELTA-20 UNGESÄTIGTE UND GESATIGTE 17--g(b)-SUBSTITUIERTE-4-AZA-5-g(a)-ANDROSTAN-3-ON VERBINDUNGEN ALS INHIBITOREN VON 5-ALPHA-REDUCTASE
UA35589C2 (uk) *	1992-05-21	2001-04-16	Андорешерш Інк.	ІНГІБІТОРИ ТЕСТОСТЕРОН 5-<font face="Symbol">a</font>-РЕДУКТАЗИ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ІНГІБУВАННЯ АКТИВНОСТІ ТЕСТОСТЕРОН 5-<font face="Symbol">a</font>-РЕДУКТАЗИ
US5468860A (en) *	1992-11-19	1995-11-21	Merck & Co., Inc.	New finasteride processes
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
EP0858455A4 (de) *	1995-10-26	2000-04-12	Merck & Co Inc	4-oxa- und 4-thia-steroide
KR20030029947A (ko) *	2000-09-07	2003-04-16	닥터 레디스 레보러터리즈 리미티드	17-β-(엔-티-부틸카르바모일)-4-아자-5-α-안드로스트-1-엔-3-온의 신규의다형태 및 그 제조방법
EP1790653A3 (de) *	2000-09-07	2010-06-02	Dr. Reddy's Laboratories Ltd.	Neue polymorphe Form von 17-beta-(n-ter.butyl carbomyol)-4-aza-5- alpha-androst-1-en-3-one und ein Verfahren zu ihrer Herstellung
PL361014A1 (en) *	2000-09-07	2004-09-20	Dr.Reddy's Laboratories Ltd.	Novel polymorphic form of 17-beta-(n-ter.butyl carbamoyl)-4-aza-5-alpha-androst-1-en-3-one and a process for preparing it
US6645974B2 (en)	2001-07-31	2003-11-11	Merck & Co., Inc.	Androgen receptor modulators and methods for use thereof
ES2185503B1 (es) *	2001-09-29	2004-08-01	Ragactives, S.L.	Procedimiento para la obtencion de 17beta-(sustituido)-3-oxoalfa1,2-4-azaesteroides e intermedios.
HU227117B1 (en)	2002-05-10	2010-07-28	Richter Gedeon Nyrt	Process for dehydrogenation of aza-androstane compounds
US7872135B2 (en)	2002-07-16	2011-01-18	Siegfried Ltd.	Method for introducing a 1,2-double bond into 3-oxo-4-azasteroid compounds
ES2206065B1 (es)	2002-10-31	2005-08-16	Ragactives, S.L.	Procedimiento para la obtencion de la forma polimorfica i de finasterida.
KR100508019B1 (ko) *	2003-07-19	2005-08-17	한미약품 주식회사	고순도 1-안드로스텐 유도체의 제조 방법
WO2005007618A1 (de) *	2003-07-21	2005-01-27	Siegfried Generics International Ag	VERFAHREN ZUR HERSTELLUNG VON α, β-UNGESÄTTIGTEN AMIDVERBINDUNGEN
EP2070943A1 (de) *	2007-12-14	2009-06-17	Crystal Pharma, S.A.	Verfahren zur Herstellung von 6-Alkylidenandrost-1,4-dien-3-onen
DE102010024714C5 (de)	2010-06-23	2018-10-18	Bwg Bergwerk- Und Walzwerk-Maschinenbau Gmbh	Verfahren zum Streckbiegerichten von Metallbändern und Streckbiegerichtanlage
KR102234106B1 (ko) *	2019-07-16	2021-04-01	한국에너지기술연구원	NOx 및 SOx 동시 제거를 위한 흡수제, 조성물 및 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS54109958A (en) *	1978-02-16	1979-08-29	Patpharma Ets	Steroid compound and its manufacture
AU527030B2 (en) *	1978-04-13	1983-02-10	Merck & Co., Inc.	4-aza-17-substituted-5a-androstan-3-ones
ZA802452B (en) *	1979-05-02	1981-04-29	Richardson Merrell Inc	Novel steroid 5 alpha-reductase inhibitors
NZ211145A (en) *	1984-02-27	1988-10-28	Merck & Co Inc	4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions

1988
- 1988-06-20 NZ NZ225100A patent/NZ225100A/xx unknown
- 1988-06-21 IL IL86821A patent/IL86821A/xx not_active IP Right Cessation
- 1988-06-21 PT PT87777A patent/PT87777B/pt not_active IP Right Cessation
- 1988-06-23 CA CA000570228A patent/CA1331601C/en not_active Expired - Lifetime
- 1988-06-27 EP EP88305926A patent/EP0298652B1/de not_active Expired - Lifetime
- 1988-06-27 AT AT88305926T patent/ATE117317T1/de not_active IP Right Cessation
- 1988-06-27 AU AU18457/88A patent/AU608860B2/en not_active Expired
- 1988-06-27 DE DE3852790T patent/DE3852790T2/de not_active Expired - Lifetime
- 1988-06-27 ES ES88305926T patent/ES2066786T3/es not_active Expired - Lifetime
- 1988-06-28 DK DK198803550A patent/DK172531B1/da not_active IP Right Cessation
- 1988-06-28 KR KR1019880007814A patent/KR960015038B1/ko not_active Expired - Fee Related
- 1988-06-28 IE IE195888A patent/IE64996B1/en not_active IP Right Cessation
- 1988-06-29 JP JP63159579A patent/JPH0725791B2/ja not_active Expired - Fee Related
1995
- 1995-04-04 GR GR950400837T patent/GR3015690T3/el unknown
- 1995-07-13 HK HK116695A patent/HK116695A/en not_active IP Right Cessation
1996
- 1996-04-05 CY CY187196A patent/CY1871A/xx unknown

Also Published As

Publication number	Publication date
JPH0725791B2 (ja)	1995-03-22
DE3852790D1 (de)	1995-03-02
IL86821A (en)	1993-05-13
HK116695A (en)	1995-07-21
CY1871A (en)	1996-04-05
KR890000512A (ko)	1989-03-15
IL86821A0 (en)	1988-11-30
AU608860B2 (en)	1991-04-18
DK355088A (da)	1989-02-24
PT87777A (pt)	1989-05-31
EP0298652A3 (en)	1990-03-07
CA1331601C (en)	1994-08-23
ES2066786T3 (es)	1995-03-16
DK355088D0 (da)	1988-06-28
AU1845788A (en)	1989-01-05
DK172531B1 (da)	1999-06-21
EP0298652A2 (de)	1989-01-11
IE64996B1 (en)	1995-10-04
EP0298652B1 (de)	1995-01-18
NZ225100A (en)	1991-09-25
DE3852790T2 (de)	1995-08-17
IE881958L (en)	1988-12-29
GR3015690T3 (en)	1995-07-31
JPS6479198A (en)	1989-03-24
KR960015038B1 (ko)	1996-10-24
PT87777B (pt)	1992-10-30

Legal Events

Date	Code	Title	Description
1995-06-15	UEP	Publication of translation of european patent specification
2008-09-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE117317T1 (de)	1995-02-15	Dehydrierungsverfahren und zwischenprodukte.
DE69532634D1 (de)	2004-04-08	Zwischenprodukte für die herstellung von pharmazeutischem camptothecin
HU906539D0 (en)	1991-04-29	Process for the production of benzinimidazole derivatives and medical preparations containing these compounds as active agents
FI922141A0 (fi)	1992-05-12	Analogiamenetelmä uusien hypoglykeemisten oksatsolidiinidionien valmistamiseksi
ATE21105T1 (de)	1986-08-15	7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
IL88657A (en)	1992-11-15	Preparation of 1-(substituted phenyl)-2-cyclopropylalkanols,novel 1-(substituted phenyl)-3-alkenol derivatives intermediates thereof,and their use as intermediates in the preparation of fungicidal compounds
AU1586588A (en)	1988-11-17	Fungicidal derivatives of propenoic acid and processes for their preparation
NZ233196A (en)	1991-09-25	Process for preparing glutaric acid derivatives and 2-alkoxycarbonylalkyl cyclohexanone derivatives
DK0536512T3 (da)	1998-07-27	Fremgangsmåde og mellemprodukter til fremstillingaf 6-fluorbenzisothiazoler
DK154837C (da)	1989-05-16	Oxadiazolylimidazobenzodiazepinforbindelse og farmaceutisk praeparat indeholdende samme
ATE42947T1 (de)	1989-05-15	Zwischenprodukte fuer die herstellung von 16phenoxy- und 16-substituierten phenoxyprostatriens\|urederivaten.
DE3782566D1 (de)	1992-12-17	Effiziente stereokonservative synthesen von 1-substituierten (s)- und (r)-2-aminomethylpyrrolidinen und zwischenprodukte dazu.
NO943548L (no)	1994-11-23	Fremgangsmåte og mellomprodukter for fremstilling av 2-substituerte benzaldehyder
DE3781986D1 (de)	1992-11-05	Substituierte chinoxaline.
IL101053A0 (en)	1992-11-15	Process for the preparation of sulfonyl isocyanates
DE3778088D1 (de)	1992-05-14	Substituierte pyrimidochinoxaline.
ATE15659T1 (de)	1985-10-15	Synthese von indolinen.
DK27987A (da)	1987-07-23	Fremgangsmaade til fremstilling af alfa-hydroxycarboxylsyreamider
ATE18757T1 (de)	1986-04-15	9,10-bis-(phenylaethinyl)-anthracene.