DK35588A - Hoejniveau-ekspression i e. coli af oploeseligt, modent humant interleukin-1beta og derivater med aendret biologisk virkning - Google Patents

Hoejniveau-ekspression i e. coli af oploeseligt, modent humant interleukin-1beta og derivater med aendret biologisk virkning

Info

Publication number
DK35588A
DK35588A DK035588A DK35588A DK35588A DK 35588 A DK35588 A DK 35588A DK 035588 A DK035588 A DK 035588A DK 35588 A DK35588 A DK 35588A DK 35588 A DK35588 A DK 35588A
Authority
DK
Denmark
Prior art keywords
1beta
coli
derivatives
soluble
high level
Prior art date
Application number
DK035588A
Other languages
English (en)
Other versions
DK35588D0 (da
Inventor
James Jea-Huang Huang
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of DK35588D0 publication Critical patent/DK35588D0/da
Publication of DK35588A publication Critical patent/DK35588A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/72—Expression systems using regulatory sequences derived from the lac-operon

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK035588A 1987-01-27 1988-01-26 Hoejniveau-ekspression i e. coli af oploeseligt, modent humant interleukin-1beta og derivater med aendret biologisk virkning DK35588A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US687087A 1987-01-27 1987-01-27
US07/132,185 US5047505A (en) 1987-01-27 1987-12-18 High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity

Publications (2)

Publication Number Publication Date
DK35588D0 DK35588D0 (da) 1988-01-26
DK35588A true DK35588A (da) 1988-07-28

Family

ID=26676180

Family Applications (1)

Application Number Title Priority Date Filing Date
DK035588A DK35588A (da) 1987-01-27 1988-01-26 Hoejniveau-ekspression i e. coli af oploeseligt, modent humant interleukin-1beta og derivater med aendret biologisk virkning

Country Status (8)

Country Link
US (1) US5047505A (da)
EP (1) EP0276778A3 (da)
KR (1) KR900004428B1 (da)
AU (1) AU597142B2 (da)
CA (1) CA1305080C (da)
DK (1) DK35588A (da)
IL (1) IL85205A0 (da)
NZ (1) NZ223280A (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3587605T2 (de) * 1984-12-25 1994-03-17 Dainippon Pharmaceutical Co Interleukin-1 und dessen Derivat.
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US5290917A (en) * 1988-02-03 1994-03-01 Dainippon Pharmaceutical Co., Ltd. Modified polypeptides of IL-1α
EP0644203A1 (en) * 1988-07-29 1995-03-22 Otsuka Pharmaceutical Co., Ltd. IL-1alpha derivatives and medicament for treating thrombocytopenia
DE69032251T2 (de) * 1989-02-27 1998-08-13 Massachusetts Institute Of Technology, Cambridge, Mass. Il-1, dessen biologische aktivität inhibiert ist
WO1992013885A1 (en) * 1991-02-05 1992-08-20 University Of Maryland MODIFIED INTERLEUKIN-1$g(b)
ES2105972B1 (es) * 1995-08-03 1998-06-01 Cantabria Ind Farmaceutica Sa Un procedimiento para la obtencion de modificadores de las respuestas biologicas con actividad recuperadora de la funcion hematopoyetica a partir, igual e indistintamente, de dos cepas bacterianas fijadoras de n2 azotobacter chroococcum y azotobacter vinelandii.
US6626939B1 (en) * 1997-12-18 2003-09-30 Boston Scientific Scimed, Inc. Stent-graft with bioabsorbable structural support
CA2539467C (en) * 2003-09-08 2012-11-13 Frank Cuttitta Non-peptide agonists and antagonists of adrenomedullin and gastric releasing peptide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468464A (en) * 1974-11-04 1984-08-28 The Board Of Trustees Of The Leland Stanford Junior University Biologically functional molecular chimeras
DE3588241T2 (de) * 1984-05-18 2002-12-05 Massachusetts Institute Of Technology, Cambridge Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
CA1341433C (en) * 1984-06-19 2003-06-24 Douglas P. Cerretti Purification of interleukin 1
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
JP2591615B2 (ja) * 1986-03-14 1997-03-19 大塚製薬株式会社 インターロイキン−１β誘導体及び医薬
AU595864B2 (en) * 1986-03-14 1990-04-12 Otsuka Pharmaceutical Co., Ltd. Il-1 alpha derivatives and drugs

Also Published As

Publication number Publication date
US5047505A (en) 1991-09-10
AU1076388A (en) 1988-07-28
IL85205A0 (en) 1988-07-31
EP0276778A3 (en) 1990-01-10
AU597142B2 (en) 1990-05-24
KR880009127A (ko) 1988-09-14
EP0276778A2 (en) 1988-08-03
CA1305080C (en) 1992-07-14
DK35588D0 (da) 1988-01-26
NZ223280A (en) 1989-11-28
KR900004428B1 (ko) 1990-06-25

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment