DK3580197T3 - Oprensning af pleuromutilin - Google Patents

Oprensning af pleuromutilin Download PDF

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Publication number
DK3580197T3
DK3580197T3 DK18703600.9T DK18703600T DK3580197T3 DK 3580197 T3 DK3580197 T3 DK 3580197T3 DK 18703600 T DK18703600 T DK 18703600T DK 3580197 T3 DK3580197 T3 DK 3580197T3
Authority
DK
Denmark
Prior art keywords
pleuromutilin
purification
Prior art date
Application number
DK18703600.9T
Other languages
English (en)
Inventor
Werner Heilmayer
Lee Spence
Peter Hinsmann
Original Assignee
Nabriva Therapeutics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nabriva Therapeutics GmbH filed Critical Nabriva Therapeutics GmbH
Application granted granted Critical
Publication of DK3580197T3 publication Critical patent/DK3580197T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/48Separation; Purification; Stabilisation; Use of additives
    • C07C67/52Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/36Ortho- or ortho- and peri-condensed systems containing three rings containing eight-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/93Spiro compounds
    • C07C2603/95Spiro compounds containing "not free" spiro atoms
    • C07C2603/98Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members
    • C07C2603/99Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members containing eight-membered rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK18703600.9T 2017-02-10 2018-02-09 Oprensning af pleuromutilin DK3580197T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17155542 2017-02-10
PCT/EP2018/053314 WO2018146264A1 (en) 2017-02-10 2018-02-09 Purification of pleuromutilin

Publications (1)

Publication Number Publication Date
DK3580197T3 true DK3580197T3 (da) 2021-02-08

Family

ID=58017956

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18703600.9T DK3580197T3 (da) 2017-02-10 2018-02-09 Oprensning af pleuromutilin

Country Status (13)

Country Link
US (1) US10913703B2 (da)
EP (1) EP3580197B1 (da)
JP (1) JP7086974B2 (da)
KR (1) KR102509871B1 (da)
CN (1) CN110225903B (da)
CA (1) CA3051643C (da)
DK (1) DK3580197T3 (da)
ES (1) ES2858431T3 (da)
IL (1) IL268550B (da)
MX (1) MX375499B (da)
PT (1) PT3580197T (da)
TW (1) TWI762573B (da)
WO (1) WO2018146264A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2843723T3 (es) * 2015-06-17 2021-07-20 Nabriva Therapeutics GmbH Formulaciones farmacéuticas inyectables de lefamulina
CN113354538A (zh) * 2020-03-03 2021-09-07 新疆上昵生物科技有限公司 一种高纯度截短侧耳素的提取方法
CN115397407A (zh) * 2020-04-17 2022-11-25 纳布里瓦治疗有限责任公司 截短侧耳素类化合物的新治疗用途
AU2021369809A1 (en) * 2020-10-29 2023-05-11 Elanco Tiergesundheit Ag Process for purification of pleuromutilins
JP7636659B2 (ja) * 2020-10-30 2025-02-27 日亜化学工業株式会社 希土類金属錯体の製造方法、希土類金属錯体及び発光装置
CA3216665A1 (en) * 2021-04-16 2022-10-20 Nabriva Therapeutics GmbH Novel 12-epi-mutilin compounds and uses thereof

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092424A (en) 1964-04-17 1978-05-30 Biochemie Ges.M.B.H. Antibiotic derivatives
GB1197942A (en) 1967-08-15 1970-07-08 Biochemie Gmbh Process for the production of the Antibiotic Pleuromutilin
US4129721A (en) 1977-12-08 1978-12-12 Eli Lilly And Company A-40104 antibiotics and process for production thereof
US4247542A (en) 1978-06-22 1981-01-27 Eli Lilly And Company A-40104 Antibiotics and process for production thereof
JP4163254B2 (ja) 1996-01-03 2008-10-08 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ムチリンのカルバモイルオキシ誘導体および抗細菌剤としてのそれらの使用
HUP0001741A3 (en) 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
GB0017031D0 (en) 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
PE20020676A1 (es) 2000-09-13 2002-08-27 Biochemie Gmbh Compuestos de mutilina como antibacterianos
GB0207495D0 (en) 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
GB0209262D0 (en) 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
DE60317208T2 (de) 2002-07-24 2008-08-07 Nabriva Therapeutics Forschungs Gmbh Pleuromutilinderivate als antimikrobielle mittel
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
EP1663220B1 (en) * 2003-09-03 2009-12-02 Glaxo Group Limited Novel process for the preparation of pleuromutilin derivatives
EP1863768A1 (en) 2004-12-13 2007-12-12 Glaxo Group Limited Novel polymorph of (5-amino-6-methoxy-3-pyridincarbonyl)carbamic acid 2-(s)-hydroxymutilin 14-ester
GB0504314D0 (en) * 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph
JP2008534443A (ja) 2005-03-10 2008-08-28 スミスクライン・ビーチャム・コーポレイション 新規な方法
US7790767B2 (en) 2005-06-27 2010-09-07 Nabriva Therapeutics Forschungs Gmbh Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
GB0513058D0 (en) 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
GB0515995D0 (en) 2005-08-03 2005-09-07 Sandoz Ag Organic compounds
TW200738599A (en) 2005-11-18 2007-10-16 Glaxo Group Ltd New pleuromutilin derivative and its use
TW200736203A (en) 2005-11-18 2007-10-01 Glaxo Group Ltd New pleuromutilin derivative and its use
EP1808431A1 (en) 2006-01-16 2007-07-18 Nabriva Therapeutics Forschungs GmbH Mutilin derivatives and their use as pharmaceutical
EP1908750A1 (en) 2006-10-05 2008-04-09 Nabriva Therapeutics Forschungs GmbH Process for the preparation of pleuromutilins
EP1972618A1 (en) 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
EP2014640A1 (en) 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives
EP2014645A1 (en) 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives and their use as antimicrobials
EP2159220A1 (en) 2008-09-02 2010-03-03 Nabriva Therapeutics AG Organic compounds
CN101838199B (zh) * 2010-05-21 2013-01-30 西南大学 截短侧耳素的溶剂提取工艺
EP2399904A1 (en) * 2010-05-26 2011-12-28 Nabriva Therapeutics AG Process for the preparation of pleuromutilins
EP2390245A1 (en) 2010-05-26 2011-11-30 Nabriva Therapeutics AG Enantiomerically pure amines
EP2433926A1 (en) 2010-09-09 2012-03-28 Nabriva Therapeutics AG Pleuromutilin derivatives for use in the treatment of diseases mediated by microbes
CN102050737B (zh) * 2010-12-10 2013-05-08 山东胜利股份有限公司 一种截短侧耳素的提取纯化方法
CN102351698A (zh) * 2011-08-15 2012-02-15 上海华震科技有限公司 一种用吸附色谱法从结晶母液中回收截短侧耳素的方法
BR112016015542B1 (pt) 2014-01-22 2022-08-30 Nabriva Therapeutics Ag 12-epi-pleuromutilinas, seus usos, e composição farmacêutica

Also Published As

Publication number Publication date
ES2858431T3 (es) 2021-09-30
PT3580197T (pt) 2021-03-02
CN110225903A (zh) 2019-09-10
EP3580197B1 (en) 2020-12-02
US10913703B2 (en) 2021-02-09
US20200231529A1 (en) 2020-07-23
CA3051643A1 (en) 2018-08-16
WO2018146264A1 (en) 2018-08-16
CN110225903B (zh) 2022-02-08
IL268550A (en) 2019-09-26
TW201835024A (zh) 2018-10-01
TWI762573B (zh) 2022-05-01
EP3580197A1 (en) 2019-12-18
IL268550B (en) 2021-05-31
KR102509871B1 (ko) 2023-03-14
JP7086974B2 (ja) 2022-06-20
CA3051643C (en) 2024-11-19
MX375499B (es) 2025-03-06
JP2020507572A (ja) 2020-03-12
MX2019008894A (es) 2019-10-09
KR20190117504A (ko) 2019-10-16

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