DK358284D0 - Insulin-derivater, fremgangsmaade til fremstilling deraf samt deres anvendelse til behandling af diabetes mellitus - Google Patents

Insulin-derivater, fremgangsmaade til fremstilling deraf samt deres anvendelse til behandling af diabetes mellitus

Info

Publication number
DK358284D0
DK358284D0 DK358284A DK358284A DK358284D0 DK 358284 D0 DK358284 D0 DK 358284D0 DK 358284 A DK358284 A DK 358284A DK 358284 A DK358284 A DK 358284A DK 358284 D0 DK358284 D0 DK 358284D0
Authority
DK
Denmark
Prior art keywords
procedures
preparing
treatment
diabetes mellitus
insulin derivatives
Prior art date
Application number
DK358284A
Other languages
English (en)
Other versions
DK172211B1 (da
DK358284A (da
Inventor
Ulrich Grau
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK358284D0 publication Critical patent/DK358284D0/da
Publication of DK358284A publication Critical patent/DK358284A/da
Application granted granted Critical
Publication of DK172211B1 publication Critical patent/DK172211B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/622—Insulins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK358284A 1983-07-22 1984-07-20 Basisk modificeret insulin-derivat DK172211B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3326472 1983-07-22
DE19833326472 DE3326472A1 (de) 1983-07-22 1983-07-22 Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus

Publications (3)

Publication Number Publication Date
DK358284D0 true DK358284D0 (da) 1984-07-20
DK358284A DK358284A (da) 1985-01-23
DK172211B1 DK172211B1 (da) 1998-01-05

Family

ID=6204660

Family Applications (2)

Application Number Title Priority Date Filing Date
DK358284A DK172211B1 (da) 1983-07-22 1984-07-20 Basisk modificeret insulin-derivat
DK001790A DK172209B1 (da) 1983-07-22 1990-01-04 Lægemidler indeholdende basisk modificerede insulinderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK001790A DK172209B1 (da) 1983-07-22 1990-01-04 Lægemidler indeholdende basisk modificerede insulinderivater

Country Status (20)

Country Link
US (1) US4701440A (da)
EP (1) EP0132770B1 (da)
JP (2) JPS6042397A (da)
AR (1) AR241864A1 (da)
AT (1) ATE29729T1 (da)
AU (1) AU569097B2 (da)
CA (1) CA1246548A (da)
DE (2) DE3326472A1 (da)
DK (2) DK172211B1 (da)
ES (2) ES534487A0 (da)
FI (1) FI79854C (da)
GR (1) GR81551B (da)
HU (1) HUT37805A (da)
IE (1) IE57709B1 (da)
IL (1) IL72469A (da)
NO (1) NO167810C (da)
NZ (1) NZ208959A (da)
PH (1) PH23014A (da)
PT (1) PT78940A (da)
ZA (1) ZA845620B (da)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
DE3717370A1 (de) * 1987-05-22 1988-12-01 Hoechst Ag Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
DE3827533A1 (de) * 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
AU641631B2 (en) * 1988-12-23 1993-09-30 Novo Nordisk A/S Human insulin analogues
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
WO1992010284A2 (en) 1990-12-07 1992-06-25 Cnc Development, Inc. Catalytic chemical reactor
YU66892A (sh) * 1991-08-20 1995-10-24 Hoechst Ag. Fosfoinositolglikan - peptid sa delovanjem kao insulin
TW224471B (da) * 1991-11-26 1994-06-01 Lilly Co Eli
EP0545198B1 (de) * 1991-11-29 1999-09-15 Hoechst Aktiengesellschaft Peptide mit insulinartiger Wirkung
US5504188A (en) * 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
DE59711533D1 (de) 1996-07-26 2004-05-27 Aventis Pharma Gmbh Insulinderivate mit erhöhter Zinkbindung
DE19649350A1 (de) * 1996-11-28 1998-06-04 Hoechst Ag Inositolglykane mit insulinartiger Wirkung
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
JP4969002B2 (ja) 1999-06-08 2012-07-04 ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン ｒＡＡＶ形質導入を増加するための化合物および方法
AU2002248464A1 (en) 2001-02-21 2002-09-12 Medtronic Minimed, Inc. Stabilized insulin formulations
EP1378492B1 (en) * 2001-02-21 2008-04-02 Seiwa Pro Co., Ltd. Remover for scale deposited on titanium material
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
JP2006521825A (ja) 2003-03-31 2006-09-28 ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン ｒＡＡＶ導入を高めるための化合物および方法
EP1625148B1 (en) * 2003-05-21 2012-09-26 Biotech Tools S.A. Peptide complex
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
KR101853606B1 (ko) 2009-07-06 2018-05-03 사노피-아벤티스 도이칠란트 게엠베하 메티오닌을 함유하는 수성 인슐린 제제
DK2498802T3 (da) 2009-11-13 2015-04-13 Sanofi Aventis Deutschland Farmaceutisk præparat omfattende en glp-1-agonist, et insulin og en methionin
KR101337322B1 (ko) 2009-11-13 2013-12-06 사노피-아벤티스 도이칠란트 게엠베하 Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
ES2606554T3 (es) 2010-08-30 2017-03-24 Sanofi-Aventis Deutschland Gmbh Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl) 2011-08-29 2015-12-31 Sanofi Aventis Deutschland Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
AU2015359376B2 (en) 2014-12-12 2021-09-09 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
WO2017139381A1 (en) 2016-02-08 2017-08-17 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
US11684679B2 (en) 2016-03-07 2023-06-27 University Of Iowa Research Foundation AAV-mediated expression using a synthetic promoter and enhancer
WO2017205739A1 (en) 2016-05-26 2017-11-30 University Of Iowa Research Foundation cis AND trans REQUIREMENTS FOR TERMINAL RESOLUTION OF HUMAN BOCAVIRUS 1
WO2018132747A1 (en) 2017-01-13 2018-07-19 University Of Iowa Research Foundation Bocaparvovirus small noncoding rna and uses thereof
CN113164764B (zh) 2018-09-19 2025-07-29 诺和诺德牛津研究中心有限公司 葡萄糖敏感性胰岛素及其用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2256215C3 (de) * 1972-11-16 1981-01-08 Hoechst Ag, 6000 Frankfurt Insulin-Zubereitung mit einem Gehalt an kristallinem Insulin und amorphem Desphenylalanin8' -insulin
DE2460753A1 (de) * 1974-12-21 1976-06-24 Hoechst Ag Verfahren zur herstellung von humaninsulin
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3334407A1 (de) * 1983-09-23 1985-04-04 Hoechst Ag, 6230 Frankfurt In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
JPH118546A (ja) * 1997-04-24 1999-01-12 Hitachi Ltd Ｃｍｏｓ回路

Also Published As

Publication number Publication date
FI79854C (fi) 1990-03-12
HUT37805A (en) 1986-02-28
IE841889L (en) 1985-01-22
EP0132770A1 (de) 1985-02-13
AR241864A1 (es) 1993-01-29
IE57709B1 (en) 1993-03-10
DE3326472A1 (de) 1985-02-14
DK172211B1 (da) 1998-01-05
NO842977L (no) 1985-01-23
DK1790A (da) 1990-01-04
JPS6042397A (ja) 1985-03-06
AU3092284A (en) 1985-01-24
JPH01294634A (ja) 1989-11-28
AU569097B2 (en) 1988-01-21
NO167810B (no) 1991-09-02
JPH052654B2 (da) 1993-01-13
ZA845620B (en) 1985-02-27
EP0132770B1 (de) 1987-09-16
DK172209B1 (da) 1998-01-05
CA1246548A (en) 1988-12-13
FI842914L (fi) 1985-01-23
FI79854B (fi) 1989-11-30
PT78940A (de) 1984-08-01
ES8505646A1 (es) 1985-06-01
GR81551B (da) 1984-12-11
NO167810C (no) 1991-12-18
DK358284A (da) 1985-01-23
US4701440A (en) 1987-10-20
FI842914A0 (fi) 1984-07-19
DE3466227D1 (en) 1987-10-22
NZ208959A (en) 1989-02-24
DK1790D0 (da) 1990-01-04
JPH0357119B2 (da) 1991-08-30
ATE29729T1 (de) 1987-10-15
IL72469A (en) 1989-07-31
ES535706A0 (es) 1985-06-01
ES8504678A1 (es) 1985-04-16
PH23014A (en) 1989-03-03
IL72469A0 (en) 1984-11-30
ES534487A0 (es) 1985-04-16

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