DK3585776T3 - 5-(pyrimidin-4-yl)-2-(pyrrolidin-1-yl)nicotinonitril-forbindelser som ikke, tbk1 og/eller sik2 kinaseinhibitorer - Google Patents
5-(pyrimidin-4-yl)-2-(pyrrolidin-1-yl)nicotinonitril-forbindelser som ikke, tbk1 og/eller sik2 kinaseinhibitorer Download PDFInfo
- Publication number
- DK3585776T3 DK3585776T3 DK18708187.2T DK18708187T DK3585776T3 DK 3585776 T3 DK3585776 T3 DK 3585776T3 DK 18708187 T DK18708187 T DK 18708187T DK 3585776 T3 DK3585776 T3 DK 3585776T3
- Authority
- DK
- Denmark
- Prior art keywords
- nicotinonitril
- chinase
- sik2
- tbk1
- pyrrolidin
- Prior art date
Links
- YRKLTEBZMAAPHL-UHFFFAOYSA-N 5-pyrimidin-4-yl-2-pyrrolidin-1-ylpyridine-3-carbonitrile Chemical class N1=CN=C(C=C1)C=1C=NC(=C(C#N)C=1)N1CCCC1 YRKLTEBZMAAPHL-UHFFFAOYSA-N 0.000 title 1
- 101000709250 Homo sapiens Serine/threonine-protein kinase SIK2 Proteins 0.000 title 1
- 101000665442 Homo sapiens Serine/threonine-protein kinase TBK1 Proteins 0.000 title 1
- 102100034377 Serine/threonine-protein kinase SIK2 Human genes 0.000 title 1
- 102100038192 Serine/threonine-protein kinase TBK1 Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1702947.1A GB201702947D0 (en) | 2017-02-23 | 2017-02-23 | Novel compounds |
| PCT/GB2018/050475 WO2018154315A1 (en) | 2017-02-23 | 2018-02-23 | 5-(pyrimidin-4-yl)-2-(pyrrolidin-1-yl)nicotinonitrile compounds as ikke, tbk1 and/or sik2 kinases inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3585776T3 true DK3585776T3 (da) | 2021-05-25 |
Family
ID=58544208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18708187.2T DK3585776T3 (da) | 2017-02-23 | 2018-02-23 | 5-(pyrimidin-4-yl)-2-(pyrrolidin-1-yl)nicotinonitril-forbindelser som ikke, tbk1 og/eller sik2 kinaseinhibitorer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11058686B2 (da) |
| EP (1) | EP3585776B1 (da) |
| JP (1) | JP7136793B2 (da) |
| AU (1) | AU2018224359B2 (da) |
| CA (1) | CA3054343A1 (da) |
| DK (1) | DK3585776T3 (da) |
| ES (1) | ES2879821T3 (da) |
| GB (1) | GB201702947D0 (da) |
| WO (1) | WO2018154315A1 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115073425B (zh) * | 2021-03-16 | 2023-11-14 | 中国科学院上海药物研究所 | 一类作为tbk1抑制剂的化合物、包含其的药物组合物及其用途 |
| CN120641410A (zh) * | 2022-12-27 | 2025-09-12 | 豪夫迈·罗氏有限公司 | 可用作sik调节剂的苯并咪唑衍生物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1648875A1 (en) | 2003-07-30 | 2006-04-26 | Cyclacel Limited | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors |
| WO2006021458A2 (en) | 2004-08-27 | 2006-03-02 | Gpc Biotech Ag | Pyrimidine derivatives |
| ES2535166T3 (es) | 2007-09-04 | 2015-05-06 | The Scripps Research Institute | Pirimidinil-aminas sustituidas como inhibidores de proteína-quinasas |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| US20100056524A1 (en) * | 2008-04-02 | 2010-03-04 | Mciver Edward Giles | Compound |
| PA8852901A1 (es) * | 2008-12-22 | 2010-07-27 | Lilly Co Eli | Inhibidores de proteina cinasa |
| CN102791697A (zh) | 2009-10-12 | 2012-11-21 | 瑞科西有限公司 | 作为TBKL和/或IKKε抑制剂的氨基-嘧啶化合物 |
| GB201012105D0 (en) * | 2010-07-19 | 2010-09-01 | Domainex Ltd | Novel pyrimidine compounds |
| DE102011008352A1 (de) | 2011-01-12 | 2012-07-12 | Merck Patent Gmbh | 5-([1,2,3]Triazol-4-yl)-7H-pyrrolo-[2,3-d]pyrimidinderivate |
| DE102011009961A1 (de) | 2011-02-01 | 2012-08-02 | Merck Patent Gmbh | 7-Azaindolderivate |
| BR112013026202A2 (pt) | 2011-04-12 | 2017-07-25 | Myrexis Inc | composições e usos terapêuticos de inibidores quinase epsilon relacionado a ikk e quinase i de ligação a tank |
| CA2832605C (en) | 2011-05-23 | 2016-03-29 | Merck Patent Gmbh | Pyridine-and pyrazine derivatives |
| GB201114051D0 (en) | 2011-08-15 | 2011-09-28 | Domainex Ltd | Compounds and their uses |
| DE102011112978A1 (de) | 2011-09-09 | 2013-03-14 | Merck Patent Gmbh | Benzonitrilderivate |
| DE102011119127A1 (de) | 2011-11-22 | 2013-05-23 | Merck Patent Gmbh | 3-Cyanaryl-1H-pyrrolo[2.3-b]pyridin-Derivate |
| SG11201404630UA (en) | 2012-02-09 | 2014-09-26 | Merck Patent Gmbh | Furo [3, 2 - b] - and thieno [3, 2 - b] pyridine derivatives as tbk1 and ikk inhibitors |
| GB201303109D0 (en) * | 2013-02-21 | 2013-04-10 | Domainex Ltd | Novel pyrimidine compounds |
-
2017
- 2017-02-23 GB GBGB1702947.1A patent/GB201702947D0/en not_active Ceased
-
2018
- 2018-02-23 AU AU2018224359A patent/AU2018224359B2/en not_active Ceased
- 2018-02-23 WO PCT/GB2018/050475 patent/WO2018154315A1/en not_active Ceased
- 2018-02-23 JP JP2019546380A patent/JP7136793B2/ja active Active
- 2018-02-23 DK DK18708187.2T patent/DK3585776T3/da active
- 2018-02-23 US US16/487,977 patent/US11058686B2/en not_active Expired - Fee Related
- 2018-02-23 EP EP18708187.2A patent/EP3585776B1/en active Active
- 2018-02-23 ES ES18708187T patent/ES2879821T3/es active Active
- 2018-02-23 CA CA3054343A patent/CA3054343A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020508341A (ja) | 2020-03-19 |
| US11058686B2 (en) | 2021-07-13 |
| EP3585776B1 (en) | 2021-02-17 |
| AU2018224359A1 (en) | 2019-10-17 |
| AU2018224359B2 (en) | 2022-03-31 |
| WO2018154315A1 (en) | 2018-08-30 |
| ES2879821T3 (es) | 2021-11-23 |
| CA3054343A1 (en) | 2018-08-30 |
| GB201702947D0 (en) | 2017-04-12 |
| US20200030326A1 (en) | 2020-01-30 |
| EP3585776A1 (en) | 2020-01-01 |
| JP7136793B2 (ja) | 2022-09-13 |
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