DK3724196T3 - Substituerede azetidindihydrothienopyridiner og anvendelse deraf som phosphodiesterasehæmmere - Google Patents
Substituerede azetidindihydrothienopyridiner og anvendelse deraf som phosphodiesterasehæmmere Download PDFInfo
- Publication number
- DK3724196T3 DK3724196T3 DK18830422.4T DK18830422T DK3724196T3 DK 3724196 T3 DK3724196 T3 DK 3724196T3 DK 18830422 T DK18830422 T DK 18830422T DK 3724196 T3 DK3724196 T3 DK 3724196T3
- Authority
- DK
- Denmark
- Prior art keywords
- dihydrothienopyridines
- azetide
- substituted
- phosphodiesterase inhibitors
- phosphodiesterase
- Prior art date
Links
- XAXXTYXMWOFKLW-UHFFFAOYSA-N [C-]1=CC=[NH+]1 Chemical class [C-]1=CC=[NH+]1 XAXXTYXMWOFKLW-UHFFFAOYSA-N 0.000 title 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 title 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17207661 | 2017-12-15 | ||
| PCT/EP2018/084978 WO2019115776A1 (en) | 2017-12-15 | 2018-12-14 | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3724196T3 true DK3724196T3 (da) | 2023-01-16 |
Family
ID=60673681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18830422.4T DK3724196T3 (da) | 2017-12-15 | 2018-12-14 | Substituerede azetidindihydrothienopyridiner og anvendelse deraf som phosphodiesterasehæmmere |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11384096B2 (da) |
| EP (1) | EP3724196B9 (da) |
| JP (1) | JP7203846B2 (da) |
| CN (1) | CN111727191B (da) |
| DK (1) | DK3724196T3 (da) |
| ES (1) | ES2935615T3 (da) |
| FI (1) | FI3724196T3 (da) |
| PT (1) | PT3724196T (da) |
| WO (1) | WO2019115776A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018286964B2 (en) | 2017-06-20 | 2022-04-14 | UNION therapeutics A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| US11365204B2 (en) | 2017-09-20 | 2022-06-21 | UNION therapeutics A/S | Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
| WO2019115776A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
| JP2025528779A (ja) * | 2022-08-09 | 2025-09-02 | シーザン ハイスーク ファーマシューティカル カンパニー リミテッド | Ｐｄｅ４ｂ阻害剤及びその用途 |
| EP4678644A1 (en) | 2023-04-13 | 2026-01-14 | Shanghai Yidi Biotechnology Co., Ltd. | Substituted dihydrothienopyrimidine compound, preparation method therefor, and use thereof |
| GB202306662D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Dosage regimen |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03148337A (ja) | 1989-10-31 | 1991-06-25 | Aisin Seiki Co Ltd | ２輪／４輪駆動制御装置 |
| AU4967697A (en) | 1996-11-19 | 1998-06-10 | Kyowa Hakko Kogyo Co. Ltd. | Oxygenic heterocyclic compounds |
| DE19730847A1 (de) * | 1997-07-18 | 1999-01-28 | Bayer Ag | Tricyclisch substituierte Oxazolidinone |
| JPH1159216A (ja) | 1997-08-26 | 1999-03-02 | Fuji Heavy Ind Ltd | ４輪駆動車の動力配分制御装置 |
| FR2799417B1 (fr) | 1999-10-08 | 2009-01-23 | Toyota Motor Co Ltd | Dispositif de controle de vehicule, notamment pour la repartition des forces de traction avant-arriere |
| WO2003055890A1 (en) | 2001-12-21 | 2003-07-10 | Bayer Pharmaceuticals Corporation | Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| US6630813B2 (en) | 2002-03-06 | 2003-10-07 | Ford Global Technologies, Llc | Method and apparatus for monitoring the state of the battery of a hybrid electric vehicle |
| CA2528603A1 (en) * | 2003-06-20 | 2004-12-29 | Celltech R & D Limited | Thienopyridone derivatives as kinase inhibitors |
| US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
| US20110034495A1 (en) * | 2005-11-23 | 2011-02-10 | Intermune, Inc. | Method of Modulating Stress-Activated Protein Kinase System |
| JP2009523805A (ja) | 2006-01-17 | 2009-06-25 | シグナル ファーマシューティカルズ，エルエルシー | ＴＮＦα、ＰＤＥ４及びＢ−ＲＡＦの阻害剤、それらの組成物及びそれらの使用法 |
| HRP20090395T1 (hr) | 2006-04-19 | 2009-08-31 | Boehringer Ingelheim International Gmbh | Dihidrotienpirimidini za liječenje upalnih bolesti |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| WO2008045664A2 (en) * | 2006-10-06 | 2008-04-17 | Kalypsys, Inc. | Heterocyclic pde4 inhibitors as antiinflammatory agents |
| WO2008064829A2 (en) * | 2006-11-30 | 2008-06-05 | Ucb Pharma, S.A. | Novel aminothienopyridinone derivatives processes for preparing them and pharmaceutical compositions thereof |
| PL2114951T3 (pl) | 2007-02-28 | 2014-10-31 | Leo Pharma As | Nowe inhibitory fosfodiesterazy |
| SI2610258T1 (sl) * | 2007-10-19 | 2014-12-31 | Boehringer Ingelheim International Gmbh | Substituirani piperidino-dihidrotienopirimidini |
| EP2215093B1 (de) | 2007-10-19 | 2011-12-14 | Boehringer Ingelheim International GmbH | Neue piperazino-dihydrothienopyrimidin-derivate |
| RU2500681C2 (ru) | 2007-10-19 | 2013-12-10 | Берингер Ингельхайм Интернациональ Гмбх | Замещенные гетероциклом пиперазинодигидротиенопиримидины |
| CA2702447A1 (en) | 2007-10-19 | 2009-04-30 | Boehringer Ingelheim International Gmbh | New phenyl-substituted piperazino-dihydrothienopyrimidines |
| PL2379548T3 (pl) | 2008-12-19 | 2016-08-31 | Leo Pharma As | Triazolopirydyny jako inhibitory fosfodiesterazy do leczenia chorób skórnych |
| JP2012519160A (ja) * | 2009-02-27 | 2012-08-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４阻害剤及びｎｓａｉｄを含有する組み合わせ薬 |
| JP5690823B2 (ja) * | 2009-07-08 | 2015-03-25 | レオ ファーマ アクティーゼルスカブ | Ｊａｋ受容体およびタンパク質チロシンキナーゼ阻害薬としての複素環化合物 |
| RU2012130929A (ru) | 2009-12-23 | 2014-01-27 | Байокрист Фармасьютикалз, Инк. | Гетероциклические соединения в качестве ингибиторов янус-киназы |
| WO2011124525A1 (de) * | 2010-04-08 | 2011-10-13 | Boehringer Ingelheim International Gmbh | Arnzeimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten |
| CA2800578A1 (en) * | 2010-05-13 | 2011-11-17 | Amgen Inc. | Nitrogen-heterocyclic compounds as phosphodiesterase 10 inhibitors |
| JP6174997B2 (ja) | 2010-06-24 | 2017-08-02 | レオ ファーマ アクティーゼルスカブ | ホスホジエステラーゼ阻害剤としてのベンゾジオキソールまたはベンゾジオキセピンヘテロ環化合物 |
| RS55624B1 (sr) * | 2011-02-07 | 2017-06-30 | Scipharm Sàrl | Nova kompozicija za lečenje cistične fibroze |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| MX2014006812A (es) | 2011-12-21 | 2014-10-13 | Leo Pharma As | [1,2,4] triazolopiridinas y su uso como inhibidores de fosfodiesterasa. |
| WO2014066659A1 (en) | 2012-10-25 | 2014-05-01 | Tetra Discovery Partners, Llc. | Heteroaryl inhibitors of pde4 |
| WO2014124860A1 (en) * | 2013-02-14 | 2014-08-21 | Boehringer Ingelheim International Gmbh | Specific pde4b-inhibitors for the treatment of diabetes mellitus |
| JP6785666B2 (ja) | 2014-06-23 | 2020-11-18 | レオ ファーマ アクティーゼルスカブ | １，３−ベンゾジオキソール複素環化合物の調製方法 |
| DK3390407T3 (da) | 2015-12-18 | 2023-11-06 | Union Therapeutics As | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser |
| CN110088108B (zh) | 2016-12-12 | 2024-06-14 | 联合疗法公司 | 取代的吡唑并氮杂䓬-4-酮类及其作为磷酸二酯酶抑制剂的用途 |
| US11065257B2 (en) | 2016-12-12 | 2021-07-20 | Leo Pharma A/S | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
| ES2874632T3 (es) | 2016-12-12 | 2021-11-05 | Union Therapeutics As | Pirazoloazepin-8-onas sustituidas y su uso como inhibidores de la fosfodiesterasa |
| AU2018286964B2 (en) | 2017-06-20 | 2022-04-14 | UNION therapeutics A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| US11365204B2 (en) | 2017-09-20 | 2022-06-21 | UNION therapeutics A/S | Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
| WO2019115776A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
| WO2019115774A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
| WO2019115775A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
| KR20210117300A (ko) | 2019-01-15 | 2021-09-28 | 유니온 테라퓨틱스 에이/에스 | 포스포디에스테라제 억제제를 함유하는 변형 방출 정제 제형 |
-
2018
- 2018-12-14 WO PCT/EP2018/084978 patent/WO2019115776A1/en not_active Ceased
- 2018-12-14 EP EP18830422.4A patent/EP3724196B9/en active Active
- 2018-12-14 CN CN201880089287.6A patent/CN111727191B/zh active Active
- 2018-12-14 ES ES18830422T patent/ES2935615T3/es active Active
- 2018-12-14 JP JP2020532754A patent/JP7203846B2/ja active Active
- 2018-12-14 US US16/772,615 patent/US11384096B2/en not_active Expired - Fee Related
- 2018-12-14 DK DK18830422.4T patent/DK3724196T3/da active
- 2018-12-14 FI FIEP18830422.4T patent/FI3724196T3/fi active
- 2018-12-14 PT PT188304224T patent/PT3724196T/pt unknown
-
2022
- 2022-06-08 US US17/805,875 patent/US11981681B2/en active Active
-
2024
- 2024-04-09 US US18/630,898 patent/US20240400578A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7203846B2 (ja) | 2023-01-13 |
| CN111727191A (zh) | 2020-09-29 |
| US11384096B2 (en) | 2022-07-12 |
| ES2935615T3 (es) | 2023-03-08 |
| EP3724196B9 (en) | 2023-03-22 |
| ES2935615T9 (es) | 2023-04-03 |
| FI3724196T3 (fi) | 2023-01-31 |
| US20230087354A1 (en) | 2023-03-23 |
| US20240400578A1 (en) | 2024-12-05 |
| US11981681B2 (en) | 2024-05-14 |
| JP2021506806A (ja) | 2021-02-22 |
| CN111727191B (zh) | 2024-01-05 |
| WO2019115776A1 (en) | 2019-06-20 |
| EP3724196A1 (en) | 2020-10-21 |
| EP3724196B1 (en) | 2022-11-16 |
| US20210079012A1 (en) | 2021-03-18 |
| PT3724196T (pt) | 2023-01-13 |
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