DK3615515T3 - Propionsyrederivater og fremgangsmåder til anvendelse deraf - Google Patents

Propionsyrederivater og fremgangsmåder til anvendelse deraf Download PDF

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Publication number
DK3615515T3
DK3615515T3 DK18799302.7T DK18799302T DK3615515T3 DK 3615515 T3 DK3615515 T3 DK 3615515T3 DK 18799302 T DK18799302 T DK 18799302T DK 3615515 T3 DK3615515 T3 DK 3615515T3
Authority
DK
Denmark
Prior art keywords
methods
propionic acid
acid derivatives
derivatives
propionic
Prior art date
Application number
DK18799302.7T
Other languages
Danish (da)
English (en)
Inventor
Ronald J Biediger
Michele A Benish
Lindsay Bonner Hardy
Vincent A Boyd
Robert V Market
Thomas P Thrash
Brandon M Young
Original Assignee
Aviara Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aviara Pharmaceuticals Inc filed Critical Aviara Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3615515T3 publication Critical patent/DK3615515T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK18799302.7T 2017-04-26 2018-06-25 Propionsyrederivater og fremgangsmåder til anvendelse deraf DK3615515T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/497,416 US10246451B2 (en) 2017-04-26 2017-04-26 Propionic acid derivatives and methods of use thereof
PCT/US2018/039291 WO2018209363A2 (en) 2017-04-26 2018-06-25 Propionic acid derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
DK3615515T3 true DK3615515T3 (da) 2024-11-11

Family

ID=63916458

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18799302.7T DK3615515T3 (da) 2017-04-26 2018-06-25 Propionsyrederivater og fremgangsmåder til anvendelse deraf

Country Status (7)

Country Link
US (2) US10246451B2 (de)
EP (1) EP3615515B1 (de)
CN (1) CN110914241B (de)
AU (1) AU2018266966B2 (de)
CA (1) CA3061363A1 (de)
DK (1) DK3615515T3 (de)
WO (1) WO2018209363A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10246451B2 (en) * 2017-04-26 2019-04-02 Aviara Pharmaceuticals, Inc. Propionic acid derivatives and methods of use thereof
EP3773573B1 (de) 2018-04-12 2026-03-18 Morphic Therapeutic, Inc. Antagonisten von humanem integrin (alpha4) (beta7)
FI3873884T3 (fi) 2018-10-30 2025-02-24 Gilead Sciences Inc 3-(kinolin-8-yyli)-1,4-dihydropyrido[3,4-d]pyrimidiini-2,4-dionijohdannaisia alfa-4-beta-7-integriinin estäjinä tulehdussairauksien hoidossa
JP7189368B2 (ja) 2018-10-30 2022-12-13 ギリアード サイエンシーズ, インコーポレイテッド アルファ4ベータ7インテグリンの阻害のための化合物
ES3013256T3 (en) 2018-10-30 2025-04-11 Gilead Sciences Inc Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases
EP3873605B1 (de) 2018-10-30 2024-10-23 Gilead Sciences, Inc. Verbindungen zur inhibierung von alpha4-beta7-integrin
WO2021030438A1 (en) 2019-08-14 2021-02-18 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
TWI775182B (zh) 2019-10-16 2022-08-21 美商莫菲克醫療股份有限公司 抑制人類整合素αβ
EP4452248A4 (de) * 2021-12-20 2025-12-10 Nimml Inst Immunregulatorische verbindungen
KR20250061759A (ko) * 2022-09-09 2025-05-08 시젱 하이스코 파마수티칼 씨오., 엘티디. 프로피온산 유도체 및 이의 의약에서의 응용

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6972296B2 (en) * 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
ATE383153T1 (de) * 1999-05-07 2008-01-15 Encysive Pharmaceuticals Inc Carbonsäurederivate die die bindung von integrinen an ihre rezeptoren hemmen
US10246451B2 (en) * 2017-04-26 2019-04-02 Aviara Pharmaceuticals, Inc. Propionic acid derivatives and methods of use thereof

Also Published As

Publication number Publication date
CN110914241B (zh) 2023-11-14
EP3615515A2 (de) 2020-03-04
EP3615515B1 (de) 2024-09-25
US20180312498A1 (en) 2018-11-01
WO2018209363A3 (en) 2019-01-03
US10494367B2 (en) 2019-12-03
AU2018266966A1 (en) 2019-12-19
WO2018209363A2 (en) 2018-11-15
CA3061363A1 (en) 2018-11-15
AU2018266966B2 (en) 2022-09-01
US20190225602A1 (en) 2019-07-25
EP3615515A4 (de) 2020-09-02
US10246451B2 (en) 2019-04-02
CN110914241A (zh) 2020-03-24

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