DK3621966T3 - Pyrazol[1,5-a]pyrimidinderivater som kinase jak-inhibitorer - Google Patents

Pyrazol[1,5-a]pyrimidinderivater som kinase jak-inhibitorer Download PDF

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Publication number
DK3621966T3
DK3621966T3 DK18723532.0T DK18723532T DK3621966T3 DK 3621966 T3 DK3621966 T3 DK 3621966T3 DK 18723532 T DK18723532 T DK 18723532T DK 3621966 T3 DK3621966 T3 DK 3621966T3
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DK
Denmark
Prior art keywords
pyrazole
chinese
pyrimidine derivatives
jak inhibitors
jak
Prior art date
Application number
DK18723532.0T
Other languages
English (en)
Inventor
Michal Mroczkiewicz
Bartosz Stypik
Anna Bujak
Krzysztof Szymczak
Pawel Gunerka
Maciej Wieczorek
Krzysztof Dubiel
Jerzy Pieczykolan
Original Assignee
Celon Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celon Pharma Sa filed Critical Celon Pharma Sa
Application granted granted Critical
Publication of DK3621966T3 publication Critical patent/DK3621966T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK18723532.0T 2017-05-12 2018-05-10 Pyrazol[1,5-a]pyrimidinderivater som kinase jak-inhibitorer DK3621966T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL421576A PL233595B1 (pl) 2017-05-12 2017-05-12 Pochodne pirazolo[1,5-a]pirymidyny jako inhibitory kinazy JAK
PCT/EP2018/062164 WO2018206739A1 (en) 2017-05-12 2018-05-10 Pyrazole[1,5-a]pyrimidine derivatives as kinase jak inhibitors

Publications (1)

Publication Number Publication Date
DK3621966T3 true DK3621966T3 (da) 2021-01-18

Family

ID=64104351

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18723532.0T DK3621966T3 (da) 2017-05-12 2018-05-10 Pyrazol[1,5-a]pyrimidinderivater som kinase jak-inhibitorer

Country Status (17)

Country Link
US (1) US11072619B2 (da)
EP (1) EP3621966B1 (da)
JP (1) JP7157084B2 (da)
KR (1) KR102533519B1 (da)
CN (1) CN110612302B (da)
AU (1) AU2018265457B2 (da)
CA (1) CA3059829A1 (da)
DK (1) DK3621966T3 (da)
EA (1) EA038273B1 (da)
ES (1) ES2845230T3 (da)
HR (1) HRP20210021T1 (da)
HU (1) HUE052997T2 (da)
MX (1) MX392641B (da)
PL (2) PL233595B1 (da)
PT (1) PT3621966T (da)
SI (1) SI3621966T1 (da)
WO (1) WO2018206739A1 (da)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4881558B2 (ja) * 2002-09-04 2012-02-22 シェーリング コーポレイション サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
EP1725235B1 (en) 2004-02-05 2009-04-15 Schering Corporation Piperidine derivatives useful as ccr3 antagonists
DE602005023763D1 (de) * 2004-11-04 2010-11-04 Vertex Pharma Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine
US20100105661A1 (en) 2007-01-12 2010-04-29 Astellas Pharma Inc. Condensed pyridine compound
UA110324C2 (en) * 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
JP2013501003A (ja) 2009-07-31 2013-01-10 バイオクライスト ファーマシューティカルズ， インコーポレイテッド ヤヌスキナーゼ阻害剤としてのピロロ［１，２−ｂ］ピリダジン誘導体
EA022120B1 (ru) * 2009-10-20 2015-11-30 Целльзом Лимитид Аналоги гетероциклил пиразолопиримидина в качестве ингибиторов jak
TW201249846A (en) 2011-03-17 2012-12-16 Bristol Myers Squibb Co Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
US8921368B2 (en) 2011-03-17 2014-12-30 Bristol-Myers Squibb Company Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
UA111854C2 (uk) * 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
EP2892899B1 (en) * 2012-09-06 2018-03-21 Bristol-Myers Squibb Company Imidazopyridazine jak3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
PL407081A1 (pl) * 2014-02-05 2015-08-17 Celon Pharma Spółka Akcyjna Pochodne pirazolo[1,5-a]pirymidyny jako inhibitory kinazy JAK-2

Also Published As

Publication number Publication date
PT3621966T (pt) 2021-01-20
PL3621966T3 (pl) 2021-06-28
BR112019023480A2 (pt) 2020-06-30
HRP20210021T1 (hr) 2021-02-19
PL233595B1 (pl) 2019-11-29
US11072619B2 (en) 2021-07-27
CN110612302A (zh) 2019-12-24
CN110612302B (zh) 2022-06-14
JP7157084B2 (ja) 2022-10-19
HUE052997T2 (hu) 2021-06-28
AU2018265457B2 (en) 2022-06-30
SI3621966T1 (sl) 2021-04-30
ES2845230T3 (es) 2021-07-26
AU2018265457A1 (en) 2019-10-24
MX392641B (es) 2025-03-24
WO2018206739A1 (en) 2018-11-15
EA201992632A1 (ru) 2020-04-13
CA3059829A1 (en) 2018-11-15
EP3621966A1 (en) 2020-03-18
KR20200005562A (ko) 2020-01-15
MX2019013462A (es) 2020-01-15
EP3621966B1 (en) 2020-11-18
EA038273B1 (ru) 2021-08-03
US20200199128A1 (en) 2020-06-25
PL421576A1 (pl) 2018-11-19
KR102533519B1 (ko) 2023-05-17
JP2020519631A (ja) 2020-07-02

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