DK3419978T3 - Pyrazolo[1,5-A]pyrazin-4-yl-derivater som JAK-hæmmere - Google Patents

Pyrazolo[1,5-A]pyrazin-4-yl-derivater som JAK-hæmmere Download PDF

Info

Publication number: DK3419978T3
Authority: DK; Denmark
Prior art keywords: pyrazin; pyrazolo; derivatives; jak inhibitors; jak
Prior art date: 2016-02-24

Application number

DK17705705.6T

Other languages

English (en)

Inventor

Matthew Frank Brown

Alpay DERMENCI

Andrew Fensome

Brian Stephen Gerstenberger

Matthew Merrill Hayward

Dafydd Rhys Owen

Stephen Wayne Wright

Li Huang Xing

Xiaojing Yang

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-02-24

Filing date

2017-02-10

Publication date

2020-06-02

2017-02-10 Application filed by Pfizer filed Critical Pfizer

2020-06-02 Application granted granted Critical

2020-06-02 Publication of DK3419978T3 publication Critical patent/DK3419978T3/da

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

DK17705705.6T 2016-02-24 2017-02-10 Pyrazolo[1,5-A]pyrazin-4-yl-derivater som JAK-hæmmere DK3419978T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201662299130P	2016-02-24	2016-02-24
PCT/IB2017/050748 WO2017144995A1 (en)	2016-02-24	2017-02-10	Pyrazolo[1,5-a]pyrazin-4-yl derivatives as jak-inhibitors

Publications (1)

Publication Number	Publication Date
DK3419978T3 true DK3419978T3 (da)	2020-06-02

Family

ID=58054385

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK17705705.6T DK3419978T3 (da)	2016-02-24	2017-02-10	Pyrazolo[1,5-A]pyrazin-4-yl-derivater som JAK-hæmmere

Country Status (44)

Country	Link
US (4)	US10144738B2 (da)
EP (2)	EP3712153B1 (da)
JP (1)	JP6505956B2 (da)
KR (1)	KR102128671B1 (da)
CN (1)	CN109071546B (da)
AR (1)	AR107714A1 (da)
AU (1)	AU2017222417B2 (da)
CA (1)	CA2958490C (da)
CL (1)	CL2018002358A1 (da)
CO (1)	CO2018008799A2 (da)
CR (1)	CR20180372A (da)
CU (1)	CU24511B1 (da)
CY (1)	CY1122949T1 (da)
DK (1)	DK3419978T3 (da)
DO (1)	DOP2018000187A (da)
EA (1)	EA035036B1 (da)
EC (1)	ECSP18072109A (da)
ES (1)	ES2794779T3 (da)
GE (1)	GEP20217242B (da)
HR (1)	HRP20200781T1 (da)
HU (1)	HUE049305T2 (da)
IL (1)	IL260923B (da)
LT (1)	LT3419978T (da)
MA (2)	MA43668B1 (da)
MD (1)	MD3419978T2 (da)
ME (1)	ME03743B (da)
MX (1)	MX383747B (da)
MY (1)	MY189118A (da)
NI (1)	NI201800080A (da)
NZ (1)	NZ744349A (da)
PH (1)	PH12018501788A1 (da)
PL (1)	PL3419978T3 (da)
PT (1)	PT3419978T (da)
RS (1)	RS60261B1 (da)
RU (1)	RU2718902C2 (da)
SG (1)	SG11201806307YA (da)
SI (1)	SI3419978T1 (da)
SV (1)	SV2018005726A (da)
TN (1)	TN2018000295A1 (da)
TW (1)	TWI665201B (da)
UA (1)	UA119835C2 (da)
UY (1)	UY37133A (da)
WO (1)	WO2017144995A1 (da)
ZA (1)	ZA201804972B (da)

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BR112020021612A2 (pt)	2018-05-17	2021-01-26	Bayer Aktiengesellschaft	derivados substituídos de di-hidropirazolo pirazina carboxamida
EP3810610A1 (en)	2018-05-18	2021-04-28	Incyte Corporation	Fused pyrimidine derivatives as a2a / a2b inhibitors
AU2019297361B2 (en)	2018-07-05	2024-06-27	Incyte Corporation	Fused pyrazine derivatives as A2A / A2B inhibitors
AR116592A1 (es)	2018-10-17	2021-05-26	Lilly Co Eli	Tratamiento de la colangitis biliar primaria y la colangitis esclerosante primaria con baricitinib
TWI829857B (zh)	2019-01-29	2024-01-21	美商英塞特公司	作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
PL3954689T3 (pl) *	2019-04-12	2024-08-05	Primegene (Beijing) Co., Ltd.	Związki pochodne pirazolopirazyny, kompozycja farmaceutyczna i ich zastosowanie
CN114269336A (zh)	2019-04-30	2022-04-01	细胞基因公司	包含阿普斯特和tyk2抑制剂的联合疗法
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CN116568299A (zh) *	2020-09-11	2023-08-08	普尔莫西姆治疗有限责任公司	用于治疗或预防肺动脉高压的组合物和方法
CN112592345B (zh)	2020-12-07	2024-09-13	嘉兴特科罗生物科技有限公司	一种三氮唑并吡嗪类化合物及其用途
TW202241859A (zh) *	2021-01-29	2022-11-01	美商富曼西公司	用於製備５－溴－２－（３－氯－吡啶－２－基）－２ｈ－吡唑－３－甲酸之方法
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CA3215278A1 (en)	2021-03-30	2022-10-06	Pfizer Inc.	Methods for treatment of vitiligo
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MX2024005778A (es) *	2021-11-12	2024-08-06	Soter Biopharma Pte Ltd	Compuesto de anillo fusionado de pirazolo, y uso del mismo.
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ES2794779T3 (es)	2016-02-24	2020-11-19	Pfizer	Derivados de pirazolo[1,5-a]pirazin-4-ilo como inhibidores de JAK
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EP3668858A1 (en)	2017-08-14	2020-06-24	Pfizer Inc	Pyrazolo[1,5-a]pyrazin-4-yl and related derivatives

2017
- 2017-02-10 ES ES17705705T patent/ES2794779T3/es active Active
- 2017-02-10 SG SG11201806307YA patent/SG11201806307YA/en unknown
- 2017-02-10 MA MA43668A patent/MA43668B1/fr unknown
- 2017-02-10 HR HRP20200781TT patent/HRP20200781T1/hr unknown
- 2017-02-10 LT LTEP17705705.6T patent/LT3419978T/lt unknown
- 2017-02-10 SI SI201730289T patent/SI3419978T1/sl unknown
- 2017-02-10 UA UAA201808148A patent/UA119835C2/uk unknown
- 2017-02-10 HU HUE17705705A patent/HUE049305T2/hu unknown
- 2017-02-10 RS RS20200584A patent/RS60261B1/sr unknown
- 2017-02-10 DK DK17705705.6T patent/DK3419978T3/da active
- 2017-02-10 KR KR1020187024431A patent/KR102128671B1/ko active Active
- 2017-02-10 RU RU2018130547A patent/RU2718902C2/ru active
- 2017-02-10 EP EP20168877.7A patent/EP3712153B1/en active Active
- 2017-02-10 MA MA052987A patent/MA52987A/fr unknown
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- 2017-02-10 JP JP2018544300A patent/JP6505956B2/ja active Active
- 2017-02-10 NZ NZ744349A patent/NZ744349A/en unknown
- 2017-02-10 CU CU2018000078A patent/CU24511B1/es unknown
- 2017-02-10 GE GEAP201714864A patent/GEP20217242B/en unknown
- 2017-02-10 TN TNP/2018/000295A patent/TN2018000295A1/en unknown
- 2017-02-10 MD MDE20190031T patent/MD3419978T2/ro unknown
- 2017-02-10 AU AU2017222417A patent/AU2017222417B2/en active Active
- 2017-02-10 CN CN201780013165.4A patent/CN109071546B/zh active Active
- 2017-02-10 EP EP17705705.6A patent/EP3419978B1/en active Active
- 2017-02-10 MX MX2018010236A patent/MX383747B/es unknown
- 2017-02-10 WO PCT/IB2017/050748 patent/WO2017144995A1/en not_active Ceased
- 2017-02-10 CR CR20180372A patent/CR20180372A/es unknown
- 2017-02-10 PL PL17705705T patent/PL3419978T3/pl unknown
- 2017-02-10 CO CONC2018/0008799A patent/CO2018008799A2/es unknown
- 2017-02-10 MY MYPI2018702937A patent/MY189118A/en unknown
- 2017-02-10 EA EA201891463A patent/EA035036B1/ru unknown
- 2017-02-10 ME MEP-2020-97A patent/ME03743B/me unknown
- 2017-02-21 CA CA2958490A patent/CA2958490C/en active Active
- 2017-02-21 US US15/437,618 patent/US10144738B2/en active Active
- 2017-02-21 TW TW106105777A patent/TWI665201B/zh active
- 2017-02-22 UY UY0001037133A patent/UY37133A/es unknown
- 2017-02-23 AR ARP170100462A patent/AR107714A1/es active IP Right Grant
2018
- 2018-07-18 SV SV2018005726A patent/SV2018005726A/es unknown
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- 2018-08-03 NI NI201800080A patent/NI201800080A/es unknown
- 2018-08-17 CL CL2018002358A patent/CL2018002358A1/es unknown
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- 2018-11-06 US US16/181,596 patent/US10822341B2/en active Active
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TWI665201B (zh)	2019-07-11
DOP2018000187A (es)	2019-01-31
CA2958490C (en)	2024-02-27
US20190071448A1 (en)	2019-03-07
EP3712153B1 (en)	2021-12-01
WO2017144995A1 (en)	2017-08-31
SI3419978T1 (sl)	2020-08-31
JP6505956B2 (ja)	2019-04-24
US12129256B2 (en)	2024-10-29
PT3419978T (pt)	2020-06-01
JP2019510003A (ja)	2019-04-11
US10822341B2 (en)	2020-11-03
US20200399281A1 (en)	2020-12-24
KR102128671B1 (ko)	2020-06-30
BR112018015501A2 (pt)	2018-12-18
HRP20200781T1 (hr)	2020-07-24
RU2018130547A (ru)	2020-03-25
US10144738B2 (en)	2018-12-04
MD3419978T2 (ro)	2020-07-31
UA119835C2 (uk)	2019-08-12
TW201741313A (zh)	2017-12-01
GEP20217242B (en)	2021-04-12
CU20180078A7 (es)	2019-02-04
LT3419978T (lt)	2020-06-10
MX2018010236A (es)	2019-01-14
US11472809B2 (en)	2022-10-18
EA035036B1 (ru)	2020-04-20
SG11201806307YA (en)	2018-09-27
KR20180103158A (ko)	2018-09-18
MY189118A (en)	2022-01-26
MX383747B (es)	2025-03-14
MA43668B1 (fr)	2020-05-29
US20230045252A1 (en)	2023-02-09
MA52987A (fr)	2021-04-28
AU2017222417A1 (en)	2018-08-02
CR20180372A (es)	2018-09-19
RS60261B1 (sr)	2020-06-30
CN109071546A (zh)	2018-12-21
NZ744349A (en)	2023-06-30
RU2718902C2 (ru)	2020-04-15
NI201800080A (es)	2018-11-22
ES2794779T3 (es)	2020-11-19
AU2017222417B2 (en)	2020-07-09
PL3419978T3 (pl)	2020-11-30
PH12018501788A1 (en)	2019-06-17
SV2018005726A (es)	2018-10-24
EP3419978B1 (en)	2020-04-15
US20170240552A1 (en)	2017-08-24
EA201891463A1 (ru)	2019-03-29
CA2958490A1 (en)	2017-08-24
ECSP18072109A (es)	2018-10-31
CU24511B1 (es)	2021-05-12
CN109071546B (zh)	2021-03-02
ZA201804972B (en)	2019-06-26
EP3712153A1 (en)	2020-09-23
CO2018008799A2 (es)	2018-09-20
ME03743B (me)	2021-04-20
UY37133A (es)	2017-09-29
HK1258157A1 (zh)	2019-11-08
RU2018130547A3 (da)	2020-03-25
AR107714A1 (es)	2018-05-23
TN2018000295A1 (en)	2020-01-16
CL2018002358A1 (es)	2018-11-30
EP3419978A1 (en)	2019-01-02
IL260923B (en)	2022-01-01
CY1122949T1 (el)	2021-10-29
HUE049305T2 (hu)	2020-09-28

Publication	Publication Date	Title
IL260923B (en)	2022-01-01	History of pyrazolo[5,1-a]pyrazin-4-yl as jak inhibitors
DK3523301T3 (da)	2020-08-03	Substituerede pyrazolo[1,5-A]pyridin-forbindelser som RET-kinase-inhibitorer
DK3523302T3 (da)	2022-08-01	Substituerede pyrazolo[1,5-A]pyridin-forbindelser som RET-kinase-inhibitorer
DK3322706T3 (da)	2021-02-01	Substituerede pyrazolo[1,5-a]pyridin-forbindelser som ret-kinaseinhibitorer
IL266305B (en)	2021-10-31	History of [4,2,1]triazolo[5,1-a]pyrimidine as pde2 inhibitors
DK3134413T3 (da)	2019-10-14	Substituerede [1,2,4]triazolo[1,5-a]pyrimidin-7-yl-forbindelser som pde2-inhibitorer
IL261231B (en)	2021-10-31	Substituted (r)-4-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2h)-one mcl-1 inhibitors
DK3478682T3 (da)	2021-09-13	[1,2,4]triazolo[1,5-a]pyridinylsubstituerede indolforbindelser
EP3268000A4 (en)	2018-08-22	Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors
DK3227297T3 (da)	2021-04-06	4,6-substitueret-pyrazolo[1,5-a]pyraziner som janus kinase-inhibitorer
DK3478681T3 (da)	2020-03-23	1h-pyrazolo[4,3-b]pyridiner som pde1-inhibitorer
IL247947B (en)	2019-03-31	7,6,5,4-tetrahydro-pyrazolo[5,1-a]pyrazine compounds and 8,7,6,5-tetrahydro-h4-pyrazolo[5,1-a][4,1]diazepine compounds as ros1 inhibitors
IL290419A (en)	2022-04-01	Imidazo[a-1,5]pyrazine derivatives as inhibitors of pi3k delta
IL247948B (en)	2019-03-31	7,6,5,4-tetrahydro-pyrazolo[5,1-a]pyrimidine derivatives and 3,2-dihydro-h1-imidazo[2,1-b]pyrazole derivatives as ros1 inhibitors
IL262673A (en)	2018-12-31	A pyrazolo[5,1-a]pyrimidine compound
DK3840832T3 (da)	2024-01-15	Imidazo[1,2-b]pyridaziner som trk-inhibitorer
DK3679042T3 (da)	2023-05-01	Imidazo[1,5-A]pyrazin-derivater som PI3Kdelta-inhibitorer
IL258070B (en)	2020-06-30	Cyclic ether history of pyrazolo[5,1–a]pyrimidine-3-carboxamide
LT3286193T (lt)	2020-08-10	Indolo dariniai
DK3194408T3 (da)	2019-07-15	Tetrahydropyrrolo[3,4-d][1,3]thiazin-derivat som bace-inhibitor
HUE052997T2 (hu)	2021-06-28	JAK kináz inhibitor pirazol[1,5-a]pirimidin származékok
TH1601001194A (th)	2017-10-19	อนุพันธ์ไตรอะโซโล[4,5-d]ไพริมิดีน ใหม่