DK3625222T3 - Phenylderivater som pge2-receptormodulatorer - Google Patents

Phenylderivater som pge2-receptormodulatorer Download PDF

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Publication number
DK3625222T3
DK3625222T3 DK18725222.6T DK18725222T DK3625222T3 DK 3625222 T3 DK3625222 T3 DK 3625222T3 DK 18725222 T DK18725222 T DK 18725222T DK 3625222 T3 DK3625222 T3 DK 3625222T3
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Prior art keywords
receptor modulators
phenyl derivatives
pge2 receptor
pge2
phenyl
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DK18725222.6T
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English (en)
Inventor
Christoph Boss
Olivier Corminboeuf
Heinz Fretz
Isabelle Lyothier
Davide Pozzi
Sylvia Richard-Bildstein
Hervé Siendt
Thierry Sifferlen
Original Assignee
Idorsia Pharmaceuticals Ltd
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Publication of DK3625222T3 publication Critical patent/DK3625222T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
DK18725222.6T 2017-05-18 2018-05-17 Phenylderivater som pge2-receptormodulatorer DK3625222T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2017062031 2017-05-18
PCT/EP2018/062862 WO2018210994A1 (en) 2017-05-18 2018-05-17 Phenyl derivatives as pge2 receptor modulators

Publications (1)

Publication Number Publication Date
DK3625222T3 true DK3625222T3 (da) 2021-10-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK18725222.6T DK3625222T3 (da) 2017-05-18 2018-05-17 Phenylderivater som pge2-receptormodulatorer

Country Status (32)

Country Link
US (1) US11712438B2 (da)
EP (1) EP3625222B1 (da)
JP (1) JP7159214B2 (da)
KR (1) KR102632028B1 (da)
CN (1) CN110612296A (da)
AR (1) AR111941A1 (da)
AU (1) AU2018269666B2 (da)
BR (1) BR112019024109A2 (da)
CA (1) CA3060597A1 (da)
CL (1) CL2019003275A1 (da)
CO (1) CO2019010578A2 (da)
CR (1) CR20190559A (da)
CY (1) CY1124608T1 (da)
DK (1) DK3625222T3 (da)
EA (1) EA201992676A1 (da)
ES (1) ES2893452T3 (da)
HR (1) HRP20211533T1 (da)
HU (1) HUE056080T2 (da)
IL (1) IL270623B2 (da)
LT (1) LT3625222T (da)
MA (1) MA49126B1 (da)
MX (1) MX388256B (da)
PE (1) PE20191814A1 (da)
PH (1) PH12019502563A1 (da)
PL (1) PL3625222T3 (da)
PT (1) PT3625222T (da)
RS (1) RS62440B1 (da)
SG (1) SG11201908729UA (da)
SI (1) SI3625222T1 (da)
TW (1) TWI765041B (da)
UA (1) UA125123C2 (da)
WO (1) WO2018210994A1 (da)

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CN111819193A (zh) 2018-01-05 2020-10-23 西奈山伊坎医学院 增加胰腺β细胞增殖的方法、治疗方法以及组合物
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Also Published As

Publication number Publication date
EP3625222B1 (en) 2021-07-21
KR20200010352A (ko) 2020-01-30
WO2018210994A1 (en) 2018-11-22
MA49126B1 (fr) 2021-10-29
IL270623B2 (en) 2023-03-01
PE20191814A1 (es) 2019-12-27
KR102632028B1 (ko) 2024-01-31
TW201900175A (zh) 2019-01-01
JP2020520356A (ja) 2020-07-09
BR112019024109A2 (pt) 2020-06-02
CN110612296A (zh) 2019-12-24
TWI765041B (zh) 2022-05-21
UA125123C2 (uk) 2022-01-12
PT3625222T (pt) 2021-10-07
MX388256B (es) 2025-03-19
CR20190559A (es) 2020-02-10
EP3625222A1 (en) 2020-03-25
AU2018269666B2 (en) 2022-02-03
CA3060597A1 (en) 2018-11-22
MX2019013718A (es) 2020-01-30
CL2019003275A1 (es) 2020-05-04
SI3625222T1 (sl) 2021-11-30
EA201992676A1 (ru) 2020-05-06
HUE056080T2 (hu) 2022-01-28
CO2019010578A2 (es) 2019-10-09
MA49126A (fr) 2020-03-25
JP7159214B2 (ja) 2022-10-24
PL3625222T3 (pl) 2021-12-27
US20200179383A1 (en) 2020-06-11
CY1124608T1 (el) 2022-07-22
IL270623A (da) 2019-12-31
HRP20211533T1 (hr) 2022-01-07
AR111941A1 (es) 2019-09-04
PH12019502563A1 (en) 2020-07-20
SG11201908729UA (en) 2019-10-30
US11712438B2 (en) 2023-08-01
IL270623B (en) 2022-11-01
RS62440B1 (sr) 2021-11-30
AU2018269666A1 (en) 2020-01-16
ES2893452T3 (es) 2022-02-09
LT3625222T (lt) 2021-11-10

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