DK3490986T3 - Piperidin-cxcr7-receptormodulatorer - Google Patents

Piperidin-cxcr7-receptormodulatorer Download PDF

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Publication number
DK3490986T3
DK3490986T3 DK17754283.4T DK17754283T DK3490986T3 DK 3490986 T3 DK3490986 T3 DK 3490986T3 DK 17754283 T DK17754283 T DK 17754283T DK 3490986 T3 DK3490986 T3 DK 3490986T3
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Prior art keywords
piperidine
receptor modulators
cxcr7 receptor
cxcr7
modulators
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DK17754283.4T
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English (en)
Inventor
Hamed Aissaoui
Philippe Guerry
Francois Lehembre
Julien Pothier
Laetitia Pouzol
Sylvia Richard-Bildstein
Shuguang Yuan
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Idorsia Pharmaceuticals Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK17754283.4T 2016-07-28 2017-07-27 Piperidin-cxcr7-receptormodulatorer DK3490986T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2016068052 2016-07-28
PCT/EP2017/068990 WO2018019929A1 (en) 2016-07-28 2017-07-27 Piperidine cxcr7 receptor modulators

Publications (1)

Publication Number Publication Date
DK3490986T3 true DK3490986T3 (da) 2022-03-07

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Application Number Title Priority Date Filing Date
DK17754283.4T DK3490986T3 (da) 2016-07-28 2017-07-27 Piperidin-cxcr7-receptormodulatorer
DK20201796.8T DK3798217T3 (da) 2016-07-28 2017-07-27 Piperidin-cxcr7-receptormodulatorer

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DK20201796.8T DK3798217T3 (da) 2016-07-28 2017-07-27 Piperidin-cxcr7-receptormodulatorer

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US (2) US10752620B2 (da)
EP (2) EP3490986B1 (da)
JP (2) JP6655754B2 (da)
KR (2) KR102497095B1 (da)
CN (2) CN110563717B (da)
AR (2) AR109180A1 (da)
AU (2) AU2017302079B2 (da)
CA (1) CA3032017C (da)
CL (2) CL2019000169A1 (da)
CY (1) CY1125016T1 (da)
DK (2) DK3490986T3 (da)
EA (2) EA037507B1 (da)
ES (2) ES2954152T3 (da)
FI (1) FI3798217T3 (da)
HR (2) HRP20230313T1 (da)
HU (2) HUE057315T2 (da)
IL (2) IL264424B (da)
LT (2) LT3490986T (da)
MA (2) MA54653B1 (da)
MX (2) MX383804B (da)
MY (2) MY198113A (da)
NZ (1) NZ751006A (da)
PH (2) PH12021552605A1 (da)
PL (2) PL3798217T3 (da)
PT (2) PT3798217T (da)
RS (2) RS64130B1 (da)
SG (2) SG11201900633XA (da)
SI (2) SI3490986T1 (da)
TW (3) TWI691494B (da)
UA (2) UA122987C2 (da)
WO (1) WO2018019929A1 (da)
ZA (1) ZA201901256B (da)

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CA3156298A1 (en) * 2019-10-31 2021-05-06 Laetitia POUZOL Combination of a cxcr7 antagonist with an s1p1 receptor modulator
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TW202434579A (zh) 2022-11-16 2024-09-01 瑞士商先正達農作物保護股份公司 殺微生物的四氫異喹啉衍生物
TW202439972A (zh) 2022-11-30 2024-10-16 瑞士商先正達農作物保護股份公司 殺真菌組成物
JP2025539452A (ja) 2022-11-30 2025-12-05 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺微生物テトラヒドロイソキノリン誘導体
PY2403614A (es) 2023-01-27 2025-09-11 Syngenta Crop Protection Ag Derivados de pirazol microbiocidas
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AR135141A1 (es) 2024-01-03 2026-07-08 Pi Industries Ltd Compuestos de pirazol para combatir hongos fitopatógenos
AR134999A1 (es) 2024-02-02 2026-05-20 Syngenta Crop Protection Ag Derivados de pirazol microbiocidas
WO2025172368A1 (en) 2024-02-13 2025-08-21 Syngenta Crop Protection Ag (5-isoxazol-3-yl)-[4-(pyrazol-4-yl)-3,4-dihydro-1h-isoquinolin-2-yl]methanone derivatives for use as fungicides
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PL3490986T3 (pl) 2022-04-04
CA3032017C (en) 2023-04-18
CN109563085B (zh) 2022-08-09
JP6655742B2 (ja) 2020-02-26
EP3490986B1 (en) 2021-11-24
HRP20230313T1 (hr) 2023-05-12
MA54653A (fr) 2021-12-29
LT3798217T (lt) 2023-05-25
EA037507B1 (ru) 2021-04-06
MX2019001042A (es) 2019-06-10
US10752620B2 (en) 2020-08-25
CN110563717A (zh) 2019-12-13
CL2019003281A1 (es) 2020-05-04
CL2019000169A1 (es) 2019-06-21
UA129887C2 (uk) 2025-09-03
NZ755815A (en) 2025-02-28
SI3490986T1 (sl) 2022-02-28
TW201922738A (zh) 2019-06-16
JP2019525927A (ja) 2019-09-12
TWI683812B (zh) 2020-02-01
AU2020204578B2 (en) 2022-03-10
EP3798217A1 (en) 2021-03-31
US20200385373A1 (en) 2020-12-10
AU2017302079B2 (en) 2021-07-22
BR112019001551A2 (pt) 2019-05-14
PH12021552605A1 (en) 2023-01-23
IL282942B (en) 2022-01-01
TW201932454A (zh) 2019-08-16
UA122987C2 (uk) 2021-01-27
CA3032017A1 (en) 2018-02-01
KR20200092420A (ko) 2020-08-03
TW201806940A (zh) 2018-03-01
JP2019142874A (ja) 2019-08-29
ES2905755T3 (es) 2022-04-12
MX2021004000A (es) 2021-06-23
SG10201906942PA (en) 2019-09-27
IL264424B (en) 2021-08-31
MY199657A (en) 2023-11-14
JP6655754B2 (ja) 2020-02-26
PT3798217T (pt) 2023-05-23
AU2020204578A1 (en) 2020-07-30
MY198113A (en) 2023-08-03
EP3490986A1 (en) 2019-06-05
KR102497091B1 (ko) 2023-02-06
AU2017302079A1 (en) 2019-03-21
EP3798217B1 (en) 2023-02-22
PH12019500188A1 (en) 2019-10-21
CN109563085A (zh) 2019-04-02
FI3798217T3 (fi) 2023-05-03
IL282942A (en) 2021-06-30
HRP20211988T1 (hr) 2022-03-18
ES2954152T3 (es) 2023-11-20
CY1125016T1 (el) 2023-03-24
MA45782A (fr) 2019-06-05
HUE062019T2 (hu) 2023-09-28
KR102497095B1 (ko) 2023-02-06
WO2018019929A1 (en) 2018-02-01
MA45782B1 (fr) 2021-12-31
US20190169180A1 (en) 2019-06-06
SI3798217T1 (sl) 2023-05-31
RS64130B1 (sr) 2023-05-31
EA201990388A1 (ru) 2019-08-30
MA54653B1 (fr) 2023-04-28
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AR109180A1 (es) 2018-11-07
MX383804B (es) 2025-03-14
TWI691494B (zh) 2020-04-21
EA202091262A1 (ru) 2020-08-13
KR20190034620A (ko) 2019-04-02
AR115662A2 (es) 2021-02-10
LT3490986T (lt) 2022-02-10
PL3798217T3 (pl) 2023-06-12
DK3798217T3 (da) 2023-05-22
HUE057315T2 (hu) 2022-04-28
TWI691497B (zh) 2020-04-21
ZA201901256B (en) 2021-08-25
CN110563717B (zh) 2022-08-09
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US11306078B2 (en) 2022-04-19
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