DK362585A - Nye derivater af guanin - Google Patents

Nye derivater af guanin Download PDF

Info

Publication number: DK362585A
Authority: DK; Denmark
Prior art keywords: image; hydrogen; guanine; poh; treating
Prior art date: 1983-12-20

Application number

DK362585A

Other languages

English (en)

Other versions

DK159683B (da

DK159683C (da

DK362585D0 (da

Inventor

Karl Nils-Gunnar Johansson

Bjoern Gunnar Lindborg

Jan-Olof Noren

Original Assignee

Astra Laekemedel Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-12-20

Filing date

1985-08-09

Publication date

1985-08-09

1983-12-20 Priority claimed from SE8307051A external-priority patent/SE8307051D0/xx

1983-12-20 Priority claimed from SE8307052A external-priority patent/SE8307052D0/xx

1985-08-09 Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab

1985-08-09 Publication of DK362585D0 publication Critical patent/DK362585D0/da

1985-08-09 Publication of DK362585A publication Critical patent/DK362585A/da

1990-11-19 Publication of DK159683B publication Critical patent/DK159683B/da

1991-04-15 Application granted granted Critical

1991-04-15 Publication of DK159683C publication Critical patent/DK159683C/da

Links

UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
201000006082 Chickenpox Diseases 0.000 abstract 1
241000689227 Cora <basidiomycete fungus> Species 0.000 abstract 1
208000007514 Herpes zoster Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010046980 Varicella Diseases 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
150000001345 alkine derivatives Chemical class 0.000 abstract 1
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
241001529453 unidentified herpesvirus Species 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
- C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1787—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings and having unsaturation outside the aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measuring Leads Or Probes (AREA)
Testing Of Short-Circuits, Discontinuities, Leakage, Or Incorrect Line Connections (AREA)
Tests Of Electronic Circuits (AREA)

DK362585A 1983-12-20 1985-08-09 9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel DK159683C (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
SE8307052		1983-12-20
SE8307051A SE8307051D0 (sv)	1983-12-20	1983-12-20	Novel derivatives of alkyl guanine novel derivatives of alkyl guanine
SE8307051		1983-12-20
SE8307052A SE8307052D0 (sv)	1983-12-20	1983-12-20	Novel derivatives of guanine novel derivatives of guanine
PCT/SE1984/000426 WO1985002845A1 (en)	1983-12-20	1984-12-13	Novel derivatives of guanine
SE8400426		1984-12-13

Publications (4)

Publication Number	Publication Date
DK362585D0 DK362585D0 (da)	1985-08-09
DK362585A true DK362585A (da)	1985-08-09
DK159683B DK159683B (da)	1990-11-19
DK159683C DK159683C (da)	1991-04-15

Family

ID=26658599

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK362585A DK159683C (da)	1983-12-20	1985-08-09	9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel

Country Status (20)

Country	Link
US (1)	US4798833A (da)
EP (2)	EP0146516A3 (da)
JP (1)	JPH0667939B2 (da)
KR (1)	KR910010048B1 (da)
AU (1)	AU586415B2 (da)
CA (1)	CA1285560C (da)
DE (1)	DE3477568D1 (da)
DK (1)	DK159683C (da)
ES (3)	ES8609325A1 (da)
FI (1)	FI80885C (da)
GB (1)	GB2151622B (da)
GR (1)	GR82499B (da)
HU (1)	HU193595B (da)
IE (1)	IE57913B1 (da)
IL (1)	IL73682A (da)
IS (1)	IS1507B (da)
MY (1)	MY102565A (da)
PH (1)	PH21410A (da)
PT (1)	PT79714B (da)
WO (1)	WO1985002845A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5684153A (en)	1984-08-16	1997-11-04	Beecham Group Plc	Process for the preparation of purine derivatives
EP0141927B1 (en) *	1983-08-18	1991-10-30	Beecham Group Plc	Antiviral guanine derivatives
CA1288098C (en) *	1984-08-24	1991-08-27	Richard L. Tolman	4-(guanin-9-yl)butanals and their 3-oxa, 3-thia and 2-ene derivatives having antiviral and antitumor activity
SE8406538D0 (sv) *	1984-12-21	1984-12-21	Astra Laekemedel Ab	Novel derivatives of purine
DE3671227D1 (de) *	1985-07-27	1990-06-21	Beecham Group Plc	9-substituierte guaninmonohydrate.
EP0219838A3 (en) *	1985-10-22	1988-04-06	Takeda Chemical Industries, Ltd.	Carbocyclic purine nucleosides, their production and use
US5565566A (en) *	1987-04-24	1996-10-15	Discovery Therapeutics, Inc.	N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5066655A (en) *	1987-04-24	1991-11-19	Whitby Research, Inc.	N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5175288A (en) *	1987-08-01	1992-12-29	Beecham Group P.L.C.	Process for preparing purine derivatives and intermediates thereof
US4935427A (en) *	1987-12-31	1990-06-19	The United States Of America As Represented By The Department Of Health And Human Services	Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
SE8801729D0 (sv) *	1988-05-06	1988-05-06	Astra Ab	Purine derivatives for use in therapy
US5284837A (en) *	1988-05-06	1994-02-08	Medivir Ab	Derivatives of purine, process for their preparation and a pharmaceutical preparation
GB8817607D0 (en) *	1988-07-23	1988-09-01	Beecham Group Plc	Novel process
GB8822236D0 (en) *	1988-09-21	1988-10-26	Beecham Group Plc	Chemical process
CA2009109A1 (en) *	1989-02-02	1990-08-02	John Hannah	Antiviral acyclonucleosides and acyclonucleotides
GB8904855D0 (en) *	1989-03-03	1989-04-12	Beecham Group Plc	Pharmaceutical treatment
GB8917959D0 (en) *	1989-08-05	1989-09-20	Beecham Group Plc	Pharmaceutical formulation
GB8922076D0 (en) *	1989-09-28	1989-11-15	Beecham Group Plc	Novel process
GB9001886D0 (en) *	1990-01-26	1990-03-28	Beecham Group Plc	Pharmaceutical formulation
US5674869A (en) *	1990-07-07	1997-10-07	Beecham Group Plc	Pharmaceutical treatment
DK0705264T3 (da) *	1993-06-23	1999-10-18	Merrell Pharma Inc	Carbo-acyliske nukleosidderivater som antivirale og antineoplastiske midler
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
GB9615253D0 (en) *	1996-07-20	1996-09-04	Smithkline Beecham Plc	Pharmaceuticals
GB9615276D0 (en) *	1996-07-20	1996-09-04	Smithkline Beecham Plc	Pharmaceuticals
AT412211B (de) *	1996-07-20	2004-11-25	Novartis Int Pharm Ltd	Verfahren zur herstellung von penciclovir und famciclovir
GB9807114D0 (en) *	1998-04-02	1998-06-03	Smithkline Beecham Plc	Novel process
US20230218644A1 (en)	2020-04-16	2023-07-13	Som Innovation Biotech, S.A.	Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4347360A (en) *	1980-09-16	1982-08-31	Ens Bio Logicals Inc.	Ring open nucleoside analogues
IL64501A (en) *	1980-12-22	1985-07-31	Astra Laekemedel Ab	9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US4355032B2 (en) *	1981-05-21	1990-10-30		9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
FI76086C (fi) *	1981-08-11	1988-09-09	Wellcome Found	Foerfarande foer framstaellning av antivirala purinderivat.
NZ201662A (en) *	1981-08-26	1986-07-11	Merck & Co Inc	9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
AU564576B2 (en) *	1981-09-24	1987-08-20	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Purine derivatives
US5250535A (en) *	1982-02-01	1993-10-05	Syntex Inc.	Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
SE8203855D0 (sv) *	1982-06-21	1982-06-21	Astra Laekemedel Ab	Novel derivatives of guanine i
SE8203856D0 (sv) *	1982-06-21	1982-06-21	Astra Laekemedel Ab	Novel derivatives of guanine ii
EP0141927B1 (en) *	1983-08-18	1991-10-30	Beecham Group Plc	Antiviral guanine derivatives
DE3671227D1 (de) *	1985-07-27	1990-06-21	Beecham Group Plc	9-substituierte guaninmonohydrate.

1984
- 1984-11-29 IL IL73682A patent/IL73682A/xx not_active IP Right Cessation
- 1984-12-13 EP EP84850390A patent/EP0146516A3/en active Pending
- 1984-12-13 WO PCT/SE1984/000426 patent/WO1985002845A1/en not_active Ceased
- 1984-12-13 JP JP60500231A patent/JPH0667939B2/ja not_active Expired - Lifetime
- 1984-12-13 AU AU37873/85A patent/AU586415B2/en not_active Expired
- 1984-12-13 HU HU84807A patent/HU193595B/hu unknown
- 1984-12-13 DE DE8585900247T patent/DE3477568D1/de not_active Expired
- 1984-12-13 KR KR1019850700161A patent/KR910010048B1/ko not_active Expired
- 1984-12-13 EP EP85900247A patent/EP0165289B1/en not_active Expired
- 1984-12-17 PH PH31589A patent/PH21410A/en unknown
- 1984-12-18 GR GR82499A patent/GR82499B/el unknown
- 1984-12-18 GB GB08431910A patent/GB2151622B/en not_active Expired
- 1984-12-18 ES ES538721A patent/ES8609325A1/es not_active Expired
- 1984-12-19 CA CA000470490A patent/CA1285560C/en not_active Expired - Lifetime
- 1984-12-19 IE IE3261/845A patent/IE57913B1/en not_active IP Right Cessation
- 1984-12-19 PT PT79714A patent/PT79714B/pt unknown
- 1984-12-19 IS IS2966A patent/IS1507B/is unknown
1985
- 1985-08-09 DK DK362585A patent/DK159683C/da not_active IP Right Cessation
- 1985-08-19 FI FI853171A patent/FI80885C/fi active IP Right Grant
- 1985-09-12 ES ES546916A patent/ES8704170A1/es not_active Expired
1986
- 1986-04-30 ES ES554546A patent/ES8800946A1/es not_active Expired
1987
- 1987-02-06 US US07/015,481 patent/US4798833A/en not_active Expired - Lifetime
- 1987-10-01 MY MYPI87002765A patent/MY102565A/en unknown

Also Published As

Publication number	Publication date
IL73682A (en)	1991-08-16
FI853171A0 (fi)	1985-08-19
EP0146516A2 (en)	1985-06-26
WO1985002845A1 (en)	1985-07-04
PT79714B (en)	1986-12-30
JPS61500730A (ja)	1986-04-17
EP0165289A1 (en)	1985-12-27
FI853171L (fi)	1985-08-19
ES554546A0 (es)	1987-12-01
ES538721A0 (es)	1986-09-01
CA1285560C (en)	1991-07-02
AU586415B2 (en)	1989-07-13
GB2151622A (en)	1985-07-24
FI80885B (fi)	1990-04-30
PT79714A (en)	1985-01-01
HUT37619A (en)	1986-01-23
IS2966A7 (is)	1985-06-21
DE3477568D1 (en)	1989-05-11
GB8431910D0 (en)	1985-01-30
DK159683B (da)	1990-11-19
IE57913B1 (en)	1993-05-19
PH21410A (en)	1987-10-15
GB2151622B (en)	1988-05-11
IL73682A0 (en)	1985-02-28
ES546916A0 (es)	1987-03-16
KR910010048B1 (ko)	1991-12-12
US4798833A (en)	1989-01-17
JPH0667939B2 (ja)	1994-08-31
EP0146516A3 (en)	1985-08-14
IE843261L (en)	1985-06-20
DK159683C (da)	1991-04-15
DK362585D0 (da)	1985-08-09
EP0165289B1 (en)	1989-04-05
KR850700136A (ko)	1985-10-25
HU193595B (en)	1987-11-30
AU3787385A (en)	1985-07-12
GR82499B (en)	1985-04-19
ES8704170A1 (es)	1987-03-16
MY102565A (en)	1992-07-31
FI80885C (fi)	1990-08-10
IS1507B (is)	1992-09-29
ES8609325A1 (es)	1986-09-01
ES8800946A1 (es)	1987-12-01

Legal Events

Date	Code	Title	Description
2005-01-03	PUP	Patent expired

Publication	Publication Date	Title
ES8609325A1 (es)	1986-09-01	Un procedimiento para preparar derivados de guanina
DK148279C (da)	1986-02-17	Analogifremgangsmaade til fremstilling af 9-substituerede guaninderivater eller fysiologisk acceptable salte eller optiske isomerer deraf
DE3575927D1 (de)	1990-03-15	Purinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitung.
NO173785C (no)	1994-02-02	Analogifremgangsmaate for fremstilling av farmasoeytisk virksomme kinuklidinderivater samt mellom-produkt for fremstillingen
DE3785198D1 (de)	1993-05-06	Liposomes praeparat und antibiotikum.
YU74292A (sh)	1996-01-08	Jedinjenja za inhibiciju hiv i srodnih virusa
DE3378470D1 (en)	1988-12-22	7-oxabicycloheptane substituted amino prostaglandin analogs
LV5273A3 (lv)	1993-10-10	Panemiens pirimidinnukleozidu iegusanai
PT82580B (pt)	1989-01-17	Processo para a preparacao de 2',3'- didesoxinucleosidos e de composicoes farmaceuticas que os contem
FI854128L (fi)	1986-04-24	Foerfarande foer framstaellning av en foedoaemneskomposition som innehaoller inosotoltrifosfat och denna komposition.
PT80079B (pt)	1987-09-18	Processo para a preparacao de composicoes farmaceuticas anti-virus contendo 2-dietilamino-2',6'-acetoxilida (lidocaina)
DK518683D0 (da)	1983-11-14	Fremgangsmade til fremstilling af 4"epi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller farmaceutisk acceptable syreadditionssalte deraf og mellemprodukter ved fremgangsmaden
SE8900192L (sv)	1989-07-21	Dideoxididehydrokarbocykliska nukleosider
FI922806A0 (fi)	1992-06-17	Substituerade 4-fenyl-4 -piperidinkarboxamider med baode lokalbedoevande och smaertstillande effekt samt foerfaranden foer deras framstaellning.
DK163181C (da)	1992-06-22	Analogifremgangsmaade til fremstilling af n,n'-di(arylalkylen)alkylendiaminer eller farmaceutisk acceptable salte deraf
ES8502097A1 (es)	1984-12-16	Un procedimiento para la preparacion de compuestos de bencimidazol.
NO933611L (no)	1993-10-08	Anti-tumor- og anti-psoriatiske midler
SE8307146L (sv)	1984-06-28	7-oxabicykloheptan-substituerade aminoprostaglandinanaloger
FI833200A0 (fi)	1983-09-07	Isokinolinderivat, foerfaranden foer deras framstaellning, pao dessa foereningar baserade farmaceutpreparat och deras anvaendning
SE8303136D0 (sv)	1983-06-03	Derives de loxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation
DE3767308D1 (de)	1991-02-14	Verwendung von sulfonamidderivaten zur herstellung eines antivirusmittels.
SE8302751L (sv)	1983-11-19	2(1h)-pyridinonderivat, deras framstellning och farmaceutiska beredningar som innehaller dem
DE3378120D1 (en)	1988-11-03	Thiazaspiro derivatives, process for their preparation and pharmaceutical composition
PT76903A (en)	1983-07-01	Process for preparing novel derivatives of guanine and of pharmaceutical compositions containing the same
FI872719A0 (fi)	1987-06-18	Nya tetrahydro-benzotiazoler, deras framstaellning och anvaendning.