DK3630112T3 - Kombination af regorafenib og nivolumab til behandling af cancer - Google Patents

Kombination af regorafenib og nivolumab til behandling af cancer Download PDF

Info

Publication number: DK3630112T3
Authority: DK; Denmark
Prior art keywords: regorafenib; nivolumab; cancer; treatment; combination
Prior art date: 2017-06-02

Application number

DK18725258.0T

Other languages

English (en)

Inventor

Dieter Zopf

Sabine Hoff

Lars Röse

Fabian Kiessling

Wiltrud Lederle

Dennis Doleschel

Original Assignee

Bayer Healthcare Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-06-02

Filing date

2018-05-25

Publication date

2024-04-22

2018-05-25 Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc

2024-04-22 Application granted granted Critical

2024-04-22 Publication of DK3630112T3 publication Critical patent/DK3630112T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Mycology (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Dermatology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)

DK18725258.0T 2017-06-02 2018-05-25 Kombination af regorafenib og nivolumab til behandling af cancer DK3630112T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP17174169		2017-06-02
PCT/EP2018/063785 WO2018219807A1 (en)	2017-06-02	2018-05-25	Combination of regorafenib and pd-1/pd-l1(2) inhibitors for treating cancer

Publications (1)

Publication Number	Publication Date
DK3630112T3 true DK3630112T3 (da)	2024-04-22

Family

ID=58992733

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK18725258.0T DK3630112T3 (da)	2017-06-02	2018-05-25	Kombination af regorafenib og nivolumab til behandling af cancer

Country Status (22)

Country	Link
US (4)	US11951166B2 (da)
EP (2)	EP4342542A3 (da)
JP (3)	JP7303122B2 (da)
KR (2)	KR102673422B1 (da)
CN (3)	CN117582495A (da)
AU (2)	AU2018276273B2 (da)
BR (1)	BR112019025478A8 (da)
CA (2)	CA3065125C (da)
DK (1)	DK3630112T3 (da)
ES (1)	ES2978337T3 (da)
FI (1)	FI3630112T3 (da)
HR (1)	HRP20240551T1 (da)
HU (1)	HUE066487T2 (da)
IL (2)	IL317015A (da)
LT (1)	LT3630112T (da)
MX (1)	MX2023001721A (da)
PE (2)	PE20200859A1 (da)
PL (1)	PL3630112T3 (da)
PT (1)	PT3630112T (da)
RS (1)	RS65488B9 (da)
SI (1)	SI3630112T1 (da)
WO (1)	WO2018219807A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20200859A1 (es) *	2017-06-02	2020-08-25	Bayer Healthcare Llc	Combinacion farmaceutica que comprende regonafenib y nivolumab como anticancerigeno
CN111001004A (zh) *	2019-10-08	2020-04-14	广州医科大学附属第二医院	一种治疗肝癌的药物组合及其应用
TW202539722A (zh) *	2023-12-01	2025-10-16	耶魯大學	治療癌症的組合物和方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
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EA010485B1 (ru)	2003-07-23	2008-10-30	Байер Фамэсьютиклс Копэрейшн	Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты)
JP2009514921A (ja)	2005-11-10	2009-04-09	バイエル・ヘルスケア・アクチェンゲゼルシャフト	糖尿病性神経障害を処置するためのジアリールウレア
AR062927A1 (es)	2006-10-11	2008-12-17	Bayer Healthcare Ag	4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
AR081060A1 (es)	2010-04-15	2012-06-06	Bayer Schering Pharma Ag	Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
UY35006A (es) *	2012-09-06	2014-03-31	Bayer Healthcare Llc	Composición farmacéutica recubierta que contiene regorafenib
US10898500B2 (en) *	2012-09-25	2021-01-26	Bayer Pharma Aktiengesellschaft	Combination of regorafenib and acetylsalicylic acid for treating cancer
JP5653489B1 (ja)	2013-07-24	2015-01-14	三菱エンジニアリングプラスチックス株式会社	薄肉光学部材用ポリカーボネート樹脂ペレット及びその製造方法
EA201691376A1 (ru)	2014-02-04	2017-01-30	Пфайзер Инк.	Комбинация антагониста pd-1 и ингибитора vegfr для лечения рака
US20170165364A1 (en)	2014-02-21	2017-06-15	Idac Theranostics, Inc.	Therapeutic agent for solid cancer
US10869926B2 (en)	2014-07-15	2020-12-22	The Johns Hopkins University	Suppression of myeloid derived suppressor cells and immune checkpoint blockade
SG11201700074YA (en)	2014-07-15	2017-02-27	Genentech Inc	Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors
US10392444B2 (en)	2014-08-08	2019-08-27	Oncoquest, Inc.	Tumor antigen specific antibodies and TLR3 stimulation to enhance the performance of checkpoint interference therapy of cancer
RU2020127099A (ru) *	2014-08-19	2020-09-02	Нэшнл Юниверсити Корпорейшн Окаяма Юниверсити	Способ улучшения функции иммунных клеток и оценки мультифункциональности иммунных клеток
AU2015327868A1 (en)	2014-10-03	2017-04-20	Novartis Ag	Combination therapies
EP4098278A1 (en)	2014-11-13	2022-12-07	The Johns Hopkins University	Checkpoint blockade and microsatellite instability
WO2016173959A1 (en)	2015-04-28	2016-11-03	Bayer Pharma Aktiengesellschaft	Regorafenib for treating colorectal cancer
US20190022092A1 (en)	2015-09-15	2019-01-24	Acerta Pharma B.V.	Therapeutic Combinations of a BTK Inhibitor and a GITR Binding Molecule, a 4-1BB Agonist, or an OX40 Agonist
US20190183972A1 (en)	2016-06-03	2019-06-20	Imclone Llc	Combination of ramucirumab and pembrolizumab for the treatment of certain cancers
US10251888B2 (en)	2016-06-13	2019-04-09	Chemocentryx, Inc.	Method of treating pancreatic cancer
PE20200859A1 (es)	2017-06-02	2020-08-25	Bayer Healthcare Llc	Combinacion farmaceutica que comprende regonafenib y nivolumab como anticancerigeno
CR20190550A (es) *	2017-06-05	2020-04-05	Janssen Biotech Inc	Anticuerpos que se unen específicamente a pd-1 y métodos de uso

2018
- 2018-05-25 PE PE2019002499A patent/PE20200859A1/es unknown
- 2018-05-25 WO PCT/EP2018/063785 patent/WO2018219807A1/en not_active Ceased
- 2018-05-25 IL IL317015A patent/IL317015A/en unknown
- 2018-05-25 BR BR112019025478A patent/BR112019025478A8/pt not_active Application Discontinuation
- 2018-05-25 JP JP2019565949A patent/JP7303122B2/ja active Active
- 2018-05-25 CA CA3065125A patent/CA3065125C/en active Active
- 2018-05-25 CA CA3244313A patent/CA3244313A1/en active Pending
- 2018-05-25 PE PE2024001939A patent/PE20242220A1/es unknown
- 2018-05-25 IL IL270948A patent/IL270948B2/en unknown
- 2018-05-25 SI SI201831091T patent/SI3630112T1/sl unknown
- 2018-05-25 EP EP24150061.0A patent/EP4342542A3/en active Pending
- 2018-05-25 RS RS20240481A patent/RS65488B9/sr unknown
- 2018-05-25 ES ES18725258T patent/ES2978337T3/es active Active
- 2018-05-25 FI FIEP18725258.0T patent/FI3630112T3/fi active
- 2018-05-25 HU HUE18725258A patent/HUE066487T2/hu unknown
- 2018-05-25 PL PL18725258.0T patent/PL3630112T3/pl unknown
- 2018-05-25 HR HRP20240551TT patent/HRP20240551T1/hr unknown
- 2018-05-25 AU AU2018276273A patent/AU2018276273B2/en active Active
- 2018-05-25 EP EP18725258.0A patent/EP3630112B9/en active Active
- 2018-05-25 DK DK18725258.0T patent/DK3630112T3/da active
- 2018-05-25 LT LTEPPCT/EP2018/063785T patent/LT3630112T/lt unknown
- 2018-05-25 CN CN202311446796.9A patent/CN117582495A/zh active Pending
- 2018-05-25 PT PT187252580T patent/PT3630112T/pt unknown
- 2018-05-25 US US16/617,642 patent/US11951166B2/en active Active
- 2018-05-25 KR KR1020197038281A patent/KR102673422B1/ko active Active
- 2018-05-25 CN CN201880036504.5A patent/CN110662540B/zh active Active
- 2018-05-25 CN CN202410088226.5A patent/CN117899212A/zh active Pending
- 2018-05-25 KR KR1020247017968A patent/KR102843438B1/ko active Active
2019
- 2019-12-02 MX MX2023001721A patent/MX2023001721A/es unknown
- 2019-12-31 US US16/731,412 patent/US11517622B2/en active Active
- 2019-12-31 US US16/731,409 patent/US20200155674A1/en not_active Abandoned
2022
- 2022-01-14 US US17/576,522 patent/US20220133888A1/en active Pending
- 2022-09-01 JP JP2022138972A patent/JP7475402B2/ja active Active
2023
- 2023-12-12 AU AU2023282197A patent/AU2023282197B2/en active Active
2024
- 2024-04-16 JP JP2024066115A patent/JP7806119B2/ja active Active

Also Published As

Publication number	Publication date
IL270948B1 (en)	2025-03-01
IL270948B2 (en)	2025-07-01
EP3630112B1 (en)	2024-01-31
EP3630112B9 (en)	2024-06-26
US20200155674A1 (en)	2020-05-21
EP3630112A1 (en)	2020-04-08
RS65488B1 (sr)	2024-05-31
KR20240091188A (ko)	2024-06-21
PE20242220A1 (es)	2024-11-19
CA3065125A1 (en)	2018-12-06
CA3065125C (en)	2025-06-10
AU2023282197A1 (en)	2024-01-04
JP2020521786A (ja)	2020-07-27
WO2018219807A1 (en)	2018-12-06
US11951166B2 (en)	2024-04-09
RU2019143599A (ru)	2021-07-09
US11517622B2 (en)	2022-12-06
JP7806119B2 (ja)	2026-01-26
US20200179354A1 (en)	2020-06-11
HUE066487T2 (hu)	2024-08-28
CA3244313A1 (en)	2025-06-13
CN110662540B (zh)	2024-01-26
PT3630112T (pt)	2024-04-23
RU2019143599A3 (da)	2021-09-10
LT3630112T (lt)	2024-05-10
BR112019025478A2 (pt)	2020-06-23
HRP20240551T1 (hr)	2024-07-05
RS65488B9 (sr)	2024-09-30
CN117899212A (zh)	2024-04-19
JP7475402B2 (ja)	2024-04-26
MX2023001721A (es)	2023-02-22
JP7303122B2 (ja)	2023-07-04
JP2022169780A (ja)	2022-11-09
EP4342542A2 (en)	2024-03-27
ES2978337T3 (es)	2024-09-10
US20200188372A1 (en)	2020-06-18
SI3630112T1 (sl)	2024-06-28
KR20200011971A (ko)	2020-02-04
PE20200859A1 (es)	2020-08-25
CN110662540A (zh)	2020-01-07
EP4342542A3 (en)	2024-06-05
CN117582495A (zh)	2024-02-23
KR102843438B1 (ko)	2025-08-06
PL3630112T3 (pl)	2024-07-01
KR102673422B1 (ko)	2024-06-07
IL270948A (en)	2020-01-30
AU2018276273B2 (en)	2023-12-21
FI3630112T3 (fi)	2024-05-02
BR112019025478A8 (pt)	2022-12-06
AU2018276273A1 (en)	2019-12-12
US20220133888A1 (en)	2022-05-05
JP2024096905A (ja)	2024-07-17
IL317015A (en)	2025-01-01
AU2023282197B2 (en)	2025-06-26

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