DK3634468T5 - Fast sammensætning til oral indgivelse - Google Patents

Fast sammensætning til oral indgivelse Download PDF

Info

Publication number
DK3634468T5
DK3634468T5 DK18730344.1T DK18730344T DK3634468T5 DK 3634468 T5 DK3634468 T5 DK 3634468T5 DK 18730344 T DK18730344 T DK 18730344T DK 3634468 T5 DK3634468 T5 DK 3634468T5
Authority
DK
Denmark
Prior art keywords
oral administration
solid composition
solid
composition
oral
Prior art date
Application number
DK18730344.1T
Other languages
English (en)
Other versions
DK3634468T3 (da
Inventor
Andreas Vegge
Susanne Schéele
Simon Bjerregaard
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59070439&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3634468(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of DK3634468T3 publication Critical patent/DK3634468T3/da
Application granted granted Critical
Publication of DK3634468T5 publication Critical patent/DK3634468T5/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK18730344.1T 2017-06-09 2018-06-11 Fast sammensætning til oral indgivelse DK3634468T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17175131 2017-06-09
PCT/EP2018/065266 WO2018224689A2 (en) 2017-06-09 2018-06-11 Solid compositions for oral administration

Publications (2)

Publication Number Publication Date
DK3634468T3 DK3634468T3 (da) 2023-02-06
DK3634468T5 true DK3634468T5 (da) 2024-09-02

Family

ID=59070439

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18730344.1T DK3634468T5 (da) 2017-06-09 2018-06-11 Fast sammensætning til oral indgivelse

Country Status (28)

Country Link
US (2) US11167014B2 (da)
EP (1) EP3634468B1 (da)
JP (1) JP7239495B2 (da)
KR (1) KR20200015564A (da)
CN (1) CN110769846A (da)
AR (1) AR112015A1 (da)
AU (1) AU2018280875A1 (da)
BR (1) BR112019025769A2 (da)
CA (1) CA3064677A1 (da)
CL (1) CL2019003402A1 (da)
CO (1) CO2019013047A2 (da)
DK (1) DK3634468T5 (da)
ES (1) ES2938050T3 (da)
FI (1) FI3634468T3 (da)
HR (1) HRP20230075T1 (da)
HU (1) HUE060962T2 (da)
IL (1) IL270812B2 (da)
MA (1) MA49253A (da)
MX (1) MX2019013965A (da)
MY (1) MY197488A (da)
PE (1) PE20200606A1 (da)
PH (1) PH12019550249A1 (da)
PL (1) PL3634468T3 (da)
PT (1) PT3634468T (da)
RS (1) RS64045B1 (da)
SI (1) SI3634468T1 (da)
TW (1) TWI797133B (da)
WO (1) WO2018224689A2 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4324475A1 (en) 2012-03-22 2024-02-21 Novo Nordisk A/S Compositions of glp-1 peptides and preparation thereof
KR20210086717A (ko) 2013-05-02 2021-07-08 노보 노르디스크 에이/에스 Glp-1 화합물의 경구 투여
WO2019149880A1 (en) 2018-02-02 2019-08-08 Novo Nordisk A/S Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant
TWI829687B (zh) 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
WO2020130502A1 (ko) * 2018-12-21 2020-06-25 (주)휴온스 엠파글리플로진 및 시타글립틴을 포함하는 약학적 조성물
KR20220044269A (ko) * 2019-08-07 2022-04-07 노보 노르디스크 에이/에스 Glp-1 작용제, sglt2 억제제, 및 n-(8-(2-하이드록시벤조일)아미노)카프릴산의 염을 포함하는 고형분 조성물
CN114641276A (zh) * 2019-11-07 2022-06-17 诺和诺德股份有限公司 包含glp-1激动剂、sglt2抑制剂和n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐的固体组合物
US20230165939A1 (en) * 2020-04-29 2023-06-01 Novo Nordisk A/S Solid compositions comprising a glp-1 agonist and histidine
WO2023065231A1 (en) * 2021-10-21 2023-04-27 Guangzhou Dazhou Biomedicine Ltd. Oral delivery of therapeutic agents
CN118742326A (zh) * 2021-12-29 2024-10-01 广州大洲生物医药科技有限公司 口服递送
EP4299052A1 (en) * 2022-06-30 2024-01-03 Adocia Solid compositions comprising a peptide or a protein and a permeation enhancer
CN114984191B (zh) * 2022-07-04 2022-10-25 北京惠之衡生物科技有限公司 一种多肽类药物口服递送组合物
IL323039A (en) * 2023-03-06 2025-10-01 Ascendis Pharma As Drug compounds containing albumin-binding moieties

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
ATE309197T1 (de) 1999-02-05 2005-11-15 Emisphere Tech Inc Verfahren zur herstellung alkylierter salicylamide
US6515117B2 (en) 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
AU2001275231A1 (en) 2000-06-02 2001-12-11 Emisphere Technologies, Inc. Method of preparing salicylamides
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
TWI372629B (en) 2005-03-18 2012-09-21 Novo Nordisk As Acylated glp-1 compounds
US7772191B2 (en) 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
AR056195A1 (es) 2005-09-15 2007-09-26 Boehringer Ingelheim Int Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos
AU2007216452A1 (en) 2006-02-15 2007-08-23 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
US8927015B2 (en) 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
BRPI0716539A2 (pt) 2006-09-07 2016-11-01 Emisphere Tech Inc métodos para sintetização de ácido n-(8-[2-hidroxibenzoil]amino) caprílico e de sal de sódio deste
AR065809A1 (es) 2007-03-22 2009-07-01 Bristol Myers Squibb Co Formulaciones farmaceuticas que contienen un inhibidor sglt2
JP2010528023A (ja) 2007-05-18 2010-08-19 ブリストル−マイヤーズ スクイブ カンパニー Ｓｇｌｔ２阻害剤の結晶構造およびその製造方法
ES2672770T3 (es) 2007-09-05 2018-06-18 Novo Nordisk A/S Derivados del péptido-1 similar al glucagón y su uso farmacéutico
EP2435033A1 (en) 2009-05-27 2012-04-04 Bristol-Myers Squibb Company Methods for treating type 2 diabetes in patients resistant to previous treatment with other anti-diabetic drugs employing an sglt2 inhibitor and compositions thereof
CN104825417A (zh) 2009-11-13 2015-08-12 阿斯利康(瑞典)有限公司 立即释放片剂
CA2784757A1 (en) 2009-12-16 2011-07-07 Novo Nordisk A/S Double-acylated glp-1 derivatives
PL2651398T3 (pl) 2010-12-16 2018-05-30 Novo Nordisk A/S Stałe kompozycje zawierające agonistę GLP-1 i sól kwasu N-(8-(2-hydroksybenzoilo)amino)kaprylowego
US20130035281A1 (en) 2011-02-09 2013-02-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
DK2696687T3 (da) 2011-04-12 2017-02-06 Novo Nordisk As Dobbeltacylerede GLP-1 derivater
US20130224300A1 (en) 2011-08-26 2013-08-29 Edward T. Maggio Compositions and methods thereof for oral administration of drugs
HUE042757T2 (hu) 2012-03-22 2019-07-29 Novo Nordisk As Szállító szert tartalmazó készítmények és elõállításuk
PL3542790T3 (pl) 2012-03-22 2024-02-26 Novo Nordisk A/S Kompozycje zawierające substancję dostarczającą i ich przygotowanie
EP4324475A1 (en) 2012-03-22 2024-02-21 Novo Nordisk A/S Compositions of glp-1 peptides and preparation thereof
JP6517690B2 (ja) * 2012-06-20 2019-05-22 ノヴォ ノルディスク アー／エス ペプチド及び送達剤を含む錠剤製剤
US20160296602A1 (en) 2013-03-20 2016-10-13 Novo Nordisk A/S Dosing Regimen
ES2741507T3 (es) 2014-04-07 2020-02-11 Novo Nordisk As Compuestos de glp-1 acilados doblemente
CA2993215C (en) * 2015-07-02 2023-10-31 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
WO2018096162A1 (en) 2016-11-28 2018-05-31 Novo Nordisk A/S Insulin degludec in cardiovascular conditions
WO2018096164A1 (en) 2016-11-28 2018-05-31 Novo Nordisk A/S Insulin degludec for treating diabetes
WO2018096163A1 (en) 2016-11-28 2018-05-31 Novo Nordisk A/S Insulin degludec for improvement of glycaemic control and reduction of acute and long-term diabetes complications
KR20220044269A (ko) * 2019-08-07 2022-04-07 노보 노르디스크 에이/에스 Glp-1 작용제, sglt2 억제제, 및 n-(8-(2-하이드록시벤조일)아미노)카프릴산의 염을 포함하는 고형분 조성물

Also Published As

Publication number Publication date
CL2019003402A1 (es) 2020-03-20
EP3634468B1 (en) 2022-12-14
WO2018224689A3 (en) 2019-02-28
CO2019013047A2 (es) 2020-04-01
HUE060962T2 (hu) 2023-04-28
FI3634468T3 (fi) 2023-02-19
CA3064677A1 (en) 2018-12-13
PT3634468T (pt) 2023-03-28
US11167014B2 (en) 2021-11-09
PL3634468T3 (pl) 2023-03-13
JP7239495B2 (ja) 2023-03-14
ES2938050T3 (es) 2023-04-04
JP2020522559A (ja) 2020-07-30
TWI797133B (zh) 2023-04-01
AU2018280875A1 (en) 2019-12-12
RS64045B1 (sr) 2023-04-28
EP3634468A2 (en) 2020-04-15
PH12019550249A1 (en) 2020-07-13
DK3634468T3 (da) 2023-02-06
IL270812B2 (en) 2024-01-01
RU2019139082A3 (da) 2021-09-16
BR112019025769A2 (pt) 2020-06-30
MX2019013965A (es) 2020-01-23
KR20200015564A (ko) 2020-02-12
CN110769846A (zh) 2020-02-07
MA49253A (fr) 2020-04-15
RU2019139082A (ru) 2021-06-02
IL270812B1 (en) 2023-09-01
US20220016216A1 (en) 2022-01-20
HRP20230075T1 (hr) 2023-03-17
TW201904583A (zh) 2019-02-01
PE20200606A1 (es) 2020-03-10
US20200147179A1 (en) 2020-05-14
MY197488A (en) 2023-06-19
AR112015A1 (es) 2019-09-11
WO2018224689A2 (en) 2018-12-13
IL270812A (en) 2020-01-30
SI3634468T1 (sl) 2023-02-28

Similar Documents

Publication Publication Date Title
DK3634468T3 (da) Fast sammensætning til oral indgivelse
DK3236943T3 (da) Sammensætninger til ileo-jejunal lægemiddeladministration
EP3513809A4 (en) MEDICAL COMPOSITION
DK3529248T3 (da) Farmaceutiske sammensætninger
DK3256138T3 (da) Farmaceutiske sammensætninger omfattende meloxicam
DK3655017T3 (da) Farmaceutisk sammensætning
DK3253382T3 (da) Farmaceutiske sammensætninger til kombinationsterapi
EP3641771A4 (en) PHARMACEUTICAL COMPOSITIONS
EP3316685A4 (en) Lyophilized Pharmaceutical Compositions
DK3244878T3 (da) Faste orale sammensætningsformer
DK3583943T3 (da) Farmaceutisk sammensætning
PL3706724T3 (pl) Doustne kompozycje ryfamycyny sv
MA49837A (fr) Compositions pharmaceutiques
LT3389633T (lt) Farmacinės kompozicijos, apimančios fenilaminopirimidino darinį
DK3908321T3 (da) Farmaceutisk sammensætning
DK3762009T3 (da) Toxin-afledte indgivelseskonstrukter til oral indgivelse
SMT202400478T1 (it) Composizione farmaceutica
EP3727485C0 (en) PHARMACEUTICAL COMPOSITION
PT3949952T (pt) Composição farmacêutica
EP3441073A4 (en) MEDICAL COMPOSITION
KR20180084728A (ko) 구강용 조성물
EP3423041A4 (en) PHARMACEUTICAL COMPOSITIONS
EP3528818A4 (en) PHARMACEUTICAL COMPOSITIONS
DK2952207T3 (da) Oliebaserede farmaceutiske sammensætninger til oral indgivelse
DK3664798T3 (da) Farmaceutisk sammensætning der omfatter eliglustat