DK363885A - Kloning af genet for human granulocyt-makrofag kolonistimulationsfaktor - Google Patents

Kloning af genet for human granulocyt-makrofag kolonistimulationsfaktor Download PDF

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Publication number
DK363885A
DK363885A DK363885A DK363885A DK363885A DK 363885 A DK363885 A DK 363885A DK 363885 A DK363885 A DK 363885A DK 363885 A DK363885 A DK 363885A DK 363885 A DK363885 A DK 363885A
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DK
Denmark
Prior art keywords
granulocyt
macrophag
cloning
genes
human
Prior art date
Application number
DK363885A
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English (en)
Other versions
DK363885D0 (da
Inventor
Dirk M Anderson
Michael A Cantrell
Douglas P Cerreti
David J Cosman
Alf D Larsen
Virginia L Price
Original Assignee
Immunex Corp
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Publication date
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Application filed by Immunex Corp filed Critical Immunex Corp
Publication of DK363885D0 publication Critical patent/DK363885D0/da
Publication of DK363885A publication Critical patent/DK363885A/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK363885A 1984-10-29 1985-08-09 Kloning af genet for human granulocyt-makrofag kolonistimulationsfaktor DK363885A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66604184A 1984-10-29 1984-10-29
US75040185A 1985-07-02 1985-07-02

Publications (2)

Publication Number Publication Date
DK363885D0 DK363885D0 (da) 1985-08-09
DK363885A true DK363885A (da) 1986-04-30

Family

ID=27099360

Family Applications (1)

Application Number Title Priority Date Filing Date
DK363885A DK363885A (da) 1984-10-29 1985-08-09 Kloning af genet for human granulocyt-makrofag kolonistimulationsfaktor

Country Status (5)

Country Link
EP (1) EP0183350B1 (da)
AU (1) AU588819B2 (da)
DE (1) DE3585210D1 (da)
DK (1) DK363885A (da)
ES (1) ES8701227A1 (da)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212645A (en) * 1984-07-06 1990-02-26 Sandoz Ltd Method for producing primate granulocyte-macrophage colony stimulating factor (gm-csf)
JPS61227526A (ja) * 1984-07-25 1986-10-09 Chugai Pharmaceut Co Ltd 新規なコロニー刺激因子
UA29377C2 (uk) * 1984-09-19 2000-11-15 Новартіс Аг Спосіб отримання білка з активністю колонієстимулювального фактора гранулоцитів та макрофагів(gm-csf) приматів
EP0202300B1 (en) * 1984-11-20 1992-11-11 Schering Biotech Corporation Cdna clones coding for polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity
DE3686794T2 (de) * 1985-02-05 1993-03-04 Cetus Oncology Corp Reinigung des natuerlichen kolonie-stimulierenden faktors-1.
US5078996A (en) * 1985-08-16 1992-01-07 Immunex Corporation Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
DE3681551D1 (de) * 1985-09-30 1991-10-24 Chugai Pharmaceutical Co Ltd Menschlicher granulozyten-colony stimulierender faktor.
DE3712985A1 (de) * 1987-04-16 1988-11-03 Hoechst Ag Bifunktionelle proteine
US5298603A (en) * 1985-12-21 1994-03-29 Hoechst Aktiengesellschaft GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use
DE3545568A1 (de) * 1985-12-21 1987-07-16 Hoechst Ag Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung
JP2583770B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 遺伝子
EP0342206A4 (en) * 1987-01-20 1990-09-19 Immunex Corporation Human interleukin-3 proteins
JPS6420097A (en) * 1987-03-02 1989-01-24 Sumitomo Chemical Co Human granulocyte-macrophage colony stimulating factor
US5063154A (en) * 1987-06-24 1991-11-05 Whitehead Institute For Biomedical Research Pheromone - inducible yeast promoter
WO1988010308A1 (en) * 1987-06-24 1988-12-29 Whitehead Institute For Biomedical Research Pheromone-inducible yeast promoter
WO1989010403A1 (en) * 1988-04-21 1989-11-02 Medvet Science Pty. Ltd. Human gm-csf variants
ES2091816T3 (es) * 1989-02-10 1996-11-16 Cetus Oncology Corp Anticuerpos monoclonales del factor estimulador de colonias de macrofagos (m-csf) que reconocen un epitope conformacional neutralizante.
US5109119A (en) * 1989-06-06 1992-04-28 Schering Corporation Crystalline r-h-gm-csf and method
CA2062975A1 (en) * 1989-07-14 1991-01-15 Gail F. Seelig Antagonists of gm-csf derived from the carboxyl terminus
US5463029A (en) * 1992-11-23 1995-10-31 Immunex Corporation Purification of fusion proteins comprising GM-CSF and IL-3
US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6153183A (en) * 1992-11-24 2000-11-28 G. D. Searle & Company Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
US6413509B1 (en) 1992-11-24 2002-07-02 S. Christopher Bauer Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US6361977B1 (en) 1992-11-24 2002-03-26 S. Christopher Bauer Methods of using multivariant IL-3 hematopoiesis fusion protein
US7091319B1 (en) 1992-11-24 2006-08-15 Bauer S Christopher IL-3 variant hematopoiesis fusion protein
US6911204B2 (en) 2000-08-11 2005-06-28 Favrille, Inc. Method and composition for altering a B cell mediated pathology
US20020141970A1 (en) * 2001-03-05 2002-10-03 Pettit Dean K. Stable aqueous solutions of granulocyte macrophage colony-stimulating factor
WO2003083066A2 (en) 2002-03-27 2003-10-09 Immunex Corporation Methods for increasing polypeptide production
EP2601287B1 (en) 2010-08-05 2015-01-07 Amgen Inc. Dipeptides to enhance yield and viability from cell cultures
WO2012145682A1 (en) 2011-04-21 2012-10-26 Amgen Inc. A method for culturing mammalian cells to improve recombinant protein production
KR101662412B1 (ko) 2011-07-01 2016-10-04 암젠 인크 포유동물 세포 배양
KR20140058669A (ko) 2011-09-02 2014-05-14 암젠 인크 의약품 및 의약품의 광 노출을 분석하는 방법
AR089231A1 (es) 2011-12-15 2014-08-06 Amgen Inc Metodo de floculacion
US20140199728A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
AU2014240596B2 (en) 2013-03-14 2018-09-27 Amgen Inc. Removal of leaked affinity purification ligand
TWI625390B (zh) 2013-03-14 2018-06-01 安美基公司 用於增加重組蛋白質之甘露糖含量之方法
US9481901B2 (en) 2013-05-30 2016-11-01 Amgen Inc. Methods for increasing mannose content of recombinant proteins
ES3030960T3 (en) 2013-10-31 2025-07-02 Amgen Inc Use of monensin to regulate glycosylation of recombinant proteins
MX376230B (es) 2014-01-13 2025-03-07 Amgen Inc Regulación del metábolismo de ornitina para manipular el contenido de glicoformas ricas en manosa de proteínas recombinantes.
BR112016017606A2 (pt) 2014-01-29 2017-10-10 Amgen Inc superexpressão de reguladores de via de n-glicosilação para modular a glicosilação de proteínas recombinantes
US10106829B2 (en) 2014-01-29 2018-10-23 Amgen Inc. Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
SG10202113019XA (en) 2014-06-04 2021-12-30 Amgen Inc Methods for harvesting mammalian cell cultures
US11275090B2 (en) 2014-11-19 2022-03-15 Amgen Inc. Quantitation of glycan moiety in recombinant glycoproteins
PL3227454T3 (pl) 2014-12-01 2020-07-27 Amgen Inc. Sposób manipulowania poziomem zawartości glikanów w glikoproteinie
IL321253A (en) 2018-05-01 2025-08-01 Amgen Inc Antibodies with a modulated glycan profile
EP4457342A1 (en) 2021-12-29 2024-11-06 Bristol-Myers Squibb Company Generation of landing pad cell lines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
DE3382547D1 (de) * 1983-01-12 1992-05-27 Chiron Corp Sekretorische expression in eukaryoten.
AU566677B2 (en) * 1984-03-16 1987-10-29 Tubemakers Of Australia Limited Security fence
NZ212645A (en) * 1984-07-06 1990-02-26 Sandoz Ltd Method for producing primate granulocyte-macrophage colony stimulating factor (gm-csf)
EP0202300B1 (en) * 1984-11-20 1992-11-11 Schering Biotech Corporation Cdna clones coding for polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity

Also Published As

Publication number Publication date
ES8701227A1 (es) 1986-11-16
EP0183350A2 (en) 1986-06-04
ES546298A0 (es) 1986-11-16
AU4563685A (en) 1986-05-08
DK363885D0 (da) 1985-08-09
EP0183350A3 (en) 1987-11-25
EP0183350B1 (en) 1992-01-15
DE3585210D1 (de) 1992-02-27
AU588819B2 (en) 1989-09-28

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