DK3652148T3 - Amorf form af vilanterol-trifenatat samt fremgangsmåde til fremstilling deraf - Google Patents

Amorf form af vilanterol-trifenatat samt fremgangsmåde til fremstilling deraf Download PDF

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Publication number
DK3652148T3
DK3652148T3 DK18752193.5T DK18752193T DK3652148T3 DK 3652148 T3 DK3652148 T3 DK 3652148T3 DK 18752193 T DK18752193 T DK 18752193T DK 3652148 T3 DK3652148 T3 DK 3652148T3
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DK
Denmark
Prior art keywords
preparation
amorphous form
vilanterol triphenate
triphenate
vilanterol
Prior art date
Application number
DK18752193.5T
Other languages
English (en)
Inventor
Joana Fernandes
Nuno Torres Lourenço
Luis Sobral
Original Assignee
Hovione Scientia Ltd
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Application filed by Hovione Scientia Ltd filed Critical Hovione Scientia Ltd
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Publication of DK3652148T3 publication Critical patent/DK3652148T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10Separation; Purification; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C07C215/58Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C07C215/60Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
DK18752193.5T 2017-07-19 2018-07-09 Amorf form af vilanterol-trifenatat samt fremgangsmåde til fremstilling deraf DK3652148T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT110209A PT110209B (pt) 2017-07-19 2017-07-19 Formas polimórficas de trifenatato de vilanterol e processos para a preparação das mesmas.
PCT/GB2018/051940 WO2019016512A1 (en) 2017-07-19 2018-07-09 POLYMORPHIC FORM OF VILANTEROL TRIFENATATE AND METHODS OF PREPARATION THEREOF

Publications (1)

Publication Number Publication Date
DK3652148T3 true DK3652148T3 (da) 2021-11-15

Family

ID=63143265

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18752193.5T DK3652148T3 (da) 2017-07-19 2018-07-09 Amorf form af vilanterol-trifenatat samt fremgangsmåde til fremstilling deraf

Country Status (16)

Country Link
US (2) US11434194B2 (da)
EP (2) EP3655386A2 (da)
JP (2) JP2020528057A (da)
KR (2) KR102572035B1 (da)
CN (3) CN115819257A (da)
AU (2) AU2018303782B9 (da)
BR (1) BR112020001171A2 (da)
CA (2) CA3069869A1 (da)
DK (1) DK3652148T3 (da)
ES (1) ES2899367T3 (da)
HU (1) HUE056419T2 (da)
IL (3) IL272109B2 (da)
MX (2) MX392899B (da)
PL (1) PL3652148T3 (da)
PT (1) PT110209B (da)
WO (2) WO2019016511A2 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT110209B (pt) 2017-07-19 2021-05-17 Hovione Farm Sa Formas polimórficas de trifenatato de vilanterol e processos para a preparação das mesmas.
EP4013398B1 (en) * 2019-08-16 2025-12-31 Melody Healthcare Pvt. Ltd. IMPROVED PROCESS FOR THE PREPARATION OF VILANTEROL OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
ES2995090T3 (en) * 2020-07-27 2025-02-05 Inke Sa Method for the purification of vilanterol trifenatate
CN114441677B (zh) * 2022-01-25 2024-06-11 上海方予健康医药科技有限公司 一种同时检测三苯乙酸维兰特罗多种基因杂质的方法
CN116199590B (zh) * 2022-12-26 2024-12-24 湖北美林药业有限公司 一种盐酸多巴酚丁胺及其注射剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090057477A (ko) 2001-09-14 2009-06-05 글락소 그룹 리미티드 호흡기 질환 치료용 펜에탄올아민 유도체
US20150239862A1 (en) * 2012-09-13 2015-08-27 Perrigo Api Ltd. Process for the preparation of vilanterol and intermediates thereof
EP3148521B1 (en) 2014-05-28 2019-12-18 GlaxoSmithKline Intellectual Property Development Limited Fluticasone furoate in the treatment of copd
WO2017001907A1 (en) * 2015-06-29 2017-01-05 Teva Pharmaceuticals International Gmbh Biocatalytic processes for the preparation of vilanterol
PT110209B (pt) 2017-07-19 2021-05-17 Hovione Farm Sa Formas polimórficas de trifenatato de vilanterol e processos para a preparação das mesmas.

Also Published As

Publication number Publication date
CA3070043A1 (en) 2019-01-24
CA3069869A1 (en) 2019-01-24
KR102572035B1 (ko) 2023-08-28
PL3652148T3 (pl) 2021-12-20
AU2018303782B2 (en) 2022-03-31
CN111108091B (zh) 2023-04-11
HUE056419T2 (hu) 2022-02-28
IL272109A (en) 2020-03-31
IL272109B2 (en) 2024-04-01
AU2018303293A1 (en) 2020-02-13
WO2019016511A2 (en) 2019-01-24
BR112020001123A2 (pt) 2020-09-01
EP3655386A2 (en) 2020-05-27
AU2018303782B9 (en) 2022-05-05
US20200165190A1 (en) 2020-05-28
MX392899B (es) 2025-03-24
CN115819257A (zh) 2023-03-21
IL272109B1 (en) 2023-12-01
CN111108091A (zh) 2020-05-05
WO2019016511A3 (en) 2019-03-21
KR20200030106A (ko) 2020-03-19
WO2019016512A1 (en) 2019-01-24
EP3652148B1 (en) 2021-08-25
US11414374B2 (en) 2022-08-16
PT110209A (pt) 2019-01-21
AU2018303782A1 (en) 2020-02-13
JP2020528057A (ja) 2020-09-17
MX2022013014A (es) 2022-11-09
KR20200030107A (ko) 2020-03-19
JP2023103328A (ja) 2023-07-26
BR112020001171A2 (pt) 2020-12-01
US11434194B2 (en) 2022-09-06
IL298421A (en) 2023-01-01
IL272108A (en) 2020-03-31
EP3652148A1 (en) 2020-05-20
AU2018303293B2 (en) 2022-03-03
US20200148626A1 (en) 2020-05-14
PT110209B (pt) 2021-05-17
ES2899367T3 (es) 2022-03-11
CN111094235A (zh) 2020-05-01

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