MX2022013014A - Nuevas formas cristalinas de trifenatato de vilanterol y procedimientos para su preparacion. - Google Patents
Nuevas formas cristalinas de trifenatato de vilanterol y procedimientos para su preparacion.Info
- Publication number
- MX2022013014A MX2022013014A MX2022013014A MX2022013014A MX2022013014A MX 2022013014 A MX2022013014 A MX 2022013014A MX 2022013014 A MX2022013014 A MX 2022013014A MX 2022013014 A MX2022013014 A MX 2022013014A MX 2022013014 A MX2022013014 A MX 2022013014A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- crystalline forms
- procedures
- new crystalline
- vilanterol trifenate
- Prior art date
Links
- KLOLZALDXGTNQE-JIDHJSLPSA-N vilanterol trifenate Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)O)C1=CC=CC=C1.C1=C(O)C(CO)=CC([C@@H](O)CNCCCCCCOCCOCC=2C(=CC=CC=2Cl)Cl)=C1 KLOLZALDXGTNQE-JIDHJSLPSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Abstract
La presente invención se refiere a nuevas formas cristalinas de trifenatato de vilanterol, a procedimientos para su preparación, y a su uso en una composición farmacéutica para el tratamiento de enfermedades respiratorias, particularmente para el tratamiento de asma y enfermedad pulmonar obstructiva crónica. En particular, la presente invención se refiere a una forma cristalina de trifenatato de vilanterol caracterizada porque la forma tiene un patrón de XRPD como se define en la presente memoria que tiene ángulos de difracción característicos (2-theta o 20 (°)) que cae dentro de o en cada extremo de uno o más de los siguientes intervalos: (a) 3 a 5°, tal como 3,8 a 4,4°; y/o (b) 7 a 9,9°, tal como 7 a 8,5°; y/o (c) 12 a 13,3°, tal como 12 a 13,3°; y/o (d) 16,4 a 17,3°, tal como 16,4 a 17,3°; y/o (e) 26,8 a 28,3°, tal como 26,8 a 28,3°.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT110209A PT110209B (pt) | 2017-07-19 | 2017-07-19 | Formas polimórficas de trifenatato de vilanterol e processos para a preparação das mesmas. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022013014A true MX2022013014A (es) | 2022-11-09 |
Family
ID=63143265
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020000548A MX392899B (es) | 2017-07-19 | 2018-07-09 | Forma amorfa de trifenatato de vilanterol y procedimientos para su preparacion |
| MX2022013014A MX2022013014A (es) | 2017-07-19 | 2020-01-15 | Nuevas formas cristalinas de trifenatato de vilanterol y procedimientos para su preparacion. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020000548A MX392899B (es) | 2017-07-19 | 2018-07-09 | Forma amorfa de trifenatato de vilanterol y procedimientos para su preparacion |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11434194B2 (es) |
| EP (2) | EP3652148B1 (es) |
| JP (2) | JP2020528057A (es) |
| KR (2) | KR102572035B1 (es) |
| CN (3) | CN111094235A (es) |
| AU (2) | AU2018303782B9 (es) |
| BR (1) | BR112020001171A2 (es) |
| CA (2) | CA3070043A1 (es) |
| DK (1) | DK3652148T3 (es) |
| ES (1) | ES2899367T3 (es) |
| HU (1) | HUE056419T2 (es) |
| IL (3) | IL298421A (es) |
| MX (2) | MX392899B (es) |
| PL (1) | PL3652148T3 (es) |
| PT (1) | PT110209B (es) |
| WO (2) | WO2019016511A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT110209B (pt) | 2017-07-19 | 2021-05-17 | Hovione Farm Sa | Formas polimórficas de trifenatato de vilanterol e processos para a preparação das mesmas. |
| EP4013398B1 (en) * | 2019-08-16 | 2025-12-31 | Melody Healthcare Pvt. Ltd. | IMPROVED PROCESS FOR THE PREPARATION OF VILANTEROL OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF |
| CN116209654B (zh) * | 2020-07-27 | 2025-03-21 | Inke股份公司 | 纯化维兰特罗三苯乙酸盐的方法 |
| CN114441677B (zh) * | 2022-01-25 | 2024-06-11 | 上海方予健康医药科技有限公司 | 一种同时检测三苯乙酸维兰特罗多种基因杂质的方法 |
| CN116199590B (zh) * | 2022-12-26 | 2024-12-24 | 湖北美林药业有限公司 | 一种盐酸多巴酚丁胺及其注射剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE417606T1 (de) * | 2001-09-14 | 2009-01-15 | Glaxo Group Ltd | Phenethanolamin-derivate zur behandlung von erkrankungen der atemwege |
| WO2014041565A2 (en) * | 2012-09-13 | 2014-03-20 | Laurus Labs Private Limited | An improved process for the preparation of vilanterol and intermediates thereof |
| EP3650019B8 (en) | 2014-05-28 | 2023-10-11 | GlaxoSmithKline Intellectual Property Development Limited | Fluticasone furoate in the treatment of copd |
| WO2017001907A1 (en) * | 2015-06-29 | 2017-01-05 | Teva Pharmaceuticals International Gmbh | Biocatalytic processes for the preparation of vilanterol |
| PT110209B (pt) | 2017-07-19 | 2021-05-17 | Hovione Farm Sa | Formas polimórficas de trifenatato de vilanterol e processos para a preparação das mesmas. |
-
2017
- 2017-07-19 PT PT110209A patent/PT110209B/pt active IP Right Grant
-
2018
- 2018-07-09 PL PL18752193T patent/PL3652148T3/pl unknown
- 2018-07-09 ES ES18752193T patent/ES2899367T3/es active Active
- 2018-07-09 US US16/631,683 patent/US11434194B2/en active Active
- 2018-07-09 KR KR1020207004628A patent/KR102572035B1/ko active Active
- 2018-07-09 HU HUE18752193A patent/HUE056419T2/hu unknown
- 2018-07-09 JP JP2020502459A patent/JP2020528057A/ja active Pending
- 2018-07-09 AU AU2018303782A patent/AU2018303782B9/en not_active Ceased
- 2018-07-09 EP EP18752193.5A patent/EP3652148B1/en active Active
- 2018-07-09 CA CA3070043A patent/CA3070043A1/en active Pending
- 2018-07-09 CN CN201880060197.4A patent/CN111094235A/zh active Pending
- 2018-07-09 KR KR1020207004626A patent/KR20200030106A/ko active Pending
- 2018-07-09 WO PCT/GB2018/051939 patent/WO2019016511A2/en not_active Ceased
- 2018-07-09 CA CA3069869A patent/CA3069869A1/en active Pending
- 2018-07-09 CN CN202211471062.1A patent/CN115819257A/zh active Pending
- 2018-07-09 DK DK18752193.5T patent/DK3652148T3/da active
- 2018-07-09 IL IL298421A patent/IL298421A/en unknown
- 2018-07-09 WO PCT/GB2018/051940 patent/WO2019016512A1/en not_active Ceased
- 2018-07-09 BR BR112020001171-1A patent/BR112020001171A2/pt not_active IP Right Cessation
- 2018-07-09 EP EP18752192.7A patent/EP3655386A2/en not_active Withdrawn
- 2018-07-09 MX MX2020000548A patent/MX392899B/es unknown
- 2018-07-09 US US16/631,685 patent/US11414374B2/en active Active
- 2018-07-09 CN CN201880060726.0A patent/CN111108091B/zh not_active Expired - Fee Related
- 2018-07-09 IL IL272109A patent/IL272109B2/en unknown
- 2018-07-09 AU AU2018303293A patent/AU2018303293B2/en not_active Ceased
-
2020
- 2020-01-15 MX MX2022013014A patent/MX2022013014A/es unknown
- 2020-01-17 IL IL272108A patent/IL272108A/en unknown
-
2023
- 2023-05-08 JP JP2023076831A patent/JP2023103328A/ja active Pending
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