DK3665176T3 - Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h[1,3]dioxolo[4,5-f]indol-7-yl)pyrrol-2,5-dion - Google Patents

Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h[1,3]dioxolo[4,5-f]indol-7-yl)pyrrol-2,5-dion Download PDF

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Publication number
DK3665176T3
DK3665176T3 DK18760168.7T DK18760168T DK3665176T3 DK 3665176 T3 DK3665176 T3 DK 3665176T3 DK 18760168 T DK18760168 T DK 18760168T DK 3665176 T3 DK3665176 T3 DK 3665176T3
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Prior art keywords
fluorbenzofuran
dioxolo
dion
indol
pyrrole
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Application number
DK18760168.7T
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English (en)
Inventor
Yamin Zhang
Original Assignee
Actuate Therapeutics Inc
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Publication date
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Application filed by Actuate Therapeutics Inc filed Critical Actuate Therapeutics Inc
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Publication of DK3665176T3 publication Critical patent/DK3665176T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/056Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
DK18760168.7T 2017-08-11 2018-08-10 Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h[1,3]dioxolo[4,5-f]indol-7-yl)pyrrol-2,5-dion DK3665176T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762544277P 2017-08-11 2017-08-11
PCT/US2018/046203 WO2019032958A1 (en) 2017-08-11 2018-08-10 SOLID FORMS OF 3- (5-FLUOROBENZOFURAN-3-YL) -4- (5-METHYL-5H [1,3] DIOXOLO [4,5-F] INDOL-7-YL) PYRROLE-2,5-DIONE

Publications (1)

Publication Number Publication Date
DK3665176T3 true DK3665176T3 (da) 2024-03-25

Family

ID=63405430

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18760168.7T DK3665176T3 (da) 2017-08-11 2018-08-10 Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h[1,3]dioxolo[4,5-f]indol-7-yl)pyrrol-2,5-dion

Country Status (16)

Country Link
US (3) US11136334B2 (da)
EP (1) EP3665176B1 (da)
JP (3) JP7424639B2 (da)
KR (3) KR20250070131A (da)
CN (2) CN117362305A (da)
AU (3) AU2018313259B2 (da)
BR (1) BR112020002892A2 (da)
CA (1) CA3072240A1 (da)
DK (1) DK3665176T3 (da)
ES (1) ES2974328T3 (da)
FI (1) FI3665176T3 (da)
IL (2) IL313800A (da)
MX (3) MX2020001547A (da)
PL (1) PL3665176T3 (da)
PT (1) PT3665176T (da)
WO (1) WO2019032958A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020003431A (es) 2017-10-16 2020-07-29 Actuate Therapeutics Inc Formas solidas de 3-(5-fluorobenzofuran-3-il)-4-(5-metil-5h-[1,3]d ioxolo[4,5-f]indol-7-il)pirrol- 2,5-diona.
CN112437663A (zh) * 2018-05-17 2021-03-02 开动疗法公司 用β型糖原合酶激酶3抑制剂治疗特发性肺纤维化
CN119630388A (zh) * 2022-06-27 2025-03-14 开动疗法公司 Elraglusib的口服剂型

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2446269T3 (es) 2006-12-19 2014-03-06 The Board Of Trustees Of The University Of Illinois 3-Benzofuranil-4-indolil-maleimidas como potentes inhibidores de GSK-3 para trastornos neurodegenerativos
KR101669707B1 (ko) 2009-12-23 2016-10-27 아르퀼 인코포레이티드 정제된 피롤로퀴놀리닐-피롤리딘-2,5-디온 조성물 및 이의 제조 방법 및 사용 방법

Also Published As

Publication number Publication date
WO2019032958A1 (en) 2019-02-14
US20200223861A1 (en) 2020-07-16
AU2023201059B2 (en) 2025-04-03
EP3665176B1 (en) 2024-01-24
US20220009939A1 (en) 2022-01-13
PT3665176T (pt) 2024-03-13
JP7778750B2 (ja) 2025-12-02
CA3072240A1 (en) 2019-02-14
KR20200040799A (ko) 2020-04-20
BR112020002892A2 (pt) 2020-08-04
CN117362305A (zh) 2024-01-09
CN111247153B (zh) 2024-04-02
AU2018313259B2 (en) 2022-11-24
JP2026012715A (ja) 2026-01-27
FI3665176T3 (fi) 2024-03-20
MX2020001547A (es) 2020-08-03
KR20250070131A (ko) 2025-05-20
US20250115616A1 (en) 2025-04-10
JP2023156372A (ja) 2023-10-24
MX2023005875A (es) 2023-06-05
AU2018313259A1 (en) 2020-02-27
US11136334B2 (en) 2021-10-05
JP7424639B2 (ja) 2024-01-30
IL272556A (en) 2020-03-31
IL272556B1 (en) 2024-09-01
CN111247153A (zh) 2020-06-05
AU2025202936A1 (en) 2025-05-15
ES2974328T3 (es) 2024-06-26
PL3665176T3 (pl) 2024-06-17
KR102700883B1 (ko) 2024-09-02
US12145943B2 (en) 2024-11-19
EP3665176A1 (en) 2020-06-17
MX2024003249A (es) 2024-04-04
JP2020530497A (ja) 2020-10-22
IL313800A (en) 2024-08-01
KR20240063198A (ko) 2024-05-09
IL272556B2 (en) 2025-01-01
AU2023201059A1 (en) 2023-03-23

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