DK3665176T3 - Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h[1,3]dioxolo[4,5-f]indol-7-yl)pyrrol-2,5-dion - Google Patents

Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h[1,3]dioxolo[4,5-f]indol-7-yl)pyrrol-2,5-dion Download PDF

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Publication number
DK3665176T3
DK3665176T3 DK18760168.7T DK18760168T DK3665176T3 DK 3665176 T3 DK3665176 T3 DK 3665176T3 DK 18760168 T DK18760168 T DK 18760168T DK 3665176 T3 DK3665176 T3 DK 3665176T3
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DK
Denmark
Prior art keywords
fluorbenzofuran
dioxolo
dion
indol
pyrrole
Prior art date
Application number
DK18760168.7T
Other languages
English (en)
Inventor
Yamin Zhang
Original Assignee
Actuate Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Actuate Therapeutics Inc filed Critical Actuate Therapeutics Inc
Application granted granted Critical
Publication of DK3665176T3 publication Critical patent/DK3665176T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
DK18760168.7T 2017-08-11 2018-08-10 Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h[1,3]dioxolo[4,5-f]indol-7-yl)pyrrol-2,5-dion DK3665176T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762544277P 2017-08-11 2017-08-11
PCT/US2018/046203 WO2019032958A1 (en) 2017-08-11 2018-08-10 SOLID FORMS OF 3- (5-FLUOROBENZOFURAN-3-YL) -4- (5-METHYL-5H [1,3] DIOXOLO [4,5-F] INDOL-7-YL) PYRROLE-2,5-DIONE

Publications (1)

Publication Number Publication Date
DK3665176T3 true DK3665176T3 (da) 2024-03-25

Family

ID=63405430

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18760168.7T DK3665176T3 (da) 2017-08-11 2018-08-10 Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h[1,3]dioxolo[4,5-f]indol-7-yl)pyrrol-2,5-dion

Country Status (16)

Country Link
US (3) US11136334B2 (da)
EP (1) EP3665176B1 (da)
JP (3) JP7424639B2 (da)
KR (3) KR20250070131A (da)
CN (2) CN117362305A (da)
AU (3) AU2018313259B2 (da)
BR (1) BR112020002892A2 (da)
CA (1) CA3072240A1 (da)
DK (1) DK3665176T3 (da)
ES (1) ES2974328T3 (da)
FI (1) FI3665176T3 (da)
IL (2) IL272556B2 (da)
MX (3) MX2020001547A (da)
PL (1) PL3665176T3 (da)
PT (1) PT3665176T (da)
WO (1) WO2019032958A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11407759B2 (en) * 2017-10-16 2022-08-09 Actuate Therapeutics Inc. Solid forms of 3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione
KR20210038429A (ko) * 2018-05-17 2021-04-07 액투에이트 테라퓨틱스 인크. 글리코겐 신타제 키나제 3 형태 베타 억제제를 사용한 특발성 폐 섬유증의 치료
CA3251821A1 (en) * 2022-06-27 2024-01-04 Actuate Therapeutics, Inc. ORAL DOSAGE FORMS OF ELRAGLUSIB

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2673368C (en) 2006-12-19 2014-10-28 The Board Of Trustees Of The University Of Illinois 3-benzofuranyl-4-indolyl maleimides as potent gsk3 inhibitors for neurogenerative disorders
JP2013515737A (ja) 2009-12-23 2013-05-09 アークル インコーポレイテッド 精製されたピロロキノリニル−ピロリジン−2,5−ジオン組成物ならびにその調製方法および使用方法

Also Published As

Publication number Publication date
WO2019032958A1 (en) 2019-02-14
US11136334B2 (en) 2021-10-05
US20200223861A1 (en) 2020-07-16
KR20250070131A (ko) 2025-05-20
PT3665176T (pt) 2024-03-13
MX2020001547A (es) 2020-08-03
IL272556A (en) 2020-03-31
US20220009939A1 (en) 2022-01-13
MX2024003249A (es) 2024-04-04
CN111247153A (zh) 2020-06-05
JP2026012715A (ja) 2026-01-27
CA3072240A1 (en) 2019-02-14
IL313800A (en) 2024-08-01
US20250115616A1 (en) 2025-04-10
EP3665176A1 (en) 2020-06-17
MX2023005875A (es) 2023-06-05
AU2023201059A1 (en) 2023-03-23
KR20240063198A (ko) 2024-05-09
ES2974328T3 (es) 2024-06-26
EP3665176B1 (en) 2024-01-24
CN111247153B (zh) 2024-04-02
IL272556B2 (en) 2025-01-01
BR112020002892A2 (pt) 2020-08-04
JP2020530497A (ja) 2020-10-22
AU2025202936A1 (en) 2025-05-15
CN117362305A (zh) 2024-01-09
JP2023156372A (ja) 2023-10-24
JP7424639B2 (ja) 2024-01-30
JP7778750B2 (ja) 2025-12-02
AU2018313259B2 (en) 2022-11-24
AU2018313259A1 (en) 2020-02-27
AU2023201059B2 (en) 2025-04-03
PL3665176T3 (pl) 2024-06-17
US12145943B2 (en) 2024-11-19
KR20200040799A (ko) 2020-04-20
FI3665176T3 (fi) 2024-03-20
KR102700883B1 (ko) 2024-09-02
IL272556B1 (en) 2024-09-01

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