DK3682247T3 - Proadrenomedullin som markør for unormale blodpladeniveauer - Google Patents
Proadrenomedullin som markør for unormale blodpladeniveauer Download PDFInfo
- Publication number
- DK3682247T3 DK3682247T3 DK18765659.0T DK18765659T DK3682247T3 DK 3682247 T3 DK3682247 T3 DK 3682247T3 DK 18765659 T DK18765659 T DK 18765659T DK 3682247 T3 DK3682247 T3 DK 3682247T3
- Authority
- DK
- Denmark
- Prior art keywords
- proadrenomedullin
- marker
- abnormal blood
- blood plate
- plate levels
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
- G01N2800/222—Platelet disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17190912 | 2017-09-13 | ||
| EP18161091 | 2018-03-09 | ||
| PCT/EP2018/074725 WO2019053118A1 (en) | 2017-09-13 | 2018-09-13 | PROADRÉNOMÉDULLINE AS A MARKER OF ABNORMAL PLATELET RATES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3682247T3 true DK3682247T3 (da) | 2022-03-21 |
Family
ID=63517904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18765659.0T DK3682247T3 (da) | 2017-09-13 | 2018-09-13 | Proadrenomedullin som markør for unormale blodpladeniveauer |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11327082B2 (da) |
| EP (3) | EP3971572A1 (da) |
| JP (1) | JP7346389B2 (da) |
| CN (1) | CN111094987B (da) |
| DK (1) | DK3682247T3 (da) |
| ES (1) | ES2909399T3 (da) |
| PL (1) | PL3682247T3 (da) |
| WO (1) | WO2019053118A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3141817A1 (en) * | 2019-05-24 | 2020-12-03 | Astute Medical, Inc. | Methods for evaluation and treatment of renal injury based on c-c motif chemokine ligand 14 measurement |
| CN114113580A (zh) * | 2020-08-25 | 2022-03-01 | 张曼 | 尿液血栓调节蛋白及其多肽片段在烧伤中的应用 |
| CN119780441B (zh) * | 2024-12-25 | 2026-02-13 | 首都医科大学附属北京胸科医院 | 一种诊断近期及远期结核感染的生物标志物 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2570703B1 (fr) | 1984-09-26 | 1988-07-08 | Commissariat Energie Atomique | Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents |
| US4882733A (en) | 1987-03-13 | 1989-11-21 | Ford Aerospace Corporation | Method and apparatus for combining encoding and modulation |
| FR2664699B1 (fr) | 1990-07-13 | 1995-08-18 | Cis Bio Int | Procede d'amplification du signal d'emission d'un compose luminescent. |
| WO1997007214A1 (en) | 1995-08-18 | 1997-02-27 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Functional role of adrenomedullin (am) and the gene-related product (pamp) in human pathology and physiology |
| DE19847690A1 (de) * | 1998-10-15 | 2000-04-20 | Brahms Diagnostica Gmbh | Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen |
| KR100425525B1 (ko) | 2000-11-21 | 2004-03-30 | 재단법인서울대학교산학협력재단 | 조산과 태아감염 및 태아손상을 산전 진단하기 위한진단시약 및 진단키트 |
| EP1453529A4 (en) * | 2001-09-19 | 2007-09-26 | Oklahoma Med Res Found | TREATMENT OF SEPSIS WITH TAFI |
| DE10316583A1 (de) * | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| US20060029589A1 (en) * | 2004-06-01 | 2006-02-09 | Hartmut Weiler | Induction of heterozygous FV Leiden carrier status to reduce mortality in sepsis and to prevent organ damage caused by inflammation and/or ischemia-reperfusion injury |
| EP1787128A2 (en) * | 2004-07-09 | 2007-05-23 | Amaox, Inc. | Immune cell biosensors and methods of using same |
| EP1619505B1 (en) * | 2004-07-22 | 2008-04-16 | BRAHMS Aktiengesellschaft | Method for the diagnosis of critically ill patients |
| US8906857B2 (en) * | 2005-12-01 | 2014-12-09 | B.R.A.H.M.S. Gmbh | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| US20070298034A9 (en) * | 2005-12-09 | 2007-12-27 | Angela Widom | Sulfotyrosine specific antibodies and uses therefor |
| DE102006027818A1 (de) * | 2006-06-16 | 2007-12-20 | B.R.A.H.M.S. Aktiengesellschaft | In vitro Multiparameter-Bestimmungsverfahren zur Diagnose und Frühdiagnose von neurodegenerativen Erkrankungen |
| DE102006034142A1 (de) | 2006-07-24 | 2008-01-31 | B.R.A.H.M.S. Aktiengesellschaft | Verfahren zur Steuerung der Therapie von Patienten mit Herzinsuffizienz anhand der vitro Bestimmung von Schwellenwerten von vasoaktiven Peptiden |
| DE102006052916A1 (de) * | 2006-11-08 | 2008-05-15 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung von Diabetes mellitus mittels MR-proADM |
| US9012151B2 (en) * | 2006-11-09 | 2015-04-21 | B.R.A.H.M.S. Gmbh | Methods of diagnosis and risk stratification of adverse events in post myocardial infarction patients using pro-adrenomedullin |
| DE102006060112A1 (de) | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| WO2008109903A1 (en) | 2007-03-12 | 2008-09-18 | Biomedica Medizinprodukte Gmbh & Co Kg | Diagnosis of septic complications |
| AU2008295046B2 (en) | 2007-09-07 | 2013-08-01 | Universitat Zurich | Method for assaying sepsis in humans |
| MX2010004615A (es) * | 2007-10-26 | 2010-07-06 | Oklahoma Med Res Found | Anticuerpos monoclonales contra proteina c. activada e inactivada. |
| ES2486268T3 (es) | 2007-11-16 | 2014-08-18 | Biocartis Nv | Biomarcadores y procedimientos de diagnóstico, predicción y/o pronóstico de septicemia y usos de los mismos |
| US9229013B2 (en) | 2009-05-05 | 2016-01-05 | B.R.A.H.M.S Gmbh | Vasoactive hormone-based stratification of patients suffering from diseases related to endothelial function/dysfunction |
| ITPI20090066A1 (it) * | 2009-05-26 | 2010-11-27 | Consiglio Nazionale Ricerche | Metodo per produrre un dispositivo applicabile a tessuti biologici, in particolare un patch per trattare tessuti danneggiati, e dispositivo ottenuto con tale metodo |
| WO2010139475A1 (en) | 2009-06-05 | 2010-12-09 | B.R.A.H.M.S Gmbh | Detection of bacterial infections in subjects suffering from dyspnea |
| WO2011027971A2 (ko) * | 2009-09-01 | 2011-03-10 | 주식회사이언메딕스 | 장내 공생 세균유래 세포밖 소포체, 및 이를 이용한 질병모델, 백신, 후보 약물 탐색 방법, 및 진단 방법 |
| ES2601104T3 (es) | 2009-10-13 | 2017-02-14 | B.R.A.H.M.S Gmbh | Procalcitonina para el diagnóstico de infecciones bacterianas y la guía del tratamiento antibiótico en pacientes con apoplejía aguda o accidente isquémico transitorio |
| BR112012022509A2 (pt) | 2010-03-08 | 2017-09-26 | Brahms Gmbh | procalcitonina para o diagnóstico de infecções bacterianas e orientação de tratamento antibiótico em pacientes com queixas não específicas. |
| RU2017110678A (ru) | 2010-11-01 | 2019-01-24 | Б.Р.А.Х.М.С Гмбх | Оценка прогноза и риска пациентов с неспецифическими жалобами |
| DK2781221T3 (da) * | 2011-11-15 | 2020-06-02 | Asahi Kasei Pharma Corp | Medicin til behandling og/eller forbedring af sepsis |
| EP2780717B1 (en) * | 2011-11-16 | 2016-12-21 | sphingotec GmbH | Adrenomedullin assays and methods for determining mature adrenomedullin |
| WO2013086359A1 (en) | 2011-12-08 | 2013-06-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2657707A1 (en) * | 2012-04-26 | 2013-10-30 | B.R.A.H.M.S GmbH | Biomakers for the diagnosis, prognosis, assessment and therapy stratification syncope |
| US9910052B2 (en) * | 2012-05-07 | 2018-03-06 | Lsi Medience Corporation | Method of diagnosing and treating infectious disseminated intravascular coagulation |
| CN108362885B (zh) | 2013-03-20 | 2021-05-14 | 斯弗因高泰克有限公司 | 用于指导血压下降疗法的肾上腺髓质素 |
| WO2015147369A1 (ko) * | 2014-03-27 | 2015-10-01 | 전북대학교산학협력단 | Sirt2 억제제를 포함하는 약학적 조성물 |
| CN119199150A (zh) | 2015-11-27 | 2024-12-27 | B.R.A.H.M.S 有限公司 | 作为对象的细胞外容量状态的标志物的MR-proADM |
| CN109716136B (zh) | 2016-07-08 | 2023-09-22 | 斯弗因高泰克有限公司 | 肾上腺髓质素用于评估急性心力衰竭患者的充血 |
| CA3033094A1 (en) | 2016-08-09 | 2018-02-15 | B.R.A.H.M.S Gmbh | Histones and/or proadm as markers indicating an adverse event |
-
2018
- 2018-09-13 EP EP21198828.2A patent/EP3971572A1/en active Pending
- 2018-09-13 US US16/646,798 patent/US11327082B2/en active Active
- 2018-09-13 WO PCT/EP2018/074725 patent/WO2019053118A1/en not_active Ceased
- 2018-09-13 EP EP21198856.3A patent/EP3971573A1/en active Pending
- 2018-09-13 EP EP18765659.0A patent/EP3682247B1/en active Active
- 2018-09-13 CN CN201880059382.1A patent/CN111094987B/zh active Active
- 2018-09-13 PL PL18765659T patent/PL3682247T3/pl unknown
- 2018-09-13 ES ES18765659T patent/ES2909399T3/es active Active
- 2018-09-13 DK DK18765659.0T patent/DK3682247T3/da active
- 2018-09-13 JP JP2020514918A patent/JP7346389B2/ja active Active
-
2022
- 2022-03-31 US US17/710,329 patent/US12405279B2/en active Active
- 2022-03-31 US US17/710,369 patent/US12000845B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3682247A1 (en) | 2020-07-22 |
| US11327082B2 (en) | 2022-05-10 |
| US12405279B2 (en) | 2025-09-02 |
| US20220221474A1 (en) | 2022-07-14 |
| US20200271675A1 (en) | 2020-08-27 |
| ES2909399T3 (es) | 2022-05-06 |
| EP3971572A1 (en) | 2022-03-23 |
| CN111094987B (zh) | 2023-10-31 |
| WO2019053118A1 (en) | 2019-03-21 |
| US12000845B2 (en) | 2024-06-04 |
| US20220229076A1 (en) | 2022-07-21 |
| CN111094987A (zh) | 2020-05-01 |
| PL3682247T3 (pl) | 2022-04-25 |
| JP7346389B2 (ja) | 2023-09-19 |
| EP3971573A1 (en) | 2022-03-23 |
| JP2020533593A (ja) | 2020-11-19 |
| EP3682247B1 (en) | 2022-02-09 |
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