DK3710439T3 - Kras g12c-hæmmere - Google Patents

Kras g12c-hæmmere Download PDF

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Publication number
DK3710439T3
DK3710439T3 DK18879484.6T DK18879484T DK3710439T3 DK 3710439 T3 DK3710439 T3 DK 3710439T3 DK 18879484 T DK18879484 T DK 18879484T DK 3710439 T3 DK3710439 T3 DK 3710439T3
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DK
Denmark
Prior art keywords
kras
inhibitors
Prior art date
Application number
DK18879484.6T
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English (en)
Inventor
James F Blake
Laurence E Burgess
Mark Joseph Chicarelli
James Gail Christensen
Adam Cook
Jay Bradford Fell
John P Fischer
Matthew Arnold Marx
Macedonio J Mejia
Pavel Savechenkov
Guy P A Vigers
Christopher Ronald Smith
Martha E Rodriguez
Tony Pisal Tang
Original Assignee
Mirati Therapeutics Inc
Array Biopharma Inc
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Publication of DK3710439T3 publication Critical patent/DK3710439T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK18879484.6T 2017-11-15 2018-11-14 Kras g12c-hæmmere DK3710439T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762586775P 2017-11-15 2017-11-15
PCT/US2018/061060 WO2019099524A1 (en) 2017-11-15 2018-11-14 Kras g12c inhibitors

Publications (1)

Publication Number Publication Date
DK3710439T3 true DK3710439T3 (da) 2023-04-24

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Country Status (35)

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US (4) US10689377B2 (da)
EP (3) EP3710439B1 (da)
JP (2) JP7322019B2 (da)
KR (1) KR102861303B1 (da)
CN (2) CN111989321B (da)
AU (1) AU2018369759B2 (da)
BR (1) BR112020009818A2 (da)
CA (1) CA3082579A1 (da)
CL (1) CL2020001271A1 (da)
CO (1) CO2020007244A2 (da)
CY (2) CY1125974T1 (da)
DK (1) DK3710439T3 (da)
EA (1) EA202091186A1 (da)
ES (2) ES2944547T3 (da)
FI (2) FI3710439T3 (da)
FR (1) FR24C1026I2 (da)
HR (1) HRP20230377T1 (da)
HU (2) HUE061599T2 (da)
IL (1) IL274601B2 (da)
LT (2) LT3710439T (da)
LU (1) LUC00350I2 (da)
MX (1) MX2020005063A (da)
MY (1) MY200356A (da)
NL (1) NL301279I2 (da)
PH (1) PH12020550622A1 (da)
PL (1) PL3710439T3 (da)
PT (1) PT3710439T (da)
RS (1) RS64182B1 (da)
SA (1) SA520411982B1 (da)
SG (1) SG11202004427TA (da)
SI (1) SI3710439T1 (da)
TW (1) TWI809005B (da)
UA (1) UA125802C2 (da)
WO (2) WO2019099524A1 (da)
ZA (1) ZA202002105B (da)

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* Cited by examiner, † Cited by third party
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