DK3720438T3 - Svampedræbende midler, der er afledt af heterocyklus-substitueret pyridin - Google Patents

Svampedræbende midler, der er afledt af heterocyklus-substitueret pyridin Download PDF

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Publication number
DK3720438T3
DK3720438T3 DK18885399.8T DK18885399T DK3720438T3 DK 3720438 T3 DK3720438 T3 DK 3720438T3 DK 18885399 T DK18885399 T DK 18885399T DK 3720438 T3 DK3720438 T3 DK 3720438T3
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Prior art keywords
heterocycle
substituted pyridine
fungicides
derived
fungicides derived
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DK18885399.8T
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English (en)
Inventor
Michael Trzoss
Jonathan Covel
Karen Joy Shaw
Peter Webb
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Amplyx Pharmaceuticals Inc
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Publication of DK3720438T3 publication Critical patent/DK3720438T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK18885399.8T 2017-12-07 2018-12-07 Svampedræbende midler, der er afledt af heterocyklus-substitueret pyridin DK3720438T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762595894P 2017-12-07 2017-12-07
US201862649225P 2018-03-28 2018-03-28
PCT/US2018/064609 WO2019113542A1 (en) 2017-12-07 2018-12-07 Heterocycle substituted pyridine derivative antifungal agents

Publications (1)

Publication Number Publication Date
DK3720438T3 true DK3720438T3 (da) 2023-10-02

Family

ID=66751743

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18885399.8T DK3720438T3 (da) 2017-12-07 2018-12-07 Svampedræbende midler, der er afledt af heterocyklus-substitueret pyridin

Country Status (18)

Country Link
US (3) US11512079B2 (da)
EP (1) EP3720438B1 (da)
JP (2) JP7292299B2 (da)
KR (1) KR102795392B1 (da)
CN (1) CN111698989B (da)
AU (1) AU2018379077B2 (da)
CA (1) CA3084298A1 (da)
DK (1) DK3720438T3 (da)
ES (1) ES2962986T3 (da)
FI (1) FI3720438T3 (da)
HU (1) HUE065201T2 (da)
IL (1) IL275121B2 (da)
MA (1) MA51052A (da)
MX (1) MX2020005927A (da)
PL (1) PL3720438T3 (da)
PT (1) PT3720438T (da)
WO (1) WO2019113542A1 (da)
ZA (1) ZA202003281B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA51052A (fr) 2017-12-07 2021-04-21 Amplyx Pharmaceuticals Inc Agents antifongiques dérivés de pyridine substitués par un hétérocycle
US11771688B2 (en) 2018-06-25 2023-10-03 Amplyx Pharmaceuticals, Inc. Pyridine derivatives substituted by heterocyclic ring and amino group
WO2020247804A1 (en) * 2019-06-07 2020-12-10 Amplyx Pharmaceuticals, Inc. Heterocycle substituted pyridine derivative antifungal agents
KR20220148881A (ko) * 2020-03-04 2022-11-07 앰플릭스 파마슈티컬스, 인크. 진균 감염 치료에서의 화합물의 용도

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
HUP0001741A3 (en) * 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
US6340690B1 (en) 1999-02-22 2002-01-22 Bio-Chem Pharma Inc. Antiviral methods using [1,8]naphthyridine derivatives
KR100785109B1 (ko) 2001-04-05 2007-12-12 토렌트 파마슈티칼스 리미티드 노화 관련 및 당뇨병 혈관성 합병증에 사용되는 헤테로사이클릭 화합물
PA8603801A1 (es) 2003-05-27 2004-12-16 Janssen Pharmaceutica Nv Derivados de la quinazolina
WO2007052615A1 (ja) 2005-10-31 2007-05-10 Eisai R & D Management Co., Ltd. ヘテロ環置換ピリジン誘導体およびそれらを含有する抗真菌剤
TWI385169B (zh) * 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
CN103121996B (zh) * 2006-04-19 2015-10-21 默克雪兰诺有限公司 用作mek抑制剂的杂芳基取代的芳基氨基吡啶衍生物
DE102006020327A1 (de) 2006-04-27 2007-12-27 Bayer Healthcare Ag Heterocyclisch substituierte, anellierte Pyrazol-Derivate und ihre Verwendung
CA2685194A1 (en) 2007-04-27 2008-11-13 Eisai R&D Management Co., Ltd. Heterocycle-substituted pyridine derivatives salt or crystal thereof
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
WO2009055042A1 (en) * 2007-10-24 2009-04-30 Amplyx Pharmaceuticals, Inc. Enhancing the efficacy of anti-infective therapeutics
EP2226320A4 (en) 2007-12-26 2012-07-11 Eisai R&D Man Co Ltd PROCESS FOR THE PRODUCTION OF A HETEROCYCLE-SUBSTITUTED PYRIDINE DERIVATIVE
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
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US8188119B2 (en) 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
JP2012176900A (ja) 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd ((ホスホノオキシ)メチル)ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤
WO2011051198A2 (de) * 2009-10-30 2011-05-05 Bayer Cropscience Ag Pyridin-derivate als pflanzenschutzmittel
MA51052A (fr) * 2017-12-07 2021-04-21 Amplyx Pharmaceuticals Inc Agents antifongiques dérivés de pyridine substitués par un hétérocycle
US11771688B2 (en) 2018-06-25 2023-10-03 Amplyx Pharmaceuticals, Inc. Pyridine derivatives substituted by heterocyclic ring and amino group
WO2020247804A1 (en) 2019-06-07 2020-12-10 Amplyx Pharmaceuticals, Inc. Heterocycle substituted pyridine derivative antifungal agents

Also Published As

Publication number Publication date
HUE065201T2 (hu) 2024-05-28
EP3720438A1 (en) 2020-10-14
EP3720438A4 (en) 2021-06-16
US11512079B2 (en) 2022-11-29
IL275121B1 (en) 2025-07-01
IL275121B2 (en) 2025-11-01
US12139479B2 (en) 2024-11-12
AU2018379077A1 (en) 2020-06-25
KR102795392B1 (ko) 2025-04-11
PT3720438T (pt) 2023-12-07
ES2962986T3 (es) 2024-03-22
AU2018379077B2 (en) 2023-04-27
WO2019113542A1 (en) 2019-06-13
JP2023113800A (ja) 2023-08-16
US20230065881A1 (en) 2023-03-02
FI3720438T3 (fi) 2023-09-01
PL3720438T3 (pl) 2024-03-18
US20210163461A1 (en) 2021-06-03
KR20200096941A (ko) 2020-08-14
MA51052A (fr) 2021-04-21
ZA202003281B (en) 2023-10-25
CN111698989B (zh) 2023-08-01
CA3084298A1 (en) 2019-06-13
EP3720438B1 (en) 2023-08-30
IL275121A (en) 2020-07-30
CN111698989A (zh) 2020-09-22
MX2020005927A (es) 2020-10-07
JP7592786B2 (ja) 2024-12-02
JP2021505672A (ja) 2021-02-18
JP7292299B2 (ja) 2023-06-16
BR112020011162A2 (pt) 2020-11-17
US20250101012A1 (en) 2025-03-27

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