DK3642210T3 - Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser - Google Patents

Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser Download PDF

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Publication number
DK3642210T3
DK3642210T3 DK18730390.4T DK18730390T DK3642210T3 DK 3642210 T3 DK3642210 T3 DK 3642210T3 DK 18730390 T DK18730390 T DK 18730390T DK 3642210 T3 DK3642210 T3 DK 3642210T3
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DK
Denmark
Prior art keywords
methods
preparing heterocyclic
benzodioxole compounds
benzodioxole
compounds
Prior art date
Application number
DK18730390.4T
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English (en)
Inventor
Allan Carsten Dahl
Johan Eriksson Bajtner
Esben Paul Krogh Olsen
Bjørn Metzler
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Union Therapeutics As
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Application filed by Union Therapeutics As filed Critical Union Therapeutics As
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Publication of DK3642210T3 publication Critical patent/DK3642210T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J21/00—Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
    • B01J21/16—Clays or other mineral silicates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK18730390.4T 2017-06-20 2018-06-19 Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser DK3642210T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17176767 2017-06-20
PCT/EP2018/066229 WO2018234299A1 (en) 2017-06-20 2018-06-19 Methods for the preparation of 1,3-benzodioxole heterocyclic compounds

Publications (1)

Publication Number Publication Date
DK3642210T3 true DK3642210T3 (da) 2024-12-09

Family

ID=59091413

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18730390.4T DK3642210T3 (da) 2017-06-20 2018-06-19 Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser

Country Status (14)

Country Link
US (2) US11220514B2 (da)
EP (1) EP3642210B1 (da)
JP (2) JP2020524131A (da)
KR (1) KR102676384B1 (da)
CN (2) CN110741005B (da)
AU (1) AU2018286964B2 (da)
BR (1) BR112019025028A2 (da)
CA (1) CA3064033A1 (da)
DK (1) DK3642210T3 (da)
ES (1) ES2998512T3 (da)
IL (1) IL271399B (da)
MX (1) MX394835B (da)
TW (1) TWI774791B (da)
WO (1) WO2018234299A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3390407T3 (da) 2015-12-18 2023-11-06 Union Therapeutics As Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser
DK3642210T3 (da) 2017-06-20 2024-12-09 Union Therapeutics As Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser
PT3724196T (pt) 2017-12-15 2023-01-13 Union Therapeutics As Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesterase
PL3911304T3 (pl) 2019-01-15 2023-12-04 UNION therapeutics A/S Preparat w postaci tabletek o zmodyfikowanym uwalnianiu, zawierający inhibitory fosfodiesterazy
KR20230159485A (ko) 2021-03-22 2023-11-21 유니온 테라퓨틱스 에이/에스 오리스밀라스트를 사용한 화농땀샘염의 치료
CN114105865A (zh) * 2021-12-07 2022-03-01 江苏宝众宝达药业股份有限公司 一种3,4,5-三氯吡啶的合成工艺
GB202205715D0 (en) 2022-04-19 2022-06-01 Union Therapeutics As Treatment of neutrophilic dermatoses
GB202306662D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Dosage regimen
GB202306663D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Combination therapy
US20250137156A1 (en) * 2023-10-26 2025-05-01 Macdermid Enthone Inc. Boric acid-free satin nickel

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03148337A (ja) 1989-10-31 1991-06-25 Aisin Seiki Co Ltd ２輪／４輪駆動制御装置
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
ATE325110T1 (de) 1995-05-19 2006-06-15 Kyowa Hakko Kogyo Kk Sauerstoff enthaltende heterocyclische verbindungen
US6169086B1 (en) * 1997-01-27 2001-01-02 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
JPH1159216A (ja) 1997-08-26 1999-03-02 Fuji Heavy Ind Ltd ４輪駆動車の動力配分制御装置
DE10049567B4 (de) 1999-10-08 2017-12-14 Toyota Jidosha Kabushiki Kaisha Fahrzeugsteuergerät zum Steuern eines allradgetriebenen Kraftfahrzeugs
DE10205274A1 (de) 2002-02-08 2003-08-21 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen
US6630813B2 (en) 2002-03-06 2003-10-07 Ford Global Technologies, Llc Method and apparatus for monitoring the state of the battery of a hybrid electric vehicle
WO2004005276A1 (ja) 2002-07-03 2004-01-15 Kyowa Hakko Kogyo Co., Ltd. １，３−ベンゾジオキソール−２−スピロシクロアルカン誘導体の製造法
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
JP2006008522A (ja) 2004-06-22 2006-01-12 Sumitomo Chemical Co Ltd ２，３−ジヒドロキシ−４−アルコキシ−アシルベンゼン類の製造方法
DE602007012105D1 (de) 2006-07-14 2011-03-03 Chiesi Farma Spa Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren
EP2125736B1 (en) 2006-12-22 2011-03-30 Leo Pharma A/S Substituted acetophenones useful as pde4 inhibitors
CA2676933C (en) 2007-02-28 2015-09-29 Leo Pharma A/S Novel phosphodiesterase inhibitors
RU2544011C2 (ru) 2008-12-19 2015-03-10 Лео Фарма А/С Триазолопиридины в качестве ингибиторов фосфодиэстеразы для лечения кожных заболеваний
WO2011124525A1 (de) 2010-04-08 2011-10-13 Boehringer Ingelheim International Gmbh Arnzeimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten
SI3070091T1 (sl) * 2010-06-24 2019-08-30 Leo Pharma A/S Derivati benzodioksola kot zaviralci fosfodiesteraze
JP2012229192A (ja) 2011-04-13 2012-11-22 Jsr Corp （ポリ）イソシアヌレート化合物の製造方法
PL2794603T3 (pl) 2011-12-21 2017-08-31 Leo Pharma A/S [1,2,4]triazolopirydyny i ich zastosowanie jako inhibitory fosfodiesterazy
WO2014096018A1 (en) 2012-12-19 2014-06-26 Leo Pharma A/S Methods for the preparation of substituted acetophenones
MX2016016378A (es) 2014-06-23 2017-10-16 Leo Pharma As Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol.
DK3390407T3 (da) 2015-12-18 2023-11-06 Union Therapeutics As Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser
WO2018108231A1 (en) 2016-12-12 2018-06-21 Leo Pharma A/S Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors
EP3551632B1 (en) 2016-12-12 2024-06-12 UNION therapeutics A/S Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
JP6850886B2 (ja) 2016-12-12 2021-03-31 レオ ファーマ アクティーゼルスカブ 置換ピラゾロアゼピン−４−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用
DK3642210T3 (da) 2017-06-20 2024-12-09 Union Therapeutics As Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser
WO2019057806A1 (en) 2017-09-20 2019-03-28 Leo Pharma A/S SUBSTITUTED DIHYDROTHIENOPYRIMIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
EP3724195B1 (en) 2017-12-15 2023-12-27 UNION therapeutics A/S Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
PT3724196T (pt) 2017-12-15 2023-01-13 Union Therapeutics As Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesterase
ES2968822T3 (es) 2017-12-15 2024-05-14 Union Therapeutics As Azetidina dihidrotienopirimidinas sustituidas y su uso como inhibidores de la fosfodiesterasa
PL3911304T3 (pl) 2019-01-15 2023-12-04 UNION therapeutics A/S Preparat w postaci tabletek o zmodyfikowanym uwalnianiu, zawierający inhibitory fosfodiesterazy
KR20230159485A (ko) 2021-03-22 2023-11-21 유니온 테라퓨틱스 에이/에스 오리스밀라스트를 사용한 화농땀샘염의 치료

Also Published As

Publication number Publication date
RU2019138518A (ru) 2021-07-20
IL271399A (en) 2020-01-30
AU2018286964A1 (en) 2019-12-05
US20210147440A1 (en) 2021-05-20
BR112019025028A2 (pt) 2020-06-16
JP2020524131A (ja) 2020-08-13
WO2018234299A1 (en) 2018-12-27
AU2018286964B2 (en) 2022-04-14
ES2998512T3 (en) 2025-02-20
KR102676384B1 (ko) 2024-06-20
JP2023029877A (ja) 2023-03-07
CA3064033A1 (en) 2018-12-27
US11220514B2 (en) 2022-01-11
KR20200013784A (ko) 2020-02-07
TW201904975A (zh) 2019-02-01
US20220162227A1 (en) 2022-05-26
JP7549635B2 (ja) 2024-09-11
IL271399B (en) 2022-07-01
CN110741005B (zh) 2024-04-12
EP3642210B1 (en) 2024-11-13
TWI774791B (zh) 2022-08-21
US12084457B2 (en) 2024-09-10
CN110741005A (zh) 2020-01-31
MX2019013979A (es) 2020-07-13
MX394835B (es) 2025-03-24
RU2019138518A3 (da) 2022-04-14
CN118344381A (zh) 2024-07-16
EP3642210A1 (en) 2020-04-29

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