DK3642210T3 - Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser - Google Patents
Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser Download PDFInfo
- Publication number
- DK3642210T3 DK3642210T3 DK18730390.4T DK18730390T DK3642210T3 DK 3642210 T3 DK3642210 T3 DK 3642210T3 DK 18730390 T DK18730390 T DK 18730390T DK 3642210 T3 DK3642210 T3 DK 3642210T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- preparing heterocyclic
- benzodioxole compounds
- benzodioxole
- compounds
- Prior art date
Links
- 150000005529 1,3-benzodioxoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J21/00—Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
- B01J21/16—Clays or other mineral silicates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17176767 | 2017-06-20 | ||
| PCT/EP2018/066229 WO2018234299A1 (en) | 2017-06-20 | 2018-06-19 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3642210T3 true DK3642210T3 (da) | 2024-12-09 |
Family
ID=59091413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18730390.4T DK3642210T3 (da) | 2017-06-20 | 2018-06-19 | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11220514B2 (da) |
| EP (1) | EP3642210B1 (da) |
| JP (2) | JP2020524131A (da) |
| KR (1) | KR102676384B1 (da) |
| CN (2) | CN118344381A (da) |
| AU (1) | AU2018286964B2 (da) |
| BR (1) | BR112019025028A2 (da) |
| CA (1) | CA3064033A1 (da) |
| DK (1) | DK3642210T3 (da) |
| ES (1) | ES2998512T3 (da) |
| IL (1) | IL271399B (da) |
| MX (1) | MX394835B (da) |
| TW (1) | TWI774791B (da) |
| WO (1) | WO2018234299A1 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3390407T3 (da) | 2015-12-18 | 2023-11-06 | Union Therapeutics As | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser |
| AU2018286964B2 (en) | 2017-06-20 | 2022-04-14 | UNION therapeutics A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| WO2019115776A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
| KR20210117300A (ko) | 2019-01-15 | 2021-09-28 | 유니온 테라퓨틱스 에이/에스 | 포스포디에스테라제 억제제를 함유하는 변형 방출 정제 제형 |
| KR20230159485A (ko) | 2021-03-22 | 2023-11-21 | 유니온 테라퓨틱스 에이/에스 | 오리스밀라스트를 사용한 화농땀샘염의 치료 |
| CN114105865A (zh) * | 2021-12-07 | 2022-03-01 | 江苏宝众宝达药业股份有限公司 | 一种3,4,5-三氯吡啶的合成工艺 |
| GB202205715D0 (en) | 2022-04-19 | 2022-06-01 | Union Therapeutics As | Treatment of neutrophilic dermatoses |
| GB202306663D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
| GB202306662D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Dosage regimen |
| US20250137156A1 (en) * | 2023-10-26 | 2025-05-01 | Macdermid Enthone Inc. | Boric acid-free satin nickel |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03148337A (ja) | 1989-10-31 | 1991-06-25 | Aisin Seiki Co Ltd | ２輪／４輪駆動制御装置 |
| HK1000785A1 (en) | 1995-05-19 | 2006-06-30 | Kyowa Hakko Kogyo Co., Ltd | Oxygen-containing heterocyclic compounds |
| US6514996B2 (en) | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
| US6169086B1 (en) * | 1997-01-27 | 2001-01-02 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
| JPH1159216A (ja) | 1997-08-26 | 1999-03-02 | Fuji Heavy Ind Ltd | ４輪駆動車の動力配分制御装置 |
| FR2799417B1 (fr) | 1999-10-08 | 2009-01-23 | Toyota Motor Co Ltd | Dispositif de controle de vehicule, notamment pour la repartition des forces de traction avant-arriere |
| DE10205274A1 (de) | 2002-02-08 | 2003-08-21 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen |
| US6630813B2 (en) | 2002-03-06 | 2003-10-07 | Ford Global Technologies, Llc | Method and apparatus for monitoring the state of the battery of a hybrid electric vehicle |
| AU2003252467A1 (en) | 2002-07-03 | 2004-01-23 | Kyowa Hakko Kogyo Co., Ltd. | Process for preparation of 1,3-benzodioxole-2-spiro- cycloalkane derivatives |
| US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
| JP2006008522A (ja) | 2004-06-22 | 2006-01-12 | Sumitomo Chemical Co Ltd | ２，３−ジヒドロキシ−４−アルコキシ−アシルベンゼン類の製造方法 |
| DE602007012105D1 (de) | 2006-07-14 | 2011-03-03 | Chiesi Farma Spa | Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren |
| US8148537B2 (en) | 2006-12-22 | 2012-04-03 | Leo Pharma A/S | Substituted acetophenones useful as PDE4 inhibitors |
| PL2114951T3 (pl) | 2007-02-28 | 2014-10-31 | Leo Pharma As | Nowe inhibitory fosfodiesterazy |
| PL2379548T3 (pl) | 2008-12-19 | 2016-08-31 | Leo Pharma As | Triazolopirydyny jako inhibitory fosfodiesterazy do leczenia chorób skórnych |
| WO2011124525A1 (de) | 2010-04-08 | 2011-10-13 | Boehringer Ingelheim International Gmbh | Arnzeimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten |
| JP6174997B2 (ja) | 2010-06-24 | 2017-08-02 | レオ ファーマ アクティーゼルスカブ | ホスホジエステラーゼ阻害剤としてのベンゾジオキソールまたはベンゾジオキセピンヘテロ環化合物 |
| JP2012229192A (ja) | 2011-04-13 | 2012-11-22 | Jsr Corp | （ポリ）イソシアヌレート化合物の製造方法 |
| MX2014006812A (es) | 2011-12-21 | 2014-10-13 | Leo Pharma As | [1,2,4] triazolopiridinas y su uso como inhibidores de fosfodiesterasa. |
| WO2014096018A1 (en) | 2012-12-19 | 2014-06-26 | Leo Pharma A/S | Methods for the preparation of substituted acetophenones |
| JP6785666B2 (ja) | 2014-06-23 | 2020-11-18 | レオ ファーマ アクティーゼルスカブ | １，３−ベンゾジオキソール複素環化合物の調製方法 |
| DK3390407T3 (da) * | 2015-12-18 | 2023-11-06 | Union Therapeutics As | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser |
| CN110088108B (zh) | 2016-12-12 | 2024-06-14 | 联合疗法公司 | 取代的吡唑并氮杂䓬-4-酮类及其作为磷酸二酯酶抑制剂的用途 |
| US11065257B2 (en) | 2016-12-12 | 2021-07-20 | Leo Pharma A/S | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
| ES2874632T3 (es) | 2016-12-12 | 2021-11-05 | Union Therapeutics As | Pirazoloazepin-8-onas sustituidas y su uso como inhibidores de la fosfodiesterasa |
| AU2018286964B2 (en) | 2017-06-20 | 2022-04-14 | UNION therapeutics A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| US11365204B2 (en) | 2017-09-20 | 2022-06-21 | UNION therapeutics A/S | Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
| WO2019115776A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
| WO2019115775A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
| WO2019115774A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors |
| KR20210117300A (ko) | 2019-01-15 | 2021-09-28 | 유니온 테라퓨틱스 에이/에스 | 포스포디에스테라제 억제제를 함유하는 변형 방출 정제 제형 |
| KR20230159485A (ko) | 2021-03-22 | 2023-11-21 | 유니온 테라퓨틱스 에이/에스 | 오리스밀라스트를 사용한 화농땀샘염의 치료 |
-
2018
- 2018-06-19 AU AU2018286964A patent/AU2018286964B2/en not_active Ceased
- 2018-06-19 JP JP2019565499A patent/JP2020524131A/ja not_active Ceased
- 2018-06-19 IL IL271399A patent/IL271399B/en unknown
- 2018-06-19 WO PCT/EP2018/066229 patent/WO2018234299A1/en not_active Ceased
- 2018-06-19 KR KR1020207001926A patent/KR102676384B1/ko active Active
- 2018-06-19 BR BR112019025028-0A patent/BR112019025028A2/pt not_active Application Discontinuation
- 2018-06-19 EP EP18730390.4A patent/EP3642210B1/en active Active
- 2018-06-19 DK DK18730390.4T patent/DK3642210T3/da active
- 2018-06-19 CN CN202410373395.3A patent/CN118344381A/zh active Pending
- 2018-06-19 CA CA3064033A patent/CA3064033A1/en active Pending
- 2018-06-19 US US16/624,491 patent/US11220514B2/en active Active
- 2018-06-19 ES ES18730390T patent/ES2998512T3/es active Active
- 2018-06-19 MX MX2019013979A patent/MX394835B/es unknown
- 2018-06-19 CN CN201880039479.6A patent/CN110741005B/zh active Active
- 2018-06-20 TW TW107121127A patent/TWI774791B/zh active
-
2021
- 2021-12-01 US US17/539,715 patent/US12084457B2/en active Active
-
2022
- 2022-11-22 JP JP2022186411A patent/JP7549635B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11220514B2 (en) | 2022-01-11 |
| RU2019138518A3 (da) | 2022-04-14 |
| CA3064033A1 (en) | 2018-12-27 |
| US20220162227A1 (en) | 2022-05-26 |
| AU2018286964B2 (en) | 2022-04-14 |
| CN110741005B (zh) | 2024-04-12 |
| JP7549635B2 (ja) | 2024-09-11 |
| JP2023029877A (ja) | 2023-03-07 |
| CN110741005A (zh) | 2020-01-31 |
| KR20200013784A (ko) | 2020-02-07 |
| RU2019138518A (ru) | 2021-07-20 |
| US20210147440A1 (en) | 2021-05-20 |
| KR102676384B1 (ko) | 2024-06-20 |
| TWI774791B (zh) | 2022-08-21 |
| IL271399A (en) | 2020-01-30 |
| MX2019013979A (es) | 2020-07-13 |
| TW201904975A (zh) | 2019-02-01 |
| ES2998512T3 (en) | 2025-02-20 |
| EP3642210B1 (en) | 2024-11-13 |
| WO2018234299A1 (en) | 2018-12-27 |
| US12084457B2 (en) | 2024-09-10 |
| EP3642210A1 (en) | 2020-04-29 |
| BR112019025028A2 (pt) | 2020-06-16 |
| IL271399B (en) | 2022-07-01 |
| AU2018286964A1 (en) | 2019-12-05 |
| JP2020524131A (ja) | 2020-08-13 |
| CN118344381A (zh) | 2024-07-16 |
| MX394835B (es) | 2025-03-24 |
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