DK374083A - Cyclovitamin-d forbindelser - Google Patents

Cyclovitamin-d forbindelser Download PDF

Info

Publication number: DK374083A
Authority: DK; Denmark
Prior art keywords: compounds; cyclovitamin; alkyl; acyl; formula
Prior art date: 1978-01-16

Application number

DK374083A

Other languages

English (en)

Other versions

DK374083D0 (da

DK169871B1 (da

Inventor

Hector F De Luca

Heinrich K Schnoes

David E Hamer

Herbert E Paaren

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-01-16

Filing date

1983-08-16

Publication date

1983-08-16

1983-08-16 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1983-08-16 Publication of DK374083D0 publication Critical patent/DK374083D0/da

1983-08-16 Publication of DK374083A publication Critical patent/DK374083A/da

1995-03-20 Application granted granted Critical

1995-03-20 Publication of DK169871B1 publication Critical patent/DK169871B1/da

Links

150000001875 compounds Chemical class 0.000 title abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
-1 and Z is H Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Nutrition Science (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrane Compounds (AREA)

DK374083A 1978-01-16 1983-08-16 3,5-cyclovitamin-D forbindelser DK169871B1 (da)

Applications Claiming Priority (10)

Application Number	Priority Date	Filing Date	Title
US86944878A	1978-01-16	1978-01-16
US86944878		1978-01-16
US91479678		1978-06-12
US05/914,796 US4195027A (en)	1978-01-16	1978-06-12	Process for preparing 1α-hydroxylated compounds
PCT/US1979/000024 WO1979000513A1 (en)	1978-01-16	1979-01-15	Process for preparing 1a-hydroxylated compounds
US7900024		1979-01-15
DK365079A DK147912C (da)	1978-01-16	1979-08-31	Fremgangsmaade til fremstilling af 1alfa-hydroxylerede vitamin d-forbindelser
DK365079		1979-08-31
DK436182A DK170437B1 (da)	1978-01-16	1982-10-01	1alfa-hydroxy-3,5-cyclovitamin D forbindelser
DK436182		1982-10-01

Publications (3)

Publication Number	Publication Date
DK374083D0 DK374083D0 (da)	1983-08-16
DK374083A true DK374083A (da)	1983-08-16
DK169871B1 DK169871B1 (da)	1995-03-20

Family

ID=27128114

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK365079A DK147912C (da)	1978-01-16	1979-08-31	Fremgangsmaade til fremstilling af 1alfa-hydroxylerede vitamin d-forbindelser
DK436182A DK170437B1 (da)	1978-01-16	1982-10-01	1alfa-hydroxy-3,5-cyclovitamin D forbindelser
DK374083A DK169871B1 (da)	1978-01-16	1983-08-16	3,5-cyclovitamin-D forbindelser

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK365079A DK147912C (da)	1978-01-16	1979-08-31	Fremgangsmaade til fremstilling af 1alfa-hydroxylerede vitamin d-forbindelser
DK436182A DK170437B1 (da)	1978-01-16	1982-10-01	1alfa-hydroxy-3,5-cyclovitamin D forbindelser

Country Status (15)

Country	Link
US (1)	US4195027A (da)
JP (1)	JPS5828876B2 (da)
AU (1)	AU525781B2 (da)
BE (1)	BE873512A (da)
CA (1)	CA1156251A (da)
CH (2)	CH653321A5 (da)
DE (2)	DE2933189T1 (da)
DK (3)	DK147912C (da)
FR (4)	FR2438035A1 (da)
GB (1)	GB2013686B (da)
IE (1)	IE48547B1 (da)
NL (1)	NL188901C (da)
NZ (1)	NZ189388A (da)
SE (1)	SE429971B (da)
WO (1)	WO1979000513A1 (da)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH16989A (en) *	1978-11-07	1984-05-04	Res Inst Medicine Chem	Process for the preparation of 1-hydroxylated vitamin d compounds
US4269777A (en) *	1979-05-21	1981-05-26	Wisconsin Alumni Research Foundation	Isotopically labeled vitamin D derivatives and processes for preparing same
JPS5626820A (en) *	1979-08-10	1981-03-16	Chugai Pharmaceut Co Ltd	Immunosuppressing agent
US4265822A (en) *	1979-09-10	1981-05-05	Wisconsin Alumni Research Foundation	Process for preparing 1-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds
US4297289A (en) *	1980-07-17	1981-10-27	Wisconsin Alumni Research Foundation	Vitamin D compounds isotopically substituted at carbon 6 and process for their preparation
EP0070588B1 (en) *	1981-07-17	1986-05-07	Duphar International Research B.V	Method of preparing 1-alpha-hydroxyvitamin d and 1-alpha-hydroxy-previtamin d compounds, and adduct of a previtamin d or tachysterol compound with a suitable dienophile
US4617297A (en) *	1982-02-12	1986-10-14	Hoffmann-La Roche Inc.	Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol
FR2545824B1 (fr) *	1983-05-09	1987-11-20	Wisconsin Alumni Res Found	Derive 1a, 25-dihydroxyles de la vitamine d2 et produits intermediaires pour leur preparation et compositions pharmaceutiques renfermant ces derives
WO1985003939A1 (en) *	1984-03-05	1985-09-12	Wisconsin Alumni Research Foundation	1alpha-HYDROXYVITAMIN D2 ANALOGS AND PROCESS FOR PREPARING SAME
US4555364A (en) *	1984-11-01	1985-11-26	Wisconsin Alumni Research Foundation	Method for preparing 1-hydroxyvitamin D compounds
US4866048A (en) *	1985-08-02	1989-09-12	Leo Pharmaceutical Products Ltd.	Novel vitamin D analogues
US5869473A (en) *	1988-08-02	1999-02-09	Bone Care International, Inc.	Method for treating and preventing hyperparathyroidism
US5602116A (en) *	1988-08-02	1997-02-11	Bone Care International, Inc.	Method for treating and preventing secondary hyperparathyroidism
US5321018A (en) *	1989-03-09	1994-06-14	Wisconsin Alumni Research Foundation	Use of 1α-hydroxylated-19-nor-vitamin D compounds to treat psoriasis
JP2645130B2 (ja) *	1989-03-31	1997-08-25	日清製粉株式会社	ステロイド誘導体
US5401731A (en) *	1989-06-29	1995-03-28	Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab)	Vitamin D analogues
US5532228A (en) *	1990-02-06	1996-07-02	Schering Aktiengesellschaft	Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
US5185150A (en) *	1990-08-24	1993-02-09	Wisconsin Alumni Research Fdn.	Cosmetic compositions containing 19-nor-vitamin D compounds
WO1992005130A1 (en) *	1990-09-21	1992-04-02	Lunar Corporation	NOVEL 1α-HYDROXY VITAMIN D4 AND NOVEL INTERMEDIATES AND ANALOGUES
US6025346A (en) *	1990-09-21	2000-02-15	Bone Care International, Inc.	1α-hydroxy vitamin D4 and novel intermediates and analogues
US5763428A (en) *	1990-09-21	1998-06-09	Bone Care International, Inc.	Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof
US5798345A (en) *	1990-09-21	1998-08-25	Bone Care International, Inc.	Method of inhibiting the hyperproliferation of malignant cells
US5801164A (en) *	1990-09-21	1998-09-01	Bone Care International, Inc.	Methods of treating osteoporosis prophylactically or therapeutically
US6538037B2 (en)	1991-01-08	2003-03-25	Bone Care International, Inc.	Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US6251883B1 (en)	1991-01-08	2001-06-26	Bone Care International, Inc.	Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2
US20040009958A1 (en) *	1991-01-08	2004-01-15	Bone Care International, Inc.	Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
DE69233074T2 (de) *	1991-01-08	2004-03-18	Bone Care International Inc., Madison	Verfahren zur Herstellung von 1-alpha-24-dihydroxy-Vitamin D2
US5786348A (en) *	1991-01-08	1998-07-28	Bone Care International, Inc.	Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2
US6166000A (en) *	1991-01-08	2000-12-26	Bone Care International, Inc.	Methods for preparation and use of 1α,24(S)-Dihydroxy vitamin . D.sub2
EP0614456B1 (en) *	1992-08-28	1999-06-09	Bone Care International, Inc.	1alpha,24(s)-dihydroxy vitamin d2, its formation and use
US5763429A (en) *	1993-09-10	1998-06-09	Bone Care International, Inc.	Method of treating prostatic diseases using active vitamin D analogues
US5869472A (en) *	1994-07-18	1999-02-09	Bone Care International, Inc.	Synthesis of 1α-hydroxy vitamin D
US20020183288A1 (en) *	1995-04-03	2002-12-05	Bone Care International, Inc.	Method for treating and preventing hyperparathyroidism
US6242434B1 (en) *	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
US20040043971A1 (en) *	1995-04-03	2004-03-04	Bone Care International, Inc.	Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US6376479B1 (en)	1995-04-03	2002-04-23	Bone Care International, Inc.	Method for treating and preventing hyperparathyroidism
JP3372259B2 (ja) *	1995-09-21	2003-01-27	ウィスコンシン・アルムニ・リサーチ・ファウンデーション	カルシトリオール誘導体およびそれらの用途
US5952317A (en) *	1995-09-21	1999-09-14	Wisconsin Alumni Research Foundation	Calcitriol derivatives and their uses
US5976784A (en) *	1996-09-20	1999-11-02	Wisconsin Alumni Research Foundation	Calcitriol derivatives and their uses
US6573256B2 (en)	1996-12-30	2003-06-03	Bone Care International, Inc.	Method of inhibiting angiogenesis using active vitamin D analogues
US6503893B2 (en)	1996-12-30	2003-01-07	Bone Care International, Inc.	Method of treating hyperproliferative diseases using active vitamin D analogues
US20020128240A1 (en) *	1996-12-30	2002-09-12	Bone Care International, Inc.	Treatment of hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en)	1996-12-30	2003-05-20	Bone Care International, Inc.	Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US20030129194A1 (en) *	1997-02-13	2003-07-10	Bone Care International, Inc.	Targeted therapeutic delivery of vitamin D compounds
JP2001511811A (ja) *	1997-02-13	2001-08-14	ボーンケアインターナショナルインコーポレイテッド	ビタミンｄ化合物の標的治療放出
US6087350A (en) *	1997-08-29	2000-07-11	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
WO1999049870A1 (en) *	1998-03-27	1999-10-07	Oregon Health Sciences University	Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders
US5972917A (en) *	1998-05-29	1999-10-26	Bone Care Int Inc	1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
EP1301479A2 (en) *	2000-07-18	2003-04-16	Bone Care International, Inc.	STABILIZED 1$g(a)-HYDROXY VITAMIN D
US7148211B2 (en) *	2002-09-18	2006-12-12	Genzyme Corporation	Formulation for lipophilic agents
US20050239756A1 (en) *	2004-04-23	2005-10-27	Bone Care International, Inc.	Methods of treating various vitamin D metabolism conditions with 1alpha-hydroxyvitamin D2
US20060003950A1 (en) *	2004-06-30	2006-01-05	Bone Care International, Inc.	Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) *	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
US7491712B1 (en)	2007-12-10	2009-02-17	Formosa Laboratories, Inc.	Process for preparation of paricalcitol and intermediates thereof
US9212136B2 (en) *	2008-07-22	2015-12-15	Azad Pharmaceuticals Ingredients Ag	Methods for producing paricalcitol
WO2011002756A2 (en) *	2009-07-01	2011-01-06	Vitamin Derivatives, Inc.	Vitamin d compounds and methods for preparing same
CN114805158B (zh) *	2022-04-24	2023-11-14	浙江花园生物医药股份有限公司	一种制备骨化三醇的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3901928A (en) *	1973-01-10	1975-08-26	Robert Henry Hesse	1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds
US3847955A (en) *	1973-07-16	1974-11-12	Wisconsin Alumni Res Found	1,24,25-trihydroxycholecalciferol
CA1034114A (en) *	1973-12-03	1978-07-04	Wisconsin Alumni Research Foundation	Processes for preparation of steroid derivatives
US3880894A (en) *	1974-05-24	1975-04-29	Wisconsin Alumni Res Found	1,25-Dihydroxyergocalciferol
US3907843A (en) *	1974-06-14	1975-09-23	Wisconsin Alumni Res Found	1{60 -Hydroxyergocalciferol and processes for preparing same
US3976636A (en) *	1974-10-10	1976-08-24	The Upjohn Company	Process and compounds

1978
- 1978-06-12 US US05/914,796 patent/US4195027A/en not_active Expired - Lifetime
1979
- 1979-01-15 WO PCT/US1979/000024 patent/WO1979000513A1/en not_active Ceased
- 1979-01-15 DE DE792933189T patent/DE2933189T1/de active Granted
- 1979-01-15 JP JP54500366A patent/JPS5828876B2/ja not_active Expired
- 1979-01-15 CH CH8364/79A patent/CH653321A5/de not_active IP Right Cessation
- 1979-01-15 CH CH2418/85A patent/CH658050A5/de not_active IP Right Cessation
- 1979-01-15 NZ NZ189388A patent/NZ189388A/xx unknown
- 1979-01-15 DE DE2954557A patent/DE2954557C2/de not_active Expired - Lifetime
- 1979-01-16 NL NLAANVRAGE7900331,A patent/NL188901C/xx not_active IP Right Cessation
- 1979-01-16 GB GB7901623A patent/GB2013686B/en not_active Expired
- 1979-01-16 AU AU43394/79A patent/AU525781B2/en not_active Expired
- 1979-01-16 FR FR7900990A patent/FR2438035A1/fr active Granted
- 1979-01-16 IE IE55/79A patent/IE48547B1/en unknown
- 1979-01-16 BE BE192927A patent/BE873512A/xx not_active IP Right Cessation
- 1979-03-16 CA CA000323656A patent/CA1156251A/en not_active Expired
- 1979-08-31 DK DK365079A patent/DK147912C/da not_active IP Right Cessation
- 1979-09-13 SE SE7907631A patent/SE429971B/sv not_active IP Right Cessation
- 1979-09-26 FR FR7923987A patent/FR2436140A1/fr not_active Withdrawn
1981
- 1981-04-27 FR FR8108368A patent/FR2478631A1/fr active Granted
1982
- 1982-10-01 DK DK436182A patent/DK170437B1/da not_active IP Right Cessation
1983
- 1983-07-06 FR FR8311299A patent/FR2529888B1/fr not_active Expired
- 1983-08-16 DK DK374083A patent/DK169871B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPS5828876B2 (ja)	1983-06-18
FR2478631B1 (da)	1984-02-24
DK436182A (da)	1982-10-01
BE873512A (fr)	1979-05-16
SE7907631L (sv)	1979-09-13
AU4339479A (en)	1979-07-26
FR2438035A1 (fr)	1980-04-30
FR2529888A1 (fr)	1984-01-13
FR2436140A1 (fr)	1980-04-11
DK365079A (da)	1979-08-31
DK374083D0 (da)	1983-08-16
FR2438035B1 (da)	1984-02-24
NZ189388A (en)	1981-02-11
NL188901C (nl)	1992-11-02
CA1156251A (en)	1983-11-01
GB2013686B (en)	1982-04-15
IE790055L (en)	1979-07-16
US4195027A (en)	1980-03-25
WO1979000513A1 (en)	1979-08-09
NL7900331A (nl)	1979-07-18
DE2954557C2 (da)	1991-07-11
SE429971B (sv)	1983-10-10
JPS54500080A (da)	1979-11-29
FR2529888B1 (fr)	1986-04-04
FR2478631A1 (fr)	1981-09-25
DE2933189T1 (de)	1980-12-18
AU525781B2 (en)	1982-12-02
DK170437B1 (da)	1995-09-04
DK147912C (da)	1985-06-17
CH653321A5 (de)	1985-12-31
DE2933189C2 (da)	1991-05-29
DK147912B (da)	1985-01-07
NL188901B (nl)	1992-06-01
IE48547B1 (en)	1985-03-06
GB2013686A (en)	1979-08-15
CH658050A5 (de)	1986-10-15
DK169871B1 (da)	1995-03-20

Legal Events

Date	Code	Title	Description
1995-03-20	B1	Patent granted (law 1993)
1999-01-25	PUP	Patent expired

Publication	Publication Date	Title
DK374083A (da)	1983-08-16	Cyclovitamin-d forbindelser
SE7908350L (sv)	1980-04-19	Nya metaboliter, framstellning och anvendning derav
SE8104132L (sv)	1982-01-11	Mjuka steroider med antiiflammatorisk verkan
FI73969B (fi)	1987-08-31	Foerfarande foer framstaellning av terapeutiskt aktiva trans-4-aminometylcyklohexankarboxylsyraderivat.
ATE24001T1 (de)	1986-12-15	Substituierte 1-hydroxyethyl-triazolyl-derivate.
GR69233B (da)	1982-05-10
DE3573424D1 (de)	1989-11-09	6-chlorobenzazolyloxy-acetamide
BR8004478A (pt)	1981-01-27	Misturas de aclaradores oticos e sua aplicacao
ES474666A1 (es)	1980-12-16	Procedimiento para la preparacion de alcohil-sulfato-betai- nas que contienen fluor
SE7813352L (sv)	1979-07-31	Nya 2-pyrrolidonforeningar och forfarande for framstellning av desamma
SE7909916L (sv)	1980-06-02	Beta,gamma-dihydropolyprenylalkoholer och farmaceutiska kompositioner innehallande desamma
SE7910072L (sv)	1980-06-08	Pyrrolo- eller pyrido(2,1-c)(1,4)tiaziner eller -tiazepiner
IL67056A0 (en)	1983-02-23	Pyridazinone derivatives,their preparation and their use as fungicides
GB2104890B (en)	1985-08-07	Pyridinecarbinols, their preparation and fungicides containing them
SE7602049L (sv)	1976-09-06	Nya butyrofenonforeningar
SE8001556L (sv)	1980-09-03	Tetrahydrobensotiazolylimidazolidinoner
FI892681A0 (fi)	1989-06-01	Nya jodade icke-joniska trijodbenzenfoereningar och dessa innehaollande kontrastmedel.
ES479444A1 (es)	1979-11-16	Un procedimiento para preparar derivados de pirrolidincarbo-xaldehido y piperidicarboxaldehido.
SE7705182L (sv)	1977-11-06	Framstellning av nya bensodiazepiner
DK392579A (da)	1980-03-22	Fremgangsmaade til fremstilling af 4,5-methano-bufadienolid-rhamnosider
FI842398A0 (fi)	1984-06-13	Foerfarande foer framstaellning av med tritium staemplade radioaktiva estradienderivat och deras mellanprodukter samt deras tillaempning foer radioimmunolog bestaemning av steroider och undersoekning av biologiska vaetskor.
FI812777L (fi)	1982-03-14	Foerfarande foer framstaellning av nya cardenolid-bis-digitoxosider
DE3369324D1 (en)	1987-02-26	Thiolphosphoric-acid esters, their preparation and use
SE8401280L (sv)	1984-09-30	Mellanprodukter och forfaraden for framstellning derav
IE801308L (en)	1981-01-04	Cyclophosphathiazenes.