DK3770160T3 - Kontrastmidler baseret på gadolinium-indeholdende pcta - Google Patents

Kontrastmidler baseret på gadolinium-indeholdende pcta Download PDF

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Publication number
DK3770160T3
DK3770160T3 DK20193824.8T DK20193824T DK3770160T3 DK 3770160 T3 DK3770160 T3 DK 3770160T3 DK 20193824 T DK20193824 T DK 20193824T DK 3770160 T3 DK3770160 T3 DK 3770160T3
Authority
DK
Denmark
Prior art keywords
pcta
gadolinium
contrast agents
agents based
contrast
Prior art date
Application number
DK20193824.8T
Other languages
English (en)
Inventor
Roberta Napolitano
Luciano Lattuada
Zsolt Baranyai
Nicole Guidolin
Giuseppe Marazzi
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63165233&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3770160(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of DK3770160T3 publication Critical patent/DK3770160T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK20193824.8T 2018-08-06 2019-08-06 Kontrastmidler baseret på gadolinium-indeholdende pcta DK3770160T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18187422 2018-08-06
EP19753296.3A EP3687994B1 (en) 2018-08-06 2019-08-06 Gadolinium bearing pcta-based contrast agents

Publications (1)

Publication Number Publication Date
DK3770160T3 true DK3770160T3 (da) 2023-02-20

Family

ID=63165233

Family Applications (3)

Application Number Title Priority Date Filing Date
DK22205189.8T DK4151637T3 (da) 2018-08-06 2019-08-06 Gadolinium-indeholdende pcta-baserede kontrastmidler
DK19753296.3T DK3687994T3 (da) 2018-08-06 2019-08-06 Gadolinium-bærende pcta-baserede kontrastmidler
DK20193824.8T DK3770160T3 (da) 2018-08-06 2019-08-06 Kontrastmidler baseret på gadolinium-indeholdende pcta

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK22205189.8T DK4151637T3 (da) 2018-08-06 2019-08-06 Gadolinium-indeholdende pcta-baserede kontrastmidler
DK19753296.3T DK3687994T3 (da) 2018-08-06 2019-08-06 Gadolinium-bærende pcta-baserede kontrastmidler

Country Status (14)

Country Link
US (3) US10973934B2 (da)
EP (4) EP4491199A3 (da)
JP (2) JP7558146B2 (da)
KR (2) KR20250079243A (da)
CN (4) CN119039292A (da)
AU (1) AU2019319599B2 (da)
BR (1) BR112021001102B1 (da)
CA (1) CA3105610C (da)
DK (3) DK4151637T3 (da)
ES (3) ES2841070T3 (da)
FI (2) FI3770160T3 (da)
PL (3) PL3687994T3 (da)
PT (3) PT4151637T (da)
WO (1) WO2020030618A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4491199A3 (en) * 2018-08-06 2025-04-16 Bracco Imaging SPA Gadolinium bearing pcta-based contrast agents
FR3091873B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
US11370804B2 (en) 2019-01-17 2022-06-28 Guerbet Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process
US11426470B2 (en) 2019-01-17 2022-08-30 Guerbet Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
JP7644095B2 (ja) * 2019-09-03 2025-03-11 ジーイー・ヘルスケア・アクスイェ・セルスカプ マンガンキレート異性体
CA3189281A1 (fr) * 2020-07-16 2022-01-20 Guerbet Procede de synthese de diesters d'acide 2-bromoglutarique
CN116209661B (zh) * 2020-07-17 2026-01-27 法国加栢 用于制备基于pcta的螯合配体的方法
EP4581640B1 (de) 2022-08-30 2026-04-22 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
EP4581641A1 (de) 2022-08-30 2025-07-09 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
US20260087709A1 (en) 2022-08-30 2026-03-26 Bayer Aktiengesellschaft Generation of synthetic radiological images
KR102845061B1 (ko) * 2022-09-01 2025-08-13 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제
CN119698423A (zh) * 2022-09-01 2025-03-25 泰瑞诺科有限公司 新型化合物以及包含其的mri造影剂
JP2025531766A (ja) 2022-09-05 2025-09-25 バイエル、アクチエンゲゼルシャフト 人工造影放射線画像の生成
WO2024083466A1 (de) 2022-10-17 2024-04-25 Bayer Aktiengesellschaft Automatisches analysieren von radiologischen aufnahmen
EP4369353A1 (de) 2022-11-12 2024-05-15 Bayer Aktiengesellschaft Erzeugung von künstlichen kontrastmittelverstärkten radiologischen aufnahmen
EP4471710B1 (de) 2023-05-30 2025-12-17 Bayer Aktiengesellschaft Erkennen von artefakten in synthetischen medizinischen aufnahmen
EP4475137B1 (de) 2023-06-05 2025-12-03 Bayer Aktiengesellschaft Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen
EP4485474B1 (de) 2023-06-05 2026-04-08 Bayer Aktiengesellschaft Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen
US20250045926A1 (en) 2023-07-25 2025-02-06 Bayer Aktiengesellschaft Detection of artifacts in synthetic images
WO2025045168A1 (zh) 2023-09-01 2025-03-06 江苏恒瑞医药股份有限公司 一种大环化合物及其用途
EP4567716A1 (en) 2023-12-06 2025-06-11 Bayer Aktiengesellschaft Generating synthetic representations
EP4567715A1 (en) 2023-12-06 2025-06-11 Bayer Aktiengesellschaft Generating synthetic representations
WO2025190828A1 (en) 2024-03-15 2025-09-18 Bayer Aktiengesellschaft Correction of an mri image
EP4664393A1 (de) 2024-06-10 2025-12-17 Bayer Aktiengesellschaft Erzeugen von synthetischen kontrastverstärkten radiologischen aufnahmen
WO2026027591A1 (en) 2024-07-31 2026-02-05 Bracco Imaging Spa Synthesis of an intermediate of a gadolinium-based contrast agent

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0992245A1 (en) 1998-09-16 2000-04-12 Goldham Bioglan Pharma GmbH Radio-contrast agents
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
FR2836916B1 (fr) * 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
FR2883562B1 (fr) * 2005-03-24 2009-02-27 Guerbet Sa Chelates lipophiles et leur utilisation en imagerie
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
JP6608805B2 (ja) * 2013-04-26 2019-11-20 ゲルベ 造影製剤および関連する調製方法
EP4491199A3 (en) 2018-08-06 2025-04-16 Bracco Imaging SPA Gadolinium bearing pcta-based contrast agents
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification

Also Published As

Publication number Publication date
BR112021001102A2 (pt) 2021-04-20
ES3015456T3 (en) 2025-05-05
EP4151637B1 (en) 2025-01-22
CA3105610A1 (en) 2020-02-13
PT3687994T (pt) 2020-12-07
BR112021001102B1 (pt) 2022-12-20
CN119954806A (zh) 2025-05-09
KR20210041566A (ko) 2021-04-15
US20210196840A1 (en) 2021-07-01
ES2938015T3 (es) 2023-04-03
FI4151637T3 (fi) 2025-03-28
PL3770160T3 (pl) 2023-05-29
FI3770160T3 (fi) 2023-03-16
JP2021533165A (ja) 2021-12-02
JP7841044B2 (ja) 2026-04-06
US20200376145A1 (en) 2020-12-03
US20240366802A1 (en) 2024-11-07
EP4491199A2 (en) 2025-01-15
EP3687994A1 (en) 2020-08-05
AU2019319599B2 (en) 2024-01-04
PT4151637T (pt) 2025-03-26
PL3687994T3 (pl) 2021-05-04
DK4151637T3 (da) 2025-03-31
AU2019319599A1 (en) 2021-01-28
EP4151637A1 (en) 2023-03-22
CN112533921B (zh) 2025-02-21
US10973934B2 (en) 2021-04-13
US12036289B2 (en) 2024-07-16
CN112533921A (zh) 2021-03-19
WO2020030618A1 (en) 2020-02-13
EP3687994B1 (en) 2020-11-04
PT3770160T (pt) 2023-02-21
EP4491199A3 (en) 2025-04-16
PL4151637T3 (pl) 2025-04-28
EP3770160A1 (en) 2021-01-27
DK3687994T3 (da) 2021-01-25
KR20250079243A (ko) 2025-06-04
CN119039292A (zh) 2024-11-29
CA3105610C (en) 2024-05-28
KR102815156B1 (ko) 2025-05-30
JP7558146B2 (ja) 2024-09-30
ES2841070T3 (es) 2021-07-07
CN119930615A (zh) 2025-05-06
EP3770160B1 (en) 2022-11-23
JP2024178261A (ja) 2024-12-24

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