PL3687994T3 - Środki kontrastowe na bazie pcta zawierające gadolin - Google Patents

Środki kontrastowe na bazie pcta zawierające gadolin

Info

Publication number
PL3687994T3
PL3687994T3 PL19753296T PL19753296T PL3687994T3 PL 3687994 T3 PL3687994 T3 PL 3687994T3 PL 19753296 T PL19753296 T PL 19753296T PL 19753296 T PL19753296 T PL 19753296T PL 3687994 T3 PL3687994 T3 PL 3687994T3
Authority
PL
Poland
Prior art keywords
gadolin
pcta
contrast agents
based contrast
agents
Prior art date
Application number
PL19753296T
Other languages
English (en)
Inventor
Roberta Napolitano
Luciano Lattuada
Zsolt Baranyai
Nicole GUIDOLIN
Giuseppe Marazzi
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63165233&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3687994(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Publication of PL3687994T3 publication Critical patent/PL3687994T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL19753296T 2018-08-06 2019-08-06 Środki kontrastowe na bazie pcta zawierające gadolin PL3687994T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18187422 2018-08-06
EP19753296.3A EP3687994B1 (en) 2018-08-06 2019-08-06 Gadolinium bearing pcta-based contrast agents
PCT/EP2019/071075 WO2020030618A1 (en) 2018-08-06 2019-08-06 Gadolinium bearing pcta-based contrast agents

Publications (1)

Publication Number Publication Date
PL3687994T3 true PL3687994T3 (pl) 2021-05-04

Family

ID=63165233

Family Applications (3)

Application Number Title Priority Date Filing Date
PL20193824.8T PL3770160T3 (pl) 2018-08-06 2019-08-06 Środki kontrastowe na bazie PCTA zawierające gadolin
PL22205189.8T PL4151637T3 (pl) 2018-08-06 2019-08-06 Środki kontrastowe na bazie PCTA zawierające gadolin
PL19753296T PL3687994T3 (pl) 2018-08-06 2019-08-06 Środki kontrastowe na bazie pcta zawierające gadolin

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL20193824.8T PL3770160T3 (pl) 2018-08-06 2019-08-06 Środki kontrastowe na bazie PCTA zawierające gadolin
PL22205189.8T PL4151637T3 (pl) 2018-08-06 2019-08-06 Środki kontrastowe na bazie PCTA zawierające gadolin

Country Status (14)

Country Link
US (3) US10973934B2 (pl)
EP (4) EP4151637B1 (pl)
JP (2) JP7558146B2 (pl)
KR (2) KR102815156B1 (pl)
CN (4) CN112533921B (pl)
AU (1) AU2019319599B2 (pl)
BR (1) BR112021001102B1 (pl)
CA (1) CA3105610C (pl)
DK (3) DK3687994T3 (pl)
ES (3) ES2841070T3 (pl)
FI (2) FI3770160T3 (pl)
PL (3) PL3770160T3 (pl)
PT (3) PT4151637T (pl)
WO (1) WO2020030618A1 (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT4151637T (pt) * 2018-08-06 2025-03-26 Bracco Imaging Spa Agentes de contraste à base de pcta que suportam gadolínio
US11426470B2 (en) 2019-01-17 2022-08-30 Guerbet Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
US11370804B2 (en) 2019-01-17 2022-06-28 Guerbet Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process
LT4025259T (lt) * 2019-09-03 2025-02-10 Ge Healthcare As Mangano chelato izomerai
KR102588221B1 (ko) * 2020-07-16 2023-10-13 게르브 2-브로모글루타르산 디에스테르를 합성하는 방법
KR20230041007A (ko) * 2020-07-17 2023-03-23 게르브 Pcta로부터 유도된 킬레이팅 리간드의 제조 방법
EP4581640B1 (de) 2022-08-30 2026-04-22 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
WO2024046833A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
EP4581641B1 (de) 2022-08-30 2026-05-06 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
KR102845061B1 (ko) * 2022-09-01 2025-08-13 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제
WO2024049087A1 (ko) * 2022-09-01 2024-03-07 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제
CN119816744B (zh) 2022-09-05 2025-09-26 拜耳公司 生成人工对比度增强的放射图像
WO2024083466A1 (de) 2022-10-17 2024-04-25 Bayer Aktiengesellschaft Automatisches analysieren von radiologischen aufnahmen
EP4369353A1 (de) 2022-11-12 2024-05-15 Bayer Aktiengesellschaft Erzeugung von künstlichen kontrastmittelverstärkten radiologischen aufnahmen
EP4471710B1 (de) 2023-05-30 2025-12-17 Bayer Aktiengesellschaft Erkennen von artefakten in synthetischen medizinischen aufnahmen
EP4475137B1 (de) 2023-06-05 2025-12-03 Bayer Aktiengesellschaft Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen
WO2024251601A1 (de) 2023-06-05 2024-12-12 Bayer Aktiengesellschaft Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen
EP4498324A1 (de) 2023-07-25 2025-01-29 Bayer AG Erkennen von artefakten in synthetischen bildern
TW202510874A (zh) 2023-09-01 2025-03-16 大陸商江蘇恆瑞醫藥股份有限公司 一種大環化合物及其用途
EP4567715A1 (en) 2023-12-06 2025-06-11 Bayer Aktiengesellschaft Generating synthetic representations
EP4567716A1 (en) 2023-12-06 2025-06-11 Bayer Aktiengesellschaft Generating synthetic representations
WO2025190828A1 (en) 2024-03-15 2025-09-18 Bayer Aktiengesellschaft Correction of an mri image
EP4664393A1 (de) 2024-06-10 2025-12-17 Bayer Aktiengesellschaft Erzeugen von synthetischen kontrastverstärkten radiologischen aufnahmen
WO2026027591A1 (en) 2024-07-31 2026-02-05 Bracco Imaging Spa Synthesis of an intermediate of a gadolinium-based contrast agent

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0992245A1 (en) 1998-09-16 2000-04-12 Goldham Bioglan Pharma GmbH Radio-contrast agents
FR2794744B1 (fr) 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
FR2836916B1 (fr) 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
FR2883562B1 (fr) * 2005-03-24 2009-02-27 Guerbet Sa Chelates lipophiles et leur utilisation en imagerie
FR2891830B1 (fr) 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
CN105142649A (zh) 2013-04-26 2015-12-09 法国加柏公司 造影剂配制品与有关制备方法
PT4151637T (pt) 2018-08-06 2025-03-26 Bracco Imaging Spa Agentes de contraste à base de pcta que suportam gadolínio
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification

Also Published As

Publication number Publication date
EP4151637B1 (en) 2025-01-22
JP7841044B2 (ja) 2026-04-06
JP2024178261A (ja) 2024-12-24
EP3687994A1 (en) 2020-08-05
AU2019319599B2 (en) 2024-01-04
US20200376145A1 (en) 2020-12-03
US12036289B2 (en) 2024-07-16
KR20250079243A (ko) 2025-06-04
EP4491199A3 (en) 2025-04-16
CN119930615A (zh) 2025-05-06
FI3770160T3 (fi) 2023-03-16
JP7558146B2 (ja) 2024-09-30
DK4151637T3 (da) 2025-03-31
DK3770160T3 (da) 2023-02-20
EP3770160B1 (en) 2022-11-23
ES2938015T3 (es) 2023-04-03
CA3105610A1 (en) 2020-02-13
US10973934B2 (en) 2021-04-13
DK3687994T3 (da) 2021-01-25
JP2021533165A (ja) 2021-12-02
PL3770160T3 (pl) 2023-05-29
US20210196840A1 (en) 2021-07-01
ES2841070T3 (es) 2021-07-07
FI4151637T3 (fi) 2025-03-28
PT3687994T (pt) 2020-12-07
CN112533921A (zh) 2021-03-19
KR102815156B1 (ko) 2025-05-30
PT4151637T (pt) 2025-03-26
EP3770160A1 (en) 2021-01-27
ES3015456T3 (en) 2025-05-05
CA3105610C (en) 2024-05-28
EP4491199A2 (en) 2025-01-15
WO2020030618A1 (en) 2020-02-13
CN119954806A (zh) 2025-05-09
AU2019319599A1 (en) 2021-01-28
EP4151637A1 (en) 2023-03-22
BR112021001102A2 (pt) 2021-04-20
EP3687994B1 (en) 2020-11-04
KR20210041566A (ko) 2021-04-15
PL4151637T3 (pl) 2025-04-28
US20240366802A1 (en) 2024-11-07
CN119039292A (zh) 2024-11-29
CN112533921B (zh) 2025-02-21
BR112021001102B1 (pt) 2022-12-20
PT3770160T (pt) 2023-02-21

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