DK3812453T3 - Metabolisk optimeret cellkultur - Google Patents

Metabolisk optimeret cellkultur

Info

Publication number
DK3812453T3
DK3812453T3 DK20193898.2T DK20193898T DK3812453T3 DK 3812453 T3 DK3812453 T3 DK 3812453T3 DK 20193898 T DK20193898 T DK 20193898T DK 3812453 T3 DK3812453 T3 DK 3812453T3
Authority
DK
Denmark
Prior art keywords
metabolicly
cell culture
optimized cell
optimized
culture
Prior art date
Application number
DK20193898.2T
Other languages
English (en)
Inventor
Shawn Lawrence
Ann Kim
Amy Johnson
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52813657&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3812453(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Application granted granted Critical
Publication of DK3812453T3 publication Critical patent/DK3812453T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
DK20193898.2T 2013-10-11 2014-10-10 Metabolisk optimeret cellkultur DK3812453T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361889815P 2013-10-11 2013-10-11
EP18161278.9A EP3351620B1 (en) 2013-10-11 2014-10-10 Metabolically optimized cell culture

Publications (1)

Publication Number Publication Date
DK3812453T3 true DK3812453T3 (da) 2026-04-13

Family

ID=52813657

Family Applications (3)

Application Number Title Priority Date Filing Date
DK18161278.9T DK3351620T3 (da) 2013-10-11 2014-10-10 Metabolsk optimeret cellekultur
DK20193898.2T DK3812453T3 (da) 2013-10-11 2014-10-10 Metabolisk optimeret cellkultur
DK14851841.8T DK3055409T3 (da) 2013-10-11 2014-10-10 Metabolisk optimeret cellekultur

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK18161278.9T DK3351620T3 (da) 2013-10-11 2014-10-10 Metabolsk optimeret cellekultur

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK14851841.8T DK3055409T3 (da) 2013-10-11 2014-10-10 Metabolisk optimeret cellekultur

Country Status (18)

Country Link
US (2) US20160244725A1 (da)
EP (3) EP3351620B1 (da)
JP (3) JP6663854B2 (da)
KR (4) KR102358807B1 (da)
CN (2) CN105637085A (da)
AU (2) AU2014331776B2 (da)
CA (1) CA2926049C (da)
DK (3) DK3351620T3 (da)
EA (2) EA033783B1 (da)
ES (2) ES2833471T3 (da)
FI (1) FI3812453T3 (da)
HU (2) HUE039551T2 (da)
IL (2) IL244511A0 (da)
MX (2) MX384960B (da)
PL (2) PL3351620T3 (da)
SG (2) SG10201800772TA (da)
WO (1) WO2015054554A1 (da)
ZA (1) ZA201601550B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
DK3351620T3 (da) 2013-10-11 2020-10-26 Regeneron Pharma Metabolsk optimeret cellekultur
US20160244726A1 (en) * 2013-10-11 2016-08-25 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
JP7260011B2 (ja) * 2017-03-31 2023-04-18 株式会社三洋物産 遊技機
JP7260018B2 (ja) * 2017-03-31 2023-04-18 株式会社三洋物産 遊技機
JP7260020B2 (ja) * 2017-03-31 2023-04-18 株式会社三洋物産 遊技機
JP7310947B2 (ja) * 2017-04-27 2023-07-19 株式会社三洋物産 遊技機
JP7260009B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
JP7260021B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
JP7310945B2 (ja) * 2017-04-27 2023-07-19 株式会社三洋物産 遊技機
JP7310952B2 (ja) * 2017-04-27 2023-07-19 株式会社三洋物産 遊技機
JP7260012B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
JP7272480B2 (ja) * 2017-04-27 2023-05-12 株式会社三洋物産 遊技機
JP7260013B2 (ja) * 2017-04-27 2023-04-18 株式会社三洋物産 遊技機
EP3692358A1 (en) 2017-10-06 2020-08-12 Lonza Ltd Automated control of cell culture using raman spectroscopy
SG11202002339XA (en) 2017-10-16 2020-04-29 Regeneron Pharma Perfusion bioreactor and related methods of use
JP7471220B2 (ja) * 2017-11-30 2024-04-19 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 哺乳動物細胞の培養方法
JP2021519073A (ja) * 2018-03-29 2021-08-10 ジェネンテック， インコーポレイテッド 哺乳動物細胞におけるラクトジェニック活性の制御
GB201810772D0 (en) * 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
JP7231355B2 (ja) * 2018-08-22 2023-03-01 日機装株式会社 細胞培養方法および細胞培養装置
CN120795059A (zh) 2018-08-27 2025-10-17 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
KR102559149B1 (ko) 2018-10-26 2023-07-24 에프. 호프만-라 로슈 아게 재조합효소 매개 카세트 교환을 이용한 다중특이적 항체 스크리닝 방법
JP2020151560A (ja) * 2020-06-24 2020-09-24 株式会社三洋物産 遊技機
JP2020151559A (ja) * 2020-06-24 2020-09-24 株式会社三洋物産 遊技機
EP3985097A1 (en) * 2020-10-14 2022-04-20 Sartorius Stedim Biotech GmbH A method and system for configuring and/or setup of a downstream process for processing a biomass

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
KR970029803A (ko) 1995-11-03 1997-06-26 김광호 반도체 메모리장치의 프리차지 회로
US6165741A (en) 1997-05-30 2000-12-26 The Trustees Of The University Of Pennsylvania Method for rapid detection of bacterial growth in cultures
US5972650A (en) 1997-06-26 1999-10-26 Brigham And Women's Hospital Tetracycline repressor regulated mammalian cell transcription and viral replication switch
WO2002057423A2 (en) 2001-01-16 2002-07-25 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
US6953692B2 (en) * 2001-12-18 2005-10-11 Bayer Pharmaceuticals Corporation Device and method for seed-train expansion of mammalian cells
US7039770B1 (en) 2002-03-05 2006-05-02 Juniper Networks, Inc. Low latency request dispatcher
CA2417689C (en) 2002-03-05 2006-05-09 F. Hoffmann-La Roche Ag Improved methods for growing mammalian cells in vitro
US8673589B2 (en) 2002-05-29 2014-03-18 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
US7429491B2 (en) 2003-05-15 2008-09-30 Wyeth Restricted glucose feed for animal cell culture
US7531327B2 (en) * 2004-07-23 2009-05-12 Immunomedics, Inc. Methods and compositions for increasing longevity and protein yield from a cell culture
TWI374935B (en) 2004-08-27 2012-10-21 Pfizer Ireland Pharmaceuticals Production of α-abeta
US7300773B2 (en) * 2004-08-27 2007-11-27 Wyeth Research Ireland Limited Production of TNFR-Ig
AU2006312014A1 (en) * 2005-11-02 2007-05-18 Wyeth Methods for adapting mammalian cells
US10155816B2 (en) 2005-11-28 2018-12-18 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
US7575890B2 (en) 2006-01-18 2009-08-18 Oxygen Enterprises, Ltd. Method for rapid detection and evaluation of cultured cell growth
US8192951B2 (en) 2006-11-03 2012-06-05 Wyeth Llc Glycolysis-inhibiting substances in cell culture
WO2008151219A1 (en) 2007-06-04 2008-12-11 Regeneron Pharmaceuticals, Inc. Enhanced expression and stability regions
EP2188371B1 (en) 2007-08-09 2017-12-20 Wyeth LLC Use of perfusion to enhance production of fed-batch cell culture in bioreactors
WO2009152413A1 (en) * 2008-06-13 2009-12-17 Centocor Ortho Biotech Inc. Methods for obtaining high viable cell density in mammalian cell culture
US8470552B2 (en) * 2009-10-12 2013-06-25 Keck Graduate Institute Strategy to reduce lactic acid production and control PH in animal cell culture
PT2563904E (pt) * 2010-04-26 2015-05-12 Novartis Ag Meio de cultura de células aperfeiçoado
WO2011150241A2 (en) * 2010-05-28 2011-12-01 Genentech, Inc. Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
TWI637057B (zh) 2012-11-09 2018-10-01 拜爾沙納有限公司 具交替生物反應器用途之不連續進料批次製程
US20140199728A1 (en) * 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
DK3351620T3 (da) 2013-10-11 2020-10-26 Regeneron Pharma Metabolsk optimeret cellekultur

Also Published As

Publication number Publication date
AU2021200193A1 (en) 2021-03-18
KR20210046835A (ko) 2021-04-28
KR102243980B1 (ko) 2021-04-26
KR102510238B1 (ko) 2023-03-16
KR102610425B1 (ko) 2023-12-06
JP2016532457A (ja) 2016-10-20
EP3055409B1 (en) 2018-04-25
PL3351620T3 (pl) 2021-03-08
AU2021200193B2 (en) 2023-08-24
EP3812453A1 (en) 2021-04-28
EP3812453B1 (en) 2026-03-25
EA201991976A1 (ru) 2020-04-02
ES2833471T3 (es) 2021-06-15
CA2926049C (en) 2023-09-05
JP6967620B2 (ja) 2021-11-17
JP7377243B2 (ja) 2023-11-09
HK1253275A1 (en) 2019-06-14
ES2678945T3 (es) 2018-08-21
JP2020072760A (ja) 2020-05-14
IL244511A0 (en) 2016-04-21
HK1223122A1 (en) 2017-07-21
IL262833A (en) 2018-12-31
DK3055409T3 (da) 2018-07-30
CN114717196A (zh) 2022-07-08
JP6663854B2 (ja) 2020-03-13
HUE051049T2 (hu) 2021-01-28
SG11201601681QA (en) 2016-04-28
AU2014331776A1 (en) 2016-03-24
KR20230038324A (ko) 2023-03-17
MX376623B (es) 2025-03-07
CA2926049A1 (en) 2015-04-16
MX2016004564A (es) 2016-07-12
PL3055409T3 (pl) 2018-10-31
AU2014331776B2 (en) 2020-10-22
JP2022009453A (ja) 2022-01-14
SG10201800772TA (en) 2018-03-28
EA033783B1 (ru) 2019-11-25
EP3351620A1 (en) 2018-07-25
ZA201601550B (en) 2023-05-31
KR20160062032A (ko) 2016-06-01
EA201690600A1 (ru) 2016-09-30
WO2015054554A1 (en) 2015-04-16
KR102358807B1 (ko) 2022-02-08
EP3055409A1 (en) 2016-08-17
FI3812453T3 (fi) 2026-05-08
KR20220020415A (ko) 2022-02-18
MX2020011334A (es) 2021-07-30
EP3055409A4 (en) 2016-09-28
CN105637085A (zh) 2016-06-01
DK3351620T3 (da) 2020-10-26
US20210087535A1 (en) 2021-03-25
US20160244725A1 (en) 2016-08-25
HUE039551T2 (hu) 2019-01-28
MX384960B (es) 2025-03-14
EP3351620B1 (en) 2020-09-02

Similar Documents

Publication Publication Date Title
IL246262A0 (en) Media for cell culture
IL245573B (en) Cell
DK3351620T3 (da) Metabolsk optimeret cellekultur
PL3017520T3 (pl) Zespół ogniw słonecznych
EP3006554A4 (en) ZELLKULTIVATOR
HUE040233T2 (hu) Szérummentes sejtkultúra-tápközeg
DK3401319T3 (da) Celledyrkningsmedium
FR3003076B1 (fr) Supercondensateur electrochimique
EP3066193C0 (en) CELL CULTURE PROCESS
CL2014002030A1 (es) Alfa-amilasa
EP2961825A4 (en) STRUCTURE FOR CULTIVATION OF CELLS
DK2825157T3 (da) Aminosyrelipider
DK3234476T3 (da) Solfanger
DK2943561T3 (da) Fotobioreaktor
GB201420277D0 (en) Cell culture system
EP3031897A4 (en) Culture vessel
EP3067936A4 (en) SOLAR CELL
EP3062822C0 (en) CELL TRANSPORT
EP3031899A4 (en) Culture apparatus
GB201308905D0 (en) Cell culture
GB201306488D0 (en) Cell culture
TH1401007645A (th) เซลล์แสงอาทิตย์ (Solar Cells)
TH1501000408A (th) โรงงานก๊าซชีวภาพ
FR3015112B1 (fr) Cellule photovoltaique
EP3067940A4 (en) SOLAR CELL