DK3823970T3 - Yderligere substituerede triazoloquinoxalinderivater - Google Patents

Yderligere substituerede triazoloquinoxalinderivater Download PDF

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Publication number
DK3823970T3
DK3823970T3 DK19742204.1T DK19742204T DK3823970T3 DK 3823970 T3 DK3823970 T3 DK 3823970T3 DK 19742204 T DK19742204 T DK 19742204T DK 3823970 T3 DK3823970 T3 DK 3823970T3
Authority
DK
Denmark
Prior art keywords
triazoloquinoxaline
derivatives
further substituted
substituted
triazoloquinoxaline derivatives
Prior art date
Application number
DK19742204.1T
Other languages
English (en)
Inventor
Florian Jakob
Jo Alen
Simon Lucas
Tobias Craan
Ingo Konetzki
Achim Kless
Stefan Schunk
Paul Ratcliffe
Sebastian Wachten
Simon Cruwys
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK3823970T3 publication Critical patent/DK3823970T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK19742204.1T 2018-07-20 2019-07-22 Yderligere substituerede triazoloquinoxalinderivater DK3823970T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18184607 2018-07-20
PCT/EP2019/069610 WO2020016452A1 (en) 2018-07-20 2019-07-22 Further substituted triazolo quinoxaline derivatives

Publications (1)

Publication Number Publication Date
DK3823970T3 true DK3823970T3 (da) 2024-02-05

Family

ID=63014345

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19742204.1T DK3823970T3 (da) 2018-07-20 2019-07-22 Yderligere substituerede triazoloquinoxalinderivater

Country Status (29)

Country Link
US (3) US10981918B2 (da)
EP (1) EP3823970B1 (da)
JP (1) JP7336505B2 (da)
KR (1) KR102798858B1 (da)
CN (1) CN112771046B (da)
AR (1) AR117951A1 (da)
AU (1) AU2019304085B2 (da)
BR (1) BR112021000857A2 (da)
CA (1) CA3106778A1 (da)
CL (1) CL2021000126A1 (da)
CO (1) CO2021000292A2 (da)
DK (1) DK3823970T3 (da)
EA (1) EA202190272A1 (da)
EC (1) ECSP21003718A (da)
ES (1) ES2973525T3 (da)
FI (1) FI3823970T3 (da)
HR (1) HRP20240429T1 (da)
HU (1) HUE065896T2 (da)
IL (1) IL280211B2 (da)
LT (1) LT3823970T (da)
MX (1) MX2021000759A (da)
PE (1) PE20211377A1 (da)
PL (1) PL3823970T3 (da)
PT (1) PT3823970T (da)
RS (1) RS65245B1 (da)
SI (1) SI3823970T1 (da)
TW (1) TWI811400B (da)
WO (1) WO2020016452A1 (da)
ZA (1) ZA202100672B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3104199A1 (en) 2018-07-20 2020-01-23 F. Hoffmann-La Roche Ag Sulfonylurea compounds as inhibitors of interleukin-1 activity
AR117951A1 (es) 2018-07-20 2021-09-08 Gruenenthal Gmbh Derivados de triazolquinoxalina adicionalmente sustituidos
BR112021001044A2 (pt) 2018-07-20 2021-04-13 F. Hoffmann-La Roche Ag Compostos de sulfonimidamida como inibidores da atividade de interleucina-1
LT3823971T (lt) * 2018-07-20 2022-09-12 Grünenthal GmbH Pakeisti triazolo chinoksalino dariniai
EP4090661B1 (en) * 2020-01-17 2025-03-12 Grünenthal GmbH Quinoxaline derivatives as modulators of the glucocorticoid receptor
EP4090660B1 (en) * 2020-01-17 2024-01-31 Grünenthal GmbH Quinoxaline derivatives
JP7843705B2 (ja) 2020-01-22 2026-04-10 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｎｌｒｐ３モジュレーターとしてのスルホンイミドアミド化合物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200400816A (en) * 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
AU2003297471A1 (en) * 2003-01-03 2004-08-10 Boehringer Ingelheim Pharmaceuticals, Inc. 1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
JP4648303B2 (ja) * 2003-02-25 2011-03-09 メルク・シャープ・エンド・ドーム・コーポレイション 選択的非ステロイド系糖質コルチコイド受容体調節剤
CN1809347A (zh) * 2003-04-23 2006-07-26 麦克公司 选择性螺环糖皮质激素受体调节剂
US7569689B2 (en) * 2004-01-16 2009-08-04 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
KR20070056060A (ko) 2004-07-14 2007-05-31 리간드 파마슈티칼스 인코포레이티드 세포내 수용체 조절화합물 및 방법
TW200800150A (en) * 2005-12-21 2008-01-01 Organon Nv Compounds with medicinal effects due to interaction with the glucocorticoid receptor
WO2007087250A2 (en) * 2006-01-23 2007-08-02 Amira Pharmaceuticals, Inc. Tricyclic inhibitors of 5-lipoxygenase
SI1995242T1 (sl) * 2006-03-14 2013-01-31 Santen Pharmaceutical Co., Ltd. Nov derivat 1,2,3,4-tetrahidrokinoksalina z aktivnostjo vezanja glukokortikoidnega receptorja
KR20090020694A (ko) * 2006-07-14 2009-02-26 일라이 릴리 앤드 캄파니 글루코코르티코이드 수용체 조절제 및 이의 사용 방법
CA2687948A1 (en) * 2007-05-29 2008-12-04 Mamoru Matsuda Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as substituent, phenyl group having sulfonic acid ester structure or sulfonic acid amide structure introduced therein andhas glucocorticoid receptor-binding activity
WO2009003567A1 (fr) 2007-06-29 2009-01-08 Johnson Controls Technology Company Procede de montage d'un composant electrique sur un element de support et dispositif de raccordement electrique
JP2009046435A (ja) 2007-08-21 2009-03-05 Mitsubishi Tanabe Pharma Corp グルココルチコイド受容体モジュレーター
JP2009084273A (ja) 2007-09-13 2009-04-23 Santen Pharmaceut Co Ltd １，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体からなるグルココルチコイド受容体アゴニスト
JP2009084274A (ja) * 2007-09-13 2009-04-23 Santen Pharmaceut Co Ltd 新規１，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体
WO2009103007A2 (en) 2008-02-13 2009-08-20 Ligand Pharmaceuticals Incorporated Steroid hormone receptor modulator compounds and methods
WO2009158380A1 (en) * 2008-06-24 2009-12-30 Bristol-Myers Squibb Company Cyclopentathiophene modulators of the glucocorticoid receptor, ap-1, and/or nf-kappa b activity and use thereof
EA018420B1 (ru) * 2008-09-12 2013-07-30 Сантен Фармасьютикал Ко., Лтд. Агонист глюкокортикоидного рецептора, содержащий новые производные 1,2,3,4-тетрагидрохиноксалина с фенильной группой, имеющей структуру эфира сульфоновой кислоты, введенной в нее в качестве заместителя
EP4219494B1 (en) * 2013-11-25 2026-03-25 Corcept Therapeutics Incorporated Octahydro fused azadecalin glucocorticoid receptor modulators
EP3342768A4 (en) 2015-08-25 2019-01-23 Santen Pharmaceutical Co., Ltd. [4- (1,3,3-TRIMETHYL-2-OXO-3,4-DIHYDRO-1H-CHINOXALIN-7-YL) PHENOXY] ETHYLOXY COMPOUND OR SALT THEREOF
JP7247092B2 (ja) * 2017-01-09 2023-03-28 上海瑛派▲薬▼▲業▼有限公司 キナーゼ阻害剤としての置換された縮合ヘテロアリール化合物及びその用途
AR117951A1 (es) * 2018-07-20 2021-09-08 Gruenenthal Gmbh Derivados de triazolquinoxalina adicionalmente sustituidos
LT3823971T (lt) * 2018-07-20 2022-09-12 Grünenthal GmbH Pakeisti triazolo chinoksalino dariniai

Also Published As

Publication number Publication date
KR102798858B1 (ko) 2025-04-23
US20210163491A1 (en) 2021-06-03
JP2021532100A (ja) 2021-11-25
CA3106778A1 (en) 2020-01-23
EP3823970A1 (en) 2021-05-26
US20200024281A1 (en) 2020-01-23
AU2019304085A1 (en) 2021-03-04
KR20210034632A (ko) 2021-03-30
CN112771046B (zh) 2023-09-19
ES2973525T3 (es) 2024-06-20
TW202007687A (zh) 2020-02-16
PL3823970T3 (pl) 2024-04-22
AR117951A1 (es) 2021-09-08
TWI811400B (zh) 2023-08-11
NZ772720A (en) 2024-08-30
ZA202100672B (en) 2024-09-25
IL280211B2 (en) 2024-09-01
IL280211B1 (en) 2024-05-01
HUE065896T2 (hu) 2024-06-28
MX2021000759A (es) 2021-03-29
HRP20240429T1 (hr) 2024-08-16
WO2020016452A1 (en) 2020-01-23
US20240327416A1 (en) 2024-10-03
US10981918B2 (en) 2021-04-20
CN112771046A (zh) 2021-05-07
RS65245B1 (sr) 2024-03-29
JP7336505B2 (ja) 2023-08-31
CO2021000292A2 (es) 2021-01-29
AU2019304085B2 (en) 2024-09-05
EP3823970B1 (en) 2024-01-03
FI3823970T3 (fi) 2024-02-01
IL280211A (en) 2021-03-01
US11981677B2 (en) 2024-05-14
EA202190272A1 (ru) 2021-06-21
CL2021000126A1 (es) 2021-07-19
ECSP21003718A (es) 2021-02-26
BR112021000857A2 (pt) 2021-04-13
PT3823970T (pt) 2024-03-27
PE20211377A1 (es) 2021-07-27
SI3823970T1 (sl) 2024-03-29
LT3823970T (lt) 2024-02-12

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