ECSP21003718A - Derivados de triazolquinoxalina adicionalmente sustituidos - Google Patents

Derivados de triazolquinoxalina adicionalmente sustituidos

Info

Publication number
ECSP21003718A
ECSP21003718A ECSENADI20213718A ECDI202103718A ECSP21003718A EC SP21003718 A ECSP21003718 A EC SP21003718A EC SENADI20213718 A ECSENADI20213718 A EC SENADI20213718A EC DI202103718 A ECDI202103718 A EC DI202103718A EC SP21003718 A ECSP21003718 A EC SP21003718A
Authority
EC
Ecuador
Prior art keywords
triazolquinoxaline
additionally substituted
derivatives additionally
derivatives
glucocorticoid receptor
Prior art date
Application number
ECSENADI20213718A
Other languages
English (en)
Inventor
Florian Jakob
Tobias Craan
Sebastian Wachten
Achim Kless
Paul Ratcliffe
Jo Alen
Simon Lucas
Ingo Konetzki
Stefan Schunk
Simon Cruwys
Original Assignee
Gruenenthal Gmbh [De/De]
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh [De/De] filed Critical Gruenenthal Gmbh [De/De]
Publication of ECSP21003718A publication Critical patent/ECSP21003718A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de acuerdo con la fórmula general (I) que actuan como moduladores del receptor de glucocorticoides y se pueden usar para el tratamiento y/o la profilaxis de trastornos que son mediados parcialmente con el receptor de glucocorticoides.
ECSENADI20213718A 2018-07-20 2021-01-18 Derivados de triazolquinoxalina adicionalmente sustituidos ECSP21003718A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18184607 2018-07-20

Publications (1)

Publication Number Publication Date
ECSP21003718A true ECSP21003718A (es) 2021-02-26

Family

ID=63014345

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI20213718A ECSP21003718A (es) 2018-07-20 2021-01-18 Derivados de triazolquinoxalina adicionalmente sustituidos

Country Status (29)

Country Link
US (3) US10981918B2 (es)
EP (1) EP3823970B1 (es)
JP (1) JP7336505B2 (es)
KR (1) KR102798858B1 (es)
CN (1) CN112771046B (es)
AR (1) AR117951A1 (es)
AU (1) AU2019304085B2 (es)
BR (1) BR112021000857A2 (es)
CA (1) CA3106778A1 (es)
CL (1) CL2021000126A1 (es)
CO (1) CO2021000292A2 (es)
DK (1) DK3823970T3 (es)
EA (1) EA202190272A1 (es)
EC (1) ECSP21003718A (es)
ES (1) ES2973525T3 (es)
FI (1) FI3823970T3 (es)
HR (1) HRP20240429T1 (es)
HU (1) HUE065896T2 (es)
IL (1) IL280211B2 (es)
LT (1) LT3823970T (es)
MX (1) MX2021000759A (es)
PE (1) PE20211377A1 (es)
PL (1) PL3823970T3 (es)
PT (1) PT3823970T (es)
RS (1) RS65245B1 (es)
SI (1) SI3823970T1 (es)
TW (1) TWI811400B (es)
WO (1) WO2020016452A1 (es)
ZA (1) ZA202100672B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3823974A1 (en) 2018-07-20 2021-05-26 F. Hoffmann-La Roche AG Sulfonimidamide compounds as inhibitors of interleukin-1 activity
SG11202012159TA (en) 2018-07-20 2021-01-28 Hoffmann La Roche Sulfonylurea compounds as inhibitors of interleukin-1 activity
US10981918B2 (en) * 2018-07-20 2021-04-20 Grünenthal GmbH Further substituted triazolo quinoxaline derivatives
DK3823971T3 (da) * 2018-07-20 2022-09-05 Gruenenthal Gmbh Substituerede triazol-quinoxalin-derivater
ES2976780T3 (es) * 2020-01-17 2024-08-08 Gruenenthal Gmbh Derivados de quinoxalina
EP4090661B1 (en) * 2020-01-17 2025-03-12 Grünenthal GmbH Quinoxaline derivatives as modulators of the glucocorticoid receptor

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200400816A (en) * 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
CA2512257A1 (en) * 2003-01-03 2004-07-29 Boehringer Ingelheim Pharmaceuticals, Inc. 1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
EP1599201B1 (en) * 2003-02-25 2010-04-14 Merck Sharp & Dohme Corp. Selective non-steroidal glucocorticoid receptor modulators
ATE447575T1 (de) * 2003-04-23 2009-11-15 Merck & Co Inc Selektive spirocyclische glucocorticoid-rezeptor- modulatoren
US7569689B2 (en) * 2004-01-16 2009-08-04 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
CN101018552A (zh) * 2004-07-14 2007-08-15 利亘制药公司 细胞内受体调节剂化合物和方法
TW200800150A (en) * 2005-12-21 2008-01-01 Organon Nv Compounds with medicinal effects due to interaction with the glucocorticoid receptor
EP1978966A4 (en) * 2006-01-23 2010-11-10 Amira Pharmaceuticals Inc TRICYCLIC INHIBITORS OF 5-LIPOXYGENASE
SI1995242T1 (sl) 2006-03-14 2013-01-31 Santen Pharmaceutical Co., Ltd. Nov derivat 1,2,3,4-tetrahidrokinoksalina z aktivnostjo vezanja glukokortikoidnega receptorja
JP5189091B2 (ja) * 2006-07-14 2013-04-24 イーライ リリー アンド カンパニー グルココルチコイド受容体モジュレーターおよびその使用方法
AU2008255733B8 (en) * 2007-05-29 2013-06-13 Santen Pharmaceutical Co., Ltd. Novel 1,2,3,4-tetrahydroquinoxaline derivative which has, as substituent, phenyl group having sulfonic acid ester structure or sulfonic acid amide structure introduced therein and has glucocorticoid receptor-binding activity
WO2009003567A1 (fr) 2007-06-29 2009-01-08 Johnson Controls Technology Company Procede de montage d'un composant electrique sur un element de support et dispositif de raccordement electrique
JP2009046435A (ja) * 2007-08-21 2009-03-05 Mitsubishi Tanabe Pharma Corp グルココルチコイド受容体モジュレーター
JP2009084273A (ja) 2007-09-13 2009-04-23 Santen Pharmaceut Co Ltd １，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体からなるグルココルチコイド受容体アゴニスト
JP2009084274A (ja) * 2007-09-13 2009-04-23 Santen Pharmaceut Co Ltd 新規１，３，３−トリメチル−７−フェニル−３，４−ジヒドロ−１ｈ−キノキサリン−２−オン誘導体
WO2009103007A2 (en) * 2008-02-13 2009-08-20 Ligand Pharmaceuticals Incorporated Steroid hormone receptor modulator compounds and methods
EP2334671A1 (en) * 2008-06-24 2011-06-22 Bristol-Myers Squibb Company Cyclopentathiophene modulators of the glucocorticoid receptor, ap-1, and/or nf-kappa b activity and use thereof
US8664221B2 (en) * 2008-09-12 2014-03-04 Santen Pharmaceutical Co., Ltd. Method for treating an inflammatory disease by administering a 1,2,3,4- tetrahydroquinoxaline compound containing a phenyl group having a sulfonic acid ester structure introduced therein as a substituent
FI3848027T3 (fi) * 2013-11-25 2023-05-04 Corcept Therapeutics Inc Oktahydrofuusioituja atsadekaliiniglukokortikoidireseptorin modulaattoreita
CN107922356A (zh) 2015-08-25 2018-04-17 参天制药株式会社 [4‑(1,3,3‑三甲基‑2‑氧代‑3,4‑二氢‑1h‑喹喔啉‑7‑基)苯氧基]乙基氧基化合物或其盐
JP7247092B2 (ja) * 2017-01-09 2023-03-28 上海瑛派▲薬▼▲業▼有限公司 キナーゼ阻害剤としての置換された縮合ヘテロアリール化合物及びその用途
DK3823971T3 (da) * 2018-07-20 2022-09-05 Gruenenthal Gmbh Substituerede triazol-quinoxalin-derivater
US10981918B2 (en) * 2018-07-20 2021-04-20 Grünenthal GmbH Further substituted triazolo quinoxaline derivatives

Also Published As

Publication number Publication date
DK3823970T3 (da) 2024-02-05
WO2020016452A1 (en) 2020-01-23
FI3823970T3 (fi) 2024-02-01
BR112021000857A2 (pt) 2021-04-13
EP3823970A1 (en) 2021-05-26
TWI811400B (zh) 2023-08-11
RS65245B1 (sr) 2024-03-29
JP2021532100A (ja) 2021-11-25
US20210163491A1 (en) 2021-06-03
IL280211A (en) 2021-03-01
AR117951A1 (es) 2021-09-08
EA202190272A1 (ru) 2021-06-21
CL2021000126A1 (es) 2021-07-19
ZA202100672B (en) 2024-09-25
TW202007687A (zh) 2020-02-16
JP7336505B2 (ja) 2023-08-31
KR20210034632A (ko) 2021-03-30
CA3106778A1 (en) 2020-01-23
PL3823970T3 (pl) 2024-04-22
AU2019304085A1 (en) 2021-03-04
AU2019304085B2 (en) 2024-09-05
SI3823970T1 (sl) 2024-03-29
PE20211377A1 (es) 2021-07-27
MX2021000759A (es) 2021-03-29
CN112771046B (zh) 2023-09-19
IL280211B1 (en) 2024-05-01
LT3823970T (lt) 2024-02-12
US20240327416A1 (en) 2024-10-03
HRP20240429T1 (hr) 2024-08-16
PT3823970T (pt) 2024-03-27
CO2021000292A2 (es) 2021-01-29
US20200024281A1 (en) 2020-01-23
IL280211B2 (en) 2024-09-01
EP3823970B1 (en) 2024-01-03
US10981918B2 (en) 2021-04-20
NZ772720A (en) 2024-08-30
HUE065896T2 (hu) 2024-06-28
KR102798858B1 (ko) 2025-04-23
CN112771046A (zh) 2021-05-07
ES2973525T3 (es) 2024-06-20
US11981677B2 (en) 2024-05-14

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