DK384582A - Fremgangsmaade til konstruktion af en dna-sekvens, der koder for et polypeptid omfattende aminosyrekvensen af humant serumalbumin - Google Patents

Fremgangsmaade til konstruktion af en dna-sekvens, der koder for et polypeptid omfattende aminosyrekvensen af humant serumalbumin Download PDF

Info

Publication number
DK384582A
DK384582A DK384582A DK384582A DK384582A DK 384582 A DK384582 A DK 384582A DK 384582 A DK384582 A DK 384582A DK 384582 A DK384582 A DK 384582A DK 384582 A DK384582 A DK 384582A
Authority
DK
Denmark
Prior art keywords
polypeptide
fragments
serum albumin
human serum
construction
Prior art date
Application number
DK384582A
Other languages
English (en)
Other versions
DK169726B1 (da
Inventor
Richard M Lawn
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23146077&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK384582(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK384582A publication Critical patent/DK384582A/da
Application granted granted Critical
Publication of DK169726B1 publication Critical patent/DK169726B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK384582A 1981-08-28 1982-08-27 DNA-isolat omfattende en kontinuert sekvens, som koder for humant serumalbumin, og fremgangsmåde til konstruktion deraf samt en replicerbar mikrobiel udtrykkelsesvektor, som er i stand til at udtrykke DNA-sekvensen, en mikroorganisme, som er transformeret med vektoren, en gæringskultur af en sådan mikroorganisme og en fremgangsmåde til fremstilling af humant serumalbumin i moden form ved dyrkning DK169726B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29738081A 1981-08-28 1981-08-28
US29738081 1981-08-28

Publications (2)

Publication Number Publication Date
DK384582A true DK384582A (da) 1983-03-01
DK169726B1 DK169726B1 (da) 1995-01-23

Family

ID=23146077

Family Applications (1)

Application Number Title Priority Date Filing Date
DK384582A DK169726B1 (da) 1981-08-28 1982-08-27 DNA-isolat omfattende en kontinuert sekvens, som koder for humant serumalbumin, og fremgangsmåde til konstruktion deraf samt en replicerbar mikrobiel udtrykkelsesvektor, som er i stand til at udtrykke DNA-sekvensen, en mikroorganisme, som er transformeret med vektoren, en gæringskultur af en sådan mikroorganisme og en fremgangsmåde til fremstilling af humant serumalbumin i moden form ved dyrkning

Country Status (14)

Country Link
EP (1) EP0073646B1 (da)
JP (4) JPS5856684A (da)
KR (1) KR840001216A (da)
AT (1) ATE43138T1 (da)
AU (2) AU8775582A (da)
CA (1) CA1221927A (da)
DE (1) DE3279699D1 (da)
DK (1) DK169726B1 (da)
ES (1) ES515259A0 (da)
GB (2) GB2105343B (da)
IE (1) IE53892B1 (da)
IL (1) IL66614A (da)
NZ (1) NZ201704A (da)
ZA (1) ZA826250B (da)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0079739A3 (en) * 1981-11-12 1984-08-08 The Upjohn Company Albumin-based nucleotides, their replication and use, and plasmids for use therein
EP0091527A3 (en) * 1981-12-14 1984-07-25 The President And Fellows Of Harvard College Dna sequences, recombinant dna molecules and processes for producing human serum albumin-like polypeptides
FR2579223B1 (fr) * 1985-03-25 1988-12-09 Genetica Procede de preparation microbiologique de la serum-albumine humaine
JPS6229985A (ja) * 1985-06-17 1987-02-07 ジエネツクス・コ−ポレ−シヨン クロ−ン化プレプロ−ヒト血清アルブミン遺伝子およびヒト血清アルブミン遺伝子、それらの遺伝子を含むプラスミド、プラスミドにより形質転換された微生物、およびその微生物を用いたプレプロ−ヒト血清アルブミン遺伝子の製造方法
US4956282A (en) * 1985-07-29 1990-09-11 Calgene, Inc. Mammalian peptide expression in plant cells
FR2594846B1 (fr) * 1986-02-21 1989-10-20 Genetica Procede de preparation de la serum albumine humaine mature
AR247761A1 (es) * 1987-07-28 1995-03-31 Gist Brocades Nv Metodo para producir un polipeptido en una celula hospedante de kluyveromyces, dicha celula hospedante transformada y secuencia a adn empleada
SE459586B (sv) * 1987-09-14 1989-07-17 Mta Szegedi Biolog Koezponti Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning
US5879907A (en) * 1987-09-14 1999-03-09 Skandigen Ab Artificial gene coding for authentic human serum albumin, use thereof and method
GB8725529D0 (en) * 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
IL88326A (en) * 1987-11-18 1993-03-15 Gist Brocades Nv Purification of serum albumin
JPH01215289A (ja) * 1988-02-22 1989-08-29 Toa Nenryo Kogyo Kk 遺伝子組換えによる正常ヒト血清アルブミンａの製造方法
US4990447A (en) * 1988-06-24 1991-02-05 Gist-Brocades Nv Process for the purification of serum albumin
GB8820951D0 (en) * 1988-09-07 1988-10-05 Delta Biotechnology Ltd Fermentation method
US5260202A (en) * 1988-09-07 1993-11-09 Delta Biotechnology Limited Fermentation method
US5759802A (en) * 1988-10-26 1998-06-02 Tonen Corporation Production of human serum alubumin A
JPH0671432B2 (ja) * 1991-03-20 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
CA2058820C (en) * 1991-04-25 2003-07-15 Kotikanyad Sreekrishna Expression cassettes and vectors for the secretion of human serum albumin in pichia pastoris cells
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
EP0933083A1 (en) 1991-07-12 1999-08-04 Dsm N.V. Process for the purification of serum albumin
US5849874A (en) * 1991-07-12 1998-12-15 Gist-Brocades, N.V. Process for the purification of serum albumin
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
JPH07102148B2 (ja) * 1992-05-20 1995-11-08 株式会社ミドリ十字 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物
US5728553A (en) * 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
JPH07308199A (ja) 1994-05-18 1995-11-28 Green Cross Corp:The ヒト血清アルブミンの製造方法
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
EP2213743A1 (en) 2000-04-12 2010-08-04 Human Genome Sciences, Inc. Albumin fusion proteins
JP4798832B2 (ja) 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法
JP4798833B2 (ja) 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 加熱処理工程を含むヒト血清アルブミンの製造方法
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
AU2002364586A1 (en) 2001-12-21 2003-07-30 Delta Biotechnology Limited Albumin fusion proteins
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
WO2006067511A1 (en) 2004-12-23 2006-06-29 Novozymes Delta Limited Gene expression technique
US9057061B2 (en) 2003-12-23 2015-06-16 Novozymes Biopharma Dk A/S Gene expression technique
KR20070020204A (ko) 2004-01-20 2007-02-20 쥬리디컬 파운데이션 더 케모-세로-쎄라퓨틱 리서치 인스티튜트 2가 양이온 존재 하에서 가열 처리에 의한 인간 혈청알부민의 제조 방법
JP4651282B2 (ja) * 2004-01-21 2011-03-16 田辺三菱製薬株式会社 造血幹細胞及び造血前駆細胞の増幅方法
JP4492156B2 (ja) 2004-03-03 2010-06-30 ニプロ株式会社 血清アルブミンドメインを含む蛋白質
RU2010151453A (ru) 2008-05-15 2012-06-20 Р-Тек Уено, Лтд. (Jp) Фармацевтическая композиция для лечения сухости глаз и/или повреждения конъюнктивы и роговицы
KR101722961B1 (ko) 2009-02-11 2017-04-04 알부메딕스 에이/에스 알부민 변이체 및 접합체
EP2417248B1 (en) 2009-04-09 2019-05-22 Sartorius Stedim Cellca GmbH Method for improved single cell cloning
JP6247210B2 (ja) 2011-07-05 2017-12-13 アルブミディクス アクティーゼルスカブ アルブミン製剤及び用途
EP4442251A1 (en) 2023-04-05 2024-10-09 Albumedix Ltd Formulations and uses thereof
WO2025158071A1 (en) 2024-01-26 2025-07-31 Sartorius Albumedix Limited Retroviral preparations containing albumin for enhancing transduction efficiency, uses thereof for cell transduction
EP4703468A1 (en) 2024-08-29 2026-03-04 Sartorius Albumedix Limited Methods and uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719177A (en) * 1981-04-20 1988-01-12 Massachusetts Institute Of Technology Production of complementary DNA representing RNA viral sequences by recombinant DNA methods and uses therefor
FR2506326A1 (fr) * 1981-05-19 1982-11-26 Pasteur Institut Fragments d'adn portant des parties de l'information genetique des poliovirus, notamment du type pv1, et procede pour leur obtention
EP0079739A3 (en) * 1981-11-12 1984-08-08 The Upjohn Company Albumin-based nucleotides, their replication and use, and plasmids for use therein
EP0091527A3 (en) * 1981-12-14 1984-07-25 The President And Fellows Of Harvard College Dna sequences, recombinant dna molecules and processes for producing human serum albumin-like polypeptides

Also Published As

Publication number Publication date
IL66614A (en) 1985-09-29
GB2105343A (en) 1983-03-23
JPH0662841A (ja) 1994-03-08
GB2147903B (en) 1985-12-24
JPS5856684A (ja) 1983-04-04
JPH05292993A (ja) 1993-11-09
ES8401133A1 (es) 1983-12-01
EP0073646B1 (en) 1989-05-17
DE3279699D1 (en) 1989-06-22
KR840001216A (ko) 1984-03-28
JPH08228790A (ja) 1996-09-10
AU8146187A (en) 1988-03-17
NZ201704A (en) 1986-08-08
EP0073646A2 (en) 1983-03-09
GB2105343B (en) 1985-12-24
IL66614A0 (en) 1982-12-31
GB2147903A (en) 1985-05-22
ES515259A0 (es) 1983-12-01
GB8423932D0 (en) 1984-10-31
ATE43138T1 (de) 1989-06-15
EP0073646A3 (en) 1984-08-01
CA1221927A (en) 1987-05-19
JPH0460639B2 (da) 1992-09-28
AU603394B2 (en) 1990-11-15
JP2968052B2 (ja) 1999-10-25
IE822085L (en) 1983-02-28
ZA826250B (en) 1983-09-28
AU8775582A (en) 1983-03-03
IE53892B1 (en) 1989-04-12
DK169726B1 (da) 1995-01-23
JPH0775538B2 (ja) 1995-08-16

Similar Documents

Publication Publication Date Title
DK384582A (da) Fremgangsmaade til konstruktion af en dna-sekvens, der koder for et polypeptid omfattende aminosyrekvensen af humant serumalbumin
DK422288A (da) Dna-konstruktioner indeholdende en kluyveromyces-alfa-faktor-ledersekvens til at dirigere sekretion af heterologe polypeptider
MX428A (es) Region regulatoria para expresion de gen heterologa en levadura.
ES8602138A1 (es) Metodo de controlar la expresion de un gen que codifica una proteinaheterologa deseada.
FI871144A0 (fi) Foerfarande foer framstaellning av proteinprodukter i aspegillus oryzae och en promotor foer anvaendning i aspergillus.
KR890014738A (ko) 단백질 합성의 cks 방법
ATE135403T1 (de) Herstellung und reinigung eines proteins, das mit einem bindungsprotein fusioniert ist
DK181386D0 (da) Proteaseresistente derivater af enkelt-kaede-urokinase, fremgangsmaade til fremstilling deraf, nucleinsyrer, replicerbare vektorer og vaertsceller til anvendelse ved fremgangsmaaden og farmaceutiske praeparater af urokinase-derivaterne
ES8600403A1 (es) Un procedimiento para producir un peptido que comprende un peptido de exo-senal unido operativamente a una proteina deseada
DE69837085D1 (de) Crsp-proteine (cystein-reiche, sekretierte proteine), die dafür kodierenden nukleinsäuren und ihre verwendungen
DE3751368D1 (de) gentechnische Herstellung von Faktor XIIIa.
NO930428D0 (no) Proteinstrukturen til plantetoksingelonin
DK0629238T3 (da) Autotaxin:Motilitetsstimulerende protein, som er nyttigt til cancerdiagnose og terapi
ATE92961T1 (de) Dns-sequenz.
KR850001286A (ko) 개량 플라스미드 벡타의 제조방법
SE8800378L (sv) Framstaellning av fuserade proteiner eller polypeptider
DK645588A (da) Fremgangsmaade til fremstilling af et polypeptid eller protein ved enzymatisk spaltning
KR860008282A (ko) 재조합 사람 레닌의 제조방법
KR920004577A (ko) 단백질 합성의 cks 방법
DK196086D0 (da) Fremgangsmaade til fremstilling af et protein
DK1233980T3 (da) Nukleinsyremolekyle, omfattende en nukleinsyresekvens, der koder for et hæmocyanin, og mindst en intronsekvens
DK0487229T3 (da) DNA, der koder for et protein, som binder til enhanceren for alfa-føtoproteingenet
DE3586580D1 (de) Zur wirksamen gen-expression faehiger vektor und verwendung desselben.
Umetsu et al. Detection of allo A-binding glycoproteins by lectinofixation
PT1241252E (pt) Acido nucleico que e amplificado em tumores e materiais e metodos relacionados

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired