DK3948276T3 - Forudsigelse af cellekulturens ydeevne i bioreaktorer - Google Patents

Forudsigelse af cellekulturens ydeevne i bioreaktorer

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Publication number
DK3948276T3
DK3948276T3 DK20782758.5T DK20782758T DK3948276T3 DK 3948276 T3 DK3948276 T3 DK 3948276T3 DK 20782758 T DK20782758 T DK 20782758T DK 3948276 T3 DK3948276 T3 DK 3948276T3
Authority
DK
Denmark
Prior art keywords
bioreactors
cell culture
culture performance
predicting cell
predicting
Prior art date
Application number
DK20782758.5T
Other languages
English (en)
Inventor
William Leigh Johnson
Behrens Martin Rodrigo Cárcamo
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK3948276T3 publication Critical patent/DK3948276T3/da

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    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/12Computing arrangements based on biological models using genetic models
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48Automatic or computerized control
    • GPHYSICS
    • G05CONTROLLING; REGULATING
    • G05BCONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B17/00Systems involving the use of models or simulators of said systems
    • G05B17/02Systems involving the use of models or simulators of said systems electric
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00Machine learning
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/04Architecture, e.g. interconnection topology
    • G06N3/045Combinations of networks
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/08Learning methods
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/12Computing arrangements based on biological models using genetic models
    • G06N3/123DNA computing
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/12Computing arrangements based on biological models using genetic models
    • G06N3/126Evolutionary algorithms, e.g. genetic algorithms or genetic programming
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00Computing arrangements using knowledge-based models
    • G06N5/01Dynamic search techniques; Heuristics; Dynamic trees; Branch-and-bound
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/10Boolean models
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20Probabilistic models
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/30Dynamic-time models
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10004Still image; Photographic image
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30024Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Software Systems (AREA)
  • Medical Informatics (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Data Mining & Analysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Mathematical Physics (AREA)
  • Computing Systems (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Computational Linguistics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Library & Information Science (AREA)
  • Sustainable Development (AREA)
  • Computer Hardware Design (AREA)
  • Microbiology (AREA)
  • Bioethics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
DK20782758.5T 2019-03-29 2020-03-27 Forudsigelse af cellekulturens ydeevne i bioreaktorer DK3948276T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962826910P 2019-03-29 2019-03-29
PCT/US2020/025444 WO2020205611A1 (en) 2019-03-29 2020-03-27 Predicting cell culture performance in bioreactors

Publications (1)

Publication Number Publication Date
DK3948276T3 true DK3948276T3 (da) 2025-10-27

Family

ID=72667059

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20782758.5T DK3948276T3 (da) 2019-03-29 2020-03-27 Forudsigelse af cellekulturens ydeevne i bioreaktorer

Country Status (19)

Country Link
US (1) US20220208297A1 (da)
EP (2) EP3948276B1 (da)
JP (1) JP7524211B2 (da)
KR (1) KR20210146918A (da)
CN (1) CN113692535B (da)
AU (1) AU2020254517B2 (da)
CA (1) CA3133474A1 (da)
DK (1) DK3948276T3 (da)
ES (1) ES3049282T3 (da)
FI (1) FI3948276T3 (da)
HU (1) HUE073441T2 (da)
IL (1) IL286741B2 (da)
LT (1) LT3948276T (da)
MX (1) MX2021011623A (da)
PL (1) PL3948276T3 (da)
PT (1) PT3948276T (da)
SG (1) SG11202110091RA (da)
SI (1) SI3948276T1 (da)
WO (1) WO2020205611A1 (da)

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WO2023276450A1 (ja) * 2021-06-29 2023-01-05 富士フイルム株式会社 細胞の培養結果を予測する方法、培養結果予測プログラム、及び、培養結果予測装置
KR102792081B1 (ko) * 2021-10-27 2025-04-08 프레스티지바이오로직스 주식회사 인공지능을 이용하여 세포 배양조건을 결정하기 위한 장치 및 장치의 동작 방법
WO2023127451A1 (en) * 2021-12-27 2023-07-06 Terumo Kabushiki Kaisha Simulation apparatus, simulation system, and simulation method
CN114675680B (zh) * 2022-03-01 2023-10-17 成都中医药大学 一种用于模拟胃肠动态参数的控制系统、方法及溶出仪
CN115206459A (zh) * 2022-07-07 2022-10-18 浙江大学杭州国际科创中心 病原真菌的代谢网络构建方法、装置、设备及存储介质
IL319609A (en) * 2022-09-14 2025-05-01 Stamm Vegh Corp Transomic systems and methods for using them
NL2033094B1 (en) * 2022-09-21 2024-03-26 Simabs Nv Method for controlling a perfusion process in a bioreactor
US20250361472A1 (en) * 2022-11-10 2025-11-27 National Resilience, Inc. Systems, Methods, and Compositions for Generation of Therapeutic Cells
JP2024081214A (ja) * 2022-12-06 2024-06-18 花王株式会社 発酵生産プロセス支援方法
KR20250127092A (ko) 2022-12-19 2025-08-26 페터 자처 확장 가능한 물리적 반응기 모델링
JP2025542453A (ja) * 2022-12-30 2025-12-25 コーニング インコーポレイテッド 細胞培養バイオリアクタのためのバイオマスモニタリングのシステムおよび方法
WO2025006837A1 (en) * 2023-06-30 2025-01-02 Corning Incorporated Systems and methods of real time prediction of biomass for cells cultured in fixed bed bioreactors
CN116913391B (zh) * 2023-07-20 2024-07-26 江南大学 一种生物制造过程的代谢通量优化求解方法和系统
US20250222746A1 (en) * 2024-01-04 2025-07-10 Gm Cruise Holdings Llc Adaptive self-heating management of processors in autonomous vehicles
WO2026018205A1 (en) * 2024-07-18 2026-01-22 C/O Algocell Ltd System and methods for generating a hybrid model-based digital simulator (hmbds) that simulates bioprocesses in a real-world cell culture container
CN119418751B (zh) * 2024-09-12 2026-04-14 华东理工大学 一种动态酶约束基因组规模代谢网络模型构建方法
WO2026082935A1 (en) 2024-10-18 2026-04-23 P4B Gmbh Removeable reactor inset
CN121427663A (zh) * 2025-09-11 2026-01-30 新疆希普生物科技股份有限公司 自动调节营养成分的发酵控制系统

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JP4776146B2 (ja) * 2001-01-10 2011-09-21 ザ・ペン・ステート・リサーチ・ファンデーション 細胞代謝をモデル化する方法及びシステム
US20030009099A1 (en) * 2001-07-09 2003-01-09 Lett Gregory Scott System and method for modeling biological systems
US8571690B2 (en) * 2006-10-31 2013-10-29 Rockwell Automation Technologies, Inc. Nonlinear model predictive control of a biofuel fermentation process
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Also Published As

Publication number Publication date
EP4617960A2 (en) 2025-09-17
CN113692535B (zh) 2024-11-08
PL3948276T3 (pl) 2025-12-08
MX2021011623A (es) 2021-10-13
CN113692535A (zh) 2021-11-23
LT3948276T (lt) 2025-11-10
ES3049282T3 (en) 2025-12-16
EP3948276A4 (en) 2022-12-14
AU2020254517A1 (en) 2021-09-30
WO2020205611A1 (en) 2020-10-08
EP3948276B1 (en) 2025-08-13
FI3948276T3 (fi) 2025-10-22
IL286741B1 (en) 2025-01-01
CA3133474A1 (en) 2020-10-08
SG11202110091RA (en) 2021-10-28
KR20210146918A (ko) 2021-12-06
HUE073441T2 (hu) 2026-01-28
SI3948276T1 (sl) 2026-01-30
IL286741A (en) 2021-10-31
EP3948276A1 (en) 2022-02-09
JP2022527282A (ja) 2022-06-01
EP4617960A3 (en) 2025-11-19
IL286741B2 (en) 2025-05-01
US20220208297A1 (en) 2022-06-30
AU2020254517B2 (en) 2025-12-18
PT3948276T (pt) 2025-10-27
JP7524211B2 (ja) 2024-07-29

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