DK3956324T3 - 1,3,4-oxadiazol-derivater som histondeacetylase-inhibitorer - Google Patents
1,3,4-oxadiazol-derivater som histondeacetylase-inhibitorer Download PDFInfo
- Publication number
- DK3956324T3 DK3956324T3 DK20717897.1T DK20717897T DK3956324T3 DK 3956324 T3 DK3956324 T3 DK 3956324T3 DK 20717897 T DK20717897 T DK 20717897T DK 3956324 T3 DK3956324 T3 DK 3956324T3
- Authority
- DK
- Denmark
- Prior art keywords
- histone deacetylase
- oxadiazole derivatives
- deacetylase inhibitors
- inhibitors
- oxadiazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19382306 | 2019-04-17 | ||
| PCT/EP2020/060695 WO2020212479A1 (en) | 2019-04-17 | 2020-04-16 | 1,3,4-oxadiazole derivatives as histone deacetylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3956324T3 true DK3956324T3 (da) | 2024-05-13 |
Family
ID=66240040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK20717897.1T DK3956324T3 (da) | 2019-04-17 | 2020-04-16 | 1,3,4-oxadiazol-derivater som histondeacetylase-inhibitorer |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12202823B2 (da) |
| EP (1) | EP3956324B1 (da) |
| JP (1) | JP7593647B2 (da) |
| KR (1) | KR20220012243A (da) |
| CN (1) | CN114269739B (da) |
| AU (1) | AU2020259100B2 (da) |
| BR (1) | BR112021020682A2 (da) |
| CA (1) | CA3137054A1 (da) |
| DK (1) | DK3956324T3 (da) |
| ES (1) | ES2984772T3 (da) |
| WO (1) | WO2020212479A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| KR102316234B1 (ko) | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| MY207444A (en) * | 2019-05-31 | 2025-02-27 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| FI3976604T3 (fi) * | 2019-05-31 | 2026-04-08 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oksadiatsolijohdannaisyhdisteitä histonideasetylaasi 6:n estäjänä ja niitä käsittävä lääkekoostumus |
| WO2021021979A2 (en) | 2019-07-30 | 2021-02-04 | Eikonizo Therapapeutics, Inc. | Hdac6 inhibitors and uses thereof |
| WO2022013728A1 (en) * | 2020-07-14 | 2022-01-20 | Chong Kun Dang Pharmaceutical Corp. | Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same |
| PE20231744A1 (es) | 2020-08-07 | 2023-10-31 | Italfarmaco Spa | Nuevos inhibidores selectivos de hdac6 basados en oxadiazol |
| KR102685058B1 (ko) | 2020-09-02 | 2024-07-15 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 새로운 구조의 화합물 및 이를 포함하는 약제학적 조성물 |
| JP7823945B2 (ja) * | 2022-03-17 | 2026-03-04 | スンミョン ウィメンズ ユニヴァーシティ インダストリー アカデミック コーポレーション ファウンデーション | 新規なヘテロ環ヒストン脱アセチル化酵素阻害剤及びそれを含む薬学組成物 |
| EP4504190A4 (en) | 2022-04-08 | 2026-03-25 | Eikonizo Therapeutics Inc | OXADIAZOLE HDAC6 INHIBITORS AND THEIR USES |
| CN114634489B (zh) * | 2022-04-19 | 2023-07-04 | 奎马特里克斯有限公司 | 结晶形式 |
| AU2023307594A1 (en) * | 2022-07-15 | 2024-11-28 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole triazole compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same |
| TW202412772A (zh) * | 2022-07-19 | 2024-04-01 | 義大利商義大利藥品股份有限公司 | 作為選擇性組蛋白去乙醯酶６抑制劑之１，３，４－㗁二唑衍生物 |
| WO2024033293A1 (en) | 2022-08-08 | 2024-02-15 | Italfarmaco S.P.A. | Difluoro- and trifluoro-acetyl hydrazides as selective hdac6 inhibitors |
| KR20240035172A (ko) * | 2022-09-08 | 2024-03-15 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이의 용도 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2305643A1 (en) | 2009-10-02 | 2011-04-06 | Ikerchem, S.L. | New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers |
| WO2013066838A1 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| NZ739211A (en) | 2015-07-27 | 2019-05-31 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same |
| PL3328843T3 (pl) | 2015-07-27 | 2023-02-27 | Chong Kun Dang Pharmaceutical Corp. | Związki będące pochodnymi 1,3,4 oksadiazolosulfonamidów jako inhibitor deacetylazy histonowej 6, oraz kompozycja farmaceutyczna je zawierająca |
| RU2695227C9 (ru) * | 2015-07-27 | 2020-03-04 | Чонг Кун Данг Фармасьютикал Корп. | Производные 1,3,4-оксадиазолсульфамида в качестве ингибитора гистондеацетилазы 6 и содержащая их фармацевтическая композиция |
| PT3331864T (pt) | 2015-08-04 | 2022-01-18 | Chong Kun Dang Pharmaceutical Corp | Compostos derivados de 1,3,4-oxadiazol como inibidor de histona desacetilase 6 e a composição farmacêutica compreendendo os mesmos |
| WO2017222951A1 (en) | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| CN107879975B (zh) * | 2016-09-30 | 2022-07-26 | 中国科学院上海药物研究所 | 组蛋白去乙酰化酶抑制剂及其应用 |
| EP3318256A1 (en) | 2016-11-08 | 2018-05-09 | Quimatryx, S.L | Compounds for the treatment of autoimmune diseases |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| EP3661931A1 (en) | 2017-07-31 | 2020-06-10 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
-
2020
- 2020-04-16 ES ES20717897T patent/ES2984772T3/es active Active
- 2020-04-16 AU AU2020259100A patent/AU2020259100B2/en active Active
- 2020-04-16 KR KR1020217037603A patent/KR20220012243A/ko active Pending
- 2020-04-16 BR BR112021020682A patent/BR112021020682A2/pt unknown
- 2020-04-16 WO PCT/EP2020/060695 patent/WO2020212479A1/en not_active Ceased
- 2020-04-16 US US17/604,017 patent/US12202823B2/en active Active
- 2020-04-16 EP EP20717897.1A patent/EP3956324B1/en active Active
- 2020-04-16 CA CA3137054A patent/CA3137054A1/en active Pending
- 2020-04-16 DK DK20717897.1T patent/DK3956324T3/da active
- 2020-04-16 CN CN202080044310.7A patent/CN114269739B/zh active Active
- 2020-04-16 JP JP2021562031A patent/JP7593647B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP7593647B2 (ja) | 2024-12-03 |
| ES2984772T3 (es) | 2024-10-31 |
| KR20220012243A (ko) | 2022-02-03 |
| WO2020212479A1 (en) | 2020-10-22 |
| US20220213084A1 (en) | 2022-07-07 |
| US12202823B2 (en) | 2025-01-21 |
| CN114269739A (zh) | 2022-04-01 |
| EP3956324A1 (en) | 2022-02-23 |
| CN114269739B (zh) | 2025-04-22 |
| AU2020259100A1 (en) | 2021-11-11 |
| EP3956324B1 (en) | 2024-02-21 |
| CA3137054A1 (en) | 2020-10-22 |
| BR112021020682A2 (pt) | 2021-12-07 |
| JP2022529695A (ja) | 2022-06-23 |
| AU2020259100B2 (en) | 2024-12-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL274973A (en) | History of 4,2,1-oxadiazole as histone deacetylase inhibitors | |
| DK3328844T3 (da) | 1,3,4-oxadiazolsulfamidderivater som histondeacetylase-6-inhibitor og farmaceutisk sammensætning omfattende samme | |
| DK3768674T3 (da) | Aminopyrimidinderivater som ctps1-hæmmere | |
| DK3331864T3 (da) | 1,3,4-Oxadiazolderivat-forbindelser som histon-deacetylase-6-hæmmer, og den farmaceutiske sammensætning omfattende disse | |
| FI3328843T3 (fi) | 1,3,4-oksadiatsolisulfonamidijohdannaisyhdisteitä histonideasetylaasi-6:n inhibiittoreina ja samaa käsittävä farmaseuttinen koostumus | |
| DK3976604T3 (da) | 1,3,4-oxadiazol-derivatforbindelser som histondeacetylase 6-hæmmer og den farmaceutiske sammensætning, der omfatter den samme | |
| DK3986890T3 (da) | Benzisoxazol-sulfonamid-derivater | |
| DK3330259T3 (da) | 1,3,4-oxadiazolamidderivativ-forbindelse som histondeacetylase-6-inhibitor og farmaceutisk sammensætning indeholdende denne | |
| DK3362445T3 (da) | Oxadiazolaminderivatforbindelser som histondeacetylase 6-inhibitor, og den farmaceutiske sammensætning dermed | |
| DK3494115T3 (da) | N-(phenylsulfonyl)benzamidderivater som bcl-2-hæmmere | |
| DK3292116T3 (da) | 3-aryl-4-amido-bicykliske [4,5,0]hydroxamsyrer som hdac-inhibitorer | |
| DK3612524T3 (da) | 6-pyrimidin-isoindol-derivat som erk1/2-inhibitor | |
| DK3762368T3 (da) | Aminopyrazindiolforbindelser som pi3k-y-inhibitorer | |
| DK3297992T3 (da) | Heterocykliske alkylderivatforbindelser som selektive histondeacetylase-inhibitorer og farmaceutiske sammensætninger omfattende samme | |
| DK4110781T3 (da) | 1,3,4-oxadiazolderivatforbindelser som histondeacetylase-6-hæmmer og farmaceutisk sammensætning, der omfatter disse | |
| EP3976602A4 (en) | 1,3,4-OXADIAZOLE HOMOPHTHALIMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE-6 INHIBITOR AND PHARMACEUTICAL COMPOSITION THEREOF | |
| DK3890828T3 (da) | Heteroaromatiske forbindelser som vanin-hæmmere | |
| DK3737470T5 (da) | 3-phenyl-4-hexynsyrederivater som gpr40-agonister | |
| DK4110780T3 (da) | 1,3,4-oxadiazolderivatforbindelser som histondeacetylase-6-hæmmer og farmaceutisk sammensætning, der omfatter disse | |
| IL318056A (en) | 1,3,4-Oxadiazole Derivatives as Selective Histone Deacetylase 6 Inhibitors | |
| EP3820859C0 (en) | HISTONE DEACETYLASE INHIBITORS | |
| EP3856174A4 (en) | HDAC1, 2 INHIBITORS | |
| DK3924361T3 (da) | Nye triterpenderivater som hiv-hæmmere | |
| HK40039295A (en) | 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors | |
| DK3632912T3 (da) | Pyridoquinazolin-derivater, der er anvendelige som proteinkinaseinhibitorer |