DK396284A - 17beta-methoxycarbonylderivater af androstan-raekken samt deres fremstilling og anvendelse - Google Patents

17beta-methoxycarbonylderivater af androstan-raekken samt deres fremstilling og anvendelse Download PDF

Info

Publication number: DK396284A
Authority: DK; Denmark
Prior art keywords: 17beta; preparation; methoxycarbonyl; derivatives; series
Prior art date: 1983-08-18

Application number

DK396284A

Other languages

English (en)

Other versions

DK396284D0 (da

DK160993C (da

DK160993B (da

Inventor

Julius Schmidlin

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-08-18

Filing date

1984-08-17

Publication date

1985-02-19

1984-08-17 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1984-08-17 Publication of DK396284D0 publication Critical patent/DK396284D0/da

1985-02-19 Publication of DK396284A publication Critical patent/DK396284A/da

1991-05-13 Publication of DK160993B publication Critical patent/DK160993B/da

1991-11-04 Application granted granted Critical

1991-11-04 Publication of DK160993C publication Critical patent/DK160993C/da

Links

QZLYKIGBANMMBK-UGCZWRCOSA-N 5α-Androstane Chemical class C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 title 1
-1 METHOXYCARBONYL Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001441 androstanes Chemical class 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Heat Sensitive Colour Forming Recording (AREA)
Photoreceptors In Electrophotography (AREA)
Fats And Perfumes (AREA)

DK396284A 1983-08-18 1984-08-17 17beta-methoxycarbonylderivater af androstan-raekken, fremgangsmaade til deres fremstilling, farmaceutisk praeparat indeholdende disse derivater samt anvendelse deraf til fremstilling af et middel til behandling af inflammation eller allergi DK160993C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH451283		1983-08-18
CH451283		1983-08-18

Publications (4)

Publication Number	Publication Date
DK396284D0 DK396284D0 (da)	1984-08-17
DK396284A true DK396284A (da)	1985-02-19
DK160993B DK160993B (da)	1991-05-13
DK160993C DK160993C (da)	1991-11-04

Family

ID=4277476

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK396284A DK160993C (da)	1983-08-18	1984-08-17	17beta-methoxycarbonylderivater af androstan-raekken, fremgangsmaade til deres fremstilling, farmaceutisk praeparat indeholdende disse derivater samt anvendelse deraf til fremstilling af et middel til behandling af inflammation eller allergi

Country Status (21)

Country	Link
US (1)	US4607028A (da)
EP (1)	EP0135476B1 (da)
JP (1)	JPS6058999A (da)
KR (1)	KR850001725A (da)
AT (1)	ATE37186T1 (da)
AU (1)	AU3204484A (da)
CA (1)	CA1234564A (da)
CY (1)	CY1593A (da)
DD (1)	DD227966A5 (da)
DE (1)	DE3474025D1 (da)
DK (1)	DK160993C (da)
ES (1)	ES535242A0 (da)
FI (1)	FI80888C (da)
GR (1)	GR80131B (da)
HK (1)	HK42791A (da)
HU (1)	HUT34991A (da)
IL (1)	IL72702A0 (da)
NO (1)	NO160212C (da)
PT (1)	PT79106B (da)
SG (1)	SG32091G (da)
ZA (1)	ZA846406B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL78144A0 (en) *	1985-04-04	1986-07-31	Draco Ab	Novel androstane-17beta-carboxylic acid esters
WO1990015816A1 (en) *	1989-06-16	1990-12-27	The Upjohn Company	Suramin type compounds and angiostatic steroids to inhibit angiogenesis
FR2701262B1 (fr) *	1993-02-05	1995-03-24	Roussel Uclaf	Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.
JPH07119308A (ja) *	1993-10-27	1995-05-09	Koa:Kk	移動作業床による外壁貼りの吊り支え工法並にその装置
GB9501286D0 (en) *	1995-01-24	1995-03-15	Ciba Geigy Ag	Pharmaceutical compositions and preparations thereof
US5981517A (en) *	1996-05-09	1999-11-09	Soft Drugs, Inc.	Androstene derivatives
AUPP583198A0 (en) *	1998-09-11	1998-10-01	Soltec Research Pty Ltd	Mousse composition
GB0015876D0 (en) *	2000-06-28	2000-08-23	Novartis Ag	Organic compounds
EP2067784A3 (en) *	2000-08-05	2012-08-22	Glaxo Group Limited	17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivatives as anti-inflammatory agents
GB0019172D0 (en) *	2000-08-05	2000-09-27	Glaxo Group Ltd	Novel compounds
US6777399B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6787532B2 (en) *	2000-08-05	2004-09-07	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivatives
US6858596B2 (en) *	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivative
US6858593B2 (en) *	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6777400B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6750210B2 (en) *	2000-08-05	2004-06-15	Smithkline Beecham Corporation	Formulation containing novel anti-inflammatory androstane derivative
US6759398B2 (en)	2000-08-05	2004-07-06	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative
GB0029562D0 (en) *	2000-12-04	2001-01-17	Novartis Ag	Organic compounds
UA77656C2 (en) *	2001-04-07	2007-01-15	Glaxo Group Ltd	S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
WO2002088167A1 (en) *	2001-04-30	2002-11-07	Glaxo Group Limited	Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
JP2003095382A (ja) *	2001-09-25	2003-04-03	Ishikawajima Harima Heavy Ind Co Ltd	タンクのマンホール構造
GB0202216D0 (en) *	2002-01-31	2002-03-20	Glaxo Group Ltd	Novel compounds
US20050175545A1 (en) *	2002-02-04	2005-08-11	Keith Biggadike	Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) *	2002-02-05	2002-03-20	Glaxo Wellcome Mfg Pte Ltd	Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) *	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
GB0507165D0 (en) *	2005-04-08	2005-05-18	Glaxo Group Ltd	Novel crystalline pharmaceutical product
GB0615108D0 (en) *	2006-07-28	2006-09-06	Glaxo Group Ltd	Novel formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1384372A (en) *	1971-01-20	1975-02-19	Glaxo Lab Ltd	Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1514476A (en) *	1974-08-30	1978-06-14	Glaxo Lab Ltd	Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
JPS5297597A (en) *	1976-02-09	1977-08-16	Walt Disney Prod	Guide device of ship
JPS5938239B2 (ja) *	1976-02-12	1984-09-14	グラクソ・ラボラトリ−ス・リミテツド	新規ステロイド化合物
CH628355A5 (de) *	1976-02-24	1982-02-26	Ciba Geigy Ag	Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.
CH634081A5 (en) *	1977-04-13	1983-01-14	Ciba Geigy Ag	Process for the preparation of novel androstadiene-17beta-carboxylic acid esters
ZA814440B (en) *	1980-07-10	1982-10-27	Otsuka Pharma Co Ltd	Soft steroids having anti-inflammatory activity

1984
- 1984-08-09 US US06/639,033 patent/US4607028A/en not_active Expired - Lifetime
- 1984-08-13 EP EP84810397A patent/EP0135476B1/de not_active Expired
- 1984-08-13 DE DE8484810397T patent/DE3474025D1/de not_active Expired
- 1984-08-13 AT AT84810397T patent/ATE37186T1/de active
- 1984-08-15 FI FI843219A patent/FI80888C/fi not_active IP Right Cessation
- 1984-08-16 CA CA000461216A patent/CA1234564A/en not_active Expired
- 1984-08-16 IL IL72702A patent/IL72702A0/xx unknown
- 1984-08-17 DK DK396284A patent/DK160993C/da not_active IP Right Cessation
- 1984-08-17 HU HU843129A patent/HUT34991A/hu unknown
- 1984-08-17 ZA ZA846406A patent/ZA846406B/xx unknown
- 1984-08-17 ES ES535242A patent/ES535242A0/es active Granted
- 1984-08-17 JP JP59170498A patent/JPS6058999A/ja active Granted
- 1984-08-17 AU AU32044/84A patent/AU3204484A/en not_active Abandoned
- 1984-08-17 DD DD84266390A patent/DD227966A5/de unknown
- 1984-08-17 NO NO843298A patent/NO160212C/no unknown
- 1984-08-17 PT PT79106A patent/PT79106B/pt not_active IP Right Cessation
- 1984-08-17 KR KR1019840004956A patent/KR850001725A/ko not_active Withdrawn
- 1984-08-17 GR GR80131A patent/GR80131B/el unknown
1991
- 1991-05-02 SG SG320/91A patent/SG32091G/en unknown
- 1991-05-30 HK HK427/91A patent/HK42791A/xx not_active IP Right Cessation
1992
- 1992-04-03 CY CY1593A patent/CY1593A/xx unknown

Also Published As

Publication number	Publication date
CA1234564A (en)	1988-03-29
FI80888C (fi)	1990-08-10
DK396284D0 (da)	1984-08-17
ES8601234A1 (es)	1985-11-01
NO160212C (no)	1989-03-22
ES535242A0 (es)	1985-11-01
ZA846406B (en)	1985-03-27
FI843219L (fi)	1985-02-19
EP0135476A2 (de)	1985-03-27
NO160212B (no)	1988-12-12
HUT34991A (en)	1985-05-28
JPH0253440B2 (da)	1990-11-16
HK42791A (en)	1991-06-07
ATE37186T1 (de)	1988-09-15
DD227966A5 (de)	1985-10-02
EP0135476B1 (de)	1988-09-14
AU3204484A (en)	1985-02-21
JPS6058999A (ja)	1985-04-05
SG32091G (en)	1991-06-21
KR850001725A (ko)	1985-04-01
FI80888B (fi)	1990-04-30
DK160993C (da)	1991-11-04
PT79106A (en)	1984-09-01
CY1593A (en)	1992-04-03
GR80131B (en)	1984-12-19
PT79106B (en)	1986-11-14
US4607028A (en)	1986-08-19
DE3474025D1 (en)	1988-10-20
IL72702A0 (en)	1984-11-30
FI843219A0 (fi)	1984-08-15
NO843298L (no)	1985-02-19
DK160993B (da)	1991-05-13
EP0135476A3 (en)	1985-12-18

Legal Events

Date	Code	Title	Description
2000-04-10	PBP	Patent lapsed

Publication	Publication Date	Title
DK396284D0 (da)	1984-08-17	17beta-methoxycarbonylderivater af androstan-raekken samt deres fremstiling og anvendelse
ES477695A1 (es)	1979-10-16	Un procedimiento para preparar derivados de deshidrociclici-minoacidos.
DK178379A (da)	1979-11-04	Fremgangsmaade til fremstilling af n-substituerede moranolinderivater eller syreadditionssalte deraf
SE9100342D0 (sv)	1991-02-04	Novel steroid esters
ES8604545A1 (es)	1986-02-01	Procedimiento para preparar nuevos derivados de acidos feni-laceticos
KR840009092A (ko)	1984-12-24	벤조푸란-또는 벤조피란-카르복사미드 유도체의 제조방법
IL49012A0 (en)	1976-04-30	Antilipidemic para-(aryl(alkyl or alkenyl)-amino)benzoic acid derivatives
JPS5331676A (en)	1978-03-25	Uracil derivatives and their preparation
DK226476A (da)	1976-11-25	Fremgangsmade til fremstilling af propargyl-2-phenylamino-imidazoliner-(2) eller syreadditionssalte heraf
ATE117987T1 (de)	1995-02-15	Dialkoxybenzylidenkampfer-derivate.
SE7908168L (sv)	1980-04-12	Cysteinderivat
DK137956B (da)	1978-06-12	Analogifremgangsmaade til fremstilling af andazolyl-(4)-oxy-propanolaminderivater
ES459423A1 (es)	1978-11-01	Procedimiento para la obtencion de derivados de la vincaminay de la apovincamina.
DK49777A (da)	1977-08-07	Fremgangsmade til fremstilling af terapeutiske midler indeholdende cholansyrederivater
ATE28754T1 (de)	1987-08-15	Farbmittelpraeparation.
SE7609229L (sv)	1977-02-22	Medel for selektiv ogresbekempning i betor
DK172479A (da)	1979-10-29	Fremgangsmaade til fremstilling af n-alkenylmoranolinderivater eller syreadditionssalte deraf
DK340478A (da)	1979-02-03	Fremgangsmaade til fremstilling af dibenzo (d,g)-(1,3,6)dioxazocinderivater eller syreadditionssalte deraf
DK1579A (da)	1979-07-04	Fremgangsmaade til fremstilling af 11-alkanoyl-4"-deoxy-4"-isonitrilo-oleandomycenderivater
SE7901100L (sv)	1979-08-09	Anti-inflammatorisk steroid
JPS5210218A (en)	1977-01-26	Preparation of beta-sulfenylacrylamides
DK205878A (da)	1978-11-12	Fremgangsmaade til fremstilling af 4!!-deoxy-4!!-sulfonylamino-oleandomycinderivater eller deres syreadditionssalte
SE8600828D0 (sv)	1986-02-24	Steroidderivat i androstanserien
DK147301C (da)	1985-01-02	Fremgangsmaade til fremstilling af 8beta-hydrazinomethylergolinderivater eller -ergolenderivater eller syreadditionssalte deraf
BE848961A (fr)	1977-06-01	Derives d'acide fusidique