DK3997103T3 - Forbindelser med fibroplast-aktiverende proteinligand og anvendelse deraf - Google Patents
Forbindelser med fibroplast-aktiverende proteinligand og anvendelse deraf Download PDFInfo
- Publication number
- DK3997103T3 DK3997103T3 DK20735646.0T DK20735646T DK3997103T3 DK 3997103 T3 DK3997103 T3 DK 3997103T3 DK 20735646 T DK20735646 T DK 20735646T DK 3997103 T3 DK3997103 T3 DK 3997103T3
- Authority
- DK
- Denmark
- Prior art keywords
- fibroblast
- activating protein
- protein ligand
- ligand compounds
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19000325.1A EP3763726A1 (en) | 2019-07-08 | 2019-07-08 | Compounds comprising a fibroblast activation protein ligand and use thereof |
| EP19198813 | 2019-09-20 | ||
| PCT/EP2020/069298 WO2021005125A1 (en) | 2019-07-08 | 2020-07-08 | Compounds comprising a fibroblast activation protein ligand and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3997103T3 true DK3997103T3 (da) | 2024-12-02 |
Family
ID=71409439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK20735646.0T DK3997103T3 (da) | 2019-07-08 | 2020-07-08 | Forbindelser med fibroplast-aktiverende proteinligand og anvendelse deraf |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US12427210B2 (da) |
| EP (2) | EP4517326A3 (da) |
| JP (3) | JP7608425B2 (da) |
| KR (1) | KR20220032079A (da) |
| CN (3) | CN118388588A (da) |
| AU (1) | AU2020310538B2 (da) |
| BR (1) | BR112022000122A2 (da) |
| CA (1) | CA3145340A1 (da) |
| CL (1) | CL2021003580A1 (da) |
| DK (1) | DK3997103T3 (da) |
| ES (1) | ES3012534T3 (da) |
| FI (1) | FI3997103T3 (da) |
| HU (1) | HUE070009T2 (da) |
| IL (2) | IL320543A (da) |
| LT (1) | LT3997103T (da) |
| MX (1) | MX2022000252A (da) |
| PL (1) | PL3997103T3 (da) |
| RS (1) | RS66480B9 (da) |
| SI (1) | SI3997103T1 (da) |
| WO (1) | WO2021005125A1 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3997104A1 (en) * | 2019-07-08 | 2022-05-18 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| CA3176497A1 (en) | 2020-05-07 | 2021-11-11 | Fatima MECHTA-GRIGORIOU | Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy |
| WO2022115778A1 (en) | 2020-11-30 | 2022-06-02 | Rayzebio, Inc. | Radiopharmaceutical conjugate compositions and uses thereof |
| CN117545481B (zh) * | 2021-02-01 | 2026-04-28 | 五一一制药股份有限公司 | 成纤维细胞活化蛋白-α显像剂的放射性标记配体及其制备方法 |
| HRP20260390T1 (hr) | 2021-02-10 | 2026-04-24 | Yantai Lannacheng Biotechnology Co., Ltd. | Inhibitor proteina aktivacije fibroblasta modificiran skraćenim evans blue, metoda njegove pripreme i njegova primjena |
| CN114369084B (zh) * | 2021-02-10 | 2023-02-03 | 烟台蓝纳成生物技术有限公司 | 一种截短型伊文思蓝修饰的成纤维细胞活化蛋白抑制剂及其制备方法和应用 |
| GB202109922D0 (en) | 2021-07-09 | 2021-08-25 | Blue Earth Diagnostics Ltd | Radiotracers and therapeutics binding to fibroblast activation protein (fap) |
| JP2025506001A (ja) | 2022-02-09 | 2025-03-05 | ノバルティス アーゲー | ２２５－アクチニウム標識錯体及びビスマス封鎖剤を含む医薬組成物 |
| EP4282439A1 (en) | 2022-05-23 | 2023-11-29 | Erasmus University Rotterdam Medical Center | Radioisotope labeled sstr2-agonists with linkers |
| CN115304582B (zh) * | 2022-07-20 | 2023-05-12 | 北京法伯新天医药科技有限公司 | FAP-α特异性肿瘤诊断显像剂 |
| EP4311557A1 (en) * | 2022-07-26 | 2024-01-31 | Oncomatryx Biopharma, S.L. | Fap-targeted antibody-drug conjugates |
| CN119923279A (zh) * | 2022-09-07 | 2025-05-02 | 3B制药有限公司 | 前列腺特异性膜抗原(psma)配体及其用途 |
| EP4342890A1 (en) | 2022-09-21 | 2024-03-27 | Erasmus University Rotterdam Medical Center | Platform and scaffold for fap targeting agents |
| CN118754936A (zh) * | 2023-03-27 | 2024-10-11 | 晶核生物医药科技(南京)有限公司 | 环状多肽类化合物及其应用 |
| AU2024276915A1 (en) | 2023-05-24 | 2026-01-15 | Beijing Changping Laboratory | Novel trifunctional compound and use thereof |
| KR20260040258A (ko) * | 2023-07-11 | 2026-03-24 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 섬유아세포 활성화 단백질 리간드 및 그 용도 |
| CN121752300A (zh) | 2023-08-31 | 2026-03-27 | 荷兰拉德堡德大学学术医学中心 | 子宫内膜异位症示踪剂 |
| WO2025063849A2 (en) | 2023-09-21 | 2025-03-27 | Erasmus University Medical Center Rotterdam | Dimeric fap targeting agents |
| WO2025082283A1 (zh) * | 2023-10-16 | 2025-04-24 | 四川科伦博泰生物医药股份有限公司 | 环肽结构的配体化合物及其核素标记物、药物组合物及应用 |
| WO2025163556A1 (en) | 2024-02-01 | 2025-08-07 | Novartis Ag | Methods for treating cancer |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2304206A1 (en) | 1997-09-29 | 1999-04-08 | Point Therapeutics, Inc. | Stimulation of hematopoietic cells in vitro |
| EP0953639A1 (en) | 1998-04-30 | 1999-11-03 | Boehringer Ingelheim International GmbH | FAPalpha-specific antibody with improved producibility |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| EP1268550A2 (en) | 2000-03-17 | 2003-01-02 | Boehringer Ingelheim Pharma KG | Human fap-alpha-specific antibodies |
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| US7374898B2 (en) | 2004-10-12 | 2008-05-20 | The Research Foundation Of State University Of New York | Peptide inhibitors against seprase |
| EP1943257A2 (en) | 2005-05-19 | 2008-07-16 | Genentech, Inc. | Fibroblast activation protein inhibitor compounds and methods |
| US8933201B2 (en) | 2006-06-07 | 2015-01-13 | The Board Of Regents Of The University Of Oklahoma | Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use |
| WO2008116054A1 (en) | 2007-03-20 | 2008-09-25 | Trustees Of Tufts College | Inhibitors of fibroblast activation protein, and methods of use thereof |
| EP2349995A1 (en) | 2008-09-25 | 2011-08-03 | Molecular Insight Pharmaceuticals, Inc. | Selective seprase inhibitors |
| CA2747721C (en) | 2008-12-19 | 2021-07-20 | Baxter International Inc. | Tfpi inhibitors and methods of use |
| JP2013506664A (ja) | 2009-10-02 | 2013-02-28 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ リミテッド | 抗線維芽細胞活性化タンパク質抗体並びにその方法及び使用 |
| EP2547355B1 (en) | 2010-03-19 | 2017-01-11 | Baxalta GmbH | Tfpi inhibitors and methods of use |
| SG187746A1 (en) | 2010-08-13 | 2013-03-28 | Roche Glycart Ag | Anti-fap antibodies and methods of use |
| EP2804859B1 (en) | 2012-01-17 | 2019-06-12 | Universiteit Antwerpen | Novel fap inhibitors |
| EP2827883B1 (en) | 2012-03-21 | 2019-05-08 | Baxalta GmbH | Tfpi inhibitors and methods of use |
| EP2740726A1 (en) | 2012-12-07 | 2014-06-11 | 3B Pharmaceuticals GmbH | Neurotensin receptor ligands |
| UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
| GB201402006D0 (en) | 2014-02-06 | 2014-03-26 | Oncomatryx Biopharma S L | Antibody-drug conjugates and immunotoxins |
| EP2954933A1 (en) | 2014-06-10 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugate comprising a neurotensin receptor ligand |
| AU2015273934B2 (en) | 2014-06-10 | 2020-08-20 | 3B Pharmaceuticals Gmbh | Conjugate comprising a neurotensin receptor ligand and use thereof |
| WO2016146174A1 (en) * | 2015-03-17 | 2016-09-22 | Biontech Ag | Compositions and methods for diagnosis and treatment of cancer |
| EP3405476B1 (en) | 2016-01-20 | 2022-05-18 | Polypeptide Laboratories Holding (PPL) AB | METHOD FOR PREPARATION OF PEPTIDES WITH psWANG LINKER |
| JP2019517547A (ja) | 2016-06-10 | 2019-06-24 | バイエル・ファルマ・アクティエンゲゼルシャフト | 放射性医薬品錯体 |
| CN106046121B (zh) | 2016-06-20 | 2020-06-16 | 郑州大学 | 一种靶向fap的抗血管生成肽z-gp-v1及其应用 |
| CN105949282B (zh) | 2016-06-20 | 2020-06-16 | 郑州大学 | 一种靶向fap的抗血管生成肽z-gp-v2及其应用 |
| JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ | 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用 |
| US20200237936A1 (en) | 2016-12-14 | 2020-07-30 | Purdue Research Foundation | Fibroblast activation protein (fap)-targeted imaging and therapy |
| AU2018355222B2 (en) * | 2017-10-23 | 2024-10-03 | The Johns Hopkins University | Imaging and radiotherapeutics agents targeting fibroblast-activation protein-α (FAP-α) |
| EP3997104A1 (en) | 2019-07-08 | 2022-05-18 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| EP4050018A1 (en) | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| EP4274835A1 (en) | 2021-01-07 | 2023-11-15 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
-
2020
- 2020-07-08 WO PCT/EP2020/069298 patent/WO2021005125A1/en not_active Ceased
- 2020-07-08 PL PL20735646.0T patent/PL3997103T3/pl unknown
- 2020-07-08 IL IL320543A patent/IL320543A/en unknown
- 2020-07-08 MX MX2022000252A patent/MX2022000252A/es unknown
- 2020-07-08 EP EP24213879.0A patent/EP4517326A3/en active Pending
- 2020-07-08 ES ES20735646T patent/ES3012534T3/es active Active
- 2020-07-08 AU AU2020310538A patent/AU2020310538B2/en active Active
- 2020-07-08 IL IL289675A patent/IL289675B2/en unknown
- 2020-07-08 DK DK20735646.0T patent/DK3997103T3/da active
- 2020-07-08 FI FIEP20735646.0T patent/FI3997103T3/fi active
- 2020-07-08 HU HUE20735646A patent/HUE070009T2/hu unknown
- 2020-07-08 SI SI202030573T patent/SI3997103T1/sl unknown
- 2020-07-08 RS RS20250117A patent/RS66480B9/sr unknown
- 2020-07-08 CN CN202410413789.7A patent/CN118388588A/zh active Pending
- 2020-07-08 EP EP20735646.0A patent/EP3997103B9/en active Active
- 2020-07-08 JP JP2022501192A patent/JP7608425B2/ja active Active
- 2020-07-08 CN CN202080062650.2A patent/CN114341159B/zh active Active
- 2020-07-08 LT LTEPPCT/EP2020/069298T patent/LT3997103T/lt unknown
- 2020-07-08 CN CN202410413792.9A patent/CN118406106A/zh active Pending
- 2020-07-08 CA CA3145340A patent/CA3145340A1/en active Pending
- 2020-07-08 KR KR1020227004043A patent/KR20220032079A/ko active Pending
- 2020-07-08 BR BR112022000122A patent/BR112022000122A2/pt unknown
- 2020-07-08 US US17/625,139 patent/US12427210B2/en active Active
-
2021
- 2021-12-30 CL CL2021003580A patent/CL2021003580A1/es unknown
-
2024
- 2024-12-18 JP JP2024221293A patent/JP7783396B2/ja active Active
-
2025
- 2025-11-18 US US19/392,245 patent/US20260061086A1/en active Pending
- 2025-11-26 JP JP2025203677A patent/JP2026035703A/ja active Pending
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