DK400679A - Fremgangsmaade til fremstilling af n-pyrrolyl-pyridazinaminderivater - Google Patents

Fremgangsmaade til fremstilling af n-pyrrolyl-pyridazinaminderivater

Info

Publication number: DK400679A
Authority: DK; Denmark
Prior art keywords: formula; lower alkyl; hydrogen; pyrrolyl; pyridazine
Prior art date: 1978-10-02

Application number

DK400679A

Other languages

English (en)

Other versions

DK151803B (da

DK151803C (da

Inventor

E Bellasio

N D Mola

A Campi

E Baldoli

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-02

Filing date

1979-09-25

Publication date

1980-04-03

1979-09-25 Application filed by Lepetit Spa filed Critical Lepetit Spa

1980-04-03 Publication of DK400679A publication Critical patent/DK400679A/da

1988-01-04 Publication of DK151803B publication Critical patent/DK151803B/da

1988-06-13 Application granted granted Critical

1988-06-13 Publication of DK151803C publication Critical patent/DK151803C/da

Links

CRPDAASFRKWQBS-UHFFFAOYSA-N 2-(1h-pyrrol-2-yl)-1h-pyridazine Chemical compound N1C=CC=CN1C1=CC=CN1 CRPDAASFRKWQBS-UHFFFAOYSA-N 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 2
125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 1
FNDJBMQTFVHDPR-UHFFFAOYSA-N 1-[4-[(2,5-dimethylpyrrol-1-yl)amino]phthalazin-1-yl]piperidin-4-ol Chemical compound CC1=CC=C(C)N1NC(C1=CC=CC=C11)=NN=C1N1CCC(O)CC1 FNDJBMQTFVHDPR-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000003377 acid catalyst Substances 0.000 abstract 1
229940030600 antihypertensive agent Drugs 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
125000005605 benzo group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 dicarbonyl compound Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
PXYUEEJAXOCGBZ-UHFFFAOYSA-N n-(1h-pyrrol-2-yl)pyridazin-3-amine Chemical class C=1C=CN=NC=1NC1=CC=CN1 PXYUEEJAXOCGBZ-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DK400679A 1978-10-02 1979-09-25 Analogifremgangsmaade til fremstilling af n-pyrrolylpyridazinaminderivater eller farmaceutisk acceptable salte deraf DK151803C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB7838898		1978-10-02
GB7838898		1978-10-02

Publications (3)

Publication Number	Publication Date
DK400679A true DK400679A (da)	1980-04-03
DK151803B DK151803B (da)	1988-01-04
DK151803C DK151803C (da)	1988-06-13

Family

ID=10500040

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK400679A DK151803C (da)	1978-10-02	1979-09-25	Analogifremgangsmaade til fremstilling af n-pyrrolylpyridazinaminderivater eller farmaceutisk acceptable salte deraf

Country Status (15)

Country	Link
EP (1)	EP0009655B1 (da)
JP (1)	JPS5569577A (da)
AT (1)	ATE3294T1 (da)
AU (1)	AU529482B2 (da)
CA (1)	CA1144165A (da)
DE (1)	DE2965377D1 (da)
DK (1)	DK151803C (da)
ES (1)	ES484616A1 (da)
FI (1)	FI65998C (da)
GR (1)	GR69856B (da)
IE (1)	IE49017B1 (da)
IL (1)	IL58256A (da)
NO (1)	NO151620C (da)
YU (1)	YU41886B (da)
ZA (1)	ZA794923B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1150070B (it) *	1980-12-22	1986-12-10	Lepetit Spa	Procedimento per preparare derivati n-pirrolipiridazinamminici
US5254622A (en) *	1988-12-09	1993-10-19	Asahi Kasei Kogyo Kabushiki Kaisha	ABS resin compositions and molded articles thereof having improved coating performances
AU2004261249B2 (en) *	2003-07-30	2008-09-04	Xenon Pharmaceuticals Inc.	Pyridazine derivatives and their use as therapeutic agents
MX2007003327A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
EP2289510A1 (en)	2004-09-20	2011-03-02	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
MX2007003332A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
JP4958786B2 (ja)	2004-09-20	2012-06-20	ゼノン・ファーマシューティカルズ・インコーポレイテッド	複素環誘導体および治療薬としてのそれらの使用
EP2269610A3 (en)	2004-09-20	2011-03-09	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP1799667B1 (en)	2004-09-20	2013-03-20	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as therapeutic agents
MX2007003319A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como agentes terapeuticos.
BRPI0611187A2 (pt)	2005-06-03	2010-08-24	Xenon Pharmaceuticals Inc	derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
USD916552S1 (en) *	2019-07-26	2021-04-20	Spectrum Diversified Designs, Llc	Trivet

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1168334A (en) *	1967-01-25	1969-10-22	Lepetit Spa	New Pharmacologically Active Pyridazines
GB1378102A (en) *	1972-03-14	1974-12-18	Lepetit Spa	Antihypertensive compositions
GB1408362A (en) *	1973-05-25	1975-10-01	Lepetit Spa	2-pyrrol-1-yl amino 4,5-dihydro-1-h-imidazole derivatives
AU477837B2 (en) *	1973-05-30	1974-12-05	I. S. F. Sp. A	New anti-hypertensive compounds having a high therapeutic index and a long-term hypotensive effect
ES431009A1 (es) *	1974-05-09	1976-10-16	Isf Spa	Procedimiento para la preparacion de derivados de 3-benci- lidenhidracino-6-aminopiridacina.

1979
- 1979-09-07 AT AT79103326T patent/ATE3294T1/de active
- 1979-09-07 EP EP79103326A patent/EP0009655B1/en not_active Expired
- 1979-09-07 DE DE7979103326T patent/DE2965377D1/de not_active Expired
- 1979-09-12 FI FI792832A patent/FI65998C/fi not_active IP Right Cessation
- 1979-09-14 AU AU50866/79A patent/AU529482B2/en not_active Ceased
- 1979-09-17 IL IL58256A patent/IL58256A/xx unknown
- 1979-09-17 ZA ZA00794923A patent/ZA794923B/xx unknown
- 1979-09-24 GR GR60097A patent/GR69856B/el unknown
- 1979-09-25 DK DK400679A patent/DK151803C/da not_active IP Right Cessation
- 1979-09-28 YU YU2374/79A patent/YU41886B/xx unknown
- 1979-10-01 NO NO793151A patent/NO151620C/no unknown
- 1979-10-01 IE IE1866/79A patent/IE49017B1/en not_active IP Right Cessation
- 1979-10-01 ES ES484616A patent/ES484616A1/es not_active Expired
- 1979-10-02 CA CA000336843A patent/CA1144165A/en not_active Expired
- 1979-10-02 JP JP12647779A patent/JPS5569577A/ja active Granted

Also Published As

Publication number	Publication date
YU237479A (en)	1983-02-28
NO151620C (no)	1985-05-08
IE49017B1 (en)	1985-07-10
AU529482B2 (en)	1983-06-09
YU41886B (en)	1988-02-29
DK151803B (da)	1988-01-04
NO151620B (no)	1985-01-28
EP0009655B1 (en)	1983-05-11
FI792832A7 (fi)	1980-04-03
EP0009655A1 (en)	1980-04-16
DK151803C (da)	1988-06-13
IL58256A0 (en)	1979-12-30
IE791866L (en)	1980-04-02
CA1144165A (en)	1983-04-05
AU5086679A (en)	1980-04-17
ATE3294T1 (de)	1983-05-15
IL58256A (en)	1984-02-29
JPH0321553B2 (da)	1991-03-22
DE2965377D1 (en)	1983-06-16
GR69856B (da)	1982-07-19
FI65998B (fi)	1984-04-30
JPS5569577A (en)	1980-05-26
FI65998C (fi)	1984-08-10
ES484616A1 (es)	1980-05-16
ZA794923B (en)	1980-09-24
NO793151L (no)	1980-04-08

Legal Events

Date	Code	Title	Description
1995-05-22	PBP	Patent lapsed

Publication	Publication Date	Title
GB1148908A (en)	1969-04-16	Indole derivatives and processes for making them
AU529482B2 (en)	1983-06-09	N-pyrrolyl-pyridazineamines
DK599385D0 (da)	1985-12-20	Fremgangsmaade til fremstilling af amidderivater
ES466366A1 (es)	1978-10-01	Un procedimiento para preparar derivados de metasulfonamido-benzamida.
DE3776044D1 (de)	1992-02-27	Pyridazinon-derivate.
DK160500C (da)	1991-08-26	Analogifremgangsmaade til fremstilling af 3-thiomethylpyridinderivater
DK412581A (da)	1982-03-18	Ethenylimidazolderivater og fremgangsmaade til fremstilling heraf
IT1244870B (it)	1994-09-12	Composti ammelinici
JPS5626873A (en)	1981-03-16	Novel nnaminoalkylindole derivative* its manufacture and gastroointestinal tract movement trouble treating drug containing it
ES520269A0 (es)	1984-10-01	Un procedimiento para la preparacion de una nueva piridazina sustituida.
ES451293A1 (es)	1977-10-01	Un procedimiento para la preparacion de derivados de tieno- tiacina.
ES445339A1 (es)	1977-06-01	Un procedimiento para la preparacion de derivados pirrolidi-nicos.
DK553482A (da)	1983-06-15	Fremgangsmaade til fremstilling af n,n-disubstituerede alkenamider og phenylalkenamider
ES418051A1 (es)	1976-05-01	Procedimiento para preparar derivados de ftalimida.
DK601883A (da)	1984-06-29	Phenyl-propanolderivater
ATE19629T1 (de)	1986-05-15	N-substituierte derivate des tetrahydroisophthalimids.
ES429926A1 (es)	1977-01-01	Procedimiento para preparar derivados de inodol.
GB951653A (en)	1964-03-11	Improvements in or relating to 6-pteridinehydrazide and amidrazone derivatives