DK400684A - Adjuvanser - Google Patents
Adjuvanser Download PDFInfo
- Publication number
- DK400684A DK400684A DK400684A DK400684A DK400684A DK 400684 A DK400684 A DK 400684A DK 400684 A DK400684 A DK 400684A DK 400684 A DK400684 A DK 400684A DK 400684 A DK400684 A DK 400684A
- Authority
- DK
- Denmark
- Prior art keywords
- amount
- volume
- phase
- toxic
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/01—Wetting, emulsifying, dispersing, or stabilizing agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/01—Wetting, emulsifying, dispersing, or stabilizing agents
- Y10S516/02—Organic and inorganic agents containing, except water
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Microbiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polyethers (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/525,190 US4606918A (en) | 1983-08-22 | 1983-08-22 | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
| US52519083 | 1983-08-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK400684D0 DK400684D0 (da) | 1984-08-21 |
| DK400684A true DK400684A (da) | 1985-02-23 |
| DK167173B1 DK167173B1 (da) | 1993-09-13 |
Family
ID=24092296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK400684A DK167173B1 (da) | 1983-08-22 | 1984-08-21 | Adjuvanspraeparat samt vaccine indeholdende dette |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4606918A (da) |
| EP (1) | EP0135376B1 (da) |
| JP (2) | JPH0617314B2 (da) |
| AT (1) | ATE58062T1 (da) |
| AU (1) | AU578907B2 (da) |
| CA (1) | CA1236017A (da) |
| DE (1) | DE3483553D1 (da) |
| DK (1) | DK167173B1 (da) |
| HK (1) | HK82392A (da) |
| IE (1) | IE58035B1 (da) |
| IL (1) | IL72740A (da) |
| NZ (1) | NZ209293A (da) |
| PH (1) | PH21112A (da) |
| ZA (1) | ZA846504B (da) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
| US4933179A (en) * | 1983-08-22 | 1990-06-12 | Syntex (U.S.A.) Inc. | Feline leukemia virus antigen vaccines |
| US4857318A (en) * | 1983-11-07 | 1989-08-15 | Syntex (U.S.A.) Inc. | Bordetella bronchiseptica pilus subunit protein vaccine effective against bordetella pertussis |
| US5171568A (en) * | 1984-04-06 | 1992-12-15 | Chiron Corporation | Recombinant herpes simplex gb-gd vaccine |
| US5244792A (en) * | 1984-04-06 | 1993-09-14 | Chiron Corporation | Expression of recombinant glyoprotein B from herpes simplex virus |
| US4713240A (en) * | 1985-04-04 | 1987-12-15 | Research Corporation | Vaccines based on insoluble supports |
| JPS6270319A (ja) * | 1985-07-30 | 1987-03-31 | インタ−ナシヨナル・ミネラルズ・アンド・ケミカル・コ−ポレイシヨン | 成長促進ホルモンの安定化 |
| US4806352A (en) * | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
| US4803070A (en) * | 1986-04-15 | 1989-02-07 | Ribi Immunochem Research Inc. | Immunological emulsion adjuvants for polysaccharide vaccines |
| US4877611A (en) * | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US5648071A (en) * | 1986-05-15 | 1997-07-15 | Emory University | Method of treating tumors |
| US5554372A (en) * | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
| US5674911A (en) * | 1987-02-20 | 1997-10-07 | Cytrx Corporation | Antiinfective polyoxypropylene/polyoxyethylene copolymers and methods of use |
| US5811088A (en) * | 1987-02-20 | 1998-09-22 | Emory University | Antiinfective compounds and methods of use |
| US5565209A (en) * | 1987-03-17 | 1996-10-15 | Akzo Nobel N.V. | Adjuvant mixture |
| EP0283085B1 (en) * | 1987-03-17 | 1992-11-11 | Akzo N.V. | Adjuvant mixture |
| DE3855807T2 (de) * | 1987-11-03 | 1997-06-12 | Syntex (U.S.A.) Inc., Palo Alto, Calif. | Einen Tetra-Polyol enthaltendes Impfstoff-Adjuvans |
| US5376369A (en) * | 1987-11-03 | 1994-12-27 | Syntex (U.S.A.) Inc. | Vaccine adjuvant |
| ZA888577B (en) * | 1987-11-27 | 1989-08-30 | Akzo Nv | Stabilization of antibodies |
| US5149529A (en) * | 1988-04-08 | 1992-09-22 | Board Of Trustees Of Leland Chiron Corporation | Compositions and treatment for herpes simplex |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| NZ238731A (en) * | 1990-06-27 | 1996-02-27 | Univ Emory | Vaccine adjuvant compositions comprising ethyleneoxy-propyleneoxy-ethyleneoxy block copolymer or a non-toxic lipopolysaccharide |
| FI925835A0 (fi) * | 1990-06-29 | 1992-12-22 | Chiron Corp | Vacciner innehaollande liposomer |
| FR2672496B3 (fr) * | 1990-07-18 | 1993-05-28 | Vacsyn France Sa | Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique. |
| FR2664813B1 (fr) * | 1990-07-18 | 1995-01-13 | Vacsyn France Sa | Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique. |
| ATE187154T1 (de) * | 1991-03-19 | 1999-12-15 | Cytrx Corp | Polyoxypropylen/polyoxyethylen copolymere mit verbesserter biologischer aktivität |
| US20020123476A1 (en) * | 1991-03-19 | 2002-09-05 | Emanuele R. Martin | Therapeutic delivery compositions and methods of use thereof |
| US5696298A (en) * | 1991-03-19 | 1997-12-09 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US7202225B1 (en) | 1993-10-15 | 2007-04-10 | Emanuele R Martin | Therapeutic delivery compositions and methods of use thereof |
| USRE38558E1 (en) | 1991-03-19 | 2004-07-20 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US6933286B2 (en) | 1991-03-19 | 2005-08-23 | R. Martin Emanuele | Therapeutic delivery compositions and methods of use thereof |
| AU2316892A (en) * | 1991-06-27 | 1993-01-25 | Emory University | Multiple emulsions and methods of preparation |
| US5622649A (en) * | 1991-06-27 | 1997-04-22 | Emory University | Multiple emulsions and methods of preparation |
| US6197311B1 (en) | 1991-07-25 | 2001-03-06 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| US5342612A (en) * | 1991-12-20 | 1994-08-30 | American Cyanamid Company | Compositions for the treatment of mammalian diseases |
| JP3723231B2 (ja) * | 1991-12-23 | 2005-12-07 | ディミナコ アクチェンゲゼルシャフト | アジュバント |
| AU3361093A (en) * | 1992-01-20 | 1993-08-03 | Peptech (Uk) Limited | Use of muramyl peptides for enhancing animal production |
| FR2702373B1 (fr) * | 1993-03-08 | 1996-06-07 | Rhone Merieux | Emulsions vaccinales fluides eau-dans-l'huile contenant une huile métabolisable. |
| US5961970A (en) * | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| GB9326253D0 (en) * | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| PT968722E (pt) * | 1994-05-10 | 2007-09-06 | Wyeth Corp | Vacina viva melhorada contra brsv. |
| US6156319A (en) * | 1994-07-25 | 2000-12-05 | The Trustees Of The University Of Pennsylvania | Soluble herpesvirus glycoprotein complex vaccine |
| EP1181937A3 (en) * | 1994-08-09 | 2004-02-04 | Cytrx Corporation | Novel vaccine adjuvant and vaccine |
| ATE214603T1 (de) * | 1995-06-30 | 2002-04-15 | American Cyanamid Co | Stabile makrolide und makrolide imptstoff- zusammensetzungen |
| EP0781559B1 (en) * | 1995-11-30 | 2007-02-07 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Oil adjuvant vaccine and method for preparing same |
| WO1997046204A2 (en) | 1996-06-05 | 1997-12-11 | Ashmont Holdings Limited | Injectable compositions |
| JP4598201B2 (ja) * | 1997-04-08 | 2010-12-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 安定化ヒトパピローマウイルス製剤 |
| AU769539B2 (en) | 1999-01-29 | 2004-01-29 | Zoetis Services Llc | Adjuvants for use in vaccines |
| NZ514323A (en) * | 1999-03-24 | 2003-03-28 | Secr Defence | A immunostimulant containing an acitive agent and an adjuvant which increases the effect of the active agent |
| SE9902364D0 (sv) * | 1999-06-21 | 1999-06-21 | Astra Ab | New process |
| US7018638B2 (en) * | 2000-12-19 | 2006-03-28 | Wyeth | Mycoplasma hyopneumoniae bacterin vaccine |
| MY129765A (en) | 2000-12-19 | 2007-04-30 | Wyeth Corp | Improved mycoplasma hyopneumoniae bacterin vaccine |
| WO2005013918A2 (en) | 2003-02-28 | 2005-02-17 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits relating to poxvirus subunit vaccines |
| KR100720213B1 (ko) * | 2003-04-04 | 2007-05-21 | 화이자 프로덕츠 인코포레이티드 | 미세 유동화된 수중 유적형 유화액 및 백신 조성물 |
| CA2571035A1 (en) * | 2004-06-25 | 2006-01-12 | Id Biomedical Corporation Of Quebec | Compositions and methods for treating neurological disorders |
| JP2008522951A (ja) * | 2004-07-19 | 2008-07-03 | ベイラー・カレツジ・オブ・メデイシン | サイトカインシグナル伝達調節物質の調節および免疫療法のための応用 |
| US7868159B2 (en) * | 2005-06-23 | 2011-01-11 | Baylor College Of Medicine | Modulation of negative immune regulators and applications for immunotherapy |
| BRPI0708842A2 (pt) * | 2006-03-28 | 2011-06-14 | Gelesis Inc | uso de materiais polimÉricos com outras substÂncias para aumento do desempenho |
| CN101678082B (zh) | 2007-03-26 | 2013-06-19 | 再生医药有限公司 | 使用cxcl9和抗cxcl9抗体促进骨髓保护和再生的方法 |
| JP5334462B2 (ja) | 2007-06-11 | 2013-11-06 | 花王株式会社 | 脂肪酸エステルの製造法 |
| US8324369B2 (en) * | 2007-11-30 | 2012-12-04 | Baylor College Of Medicine | Dendritic cell vaccine compositions and uses of same |
| WO2009073179A2 (en) | 2007-12-03 | 2009-06-11 | President And Fellows Of Harvard College | Chlamydia antigens |
| WO2011038002A1 (en) | 2009-09-22 | 2011-03-31 | Yale University | Immunogenic epitopes as targets for universal cancer vaccines |
| CA2797052A1 (en) | 2010-04-23 | 2011-10-27 | Ancora Pharmaceuticals Inc. | Synthetic oligosaccharides for staphyloccocus vaccine |
| US8716469B2 (en) | 2010-04-27 | 2014-05-06 | Ancora Pharmaceuticals, Inc. | Synthetic oligosaccharides for Moraxella vaccine |
| WO2011149778A1 (en) | 2010-05-26 | 2011-12-01 | Ancora Pharmaceuticals Inc. | Synthetic oligosaccharides for neisseria meningitis vaccine |
| ES2657705T3 (es) | 2010-06-23 | 2018-03-06 | Deutsches Krebsforschungszentrum | Secuencias de virus TT específicas y moléculas de ADN quiméricas de células hospedadoras de virus TT para uso en el diagnóstico, prevención y tratamiento del cáncer y la autoinmunidad |
| US9550811B2 (en) | 2010-12-02 | 2017-01-24 | Bionor Immuno As | Peptide scaffold design |
| US9493514B2 (en) | 2011-01-06 | 2016-11-15 | Bionor Immuno As | Dimeric scaffold proteins comprising HIV-1 GP120 and GP41 epitopes |
| US9446112B2 (en) | 2011-07-12 | 2016-09-20 | Philadelphia Health & Education Corporation | Clostridium difficile DNA vaccine |
| UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
| UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
| US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
| JP6310909B2 (ja) | 2012-06-06 | 2018-04-11 | ビオノール イミュノ エーエスBionor Immuno As | 免疫原及び投薬反応物として使用するためのウイルスタンパク質に由来するペプチド |
| JP5971652B2 (ja) | 2012-10-09 | 2016-08-17 | 三菱重工業株式会社 | 石炭不活性化処理装置 |
| EP2951199A4 (en) | 2013-01-31 | 2016-07-20 | Univ Jefferson | Fusion proteins for the modulation of regulatory and effector T cells |
| WO2015116178A1 (en) | 2014-01-31 | 2015-08-06 | Thomas Jefferson University | Fusion proteins for modulating regulatory and effector t cells |
| EP2868751A1 (en) | 2013-10-30 | 2015-05-06 | Deutsches Krebsforschungszentrum | HCBI sequences as an early marker for the future development of cancer and diseases of the CNS and as a target for cancer treatment and prevention |
| EP2966176A1 (en) | 2014-07-10 | 2016-01-13 | Deutsches Krebsforschungszentrum | HCBI, MSBI, MSSI and CMI sequences as an early marker for the future development of cancer and diseases of the CNS and as a target for the treatment and prevention of these diseases |
| US20220089670A1 (en) | 2018-12-28 | 2022-03-24 | University Of Rochester | Gene Therapy for BEST1 Dominant Mutations |
| EP3686289A1 (en) | 2019-01-24 | 2020-07-29 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Cmi sequences as an early marker for the future development of cancer, atherosclerosis, diabetes and diseases of the cns and as a target for the treatment and prevention of these diseases |
| US20230109142A1 (en) | 2020-02-14 | 2023-04-06 | Immunor As | Corona virus vaccine |
| WO2025096754A1 (en) | 2023-10-31 | 2025-05-08 | Musc Foundation For Research Development | The use of enolase inhibitor pomhex for treatment of fibrosis |
| WO2026015821A1 (en) | 2024-07-12 | 2026-01-15 | University Of Rochester | Antibiotic alkaloid and methods of generating and use thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2674619A (en) * | 1953-10-19 | 1954-04-06 | Wyandotte Chemicals Corp | Polyoxyalkylene compounds |
| US3867521A (en) * | 1970-08-26 | 1975-02-18 | Scherer Corp R P | Method for absorption of drugs |
| BE795516A (fr) * | 1972-02-17 | 1973-08-16 | Ciba Geigy | Preparations de peptides huileuses et injectables et procede pour leur preparation |
| US3869546A (en) * | 1972-12-22 | 1975-03-04 | Cutter Lab | Adjuvant compositions and medicinal mixtures comprising them |
| US4186194A (en) * | 1973-10-23 | 1980-01-29 | Agence Nationale De Valorisation De La Recherche (Anvar) | Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents |
| IL48325A (en) * | 1974-10-22 | 1979-05-31 | Anvar | Immunological-free adjuvant compositions containing n-acetyl muramyl-alanyl-d-isoglutamine or n-acetyl-muramyl-l-alanyl-d-glutamicn acid |
| US4370265A (en) * | 1974-10-22 | 1983-01-25 | Agence Nationale De Valorisation | Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents |
| US4148869A (en) * | 1975-03-06 | 1979-04-10 | Baxter Travenol Laboratories, Inc. | Immunological reagent and method of using same |
| FR2313078A1 (fr) * | 1975-02-07 | 1976-12-31 | Anvar | Composition a base d'huile vegetale metabolisable et d'eau, utilisable notamment pour la constitution de preparations adjuvantes, ces preparations adjuvantes et leur procede d'obtention |
| US4082736A (en) * | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
| US4082735A (en) * | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
| GB1563561A (en) * | 1976-06-23 | 1980-03-26 | Daiichi Seiyaku Co | Muramyldipeptide derivatives and process for the preparation thereof |
| FR2358159A1 (fr) * | 1976-07-16 | 1978-02-10 | Anvar | Le diamide de l'acide 2-(2-acetamido-2-deoxy-3 - o-d-glucopyranosyl) - d-propionyl-l-alanyl-d-glutamique et medicaments le contenant |
| FR2368282A1 (fr) * | 1976-10-22 | 1978-05-19 | Anvar | Adjuvant immunologique constitue par le p-amino-phenyl de n-acetyl-muramyl-l-alanyl-d-isoglutamine |
| FR2428050A1 (fr) * | 1978-06-05 | 1980-01-04 | Anvar | Oligomeres de composes du type muramyl-peptide et medicaments les contenant |
| JPS5543030A (en) * | 1978-09-21 | 1980-03-26 | Dai Ichi Seiyaku Co Ltd | Prophylactic and remedy for microbial infection disease |
| FR2449697A1 (fr) * | 1979-02-20 | 1980-09-19 | Anvar | Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant |
| JPS55111499A (en) * | 1979-02-21 | 1980-08-28 | Takeda Chem Ind Ltd | Glucosamine derivative and its preparation |
| CA1185237A (en) * | 1979-02-28 | 1985-04-09 | Yuichi Yamamura | 6-deoxyglucosamine-peptide derivatives, their production and use |
| US4384974A (en) * | 1979-07-27 | 1983-05-24 | Revlon, Inc. | Stable water-in-oil emulsions |
| FI803077A7 (fi) * | 1979-10-12 | 1981-04-13 | Ciba Geigy Ag | Foerfarande foer framstaellning av myramylpeptider |
| US4409209A (en) * | 1979-10-12 | 1983-10-11 | Ciba-Geigy Corporation | Novel phosphorylmuramyl peptides and processes for the manufacture thereof |
| US4406889A (en) * | 1980-02-15 | 1983-09-27 | Ciba-Geigy Corporation | Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use |
| GR78246B (da) * | 1981-01-23 | 1984-09-26 | Ciba Geigy Ag | |
| US4397870A (en) * | 1982-07-27 | 1983-08-09 | The University Of Pennsylvania | Process for prolonging retention of emulsion particles in the bloodstream |
| US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
-
1983
- 1983-08-22 US US06/525,190 patent/US4606918A/en not_active Expired - Lifetime
-
1984
- 1984-08-20 PH PH31121A patent/PH21112A/en unknown
- 1984-08-21 CA CA000461465A patent/CA1236017A/en not_active Expired
- 1984-08-21 ZA ZA846504A patent/ZA846504B/xx unknown
- 1984-08-21 EP EP84305687A patent/EP0135376B1/en not_active Expired - Lifetime
- 1984-08-21 AT AT84305687T patent/ATE58062T1/de not_active IP Right Cessation
- 1984-08-21 IL IL72740A patent/IL72740A/xx not_active IP Right Cessation
- 1984-08-21 NZ NZ209293A patent/NZ209293A/xx unknown
- 1984-08-21 DK DK400684A patent/DK167173B1/da not_active IP Right Cessation
- 1984-08-21 IE IE214884A patent/IE58035B1/en not_active IP Right Cessation
- 1984-08-21 AU AU32251/84A patent/AU578907B2/en not_active Expired
- 1984-08-21 DE DE8484305687T patent/DE3483553D1/de not_active Expired - Lifetime
- 1984-08-21 JP JP59174861A patent/JPH0617314B2/ja not_active Expired - Lifetime
-
1992
- 1992-10-22 HK HK823/92A patent/HK82392A/en not_active IP Right Cessation
-
1993
- 1993-08-17 JP JP5203231A patent/JP2557603B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK400684D0 (da) | 1984-08-21 |
| IE58035B1 (en) | 1993-06-16 |
| IL72740A (en) | 1988-02-29 |
| IL72740A0 (en) | 1984-11-30 |
| EP0135376A3 (en) | 1986-12-30 |
| US4606918A (en) | 1986-08-19 |
| JPH0617314B2 (ja) | 1994-03-09 |
| DE3483553D1 (de) | 1990-12-13 |
| DK167173B1 (da) | 1993-09-13 |
| JPH0665097A (ja) | 1994-03-08 |
| HK82392A (en) | 1992-10-30 |
| AU578907B2 (en) | 1988-11-10 |
| JP2557603B2 (ja) | 1996-11-27 |
| PH21112A (en) | 1987-07-16 |
| CA1236017A (en) | 1988-05-03 |
| AU3225184A (en) | 1985-02-28 |
| JPS60105630A (ja) | 1985-06-11 |
| IE842148L (en) | 1985-02-22 |
| ATE58062T1 (de) | 1990-11-15 |
| ZA846504B (en) | 1986-03-26 |
| NZ209293A (en) | 1988-10-28 |
| EP0135376A2 (en) | 1985-03-27 |
| EP0135376B1 (en) | 1990-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |