DK4039800T5 - Konstrueret flerkomponentsystem til identifikation og karakterisering af t-cellreceptorer og t-cellantigener - Google Patents

Konstrueret flerkomponentsystem til identifikation og karakterisering af t-cellreceptorer og t-cellantigener Download PDF

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DK4039800T5
DK4039800T5 DK22150892.2T DK22150892T DK4039800T5 DK 4039800 T5 DK4039800 T5 DK 4039800T5 DK 22150892 T DK22150892 T DK 22150892T DK 4039800 T5 DK4039800 T5 DK 4039800T5
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cell
characterization
identification
component system
designed multi
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DK22150892.2T
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DK4039800T3 (da
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Reagan Micheal Jarvis
Ryan Edward Hill
Luke Benjamin Pase
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Genovie Ab
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    • CCHEMISTRY; METALLURGY
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • C12N15/902Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5154Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K2039/5156Animal cells expressing foreign proteins
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/15Nucleic acids forming more than 2 strands, e.g. TFOs
    • C12N2310/153Nucleic acids forming more than 2 strands, e.g. TFOs with the aid of a protein, e.g. recombinase
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/18Type of nucleic acid acting by a non-sequence specific mechanism
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    • C12N2810/00Vectors comprising a targeting moiety
    • C12N2810/10Vectors comprising a non-peptidic targeting moiety

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  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
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  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Cell Biology (AREA)
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  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
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  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
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DK22150892.2T 2016-11-07 2017-11-07 Konstrueret flerkomponentsystem til identifikation og karakterisering af t-cellreceptorer og t-cellantigener DK4039800T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201670872 2016-11-07
EP17800759.7A EP3535387B1 (en) 2016-11-07 2017-11-07 An engineered multi-component system for identification and characterisation of t-cell receptors and t-cell antigens

Publications (2)

Publication Number Publication Date
DK4039800T3 DK4039800T3 (da) 2024-01-02
DK4039800T5 true DK4039800T5 (da) 2024-07-29

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Application Number Title Priority Date Filing Date
DK22150892.2T DK4039800T5 (da) 2016-11-07 2017-11-07 Konstrueret flerkomponentsystem til identifikation og karakterisering af t-cellreceptorer og t-cellantigener
DK17800759.7T DK3535387T3 (da) 2016-11-07 2017-11-07 Konstrueret flerkomponentsystem til identifikation og karakterisering af t-cellereceptorer og t-celleantigener

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DK17800759.7T DK3535387T3 (da) 2016-11-07 2017-11-07 Konstrueret flerkomponentsystem til identifikation og karakterisering af t-cellereceptorer og t-celleantigener

Country Status (12)

Country Link
US (3) US12012610B2 (da)
EP (4) EP4039800B1 (da)
JP (3) JP7645606B2 (da)
KR (2) KR102833088B1 (da)
CN (3) CN118909953A (da)
AU (2) AU2017352589B2 (da)
CA (1) CA3038917A1 (da)
DK (2) DK4039800T5 (da)
ES (3) ES2968633T3 (da)
FI (1) FI4039800T3 (da)
NZ (2) NZ794207A (da)
WO (1) WO2018083316A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6803480B2 (ja) 2016-11-07 2020-12-23 ジェノヴィー エービーGenovie Ab T細胞受容体の合成及びtcr提示細胞への安定なゲノム組込みのための二部分装置
DK4039800T5 (da) 2016-11-07 2024-07-29 Genovie Ab Konstrueret flerkomponentsystem til identifikation og karakterisering af t-cellreceptorer og t-cellantigener
KR20210030414A (ko) * 2018-07-09 2021-03-17 제노비에 에이비 조작된 수용체 세포로의 핵산 서열의 재조합효소 매개 카세트 교환 통합 동안 세포의 추적 및 조작을 위한 세포 표면 태그 교환(cste) 시스템
KR20230003122A (ko) 2020-04-27 2023-01-05 제노비에 에이비 바이러스 비-비리온-통합 유래 에피토프에 대한 인간 백혈구 항원 클래스 i 제한 cd8 t-세포 반응을 프라이밍하기 위한 백신 조성물의 생성 방법
WO2025125590A2 (en) 2023-12-15 2025-06-19 Genovie Ab Tcr recognizing g12v mutated ras and uses thereof
EP4570263A1 (en) 2023-12-15 2025-06-18 Genovie AB Tcrs recognizing g12v mutated ras and uses thereof

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EP1458241A4 (en) 2001-11-20 2005-11-09 Dana Farber Cancer Inst Inc MODIFIED ANTIGEN-PRESENTING CELLS
AU2008212907A1 (en) 2007-02-05 2008-08-14 Philipps-Universitat Marburg Method of cloning at least one nucleic acid molecule of interest using type IIS restriction endonucleases, and corresponding cloning vectors, kits and system using type IIS restriction endonucleases
EP2395087A1 (en) 2010-06-11 2011-12-14 Icon Genetics GmbH System and method of modular cloning
EP2601521B1 (en) 2010-08-06 2018-05-02 Ludwig-Maximilians-Universität München Identification of t cell target antigens
EP2831238B1 (en) 2012-03-27 2018-01-03 DSM IP Assets B.V. Cloning method
JP6126804B2 (ja) 2012-07-25 2017-05-10 国立大学法人富山大学 T細胞受容体のクローニング方法
US9937207B2 (en) 2013-03-21 2018-04-10 Sangamo Therapeutics, Inc. Targeted disruption of T cell receptor genes using talens
NZ724320A (en) 2014-03-14 2022-05-27 Adaptimmune Ltd Tcr libraries
KR20200138445A (ko) 2014-04-24 2020-12-09 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용
GB201407852D0 (en) * 2014-05-02 2014-06-18 Iontas Ltd Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
US20170335331A1 (en) 2014-10-31 2017-11-23 The Trustees Of The University Of Pennsylvania Altering Gene Expression in CART Cells and Uses Thereof
US20170333480A1 (en) * 2014-11-05 2017-11-23 Board Of Regents, The University Of Texas System Gene modified immune effector cells and engineered cells for expansion of immune effector cells
DK3271382T3 (da) * 2015-03-16 2020-05-04 Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft Fremgangsmåde til detektion af nye immunogene T-celleepitoper og isolering af nye antigenspecifikke T-cellereceptorer ved hjælp af et MHC-cellebibliotek
EA201792660A1 (ru) 2015-06-01 2018-05-31 Медиджин Иммьюнотерапиз Гмбх Библиотека т-клеточных рецепторов
CN105316362B (zh) * 2015-08-19 2020-03-17 暨南大学 一种Dual-RMCE介导的TCR基因置换系统及其方法
EP3535290B1 (en) 2016-11-07 2024-01-10 Genovie AB An engineered two-part cellular device for discovery and characterisation of t-cell receptor interaction with cognate antigen
NZ753794A (en) 2016-11-07 2023-05-26 Genovie Ab An engineered multi-component system for identification and characterisation of t-cell receptors, t-cell antigens and their functional interaction
JP6803480B2 (ja) 2016-11-07 2020-12-23 ジェノヴィー エービーGenovie Ab T細胞受容体の合成及びtcr提示細胞への安定なゲノム組込みのための二部分装置
DK4039800T5 (da) 2016-11-07 2024-07-29 Genovie Ab Konstrueret flerkomponentsystem til identifikation og karakterisering af t-cellreceptorer og t-cellantigener
US20200231974A1 (en) 2017-07-18 2020-07-23 Genovie Ab A two-component vector library system for rapid assembly and diversification of full-length t-cell receptor open reading frames

Also Published As

Publication number Publication date
US20190359934A1 (en) 2019-11-28
KR102625785B1 (ko) 2024-01-16
JP2025122051A (ja) 2025-08-20
DK4039800T3 (da) 2024-01-02
KR20190076991A (ko) 2019-07-02
ES2968633T3 (es) 2024-05-13
JP7645606B2 (ja) 2025-03-14
US12270047B2 (en) 2025-04-08
AU2017352589B2 (en) 2024-08-08
NZ794207A (en) 2026-03-27
EP4332232A2 (en) 2024-03-06
JP2023025182A (ja) 2023-02-21
AU2024205017A1 (en) 2024-08-15
CN109923207B (zh) 2024-08-16
DK3535387T3 (da) 2022-02-14
EP3535387A1 (en) 2019-09-11
WO2018083316A1 (en) 2018-05-11
AU2017352589A1 (en) 2019-05-16
CN109923207A (zh) 2019-06-21
EP4019625C0 (en) 2025-04-02
KR20240010545A (ko) 2024-01-23
NZ752629A (en) 2023-04-28
KR20240010103A (ko) 2024-01-23
EP4019625B1 (en) 2025-04-02
EP4332232A3 (en) 2024-05-08
JP2019534047A (ja) 2019-11-28
ES3034256T3 (en) 2025-08-14
CN118909953A (zh) 2024-11-08
JP7684271B2 (ja) 2025-05-27
US20250297211A1 (en) 2025-09-25
EP3535387B1 (en) 2022-01-12
EP4019625A1 (en) 2022-06-29
EP4039800A1 (en) 2022-08-10
KR102833088B1 (ko) 2025-07-10
US12012610B2 (en) 2024-06-18
US20200339946A1 (en) 2020-10-29
ES2906827T3 (es) 2022-04-20
EP4039800B1 (en) 2023-10-25
CA3038917A1 (en) 2018-05-11
FI4039800T3 (fi) 2023-12-15
CN118931845A (zh) 2024-11-12

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