DK4110957T3 - Fremgangsmåder til analyse af cellefrie nukleinsyrer og anvendelser heraf - Google Patents
Fremgangsmåder til analyse af cellefrie nukleinsyrer og anvendelser herafInfo
- Publication number
- DK4110957T3 DK4110957T3 DK21759938.0T DK21759938T DK4110957T3 DK 4110957 T3 DK4110957 T3 DK 4110957T3 DK 21759938 T DK21759938 T DK 21759938T DK 4110957 T3 DK4110957 T3 DK 4110957T3
- Authority
- DK
- Denmark
- Prior art keywords
- analysis
- applications
- cell
- methods
- nucleic acids
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Data Mining & Analysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Databases & Information Systems (AREA)
- Evolutionary Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Software Systems (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Evolutionary Computation (AREA)
- Bioethics (AREA)
- Artificial Intelligence (AREA)
- Primary Health Care (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062980972P | 2020-02-24 | 2020-02-24 | |
| PCT/US2021/019478 WO2021173722A2 (en) | 2020-02-24 | 2021-02-24 | Methods of analyzing cell free nucleic acids and applications thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK4110957T3 true DK4110957T3 (da) | 2025-10-27 |
Family
ID=77490525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21759938.0T DK4110957T3 (da) | 2020-02-24 | 2021-02-24 | Fremgangsmåder til analyse af cellefrie nukleinsyrer og anvendelser heraf |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20230242980A1 (da) |
| EP (3) | EP4660324A3 (da) |
| KR (2) | KR20220157976A (da) |
| CN (2) | CN116113436A (da) |
| AU (2) | AU2021227229A1 (da) |
| CA (2) | CA3172670A1 (da) |
| DK (1) | DK4110957T3 (da) |
| ES (1) | ES3040741T3 (da) |
| WO (2) | WO2021173724A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11728007B2 (en) * | 2017-11-30 | 2023-08-15 | Grail, Llc | Methods and systems for analyzing nucleic acid sequences using mappability analysis and de novo sequence assembly |
| GB2623904B (en) | 2019-11-06 | 2024-07-24 | Univ Leland Stanford Junior | Methods and systems for analyzing nucleic acid molecules |
| US11783912B2 (en) | 2021-05-05 | 2023-10-10 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and systems for analyzing nucleic acid molecules |
| MX2024003132A (es) * | 2021-09-13 | 2024-04-10 | Regeneron Pharma | Metodos para tratar la hematopoyesis clonal de potencial indeterminado (chip) con inhibidores del antigeno linfocitario 75 (ly75), grupo de diferenciacion 164 (cd164) o poli (adp-ribosa) polimerasa 1 (parp1). |
| EP4433611A4 (en) * | 2021-11-17 | 2025-10-08 | Univ Leland Stanford Junior | SYSTEMS AND METHODS FOR GENE EXPRESSION AND TISSUE OF ORIGIN INFERENCE FROM CIRCULATING FREE DNA |
| JP2025536559A (ja) * | 2022-11-01 | 2025-11-07 | ゾエティス・サービシーズ・エルエルシー | 非がん性体細胞変異の検出 |
| WO2025096466A2 (en) * | 2023-10-30 | 2025-05-08 | Myriad Women's Health, Inc. | Methods for improving minimal residual disease assays |
| WO2025212823A1 (en) * | 2024-04-03 | 2025-10-09 | Memorial Sloan-Kettering Cancer Center | Methods for predicting risk of recurrence and metastases in lung cancer patients using circulating tumor dna and spatial biomarkers |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA186569A (en) | 1918-04-02 | 1918-09-17 | Henry Arthur Dygert | Surgical appliance |
| CA188298A (en) | 1918-04-08 | 1919-01-14 | William H. Bot | Grain separator |
| US6171856B1 (en) * | 1997-07-30 | 2001-01-09 | Board Of Regents, The University Of Texas System | Methods and compositions relating to no-mediated cytotoxicity |
| KR20030007463A (ko) * | 2000-03-16 | 2003-01-23 | 이콜로지컬 테크놀로지 리서치, 엘티디. | Dna 손상 지표를 이용한 천연 및 인공 화학물질의 간이생물학적 평가법, 및 그 장치 |
| AU2001255518A1 (en) * | 2000-06-07 | 2001-12-17 | Baylor College Of Medicine | Compositions and methods for array-based nucleic acid hybridization |
| DE10032165A1 (de) * | 2000-07-01 | 2002-01-10 | Beiersdorf Ag | Verwendung von physiologisch verträglichen Sulfinsäuren als Antioxidans oder Radikalfänger in kosmetischen oder dermatologischen Zubereitungen |
| EP3290530B1 (en) * | 2009-02-18 | 2020-09-02 | Streck Inc. | Preservation of cell-free nucleic acids |
| ES2925014T3 (es) * | 2014-09-12 | 2022-10-13 | Univ Leland Stanford Junior | Identificación y uso de ácidos nucleicos circulantes |
| WO2018081161A1 (en) * | 2016-10-24 | 2018-05-03 | Biomatrica, Inc. | Stabilization of nucleic acids on paper |
| US11479807B2 (en) * | 2017-03-23 | 2022-10-25 | University Of Washington | Methods for targeted nucleic acid sequence enrichment with applications to error corrected nucleic acid sequencing |
| US11584958B2 (en) * | 2017-03-31 | 2023-02-21 | Grail, Llc | Library preparation and use thereof for sequencing based error correction and/or variant identification |
| US11542540B2 (en) * | 2017-06-16 | 2023-01-03 | Life Technologies Corporation | Control nucleic acids, and compositions, kits, and uses thereof |
| US11447818B2 (en) | 2017-09-15 | 2022-09-20 | Illumina, Inc. | Universal short adapters with variable length non-random unique molecular identifiers |
-
2021
- 2021-02-24 AU AU2021227229A patent/AU2021227229A1/en active Pending
- 2021-02-24 EP EP25197637.9A patent/EP4660324A3/en active Pending
- 2021-02-24 AU AU2021225854A patent/AU2021225854A1/en active Pending
- 2021-02-24 WO PCT/US2021/019481 patent/WO2021173724A1/en not_active Ceased
- 2021-02-24 CA CA3172670A patent/CA3172670A1/en active Pending
- 2021-02-24 EP EP21759938.0A patent/EP4110957B1/en active Active
- 2021-02-24 ES ES21759938T patent/ES3040741T3/es active Active
- 2021-02-24 CA CA3172675A patent/CA3172675A1/en active Pending
- 2021-02-24 EP EP21761302.5A patent/EP4110397A4/en active Pending
- 2021-02-24 WO PCT/US2021/019478 patent/WO2021173722A2/en not_active Ceased
- 2021-02-24 KR KR1020227033217A patent/KR20220157976A/ko active Pending
- 2021-02-24 DK DK21759938.0T patent/DK4110957T3/da active
- 2021-02-24 CN CN202180030202.9A patent/CN116113436A/zh active Pending
- 2021-02-24 CN CN202180030144.XA patent/CN115443341A/zh active Pending
- 2021-02-24 KR KR1020227033309A patent/KR20220145891A/ko active Pending
-
2022
- 2022-08-24 US US17/822,028 patent/US20230242980A1/en active Pending
- 2022-08-24 US US17/822,016 patent/US20250263789A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN115443341A (zh) | 2022-12-06 |
| AU2021227229A1 (en) | 2022-10-13 |
| CA3172670A1 (en) | 2021-09-02 |
| EP4110957B1 (en) | 2025-08-27 |
| US20250263789A1 (en) | 2025-08-21 |
| WO2021173722A2 (en) | 2021-09-02 |
| US20230242980A1 (en) | 2023-08-03 |
| ES3040741T3 (en) | 2025-11-04 |
| WO2021173724A1 (en) | 2021-09-02 |
| EP4660324A2 (en) | 2025-12-10 |
| EP4110957A4 (en) | 2024-03-06 |
| AU2021225854A1 (en) | 2022-10-13 |
| EP4110397A1 (en) | 2023-01-04 |
| EP4660324A3 (en) | 2026-02-18 |
| EP4110957A2 (en) | 2023-01-04 |
| EP4110397A4 (en) | 2024-05-01 |
| CA3172675A1 (en) | 2021-09-02 |
| KR20220157976A (ko) | 2022-11-29 |
| KR20220145891A (ko) | 2022-10-31 |
| CN116113436A (zh) | 2023-05-12 |
| WO2021173722A3 (en) | 2021-10-07 |
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