DK4132909T3 - Organiske syreadditionssalte af S-pindolol - Google Patents

Organiske syreadditionssalte af S-pindolol Download PDF

Info

Publication number: DK4132909T3
Authority: DK; Denmark
Prior art keywords: pindolol; organic acid; acid addition; addition salts; salts
Prior art date: 2020-04-07

Application number

DK21717172.7T

Other languages

English (en)

Inventor

Robin Chandra Bhattacherjee

Andrew Justin Stewart Coats

Elaine Morten

Ronnie Maxwell Lawrence

Jaclyn Raeburn

Kiara Marissa Lobato

Jonathan James Loughrey

Original Assignee

Actimed Therapeutics Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2020-04-07

Filing date

2021-03-31

Publication date

2024-05-13

2021-03-31 Application filed by Actimed Therapeutics Ltd filed Critical Actimed Therapeutics Ltd

2024-05-13 Application granted granted Critical

2024-05-13 Publication of DK4132909T3 publication Critical patent/DK4132909T3/da

Links

150000007524 organic acids Chemical class 0.000 title 1
229960002508 pindolol Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/43—Indoles; Hydrogenated indoles with an —OCH2CH(OH)CH2NH2 radical, which may be further substituted, attached in positions 4, 5, 6 or 7
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/08—Acetic acid
- C07C53/10—Salts thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/122—Propionic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/08—Malonic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/10—Succinic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/12—Glutaric acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/14—Adipic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/32—Phenylacetic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/04—Monocyclic monocarboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/04—Monocyclic monocarboxylic acids
- C07C63/06—Benzoic acid
- C07C63/08—Salts thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/33—Polycyclic acids
- C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
- C07C63/34—Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings
- C07C63/36—Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings containing one carboxyl group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

DK21717172.7T 2020-04-07 2021-03-31 Organiske syreadditionssalte af S-pindolol DK4132909T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB2005112.4A GB2593902B (en)	2020-04-07	2020-04-07	Salt of a pharmaceutical compound
PCT/GB2021/050799 WO2021205144A1 (en)	2020-04-07	2021-03-31	Organic acid addition salts of s-pindolol

Publications (1)

Publication Number	Publication Date
DK4132909T3 true DK4132909T3 (da)	2024-05-13

Family

ID=70768820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK21717172.7T DK4132909T3 (da)	2020-04-07	2021-03-31	Organiske syreadditionssalte af S-pindolol

Country Status (24)

Country	Link
US (3)	US12109192B2 (da)
EP (2)	EP4385566A3 (da)
JP (2)	JP7668288B2 (da)
KR (1)	KR20220164521A (da)
CN (3)	CN121293146A (da)
AU (1)	AU2021253747A1 (da)
BR (1)	BR112022020198A2 (da)
CA (1)	CA3173878A1 (da)
DK (1)	DK4132909T3 (da)
ES (1)	ES2982095T3 (da)
FI (1)	FI4132909T3 (da)
GB (1)	GB2593902B (da)
HR (1)	HRP20240922T1 (da)
HU (1)	HUE067298T2 (da)
IL (1)	IL297045A (da)
LT (1)	LT4132909T (da)
MX (2)	MX2022012492A (da)
PH (1)	PH12022552671A1 (da)
PL (1)	PL4132909T3 (da)
PT (1)	PT4132909T (da)
RS (1)	RS65710B1 (da)
SI (1)	SI4132909T1 (da)
SM (1)	SMT202400188T1 (da)
WO (1)	WO2021205144A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB202114564D0 (en) *	2021-10-12	2021-11-24	Actimed Therapeutics Ltd	Oral formulation
WO2025222169A1 (en)	2024-04-19	2025-10-23	Faraday Pharmaceuticals, Inc.	S-oxprenolol for preserving muscle mass, bone density, and cardiac function in weight loss treatments

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL98245C (da) *	1956-04-09	1900-01-01
US2866788A (en) *	1956-10-18	1958-12-30	Smith Kline French Lab	Preparation of indolo [2, 3-c] quinazo [3, 2-a] pyridine derivatives
US3260729A (en) *	1957-09-30	1966-07-12	Roussel Uclaf	Benzoate of 1-(6'-methoxy-3'-indolyl)-2-propylamine
US3471515A (en) *	1965-02-01	1969-10-07	Sandoz Ag	(2-hydroxy-3-substituted aminopropoxy)indoles
AT336176B (de) *	1971-12-10	1977-04-25	Sandoz Ag	Verfahren zur herstellung eines pharmazeutischen praparates
DE3544172A1 (de)	1985-12-13	1987-06-19	Lentia Gmbh	Neue kristalline salze von aryloxy-propanolaminen, verfahren zu ihrer herstellung und ihre verwendung
US4849224A (en)	1987-11-12	1989-07-18	Theratech Inc.	Device for administering an active agent to the skin or mucosa
JPH01287064A (ja)	1988-05-13	1989-11-17	Lion Corp	光学活性アミノプロパノール誘導体の製造方法
HU209251B (en)	1992-03-13	1994-04-28	Synepos Ag	Process for producing stable, peroral solution drug forms with controlled release of active ingredient and comprising beta-blocking pharmacons
US5985317A (en)	1996-09-06	1999-11-16	Theratech, Inc.	Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
EP1117389A1 (en)	1998-09-08	2001-07-25	TheraTech, Inc.	Method of making pressure sensitive adhesive matrix patches containing hydrophilic salts of drugs
US7417038B1 (en)	1998-10-15	2008-08-26	Imperial Innovations Limited	Methods of treating cachexia
GB0624282D0 (en)	2006-12-05	2007-01-10	Cavalla David	Treatment of cachexia
GB0907350D0 (en)	2009-04-29	2009-06-10	Myotec Therapeutics Ltd	Methods
EP2877247A1 (en) *	2012-07-25	2015-06-03	Psioxus Therapeutics Limited	Use of s-pindolol for treating cachexia and sarcopenia
CN105358140A (zh)	2013-03-14	2016-02-24	安德鲁·J·S·科茨	一种用于治疗肌萎缩性侧索硬化症的β受体阻滞剂的S-对映体富集组合物
ES2698363T3 (es)	2013-03-14	2019-02-04	Actimed Therapeutics Ltd	Composiciones de oxprenolol para tratar el cáncer
EP3419610A4 (en)	2016-02-26	2019-10-16	Actimed Therapeutics Ltd	S-ENANTIOMER ENHANCED COMPOSITIONS OF BETA LOAD FOR THE TREATMENT OF MUSCLE WEAKNESSES

2020
- 2020-04-07 GB GB2005112.4A patent/GB2593902B/en active Active
2021
- 2021-03-31 RS RS20240763A patent/RS65710B1/sr unknown
- 2021-03-31 PH PH1/2022/552671A patent/PH12022552671A1/en unknown
- 2021-03-31 PL PL21717172.7T patent/PL4132909T3/pl unknown
- 2021-03-31 HR HRP20240922TT patent/HRP20240922T1/hr unknown
- 2021-03-31 BR BR112022020198A patent/BR112022020198A2/pt unknown
- 2021-03-31 CN CN202511453279.3A patent/CN121293146A/zh active Pending
- 2021-03-31 JP JP2022561648A patent/JP7668288B2/ja active Active
- 2021-03-31 IL IL297045A patent/IL297045A/en unknown
- 2021-03-31 US US17/995,621 patent/US12109192B2/en active Active
- 2021-03-31 CN CN202180040441.2A patent/CN115916751B/zh active Active
- 2021-03-31 LT LTEPPCT/GB2021/050799T patent/LT4132909T/lt unknown
- 2021-03-31 FI FIEP21717172.7T patent/FI4132909T3/fi active
- 2021-03-31 SM SM20240188T patent/SMT202400188T1/it unknown
- 2021-03-31 HU HUE21717172A patent/HUE067298T2/hu unknown
- 2021-03-31 KR KR1020227037233A patent/KR20220164521A/ko active Pending
- 2021-03-31 ES ES21717172T patent/ES2982095T3/es active Active
- 2021-03-31 PT PT217171727T patent/PT4132909T/pt unknown
- 2021-03-31 CA CA3173878A patent/CA3173878A1/en active Pending
- 2021-03-31 DK DK21717172.7T patent/DK4132909T3/da active
- 2021-03-31 CN CN202511453282.5A patent/CN121293147A/zh active Pending
- 2021-03-31 SI SI202130139T patent/SI4132909T1/sl unknown
- 2021-03-31 MX MX2022012492A patent/MX2022012492A/es unknown
- 2021-03-31 EP EP24160044.4A patent/EP4385566A3/en active Pending
- 2021-03-31 EP EP21717172.7A patent/EP4132909B1/en active Active
- 2021-03-31 WO PCT/GB2021/050799 patent/WO2021205144A1/en not_active Ceased
- 2021-03-31 AU AU2021253747A patent/AU2021253747A1/en active Pending
2022
- 2022-10-05 MX MX2025008913A patent/MX2025008913A/es unknown
2024
- 2024-08-29 US US18/819,177 patent/US20240423955A1/en active Pending
2025
- 2025-04-14 JP JP2025066189A patent/JP2025106529A/ja active Pending
- 2025-06-12 US US19/235,792 patent/US20250302806A1/en active Pending

Also Published As

Publication number	Publication date
LT4132909T (lt)	2024-05-27
US20230190706A1 (en)	2023-06-22
CN121293147A (zh)	2026-01-09
RS65710B1 (sr)	2024-08-30
US20240423955A1 (en)	2024-12-26
US20250302806A1 (en)	2025-10-02
WO2021205144A1 (en)	2021-10-14
GB202005112D0 (en)	2020-05-20
EP4385566A2 (en)	2024-06-19
JP2023521985A (ja)	2023-05-26
EP4132909B1 (en)	2024-04-10
KR20220164521A (ko)	2022-12-13
GB2593902A (en)	2021-10-13
HRP20240922T1 (hr)	2024-10-11
JP2025106529A (ja)	2025-07-15
HUE067298T2 (hu)	2024-10-28
EP4385566A3 (en)	2024-09-18
SI4132909T1 (sl)	2024-06-28
CN121293146A (zh)	2026-01-09
CA3173878A1 (en)	2021-10-14
IL297045A (en)	2022-12-01
ES2982095T3 (es)	2024-10-14
EP4132909A1 (en)	2023-02-15
MX2025008913A (es)	2025-09-02
SMT202400188T1 (it)	2024-07-09
US12109192B2 (en)	2024-10-08
CN115916751A (zh)	2023-04-04
PH12022552671A1 (en)	2023-06-26
BR112022020198A2 (pt)	2022-11-22
MX2022012492A (es)	2023-01-11
GB2593902B (en)	2022-04-13
JP7668288B2 (ja)	2025-04-24
FI4132909T3 (fi)	2024-05-23
PL4132909T3 (pl)	2024-08-05
AU2021253747A1 (en)	2022-11-10
PT4132909T (pt)	2024-05-02
CN115916751B (zh)	2025-11-04

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