DK417377A - SUBSTITUTED 6-PHENYL-1,2,4-TRIAZOLO (4,3-B) -PYRIDAZINES AND THEIR PREPARATION AND USE - Google Patents

SUBSTITUTED 6-PHENYL-1,2,4-TRIAZOLO (4,3-B) -PYRIDAZINES AND THEIR PREPARATION AND USE

Info

Publication number
DK417377A
DK417377A DK417377A DK417377A DK417377A DK 417377 A DK417377 A DK 417377A DK 417377 A DK417377 A DK 417377A DK 417377 A DK417377 A DK 417377A DK 417377 A DK417377 A DK 417377A
Authority
DK
Denmark
Prior art keywords
pyridazines
triazolo
phenyl
substituted
preparation
Prior art date
Application number
DK417377A
Other languages
Danish (da)
Inventor
G R Allen
J W Hanifin
D B Moran
D Albright
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/725,597 external-priority patent/US4230705A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DK417377A publication Critical patent/DK417377A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/12—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK417377A 1976-09-22 1977-09-21 SUBSTITUTED 6-PHENYL-1,2,4-TRIAZOLO (4,3-B) -PYRIDAZINES AND THEIR PREPARATION AND USE DK417377A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/725,597 US4230705A (en) 1976-09-22 1976-09-22 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
US73039576A 1976-10-07 1976-10-07
US73547576A 1976-10-26 1976-10-26

Publications (1)

Publication Number Publication Date
DK417377A true DK417377A (en) 1978-03-23

Family

ID=27419081

Family Applications (1)

Application Number Title Priority Date Filing Date
DK417377A DK417377A (en) 1976-09-22 1977-09-21 SUBSTITUTED 6-PHENYL-1,2,4-TRIAZOLO (4,3-B) -PYRIDAZINES AND THEIR PREPARATION AND USE

Country Status (19)

Country Link
JP (1) JPS5340798A (en)
AR (2) AR218036A1 (en)
AT (1) AT360034B (en)
AU (1) AU513760B2 (en)
BG (1) BG29287A3 (en)
CA (1) CA1080712A (en)
DD (1) DD132586A5 (en)
DE (1) DE2741763A1 (en)
DK (1) DK417377A (en)
ES (3) ES462543A1 (en)
FI (1) FI772802A7 (en)
FR (1) FR2442848A1 (en)
GB (1) GB1589237A (en)
GR (1) GR71699B (en)
LU (1) LU78150A1 (en)
NL (1) NL7710389A (en)
NO (1) NO773245L (en)
PT (1) PT67067B (en)
RO (1) RO72226A (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR70309B (en) * 1979-10-29 1982-09-08 Dow Chemical Co
FR2473522A1 (en) * 1980-01-16 1981-07-17 Synthelabo NOVEL DIHYDRO-2,3 IMIDAZO (1,2-B) PYRIDAZINE SUBSTITUTED DERIVATIVES AND MEDICAMENTS, PARTICULARLY USEFUL AS ANTIDEPRESSANTS, CONTAINING THEM
DE3173083D1 (en) * 1980-03-22 1986-01-16 Fbc Ltd Pesticidal heterocyclic compounds, processes for preparing them, compositions containing them, and their use
DE3217325A1 (en) * 1982-05-08 1983-11-10 Hoechst Ag, 6230 Frankfurt 3-AMINO-6-ARYL-1,2,4-TRIAZOLO (4,3-B) -PYRIDAZINE, THEIR PRODUCTION AND USE
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines
FR2562071B1 (en) * 1984-03-30 1986-12-19 Sanofi Sa TRIAZOLO (4,3-B) PYRIDAZINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US4654343A (en) * 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
US4767765A (en) * 1985-10-31 1988-08-30 American Cyanamid Company N-substituted-N-[3-(1,2,4-triazolo-[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
ATE236904T1 (en) 1996-07-25 2003-04-15 Merck Sharp & Dohme SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS OF GABA RECEPTORS
EP1047697A1 (en) * 1998-01-14 2000-11-02 MERCK SHARP & DOHME LTD. Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801208D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801234D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
US6579875B1 (en) * 1998-01-21 2003-06-17 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801210D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801202D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801397D0 (en) * 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
CA2556404A1 (en) * 2004-02-18 2005-08-25 Banyu Pharmaceutical Co., Ltd. Nitrogenous fused heteroaromatic ring derivative
BR112019010880A2 (en) * 2016-11-28 2019-10-01 Praxis Precision Medicines, Inc. compounds and their methods of use
CN117756800A (en) 2018-05-30 2024-03-26 普拉克西斯精密药物股份有限公司 Ion channel modulator
EA202092908A1 (en) 2018-09-28 2021-05-14 Праксис Пресижн Медсинз, Инк. ION CHANNEL MODULATORS
US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11505554B2 (en) 2019-05-31 2022-11-22 Praxis Precision Medicines, Inc. Substituted pyridines as ion channel modulators
AU2020392128A1 (en) 2019-11-27 2022-06-09 Praxis Precision Medicines, Inc. Formulations of ion channel modulators and methods of preparation and use of ion channel modulators
WO2021126779A1 (en) * 2019-12-18 2021-06-24 The Regents Of The University Of California Inhibitors of lin28 and methods of use thereof

Also Published As

Publication number Publication date
LU78150A1 (en) 1978-01-23
GR71699B (en) 1983-06-21
DD132586A5 (en) 1978-10-11
AT360034B (en) 1980-12-10
BG29287A3 (en) 1980-10-15
AR217886A1 (en) 1980-04-30
ES462543A1 (en) 1979-06-16
AU2899577A (en) 1979-03-29
PT67067A (en) 1977-10-01
CA1080712A (en) 1980-07-01
RO72226A (en) 1982-09-09
ES477799A1 (en) 1980-04-01
FR2442848A1 (en) 1980-06-27
DE2741763A1 (en) 1978-03-23
NO773245L (en) 1978-03-28
GB1589237A (en) 1981-05-07
AU513760B2 (en) 1980-12-18
PT67067B (en) 1979-02-19
ATA677577A (en) 1980-05-15
FI772802A7 (en) 1978-03-23
ES477800A1 (en) 1979-10-16
NL7710389A (en) 1978-03-28
JPS5340798A (en) 1978-04-13
AR218036A1 (en) 1980-05-15

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