DK41791D0 - Antibiotikum cc 1065-analoge - Google Patents

Antibiotikum cc 1065-analoge

Info

Publication number: DK41791D0
Authority: DK; Denmark
Prior art keywords: pct; formula; date mar; compounds; sec
Prior art date: 1988-09-12

Application number

DK91417A

Other languages

English (en)

Other versions

DK41791A (da

DK175458B1 (da

Inventor

Paul A Aristoff

Robert C Kelly

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-12

Filing date

1991-03-08

Publication date

1991-03-08

1991-03-08 Application filed by Upjohn Co filed Critical Upjohn Co

1991-03-08 Publication of DK41791A publication Critical patent/DK41791A/da

1991-03-08 Publication of DK41791D0 publication Critical patent/DK41791D0/da

2004-11-01 Application granted granted Critical

2004-11-01 Publication of DK175458B1 publication Critical patent/DK175458B1/da

Links

UOWVMDUEMSNCAV-UHFFFAOYSA-N antibiotic cc 1065 Chemical class N1C=2C(OC)=C(O)C=3N(C(N)=O)CCC=3C=2C=C1C(=O)N1CCC(C=2C=3)=C1C(O)=C(OC)C=2NC=3C(=O)N1CC2CC22C1=CC(=O)C1=C2C(C)=CN1 UOWVMDUEMSNCAV-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
241001465754 Metazoa Species 0.000 abstract 1
239000006096 absorbing agent Substances 0.000 abstract 1
238000010171 animal model Methods 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Error Detection And Correction (AREA)
Artificial Filaments (AREA)
Amplifiers (AREA)
Semiconductor Integrated Circuits (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Solid State Image Pick-Up Elements (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Peptides Or Proteins (AREA)
Television Systems (AREA)
Television Receiver Circuits (AREA)
Stereophonic System (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK41791A 1988-09-12 1991-03-08 Antibiotikum CC 1065-analoge DK175458B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US24335088A	1988-09-12	1988-09-12
US24335088		1988-09-12
PCT/US1989/003329 WO1990002746A1 (en)	1988-09-12	1989-08-07	Novel cc-1065 analogs having two cpi subunits
US8903329		1989-08-07

Publications (3)

Publication Number	Publication Date
DK41791A DK41791A (da)	1991-03-08
DK41791D0 true DK41791D0 (da)	1991-03-08
DK175458B1 DK175458B1 (da)	2004-11-01

Family

ID=22918400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK41791A DK175458B1 (da)	1988-09-12	1991-03-08	Antibiotikum CC 1065-analoge

Country Status (14)

Country	Link
US (1)	US5541339A (da)
JP (1)	JP3380237B2 (da)
KR (1)	KR0137959B1 (da)
AT (1)	ATE198335T1 (da)
AU (1)	AU632288B2 (da)
CA (1)	CA1340215C (da)
DE (1)	DE68929275T2 (da)
DK (1)	DK175458B1 (da)
FI (1)	FI103668B1 (da)
GR (1)	GR3035589T3 (da)
LV (1)	LV12806B (da)
NO (1)	NO303498B1 (da)
TW (1)	TW217383B (da)
WO (1)	WO1990002746A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2149768T3 (es) *	1992-03-25	2000-11-16	Immunogen Inc	Conjugados de agentes enlazantes de celulas derivados de cc-1065.
US5502068A (en) *	1995-01-31	1996-03-26	Synphar Laboratories, Inc.	Cyclopropylpyrroloindole-oligopeptide anticancer agents
US20100056762A1 (en)	2001-05-11	2010-03-04	Old Lloyd J	Specific binding proteins and uses thereof
EP1392359B2 (en)	2001-05-11	2013-03-13	Ludwig Institute for Cancer Research Ltd.	Specific binding proteins and uses thereof
CA2464419A1 (en)	2001-11-09	2003-05-22	Boehringer Ingelheim Pharmaceuticals, Inc.	Benzimidazoles useful as protein kinase inhibitors
JP2005536533A (ja) *	2002-08-08	2005-12-02	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	置換ベンゾイミダゾール化合物
EP1554271A1 (en) *	2002-10-15	2005-07-20	Rigel Pharmaceuticals, Inc.	Substituted indoles and their use as hcv inhibitors
WO2005005389A2 (en) *	2003-07-07	2005-01-20	Merck Patent Gmbh	Malonamide derivatives
WO2005079791A1 (en) *	2004-02-12	2005-09-01	Boehringer Ingelheim Pharmaceuticals, Inc.	Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
CA2619790A1 (en) *	2005-08-17	2007-02-22	Schering Corporation	Novel high affinity thiophene-based and furan-based kinase ligands
US9090693B2 (en)	2007-01-25	2015-07-28	Dana-Farber Cancer Institute	Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
CN101688229B (zh)	2007-03-15	2013-06-12	路德维格癌症研究所	包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途
US9901567B2 (en)	2007-08-01	2018-02-27	Syntarga B.V.	Substituted CC-1065 analogs and their conjugates
ES2609915T3 (es)	2007-08-14	2017-04-25	Ludwig Institute For Cancer Research Ltd.	Anticuerpo monoclonal 175 direccionado al receptor de EGF y derivados y usos del mismo
EP2344478B1 (en)	2008-11-03	2017-09-27	Syntarga B.V.	Cc-1065 analogs and their conjugates
EP2560645B1 (en)	2010-04-21	2016-07-13	Syntarga B.V.	Conjugates of cc-1065 analogs and bifunctional linkers
US20150265641A1 (en)	2012-10-22	2015-09-24	Arnold Glazier	Methods for the Effective Treatment of Metastatic Cancer
DE102013012622A1 (de) *	2013-07-30	2015-02-05	Clariant lnternational Ltd	Neue sterisch gehinderte cyclische Amine
PL3092010T3 (pl)	2014-01-10	2019-01-31	Synthon Biopharmaceuticals B.V.	Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek
SG11201605437YA (en) *	2014-01-27	2016-08-30	Pfizer	Bifunctional cytotoxic agents
DK3160513T3 (da)	2014-06-30	2020-04-06	Glykos Finland Oy	Saccharidderivat af en toksisk payload og antistofkonjugater deraf
DE102015000124A1 (de) *	2015-01-07	2016-07-07	Clariant International Ltd.	Verfahren zur Stabilisierung von Polyamiden
KR102046862B1 (ko) *	2015-03-20	2019-11-20	화이자 인코포레이티드	Cti 약물작용발생단을 함유하는 이관능성 세포독성제

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4169888A (en) *	1977-10-17	1979-10-02	The Upjohn Company	Composition of matter and process
US4301248A (en) *	1979-12-21	1981-11-17	Bristol-Myers Company	Fermentation process for making rachelmycin
US4413132A (en) *	1980-11-18	1983-11-01	The Upjohn Company	Antibiotic CC-1065 indoline intermediates
CA1238907A (en) *	1984-02-21	1988-07-05	Robert C. Kelly	1,2,8,8a-tetrahydrocyclopropa¬c\|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
US4912227A (en) *	1984-02-21	1990-03-27	The Upjohn Company	1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
GB8528848D0 (en) *	1985-11-22	1985-12-24	Davy Mckee Poole	Rolling mills
EP0340243B1 (en) *	1986-12-19	1994-09-28	The Upjohn Company	Cc-1065 analogs

1989
- 1989-08-07 AU AU41922/89A patent/AU632288B2/en not_active Ceased
- 1989-08-07 US US07/659,415 patent/US5541339A/en not_active Expired - Fee Related
- 1989-08-07 WO PCT/US1989/003329 patent/WO1990002746A1/en not_active Ceased
- 1989-08-07 KR KR1019900700977A patent/KR0137959B1/ko not_active Expired - Fee Related
- 1989-08-07 JP JP50923689A patent/JP3380237B2/ja not_active Expired - Fee Related
- 1989-08-21 CA CA000608908A patent/CA1340215C/en not_active Expired - Fee Related
- 1989-08-23 TW TW078106510A patent/TW217383B/zh active
- 1989-09-04 AT AT89308920T patent/ATE198335T1/de not_active IP Right Cessation
- 1989-09-04 DE DE68929275T patent/DE68929275T2/de not_active Expired - Fee Related
1991
- 1991-03-08 DK DK41791A patent/DK175458B1/da not_active IP Right Cessation
- 1991-03-11 NO NO910958A patent/NO303498B1/no unknown
- 1991-03-11 FI FI911193A patent/FI103668B1/fi not_active IP Right Cessation
2001
- 2001-03-15 GR GR20010400433T patent/GR3035589T3/el not_active IP Right Cessation
- 2001-12-27 LV LV010180A patent/LV12806B/xx unknown

Also Published As

Publication number	Publication date
AU4192289A (en)	1990-04-02
JPH04500664A (ja)	1992-02-06
WO1990002746A1 (en)	1990-03-22
AU632288B2 (en)	1992-12-24
ATE198335T1 (de)	2001-01-15
US5541339A (en)	1996-07-30
DK41791A (da)	1991-03-08
KR0137959B1 (ko)	1998-05-15
GR3035589T3 (en)	2001-06-29
NO303498B1 (no)	1998-07-20
FI911193A0 (fi)	1991-03-11
DK175458B1 (da)	2004-11-01
LV12806A (en)	2002-03-20
KR900701801A (ko)	1990-12-04
FI103668B (fi)	1999-08-13
CA1340215C (en)	1998-12-15
LV12806B (lv)	2002-05-20
FI103668B1 (fi)	1999-08-13
NO910958D0 (no)	1991-03-11
JP3380237B2 (ja)	2003-02-24
NO910958L (no)	1991-05-10
DE68929275T2 (de)	2001-05-23
TW217383B (da)	1993-12-11
DE68929275D1 (de)	2001-02-01

Legal Events

Date	Code	Title	Description
2007-03-26	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK41791A (da)	1991-03-08	Antibiotikum cc 1065-analoge
ES2082003T3 (es)	1996-03-16	Deshidrodidemnina b.
MX9206008A (es)	1993-11-01	Inhibidores de enzima proteolitica, derivados de sacarina 2-substituida.
FI931708A0 (fi)	1993-04-15	Herbicida substituerade aryl-haloalkylpyrazoler
FI865233A0 (fi)	1986-12-19	Pyrazolinderivat, deras framstaellning och anvaendning som medel med insekticid och akaricid verkan.
FI863836A0 (fi)	1986-09-23	Kinolinderivat.
TR199701576T1 (xx)	1998-05-21	N-aril-1,2,4,-triazolin-5-onlar.
ATE141796T1 (de)	1996-09-15	2',5'-oligoadenylat-derivate zur verwendung als heilmittel
BG98238A (bg)	1995-02-28	Заместени бензотиазолови производни,получаванетоим и приложението им като хербициди
ATE195055T1 (de)	2000-08-15	Insektizide zusammensetzung die diatomeenerde und siliziumdioxid enthalten
DE69003050D1 (de)	1993-10-07	S-substituierte beta-Thioacrylamide und deren Verwendung als Mikrobizide.
ES2095431T3 (es)	1997-02-16	N-(isoquinolein-5-il)-sulfonil-azacicloalcanos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
MX9302735A (es)	1994-08-31	4'-metoxiacetofenonas halogenadas como microbicidas y preservativos.
ES2037597B1 (es)	1994-03-16	Perfeccionamientos en o relacionados con compuestos organicos.
ATE247649T1 (de)	2003-09-15	Disubstituierte biphenyloxazoline
ES2055700T3 (es)	1994-09-01	Mezclas bactericidas.
BR8906802A (pt)	1990-09-18	Processo para preparar composto contendo agrupamento de guanidina ou amidina substituidas
BR9911522A (pt)	2001-09-18	Composição artropodicida e método de controle de artrópodes em ambientes não agronÈmicos e em ambientes da saúde animal
NO960271L (no)	1996-01-23	Tiokarbamoylforbindelser anvendt som mikrobiocider
DE3768322D1 (de)	1991-04-11	Substituierte alkynische thiocyanate, sie enthaltende biozide zusammensetzungen und deren verwendung.
ATE87314T1 (de)	1993-04-15	Platin-arzneimittel.
DE3660426D1 (de)	1988-09-01	Urea acryl derivatives
DE3782831D1 (de)	1993-01-14	(gem-heterocyclodimethanamin-n,n')platin komplexe.
DE3571975D1 (de)	1989-09-07	Azidobenzazepines
FR2574798B1 (fr)	1987-11-20	Nouvelle adenosine substituee en n6 et medicament la contenant comme principe actif