DK41791D0 - Antibiotikum cc 1065-analoge - Google Patents

Antibiotikum cc 1065-analoge

Info

Publication number: DK41791D0
Authority: DK; Denmark
Prior art keywords: pct; formula; date mar; compounds; sec
Prior art date: 1988-09-12

Application number

DK91417A

Other languages

English (en)

Other versions

DK175458B1 (da

DK41791A (da

Inventor

Paul A Aristoff

Robert C Kelly

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-12

Filing date

1991-03-08

Publication date

1991-03-08

1991-03-08 Application filed by Upjohn Co filed Critical Upjohn Co

1991-03-08 Publication of DK41791D0 publication Critical patent/DK41791D0/da

1991-03-08 Publication of DK41791A publication Critical patent/DK41791A/da

2004-11-01 Application granted granted Critical

2004-11-01 Publication of DK175458B1 publication Critical patent/DK175458B1/da

Links

UOWVMDUEMSNCAV-UHFFFAOYSA-N antibiotic cc 1065 Chemical class N1C=2C(OC)=C(O)C=3N(C(N)=O)CCC=3C=2C=C1C(=O)N1CCC(C=2C=3)=C1C(O)=C(OC)C=2NC=3C(=O)N1CC2CC22C1=CC(=O)C1=C2C(C)=CN1 UOWVMDUEMSNCAV-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
241001465754 Metazoa Species 0.000 abstract 1
239000006096 absorbing agent Substances 0.000 abstract 1
238000010171 animal model Methods 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Error Detection And Correction (AREA)
Semiconductor Integrated Circuits (AREA)
Amplifiers (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Artificial Filaments (AREA)
Solid State Image Pick-Up Elements (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Television Receiver Circuits (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Stereophonic System (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Television Systems (AREA)
Magnetic Resonance Imaging Apparatus (AREA)

DK41791A 1988-09-12 1991-03-08 Antibiotikum CC 1065-analoge DK175458B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US24335088A	1988-09-12	1988-09-12
US24335088		1988-09-12
US8903329		1989-08-07
PCT/US1989/003329 WO1990002746A1 (en)	1988-09-12	1989-08-07	Novel cc-1065 analogs having two cpi subunits

Publications (3)

Publication Number	Publication Date
DK41791D0 true DK41791D0 (da)	1991-03-08
DK41791A DK41791A (da)	1991-03-08
DK175458B1 DK175458B1 (da)	2004-11-01

Family

ID=22918400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK41791A DK175458B1 (da)	1988-09-12	1991-03-08	Antibiotikum CC 1065-analoge

Country Status (14)

Country	Link
US (1)	US5541339A (da)
JP (1)	JP3380237B2 (da)
KR (1)	KR0137959B1 (da)
AT (1)	ATE198335T1 (da)
AU (1)	AU632288B2 (da)
CA (1)	CA1340215C (da)
DE (1)	DE68929275T2 (da)
DK (1)	DK175458B1 (da)
FI (1)	FI103668B1 (da)
GR (1)	GR3035589T3 (da)
LV (1)	LV12806B (da)
NO (1)	NO303498B1 (da)
TW (1)	TW217383B (da)
WO (1)	WO1990002746A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0563475B1 (en) *	1992-03-25	2000-05-31	Immunogen Inc	Cell binding agent conjugates of derivatives of CC-1065
US5502068A (en) *	1995-01-31	1996-03-26	Synphar Laboratories, Inc.	Cyclopropylpyrroloindole-oligopeptide anticancer agents
US20100056762A1 (en)	2001-05-11	2010-03-04	Old Lloyd J	Specific binding proteins and uses thereof
AU2002311919B8 (en)	2001-05-11	2007-03-22	Ludwig Institute For Cancer Research Ltd	Specific binding proteins and uses thereof
JP2005509003A (ja)	2001-11-09	2005-04-07	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	タンパク質キナーゼインヒビターとして有用なベンゾイミダゾール化合物
AU2003257094A1 (en) *	2002-08-08	2004-02-25	Boehringer Ingelheim Pharmaceuticals, Inc.	Substituted benzimidazole compounds
WO2004035571A1 (en) *	2002-10-15	2004-04-29	Rigel Pharmaceuticals, Inc.	Substituted indoles and their use as hcv inhibitors
EP1641759B1 (en) *	2003-07-07	2014-03-12	Merck Patent GmbH	Malonamide derivatives
WO2005079791A1 (en) *	2004-02-12	2005-09-01	Boehringer Ingelheim Pharmaceuticals, Inc.	Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
CN101287728A (zh) *	2005-08-17	2008-10-15	先灵公司	新的高亲和力噻吩基和呋喃基激酶配体
US9090693B2 (en)	2007-01-25	2015-07-28	Dana-Farber Cancer Institute	Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
CA2680854C (en)	2007-03-15	2017-02-14	Ludwig Institute For Cancer Research	Treatment method using egfr antibodies and src inhibitors and related formulations
US9901567B2 (en)	2007-08-01	2018-02-27	Syntarga B.V.	Substituted CC-1065 analogs and their conjugates
CN108424454B (zh)	2007-08-14	2022-05-31	路德维格癌症研究所有限公司	靶向egf受体的单克隆抗体175及其衍生物和用途
ES2647317T3 (es)	2008-11-03	2017-12-20	Syntarga B.V.	Análogos de CC-1065 y sus conjugados
PT3056203T (pt)	2010-04-21	2018-02-15	Syntarga Bv	Conjugados de análogos de cc-1065 e ligantes bifuncionais
US20150265641A1 (en)	2012-10-22	2015-09-24	Arnold Glazier	Methods for the Effective Treatment of Metastatic Cancer
DE102013012622A1 (de) *	2013-07-30	2015-02-05	Clariant lnternational Ltd	Neue sterisch gehinderte cyclische Amine
RU2680404C2 (ru)	2014-01-10	2019-02-21	Синтон Байофармасьютикалс Б. В.	Способ очистки cys-связанных конъюгатов антитело-лекарственное средство
SG11201605437YA (en) *	2014-01-27	2016-08-30	Pfizer	Bifunctional cytotoxic agents
EP3160513B1 (en)	2014-06-30	2020-02-12	Glykos Finland Oy	Saccharide derivative of a toxic payload and antibody conjugates thereof
DE102015000124A1 (de) *	2015-01-07	2016-07-07	Clariant International Ltd.	Verfahren zur Stabilisierung von Polyamiden
US10870706B2 (en) *	2015-03-20	2020-12-22	Pfizer Inc.	Bifunctional cytotoxic agents containing the CTI pharmacophore

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4169888A (en) *	1977-10-17	1979-10-02	The Upjohn Company	Composition of matter and process
US4301248A (en) *	1979-12-21	1981-11-17	Bristol-Myers Company	Fermentation process for making rachelmycin
US4413132A (en) *	1980-11-18	1983-11-01	The Upjohn Company	Antibiotic CC-1065 indoline intermediates
US4912227A (en) *	1984-02-21	1990-03-27	The Upjohn Company	1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
CA1238907A (en) *	1984-02-21	1988-07-05	Robert C. Kelly	1,2,8,8a-tetrahydrocyclopropa¬c\|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8528848D0 (en) *	1985-11-22	1985-12-24	Davy Mckee Poole	Rolling mills
DE3750612T2 (de) *	1986-12-19	1995-03-02	Upjohn Co	Cc-1065 analoge.

1989
- 1989-08-07 US US07/659,415 patent/US5541339A/en not_active Expired - Fee Related
- 1989-08-07 AU AU41922/89A patent/AU632288B2/en not_active Ceased
- 1989-08-07 WO PCT/US1989/003329 patent/WO1990002746A1/en not_active Ceased
- 1989-08-07 JP JP50923689A patent/JP3380237B2/ja not_active Expired - Fee Related
- 1989-08-07 KR KR1019900700977A patent/KR0137959B1/ko not_active Expired - Fee Related
- 1989-08-21 CA CA000608908A patent/CA1340215C/en not_active Expired - Fee Related
- 1989-08-23 TW TW078106510A patent/TW217383B/zh active
- 1989-09-04 DE DE68929275T patent/DE68929275T2/de not_active Expired - Fee Related
- 1989-09-04 AT AT89308920T patent/ATE198335T1/de not_active IP Right Cessation
1991
- 1991-03-08 DK DK41791A patent/DK175458B1/da not_active IP Right Cessation
- 1991-03-11 FI FI911193A patent/FI103668B1/fi not_active IP Right Cessation
- 1991-03-11 NO NO910958A patent/NO303498B1/no unknown
2001
- 2001-03-15 GR GR20010400433T patent/GR3035589T3/el not_active IP Right Cessation
- 2001-12-27 LV LV010180A patent/LV12806B/xx unknown

Also Published As

Publication number	Publication date
AU632288B2 (en)	1992-12-24
NO910958L (no)	1991-05-10
LV12806B (lv)	2002-05-20
JPH04500664A (ja)	1992-02-06
KR0137959B1 (ko)	1998-05-15
FI911193A0 (fi)	1991-03-11
DK175458B1 (da)	2004-11-01
US5541339A (en)	1996-07-30
DE68929275T2 (de)	2001-05-23
GR3035589T3 (en)	2001-06-29
WO1990002746A1 (en)	1990-03-22
JP3380237B2 (ja)	2003-02-24
NO910958D0 (no)	1991-03-11
FI103668B (fi)	1999-08-13
TW217383B (da)	1993-12-11
DE68929275D1 (de)	2001-02-01
CA1340215C (en)	1998-12-15
NO303498B1 (no)	1998-07-20
FI103668B1 (fi)	1999-08-13
LV12806A (en)	2002-03-20
AU4192289A (en)	1990-04-02
DK41791A (da)	1991-03-08
ATE198335T1 (de)	2001-01-15
KR900701801A (ko)	1990-12-04

Legal Events

Date	Code	Title	Description
2007-03-26	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK41791A (da)	1991-03-08	Antibiotikum cc 1065-analoge
ATE133181T1 (de)	1996-02-15	Dehydrodidemnin b
MX9206008A (es)	1993-11-01	Inhibidores de enzima proteolitica, derivados de sacarina 2-substituida.
DE69130614D1 (de)	1999-01-21	Herbizide, substituierte aryl-haloalkylpyrazole
BR8606336A (pt)	1987-10-06	Derivados de pirazolina,processo para sua preparacao,composicoes inseticidas e emprego
FI863836A0 (fi)	1986-09-23	Kinolinderivat.
ATE63111T1 (de)	1991-05-15	Substituierte oximether, ihre verwendung als bioregulatoren zur senkung des endogenen ethylenspiegels in pflanzen.
ATE141796T1 (de)	1996-09-15	2',5'-oligoadenylat-derivate zur verwendung als heilmittel
BG98238A (bg)	1995-02-28	Заместени бензотиазолови производни,получаванетоим и приложението им като хербициди
ATE195055T1 (de)	2000-08-15	Insektizide zusammensetzung die diatomeenerde und siliziumdioxid enthalten
DE69003050D1 (de)	1993-10-07	S-substituierte beta-Thioacrylamide und deren Verwendung als Mikrobizide.
MX9302735A (es)	1994-08-31	4'-metoxiacetofenonas halogenadas como microbicidas y preservativos.
ES2037597B1 (es)	1994-03-16	Perfeccionamientos en o relacionados con compuestos organicos.
DE3772909D1 (de)	1991-10-17	3-methylphthalimide.
KR880010669A (ko)	1988-10-24	식물 성장 조절제
ATE247649T1 (de)	2003-09-15	Disubstituierte biphenyloxazoline
ES2055700T3 (es)	1994-09-01	Mezclas bactericidas.
NO960271L (no)	1996-01-23	Tiokarbamoylforbindelser anvendt som mikrobiocider
DE3768322D1 (de)	1991-04-11	Substituierte alkynische thiocyanate, sie enthaltende biozide zusammensetzungen und deren verwendung.
ATE87314T1 (de)	1993-04-15	Platin-arzneimittel.
DE3660426D1 (de)	1988-09-01	Urea acryl derivatives
ATE3751T1 (de)	1983-06-15	Wasserloesliche polyester und polycarbonate zur verwendung als antitumorwirkstoffe.
DE3782831D1 (de)	1993-01-14	(gem-heterocyclodimethanamin-n,n')platin komplexe.
FR2574798B1 (fr)	1987-11-20	Nouvelle adenosine substituee en n6 et medicament la contenant comme principe actif
DE3853677D1 (de)	1995-06-01	Silylgruppen enthaltende Aminverbindungen zur Verwendung als antimikrobische Wirkstoffe.