DK4190355T3 - Formuleringer af humane anti-rankl-antistoffer og fremgangsmåder til anvendelse deraf - Google Patents

Formuleringer af humane anti-rankl-antistoffer og fremgangsmåder til anvendelse deraf Download PDF

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Publication number
DK4190355T3
DK4190355T3 DK22206709.2T DK22206709T DK4190355T3 DK 4190355 T3 DK4190355 T3 DK 4190355T3 DK 22206709 T DK22206709 T DK 22206709T DK 4190355 T3 DK4190355 T3 DK 4190355T3
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Denmark
Prior art keywords
formulations
methods
human anti
rankl antibodies
rankl
Prior art date
Application number
DK22206709.2T
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English (en)
Inventor
Stephen Robert Brych
Lyanne M Wong
Jaymille Fallon
Monica Michelle Goss
Jian Hua Gu
Pavan K Ghattyvenkatakrishna
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Amgen Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62165668&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK4190355(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
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Publication of DK4190355T3 publication Critical patent/DK4190355T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
DK22206709.2T 2017-04-28 2018-04-27 Formuleringer af humane anti-rankl-antistoffer og fremgangsmåder til anvendelse deraf DK4190355T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762492056P 2017-04-28 2017-04-28
EP18724690.5A EP3615066B1 (en) 2017-04-28 2018-04-27 Formulations of human anti-rankl antibodies, and methods of using the same

Publications (1)

Publication Number Publication Date
DK4190355T3 true DK4190355T3 (da) 2024-12-09

Family

ID=62165668

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18724690.5T DK3615066T5 (da) 2017-04-28 2018-04-27 Formuleringer af humane anti-rankl-antistoffer og fremgangsmåder til anvendelse deraf
DK22206709.2T DK4190355T3 (da) 2017-04-28 2018-04-27 Formuleringer af humane anti-rankl-antistoffer og fremgangsmåder til anvendelse deraf

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Application Number Title Priority Date Filing Date
DK18724690.5T DK3615066T5 (da) 2017-04-28 2018-04-27 Formuleringer af humane anti-rankl-antistoffer og fremgangsmåder til anvendelse deraf

Country Status (37)

Country Link
US (3) US11192952B2 (da)
EP (3) EP4190355B1 (da)
JP (4) JP7190822B2 (da)
KR (2) KR20240110083A (da)
CN (2) CN110621342B (da)
AR (1) AR111497A1 (da)
AU (2) AU2018260750B2 (da)
BR (1) BR112019022188A2 (da)
CA (1) CA3054165A1 (da)
CL (3) CL2019003032A1 (da)
CO (1) CO2019011463A2 (da)
CR (2) CR20190538A (da)
DK (2) DK3615066T5 (da)
EA (1) EA201992570A1 (da)
ES (2) ES2973572T3 (da)
FI (2) FI4190355T3 (da)
HR (2) HRP20240167T1 (da)
HU (2) HUE069382T2 (da)
IL (2) IL293127B2 (da)
JO (2) JOP20190255B1 (da)
LT (2) LT3615066T (da)
MA (2) MA62173B1 (da)
MX (1) MX2023013460A (da)
MY (1) MY202479A (da)
PE (2) PE20200343A1 (da)
PH (1) PH12019502444A1 (da)
PL (2) PL4190355T3 (da)
PT (2) PT4190355T (da)
RS (2) RS65299B1 (da)
SG (1) SG11201909998TA (da)
SI (2) SI3615066T1 (da)
SM (2) SMT202400095T1 (da)
TN (2) TN2019000297A1 (da)
TW (2) TWI903512B (da)
UY (2) UY37707A (da)
WO (1) WO2018200918A1 (da)
ZA (1) ZA202205141B (da)

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WO2018200533A1 (en) * 2017-04-28 2018-11-01 Amgen Inc. Excipients to reduce the viscosity of antibody formulations and formulation compositions
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CN109374779A (zh) * 2018-12-17 2019-02-22 杭州奕安济世生物药业有限公司 一种蔗糖含量的快速检测方法
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TWI759867B (zh) * 2019-09-19 2022-04-01 大陸商信達生物製藥（蘇州）有限公司 抗前蛋白轉化酶枯草桿菌蛋白酶／ｋｅｘｉｎ型９抗體用於製備治療膽固醇相關疾病之藥物的用途
CN111704670B (zh) * 2020-08-18 2020-11-03 迈威(上海)生物科技股份有限公司 重组抗RANKL抗体IgG2型的二硫键异构体及其纯化方法
AU2021377176A1 (en) * 2020-11-11 2023-06-22 Hq Han Bifunctional antagonists of activin/tgf-beta and rankl and uses thereof
CA3218542A1 (en) * 2021-05-12 2022-11-17 Hua Ying Antigen binding molecule specifically binding to rankl and ngf, and medical use thereof
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US20250297020A1 (en) * 2021-11-23 2025-09-25 Adalta Limited Rank-l binding molecules
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JP2025532122A (ja) 2022-09-23 2025-09-29 ザ ユニヴァーシティー オブ ノース カロライナ アト チャペル ヒル 黒色腫の治療のための方法及び組成物
WO2024104409A1 (zh) * 2022-11-16 2024-05-23 苏州盛迪亚生物医药有限公司 一种含抗rankl-ngf双特异性抗体的药物组合物
WO2024184280A1 (en) * 2023-03-03 2024-09-12 Alvotech Hf Denosumab formulation
CN121752600A (zh) * 2023-08-17 2026-03-27 中国抗体制药有限公司 靶向rankl和硬骨素的抗体及其用途
WO2025116648A1 (ko) * 2023-12-01 2025-06-05 삼성바이오에피스 주식회사 항-IL-4Rα 항체의 안정한 완충제-프리 액상 제형

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Publication number Publication date
MA48462A (fr) 2020-03-04
TN2021000055A1 (en) 2022-10-03
FI4190355T3 (fi) 2024-12-07
TWI903512B (zh) 2025-11-01
PH12019502444A1 (en) 2020-07-20
IL293127B2 (en) 2024-06-01
UY37707A (es) 2018-10-31
SMT202400095T1 (it) 2024-05-14
US11192952B2 (en) 2021-12-07
CL2019003032A1 (es) 2020-02-21
EP4477667A3 (en) 2025-05-07
DK3615066T3 (da) 2024-03-11
KR20190140464A (ko) 2019-12-19
TW201841654A (zh) 2018-12-01
EP4477667A2 (en) 2024-12-18
PE20251534A1 (es) 2025-06-05
JOP20240115B1 (ar) 2025-10-01
AU2018260750A1 (en) 2019-08-29
CL2020002012A1 (es) 2020-10-16
LT3615066T (lt) 2024-02-26
US20220143181A1 (en) 2022-05-12
KR20240110083A (ko) 2024-07-12
TN2019000297A1 (en) 2021-05-07
SG11201909998TA (en) 2019-11-28
EP3615066B1 (en) 2023-12-27
TW202435914A (zh) 2024-09-16
MX2023013460A (es) 2023-12-15
CR20250034A (es) 2025-03-06
EP4190355A1 (en) 2023-06-07
HUE065544T2 (hu) 2024-05-28
IL268704A (en) 2019-10-31
AR111497A1 (es) 2019-07-17
CN118987200A (zh) 2024-11-22
MY202479A (en) 2024-04-30
AU2018260750B2 (en) 2025-04-17
PL3615066T3 (pl) 2024-04-29
EP4190355B1 (en) 2024-09-25
MA62173B1 (fr) 2025-01-31
EA201992570A1 (ru) 2020-03-20
WO2018200918A8 (en) 2019-10-17
CA3054165A1 (en) 2018-11-01
PT3615066T (pt) 2024-03-08
RS66284B1 (sr) 2025-01-31
SI4190355T1 (sl) 2025-02-28
PE20200343A1 (es) 2020-02-14
ES2997833T3 (en) 2025-02-18
CN110621342B (zh) 2024-08-02
BR112019022188A2 (pt) 2020-05-12
CL2023002505A1 (es) 2024-03-08
EP3615066A1 (en) 2020-03-04
UY40974A (es) 2024-12-13
JOP20190255B1 (ar) 2024-12-22
JOP20190255A1 (ar) 2019-10-27
JP7851438B2 (ja) 2026-04-24
DK3615066T5 (da) 2024-09-02
ZA202205141B (en) 2025-04-30
TWI839331B (zh) 2024-04-21
JP2018188430A (ja) 2018-11-29
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HUE069382T2 (hu) 2025-03-28
US20200354463A1 (en) 2020-11-12
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CR20190538A (es) 2020-02-26
JP7356525B2 (ja) 2023-10-04
SI3615066T1 (sl) 2024-04-30
JP2023166396A (ja) 2023-11-21
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IL268704B (en) 2022-06-01
HRP20241604T1 (hr) 2025-01-31
AU2025205470A1 (en) 2025-08-14
FI3615066T3 (fi) 2024-02-29
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IL293127A (en) 2022-07-01
CN110621342A (zh) 2019-12-27
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MA48462B1 (fr) 2024-05-31
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