DK425487A - Pharmaceutisk aktive derivater af glutamin- og asparginsyre - Google Patents

Pharmaceutisk aktive derivater af glutamin- og asparginsyre

Info

Publication number: DK425487A
Authority: DK; Denmark
Prior art keywords: group; glutaminic; carbon atoms; pharmaceutical active; active derivatives
Prior art date: 1985-12-17

Application number

DK425487A

Other languages

English (en)

Other versions

DK425487D0 (da

DK169666B1 (da

Inventor

Francesco Makovec

Rolando Chiste

Claudio Lucio Rovati

Angelo Luigi Rovati

Original Assignee

Rotta Research Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-17

Filing date

1987-08-14

Publication date

1987-08-14

1987-08-14 Application filed by Rotta Research Lab filed Critical Rotta Research Lab

1987-08-14 Publication of DK425487D0 publication Critical patent/DK425487D0/da

1987-08-14 Publication of DK425487A publication Critical patent/DK425487A/da

1995-01-09 Application granted granted Critical

1995-01-09 Publication of DK169666B1 publication Critical patent/DK169666B1/da

Links

239000002253 acid Substances 0.000 title 1
230000000975 bioactive effect Effects 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
229920001184 polypeptide Polymers 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
208000022531 anorexia Diseases 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
206010061428 decreased appetite Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N glutamic acid Chemical class OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK425487A 1985-12-17 1987-08-14 Farmaceutisk aktive derivater af D,L-glutamin- og D,L-asparaginsyre, fremgangsmåde til deres fremstilling samt farmaceutisk sammensætning og sammensætning til anvendelse ved husdyrbrug indeholdende sådanne derivater DK169666B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
IT6806285		1985-12-17
IT8568062A IT1215169B (it)	1985-12-17	1985-12-17	Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione
EP8600724		1986-12-08
PCT/EP1986/000724 WO1987003869A2 (en)	1985-12-17	1986-12-08	Pharmaceutically active derivatives of glutamic and aspartic acids

Publications (3)

Publication Number	Publication Date
DK425487D0 DK425487D0 (da)	1987-08-14
DK425487A true DK425487A (da)	1987-08-14
DK169666B1 DK169666B1 (da)	1995-01-09

Family

ID=11307569

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK425487A DK169666B1 (da)	1985-12-17	1987-08-14	Farmaceutisk aktive derivater af D,L-glutamin- og D,L-asparaginsyre, fremgangsmåde til deres fremstilling samt farmaceutisk sammensætning og sammensætning til anvendelse ved husdyrbrug indeholdende sådanne derivater

Country Status (13)

Country	Link
US (1)	US4769389A (da)
EP (1)	EP0286643B1 (da)
JP (1)	JPS62181246A (da)
AU (1)	AU595858B2 (da)
CA (1)	CA1269110A (da)
DK (1)	DK169666B1 (da)
ES (1)	ES2081777A6 (da)
GR (1)	GR862921B (da)
IE (1)	IE59534B1 (da)
IT (1)	IT1215169B (da)
PT (1)	PT83952B (da)
WO (1)	WO1987003869A2 (da)
ZA (1)	ZA869460B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1196849B (it) *	1986-02-16	1988-11-25	Rotta Research Lab	Nuovi derivati degli acidi 5 pentilammino 5 oxo pentaoico e 4 pentilammino 4 oxo butanoico ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
US4880938A (en) *	1986-06-16	1989-11-14	Merck & Co., Inc.	Amino acid analogs
US5089638A (en) *	1986-06-16	1992-02-18	Merck & Co., Inc.	Amino acid analogs as CCK-antagonists
IT1217123B (it) *	1987-02-05	1990-03-14	Rotta Research Lab	Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
US5105007A (en) *	1987-10-19	1992-04-14	Abbott Laboratories	Phenylacetylglutamine (PAG) analytical test
JPH0374328A (ja) *	1989-08-04	1991-03-28	Warner Lambert Co	薬学的活性を有する中枢コレシストキニン拮抗剤
US5066828A (en) *	1990-04-12	1991-11-19	Merrell Dow Pharmaceuticals Inc.	Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
EP0617621A4 (en) *	1991-12-20	1995-04-05	Merck Sharp & Dohme	CENTRAL CHOLECYSTOKININE ANTAGONISTS WITH PHARMACEUTICAL EFFECTIVENESS.
GB9200420D0 (en) *	1992-01-09	1992-02-26	James Black Foundation The Lim	Amino acid derivatives
US5716958A (en)	1994-10-27	1998-02-10	Tobishi Pharmaceutical Co., Ltd.	Amino acid derivative having anti-CCK activity
UA94412C2 (en) *	2005-07-11	2011-05-10	Уайет	Glutamate aggrecanase inhibitors
US7863330B2 (en) *	2006-06-14	2011-01-04	Rottapharm S.P.A.	Deloxiglumide and proton pump inhibitor combination in the treatment of gastrointestinal disorders
CN108912007B (zh) *	2018-06-20	2021-02-26	中国农业科学院兰州畜牧与兽药研究所	一种右氯谷胺的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1108819A (en) *	1964-07-31	1968-04-03	Rotta Research Lab	Derivatives of 2-acylaminobicarboxylic acids and method for preparing same
US3465081A (en) *	1966-05-13	1969-09-02	Thompson Chem Co Hayward	Method of controlling pestiferous organisms
AT293368B (de) *	1969-10-13	1971-10-11	Rotta Research Lab	Verfahren zur Herstellung von N-Benzoyl-L-(D- oder DL)-glutaminsäure-l-amiden
US3803223A (en) *	1970-07-20	1974-04-09	Searle & Co	3-amino-n-substituted succinamic acids and intermediates thereto
US4243678A (en) *	1977-12-30	1981-01-06	Byk Gulden Lomberg Chemische Fabrik Gmbh	Acylhydrocarbylaminoalkanoic acids, compositions and uses
IE57892B1 (en) *	1984-06-25	1993-05-05	Rotta Research Lab	Glutamic and aspartic acid derivatives
GB8704671D0 (en) *	1987-02-27	1987-04-01	Shell Int Research	Glycine compounds

1985
- 1985-12-17 IT IT8568062A patent/IT1215169B/it active
1986
- 1986-12-08 AU AU69497/87A patent/AU595858B2/en not_active Ceased
- 1986-12-08 WO PCT/EP1986/000724 patent/WO1987003869A2/en not_active Ceased
- 1986-12-08 EP EP87901263A patent/EP0286643B1/en not_active Expired - Lifetime
- 1986-12-10 IE IE323386A patent/IE59534B1/en not_active IP Right Cessation
- 1986-12-15 CA CA000525358A patent/CA1269110A/en not_active Expired - Fee Related
- 1986-12-16 ES ES08603651A patent/ES2081777A6/es not_active Expired - Fee Related
- 1986-12-16 JP JP61301132A patent/JPS62181246A/ja active Granted
- 1986-12-17 US US06/942,751 patent/US4769389A/en not_active Expired - Lifetime
- 1986-12-17 PT PT83952A patent/PT83952B/pt not_active IP Right Cessation
- 1986-12-17 GR GR862921A patent/GR862921B/el unknown
- 1986-12-17 ZA ZA869460A patent/ZA869460B/xx unknown
1987
- 1987-08-14 DK DK425487A patent/DK169666B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2081777A6 (es)	1996-03-01
JPS62181246A (ja)	1987-08-08
DK425487D0 (da)	1987-08-14
ZA869460B (en)	1987-08-26
AU6949787A (en)	1987-07-15
WO1987003869A3 (en)	1987-08-13
PT83952A (en)	1987-01-01
IE863233L (en)	1987-06-17
IT1215169B (it)	1990-01-31
WO1987003869A2 (en)	1987-07-02
CA1269110A (en)	1990-05-15
EP0286643A1 (en)	1988-10-19
AU595858B2 (en)	1990-04-12
IE59534B1 (en)	1994-03-09
DK169666B1 (da)	1995-01-09
US4769389A (en)	1988-09-06
IT8568062A0 (it)	1985-12-17
GR862921B (en)	1987-04-27
EP0286643B1 (en)	1991-05-15
PT83952B (pt)	1989-06-30
JPH0543698B2 (da)	1993-07-02

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Legal Events

Date	Code	Title	Description
1995-01-09	B1	Patent granted (law 1993)
2004-08-09	PBP	Patent lapsed	Country of ref document: DK