DK438580A - INTERMEDIATE FOR THE MANUFACTURE OF AZABICYCLO COMPOUNDS - Google Patents

INTERMEDIATE FOR THE MANUFACTURE OF AZABICYCLO COMPOUNDS

Info

Publication number: DK438580A
Authority: DK; Denmark
Prior art keywords: manufacture; azabicyclo compounds; azabicyclo; compounds
Prior art date: 1976-09-15

Application number

DK438580A

Other languages

Danish (da)

Inventor

W J Fanshawe

J W Epstein

L S Crawley

C M Hofmann

S R Safir

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-15

Filing date

1980-10-16

Publication date

1980-10-16

1977-06-23 Priority claimed from US05/809,339 external-priority patent/US4131611A/en

1977-06-23 Priority claimed from US05/809,341 external-priority patent/US4118393A/en

1977-06-23 Priority claimed from US05/809,340 external-priority patent/US4118417A/en

1980-10-16 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1980-10-16 Priority to DK438580A priority Critical patent/DK438580A/en

1980-10-16 Publication of DK438580A publication Critical patent/DK438580A/en

Links

150000001875 compounds Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/40—Unsaturated compounds containing halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/28—Unsaturated compounds polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK438580A 1976-09-15 1980-10-16 INTERMEDIATE FOR THE MANUFACTURE OF AZABICYCLO COMPOUNDS DK438580A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK438580A DK438580A (en)	1976-09-15	1980-10-16	INTERMEDIATE FOR THE MANUFACTURE OF AZABICYCLO COMPOUNDS

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US72340276A	1976-09-15	1976-09-15
US05/809,339 US4131611A (en)	1975-07-31	1977-06-23	Azabicyclohexanes
US05/809,341 US4118393A (en)	1977-06-23	1977-06-23	Phenyl azabicyclohexanones
US05/809,340 US4118417A (en)	1977-06-23	1977-06-23	Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
DK407577A DK146245C (en)	1976-09-15	1977-09-14	METHOD OF ANALOGUE FOR PREPARING RACEMIC OR OPTICALLY ACTIVE AZABICYCLO COMPOUNDS OR ACID ADDITION SALTS THEREOF
DK438580A DK438580A (en)	1976-09-15	1980-10-16	INTERMEDIATE FOR THE MANUFACTURE OF AZABICYCLO COMPOUNDS

Publications (1)

Publication Number	Publication Date
DK438580A true DK438580A (en)	1980-10-16

Family

ID=27505564

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK407577A DK146245C (en)	1976-09-15	1977-09-14	METHOD OF ANALOGUE FOR PREPARING RACEMIC OR OPTICALLY ACTIVE AZABICYCLO COMPOUNDS OR ACID ADDITION SALTS THEREOF
DK438580A DK438580A (en)	1976-09-15	1980-10-16	INTERMEDIATE FOR THE MANUFACTURE OF AZABICYCLO COMPOUNDS
DK438480A DK438480A (en)	1976-09-15	1980-10-16	PROCEDURE FOR PREPARING AN OPTICALLY ACTIVE AZABICYCLO COMPOUND

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK407577A DK146245C (en)	1976-09-15	1977-09-14	METHOD OF ANALOGUE FOR PREPARING RACEMIC OR OPTICALLY ACTIVE AZABICYCLO COMPOUNDS OR ACID ADDITION SALTS THEREOF

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK438480A DK438480A (en)	1976-09-15	1980-10-16	PROCEDURE FOR PREPARING AN OPTICALLY ACTIVE AZABICYCLO COMPOUND

Country Status (16)

Country	Link
JP (1)	JPS5337656A (en)
AR (2)	AR220684A1 (en)
AT (2)	AT367036B (en)
AU (1)	AU519620B2 (en)
BE (1)	BE858683A (en)
CH (2)	CH637929A5 (en)
DD (1)	DD133943A5 (en)
DE (1)	DE2740562A1 (en)
DK (3)	DK146245C (en)
FR (1)	FR2375212A1 (en)
GR (1)	GR72713B (en)
HU (1)	HU177531B (en)
NL (1)	NL189041C (en)
PL (1)	PL115869B1 (en)
SE (2)	SE435384B (en)
YU (2)	YU39499B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4183857A (en) *	1978-07-06	1980-01-15	Shell Oil Company	3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
IL65843A (en) *	1977-08-11	1986-12-31	American Cyanamid Co	Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
CA1117127A (en) *	1978-06-27	1982-01-26	Janet A. Day	Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
US4225499A (en) *	1978-07-06	1980-09-30	Shell Oil Company	Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
JPS6332100A (en) *	1986-07-25	1988-02-10	東京電力株式会社	Shield excavator
JPH0658037B2 (en) *	1989-09-01	1994-08-03	日本鋼管株式会社	Shield excavator
US6372919B1 (en)	2001-01-11	2002-04-16	Dov Pharmaceutical, Inc.	(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en)	2001-08-24	2003-05-27	Dov Pharmaceuticals Inc.	(−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20080081834A1 (en)	2002-07-31	2008-04-03	Lippa Arnold S	Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
CN101410106A (en) *	2004-07-22	2009-04-15	惠氏公司	Methods of treating neurological disorders and conditions
MX2007000851A (en) *	2004-07-22	2007-03-26	Wyeth Corp	Method for treating nervous system disorders and conditions.
US20070043100A1 (en)	2005-08-16	2007-02-22	Hagen Eric J	Novel polymorphs of azabicyclohexane
AU2006275870B2 (en) *	2005-07-27	2013-01-10	Otsuka America Pharmaceutical, Inc.	Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en)	2006-04-28	2008-02-21	Murry Jerry A	Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en)	2006-11-07	2012-03-20	Dov Pharmaceutical, Inc.	Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en)	2007-06-06	2015-09-15	Neurovance, Inc.	1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20140206740A1 (en)	2011-07-30	2014-07-24	Neurovance, Inc.	Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1351754A (en) *	1970-07-02	1974-05-01	Allen & Hanburys Ltd	Indenopyrrole derivatives

1977
- 1977-08-16 GR GR54169A patent/GR72713B/el unknown
- 1977-08-26 AR AR268968A patent/AR220684A1/en active
- 1977-09-01 AU AU28441/77A patent/AU519620B2/en not_active Ceased
- 1977-09-02 NL NLAANVRAGE7709691,A patent/NL189041C/en not_active IP Right Cessation
- 1977-09-08 DE DE19772740562 patent/DE2740562A1/en active Granted
- 1977-09-13 YU YU2174/77A patent/YU39499B/en unknown
- 1977-09-13 CH CH1118977A patent/CH637929A5/en not_active IP Right Cessation
- 1977-09-14 PL PL1977200831A patent/PL115869B1/en unknown
- 1977-09-14 AT AT0661577A patent/AT367036B/en not_active IP Right Cessation
- 1977-09-14 DK DK407577A patent/DK146245C/en not_active IP Right Cessation
- 1977-09-14 FR FR7727755A patent/FR2375212A1/en active Granted
- 1977-09-14 BE BE180894A patent/BE858683A/en not_active IP Right Cessation
- 1977-09-14 HU HU77AE508A patent/HU177531B/en unknown
- 1977-09-15 DD DD77201039A patent/DD133943A5/en unknown
- 1977-09-15 SE SE7710367A patent/SE435384B/en not_active IP Right Cessation
- 1977-09-16 JP JP11064777A patent/JPS5337656A/en active Granted
1978
- 1978-09-19 AR AR273764A patent/AR227507A1/en active
1980
- 1980-05-30 AT AT0288280A patent/AT367037B/en not_active IP Right Cessation
- 1980-10-16 DK DK438580A patent/DK438580A/en not_active Application Discontinuation
- 1980-10-16 DK DK438480A patent/DK438480A/en not_active Application Discontinuation
1982
- 1982-04-05 CH CH209382A patent/CH637931A5/en not_active IP Right Cessation
- 1982-06-03 SE SE8203437A patent/SE452610B/en not_active IP Right Cessation
- 1982-08-23 YU YU1885/82A patent/YU43523B/en unknown

Also Published As

Publication number	Publication date
DE2740562C2 (en)	1989-05-03
YU217477A (en)	1983-01-21
DK146245B (en)	1983-08-08
FR2375212A1 (en)	1978-07-21
GR72713B (en)	1983-12-01
NL189041C (en)	1992-12-16
PL115869B1 (en)	1981-05-30
SE452610B (en)	1987-12-07
AR227507A1 (en)	1982-11-15
FR2375212B1 (en)	1981-07-31
SE7710367L (en)	1978-03-16
AT367036B (en)	1982-05-25
SE435384B (en)	1984-09-24
NL7709691A (en)	1978-03-17
HU177531B (en)	1981-11-28
DK407577A (en)	1978-03-16
AT367037B (en)	1982-05-25
DD133943A5 (en)	1979-01-31
YU39499B (en)	1984-12-31
AR220684A1 (en)	1980-11-28
PL200831A1 (en)	1980-02-11
DK438480A (en)	1980-10-16
DE2740562A1 (en)	1978-03-23
NL189041B (en)	1992-07-16
AU2844177A (en)	1979-03-08
CH637931A5 (en)	1983-08-31
ATA288280A (en)	1981-10-15
DK146245C (en)	1984-01-16
JPS5337656A (en)	1978-04-06
ATA661577A (en)	1981-10-15
SE8203437L (en)	1982-06-03
JPS6129341B2 (en)	1986-07-05
CH637929A5 (en)	1983-08-31
BE858683A (en)	1978-03-14
YU188582A (en)	1985-03-20
YU43523B (en)	1989-08-31
AU519620B2 (en)	1981-12-17

Legal Events

Date	Code	Title	Description
1993-05-24	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK492677A (en)	1978-05-06	PROCEDURE FOR THE PRODUCTION OF SUBSTITUTED BENZAMES
DK81277A (en)	1977-08-26	PROCEDURE FOR MAKING BIS-PYRIDINIUM COMPOUNDS
DK30277A (en)	1977-07-27	PROCEDURE FOR THE PREPARATION OF SUBSTITUTED PHENYLAMIDINES
DK149062C (en)	1986-06-16	ANALOGY PROCEDURE FOR THE MANUFACTURE OF CEFUROXIMESTERS
DK377A (en)	1977-07-06	PROCEDURE FOR THE PREPARATION OF N-PHOSPHONOMETHYL-GLYCIN
DK37879A (en)	1980-06-20	PROCEDURE FOR THE MANUFACTURE OF OLIGOIMIDS
DK244577A (en)	1977-12-04	PROCEDURE FOR THE PREPARATION OF HYDANTO INTERVENTIVES
DK276177A (en)	1978-02-03	PROCEDURE FOR THE PREPARATION OF GAMMAPYRON COMPOUNDS
DK339677A (en)	1978-01-29	PROCEDURE FOR THE PREPARATION OF 2-BENZYLPYRROLIDINES
DK91277A (en)	1977-09-04	PROCEDURE FOR THE PREPARATION OF CEPHALOSPORINS
DK123277A (en)	1977-09-23	PROCEDURE FOR MAKING 3-HALOGENMETHYL-3-CEPHEM COMPOUNDS
DK446277A (en)	1978-04-09	PROCEDURE FOR THE MANUFACTURE OF ORTHOPHIC ACID CHYLESTERS
DK144377A (en)	1977-10-03	PROCEDURE FOR THE PREPARATION OF ACYLCYANIDES
DK88777A (en)	1977-09-02	PROCEDURE FOR THE PREPARATION OF SUBSTITUTED AZAPURINES
DK271377A (en)	1977-12-22	PROCEDURE FOR THE PREPARATION OF SUBSTITUTED ARYLACETAMIDOCEPHALOSPORINES
DK139029B (en)	1978-12-04	Analogous process for the preparation of 5-m-tolyloxyuracil.
DK87977A (en)	1977-09-02	PROCEDURE FOR THE PRODUCTION OF BENZYLESTERES
DK144277A (en)	1977-10-03	PROCEDURE FOR THE PREPARATION OF ACYLCYANIDES
DK216977A (en)	1977-11-22	PROCEDURE FOR THE PREPARATION OF IMIDAZOBENZOXAZINES
DK73977A (en)	1977-08-24	PROCEDURE FOR THE MANUFACTURE OF D-HOMOSTEROIDS
DK199981A (en)	1981-05-05	PROCEDURE FOR THE MANUFACTURE OF THIOBISCARBAMATES
DK575277A (en)	1978-06-25	PROCEDURE FOR THE PREPARATION OF BASIC SUBSTITUTED 0-PROPYLOXIMER
DK148775C (en)	1986-03-03	PROCEDURE FOR THE PRODUCTION OF OELURT
DK196577A (en)	1977-11-06	PROCEDURE FOR THE PREPARATION OF CHOLECYSTOKININ-PANCREOZYMIN-OCTAPEPTIDAMIDE SULFATESTER
DK538977A (en)	1978-06-05	PROCEDURE FOR THE PREPARATION OF 17ALFA-HYDROXY-21-ACETOXY-PROGESTERONE