DK438580A - Mellemprodukt til fremstilling af azabicycloforbindelser - Google Patents

Mellemprodukt til fremstilling af azabicycloforbindelser

Info

Publication number: DK438580A
Authority: DK; Denmark
Prior art keywords: manufacture; azabicyclo compounds; azabicyclo; compounds
Prior art date: 1976-09-15

Application number

DK438580A

Other languages

English (en)

Inventor

W J Fanshawe

J W Epstein

L S Crawley

C M Hofmann

S R Safir

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-15

Filing date

1980-10-16

Publication date

1980-10-16

1977-06-23 Priority claimed from US05/809,340 external-priority patent/US4118417A/en

1977-06-23 Priority claimed from US05/809,339 external-priority patent/US4131611A/en

1977-06-23 Priority claimed from US05/809,341 external-priority patent/US4118393A/en

1980-10-16 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1980-10-16 Priority to DK438580A priority Critical patent/DK438580A/da

1980-10-16 Publication of DK438580A publication Critical patent/DK438580A/da

Links

150000001875 compounds Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/40—Unsaturated compounds containing halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/28—Unsaturated compounds polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK438580A 1976-09-15 1980-10-16 Mellemprodukt til fremstilling af azabicycloforbindelser DK438580A (da)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK438580A DK438580A (da)	1976-09-15	1980-10-16	Mellemprodukt til fremstilling af azabicycloforbindelser

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US72340276A	1976-09-15	1976-09-15
US05/809,340 US4118417A (en)	1977-06-23	1977-06-23	Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
US05/809,339 US4131611A (en)	1975-07-31	1977-06-23	Azabicyclohexanes
US05/809,341 US4118393A (en)	1977-06-23	1977-06-23	Phenyl azabicyclohexanones
DK407577A DK146245C (da)	1976-09-15	1977-09-14	Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive azabicycloforbindelser eller syreadditionssalte deraf
DK438580A DK438580A (da)	1976-09-15	1980-10-16	Mellemprodukt til fremstilling af azabicycloforbindelser

Publications (1)

Publication Number	Publication Date
DK438580A true DK438580A (da)	1980-10-16

Family

ID=27505564

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK407577A DK146245C (da)	1976-09-15	1977-09-14	Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive azabicycloforbindelser eller syreadditionssalte deraf
DK438480A DK438480A (da)	1976-09-15	1980-10-16	Fremgangsmaade til fremstilling af en optisk aktiv azabicycloforbindelse
DK438580A DK438580A (da)	1976-09-15	1980-10-16	Mellemprodukt til fremstilling af azabicycloforbindelser

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK407577A DK146245C (da)	1976-09-15	1977-09-14	Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive azabicycloforbindelser eller syreadditionssalte deraf
DK438480A DK438480A (da)	1976-09-15	1980-10-16	Fremgangsmaade til fremstilling af en optisk aktiv azabicycloforbindelse

Country Status (16)

Country	Link
JP (1)	JPS5337656A (da)
AR (2)	AR220684A1 (da)
AT (2)	AT367036B (da)
AU (1)	AU519620B2 (da)
BE (1)	BE858683A (da)
CH (2)	CH637929A5 (da)
DD (1)	DD133943A5 (da)
DE (1)	DE2740562A1 (da)
DK (3)	DK146245C (da)
FR (1)	FR2375212A1 (da)
GR (1)	GR72713B (da)
HU (1)	HU177531B (da)
NL (1)	NL189041C (da)
PL (1)	PL115869B1 (da)
SE (2)	SE435384B (da)
YU (2)	YU39499B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4183857A (en) *	1978-07-06	1980-01-15	Shell Oil Company	3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
IL65843A (en) *	1977-08-11	1986-12-31	American Cyanamid Co	Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
CA1117127A (en) *	1978-06-27	1982-01-26	Janet A. Day	Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
US4225499A (en) *	1978-07-06	1980-09-30	Shell Oil Company	Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
JPS6332100A (ja) *	1986-07-25	1988-02-10	東京電力株式会社	シ−ルド掘進機
JPH0658037B2 (ja) *	1989-09-01	1994-08-03	日本鋼管株式会社	シールド掘進装置
US6372919B1 (en)	2001-01-11	2002-04-16	Dov Pharmaceutical, Inc.	(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en)	2001-08-24	2003-05-27	Dov Pharmaceuticals Inc.	(−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20080081834A1 (en)	2002-07-31	2008-04-03	Lippa Arnold S	Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
KR20070034129A (ko) *	2004-07-22	2007-03-27	와이어쓰	신경계 질환 및 장애의 치료 방법
RU2007102292A (ru) *	2004-07-22	2008-08-27	Вайет (Us)	Способ лечения расстройств и заболеваний нервной системы
US20070043100A1 (en)	2005-08-16	2007-02-22	Hagen Eric J	Novel polymorphs of azabicyclohexane
ZA200801825B (en)	2005-07-27	2009-12-30	Dov Pharmaceutical Inc	Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: Preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en)	2006-04-28	2008-02-21	Murry Jerry A	Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en)	2006-11-07	2012-03-20	Dov Pharmaceutical, Inc.	Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en)	2007-06-06	2015-09-15	Neurovance, Inc.	1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20140206740A1 (en)	2011-07-30	2014-07-24	Neurovance, Inc.	Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1351754A (en) *	1970-07-02	1974-05-01	Allen & Hanburys Ltd	Indenopyrrole derivatives

1977
- 1977-08-16 GR GR54169A patent/GR72713B/el unknown
- 1977-08-26 AR AR268968A patent/AR220684A1/es active
- 1977-09-01 AU AU28441/77A patent/AU519620B2/en not_active Ceased
- 1977-09-02 NL NLAANVRAGE7709691,A patent/NL189041C/xx not_active IP Right Cessation
- 1977-09-08 DE DE19772740562 patent/DE2740562A1/de active Granted
- 1977-09-13 YU YU2174/77A patent/YU39499B/xx unknown
- 1977-09-13 CH CH1118977A patent/CH637929A5/de not_active IP Right Cessation
- 1977-09-14 DK DK407577A patent/DK146245C/da not_active IP Right Cessation
- 1977-09-14 BE BE180894A patent/BE858683A/xx not_active IP Right Cessation
- 1977-09-14 HU HU77AE508A patent/HU177531B/hu unknown
- 1977-09-14 FR FR7727755A patent/FR2375212A1/fr active Granted
- 1977-09-14 PL PL1977200831A patent/PL115869B1/pl unknown
- 1977-09-14 AT AT0661577A patent/AT367036B/de not_active IP Right Cessation
- 1977-09-15 SE SE7710367A patent/SE435384B/xx not_active IP Right Cessation
- 1977-09-15 DD DD77201039A patent/DD133943A5/xx unknown
- 1977-09-16 JP JP11064777A patent/JPS5337656A/ja active Granted
1978
- 1978-09-19 AR AR273764A patent/AR227507A1/es active
1980
- 1980-05-30 AT AT0288280A patent/AT367037B/de not_active IP Right Cessation
- 1980-10-16 DK DK438480A patent/DK438480A/da not_active Application Discontinuation
- 1980-10-16 DK DK438580A patent/DK438580A/da not_active Application Discontinuation
1982
- 1982-04-05 CH CH209382A patent/CH637931A5/de not_active IP Right Cessation
- 1982-06-03 SE SE8203437A patent/SE452610B/sv not_active IP Right Cessation
- 1982-08-23 YU YU1885/82A patent/YU43523B/xx unknown

Also Published As

Publication number	Publication date
DK146245C (da)	1984-01-16
NL189041B (nl)	1992-07-16
DK407577A (da)	1978-03-16
YU43523B (en)	1989-08-31
PL200831A1 (da)	1980-02-11
AU519620B2 (en)	1981-12-17
ATA661577A (de)	1981-10-15
AR220684A1 (es)	1980-11-28
HU177531B (en)	1981-11-28
DE2740562A1 (de)	1978-03-23
DE2740562C2 (da)	1989-05-03
AU2844177A (en)	1979-03-08
AT367037B (de)	1982-05-25
DK438480A (da)	1980-10-16
BE858683A (fr)	1978-03-14
SE435384B (sv)	1984-09-24
YU39499B (en)	1984-12-31
SE7710367L (sv)	1978-03-16
PL115869B1 (en)	1981-05-30
NL7709691A (nl)	1978-03-17
CH637931A5 (en)	1983-08-31
FR2375212B1 (da)	1981-07-31
DK146245B (da)	1983-08-08
CH637929A5 (en)	1983-08-31
JPS5337656A (en)	1978-04-06
GR72713B (da)	1983-12-01
JPS6129341B2 (da)	1986-07-05
FR2375212A1 (fr)	1978-07-21
DD133943A5 (de)	1979-01-31
YU188582A (en)	1985-03-20
YU217477A (en)	1983-01-21
SE452610B (sv)	1987-12-07
ATA288280A (de)	1981-10-15
AT367036B (de)	1982-05-25
NL189041C (nl)	1992-12-16
SE8203437L (sv)	1982-06-03
AR227507A1 (es)	1982-11-15

Legal Events

Date	Code	Title	Description
1993-05-24	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK492677A (da)	1978-05-06	Fremgangsmaade til fremstilling af substituerede benzam9der
DK81277A (da)	1977-08-26	Fremgangsmade til fremstilling af bis-pyridinium-forbindelser
DK30277A (da)	1977-07-27	Fremgangsmade til fremstilling af substituerede phenylamidiner
DK149062C (da)	1986-06-16	Analogifremgangsmaade til fremstilling af cefuroximestere
DK377A (da)	1977-07-06	Fremgangsmade til fremstilling af n-phosphonomethyl-glycin
DK37879A (da)	1980-06-20	Fremgangsmaade til fremstilling af oligoimider
DK244577A (da)	1977-12-04	Fremgangsmade til fremstilling af hydantoinderivater
DK276177A (da)	1978-02-03	Fremgangsmade til fremstilling af gammapyron-forbindelser
DK339677A (da)	1978-01-29	Fremgangsmade til fremstilling af 2-benzylpyrrolidiner
DK91277A (da)	1977-09-04	Fremgangsmade til fremstilling af cephalosporiner
DK123277A (da)	1977-09-23	Fremgangsmade til fremstilling af 3-halogenmethyl-3-cephem-forbindelser
DK446277A (da)	1978-04-09	Fremgangsmaade til fremstilling af orthoeddikesyrealkylestere
DK144377A (da)	1977-10-03	Fremgangsmade til fremstilling af acylcyanider
DK88777A (da)	1977-09-02	Fremgangsmade til fremstilling af substituerede azapuriner
DK139029B (da)	1978-12-04	Analogifremgangsmåde til fremstilling af 5-m-tolyloxyuracil.
DK271377A (da)	1977-12-22	Fremgangsmade til fremstilling af substituerede arylacetamidocephalosporiner
DK87977A (da)	1977-09-02	Fremgangsmade til fremstilling af benzylestere
DK144277A (da)	1977-10-03	Fremgangsmade til fremstilling af acylcyanider
DK216977A (da)	1977-11-22	Fremgangsmade til fremstilling af imidazobenzoxaziner
DK73977A (da)	1977-08-24	Fremgangsmade til fremstilling af d-homosteroider
DK199981A (da)	1981-05-05	Fremgangsmaade til fremstilling af thiobiscarbamater
DK575277A (da)	1978-06-25	Fremgangsmaade til fremstilling af basisk substituerede 0-propyloximer
DK148775C (da)	1986-03-03	Fremgangsmaade til fremstilling af oelurt
DK196577A (da)	1977-11-06	Fremgangsmade til fremstilling af kolecystokinin-pankreozymin-oktapeptidamidsulfatester
DK538977A (da)	1978-06-05	Fremgangsmaade til fremstilling af 17alfa-hydroxy-21-acetoxy-progesteron