DK450584A - Ekspressionsvektorer og anvendelse deraf til fremstilling af et protein med aktiviteten af humant antitrypsin-alfa1 - Google Patents

Ekspressionsvektorer og anvendelse deraf til fremstilling af et protein med aktiviteten af humant antitrypsin-alfa1 Download PDF

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Publication number
DK450584A
DK450584A DK450584A DK450584A DK450584A DK 450584 A DK450584 A DK 450584A DK 450584 A DK450584 A DK 450584A DK 450584 A DK450584 A DK 450584A DK 450584 A DK450584 A DK 450584A
Authority
DK
Denmark
Prior art keywords
alfa1
protein
preparing
activity
expression vectors
Prior art date
Application number
DK450584A
Other languages
English (en)
Other versions
DK450584D0 (da
Inventor
Michael Courtney
Anne Buchwalder
Luc-Henri Tessier
Michael Jaye
Richard Lathe
Paul Tolstoshev
Jean-Pierre Lecocq
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8300909A external-priority patent/FR2539758B1/fr
Priority claimed from FR8311594A external-priority patent/FR2549082B2/fr
Application filed by Transgene Sa filed Critical Transgene Sa
Publication of DK450584D0 publication Critical patent/DK450584D0/da
Publication of DK450584A publication Critical patent/DK450584A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/73—Expression systems using phage (lambda) regulatory sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK450584A 1983-01-21 1984-09-20 Ekspressionsvektorer og anvendelse deraf til fremstilling af et protein med aktiviteten af humant antitrypsin-alfa1 DK450584A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8300909A FR2539758B1 (fr) 1983-01-21 1983-01-21 Nouveaux vecteurs d'expression et leur application a la preparation d'une proteine ayant l'activite de l'antitrypsine-a1 humaine
FR8311594A FR2549082B2 (fr) 1983-07-12 1983-07-12 Vecteurs perfectionnes d'expression d'une proteine ayant l'activite de l'antitrypsine-a1 humaine
PCT/FR1984/000014 WO1984002918A1 (fr) 1983-01-21 1984-01-20 NOUVEAUX VECTEURS D'EXPRESSION ET LEUR APPLICATION A LA PREPARATION D'UNE PROTEINE AYANT L'ACTIVITE DE L'ANTITRYPSINE-alpha1 HUMAINE

Publications (2)

Publication Number Publication Date
DK450584D0 DK450584D0 (da) 1984-09-20
DK450584A true DK450584A (da) 1984-09-20

Family

ID=26223249

Family Applications (1)

Application Number Title Priority Date Filing Date
DK450584A DK450584A (da) 1983-01-21 1984-09-20 Ekspressionsvektorer og anvendelse deraf til fremstilling af et protein med aktiviteten af humant antitrypsin-alfa1

Country Status (5)

Country Link
EP (1) EP0114777B1 (da)
CA (1) CA1303530C (da)
DE (1) DE3482840D1 (da)
DK (1) DK450584A (da)
WO (1) WO1984002918A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
EP0304971B1 (en) * 1982-08-13 1998-02-04 ZymoGenetics, Inc. A method of producing a polypeptide having the protease inhibition activity of mammalian alpha-1-antitrypsin
BE895961A (fr) * 1983-02-21 1983-06-16 Wallone Region Procede de preparation d'un clone bacterien produisant de 1'alpha 1-antitrypsine humaine
US5670371A (en) * 1983-07-15 1997-09-23 Bio-Technology General Corp. Bacterial expression of superoxide dismutase
JPS60186290A (ja) * 1983-08-10 1985-09-21 チモ−ジエネテイツクス　インコ−ポレ−テツド アルフア−１−アンチトリプシンを細菌に表現させる方法
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
US5759816A (en) * 1984-08-27 1998-06-02 Bio-Technology General Corp. Expression vectors containing λPL promoter and T1 T2 rRNA termination sequence plasmids containing the vectors hosts containing the plasmids and related methods
CA1340597C (en) * 1984-08-27 1999-06-22 Haim Aviv Expression vectors containing pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, plasmids containing the vectors, hosts containing the plasmids and related methods
US4766066A (en) * 1984-09-27 1988-08-23 Eli Lilly And Company Method of using bacteriophage lambda p1 promoter to produce a functional polypeptide in streptomyces
AU6469886A (en) * 1985-11-08 1987-05-14 Smithkline Beckman Corporation Mutant alpha-1-antitryosin and dna sequence therefor
FR2594845B1 (fr) * 1986-02-21 1989-12-01 Genetica Preparation par voie microbiologique de l'activateur tissulaire humain du plasminogene (t-pa) et conversion de l'enzyme ainsi obtenue en sa forme active
US4828988A (en) * 1986-05-15 1989-05-09 Smith Kline - Rit Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine
FR2601033B1 (fr) * 1986-07-02 1990-01-19 Transgene Sa Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation
US4839283A (en) * 1986-12-30 1989-06-13 Zymogenetics, Inc. Method of expressing alpha-1-antitrypsin in yeast
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
JP2003505518A (ja) * 1999-07-29 2003-02-12 ケース ウェスタン リザーブ ユニバーシティ セルピン酵素複合体受容体を介する増強された送達
JP4813720B2 (ja) 1999-11-08 2011-11-09 イーペーエフ ファルマシューティカルス ゲゼルシャフト ミット ベシュレンクテル ハフツング ヒト循環ウイルス阻害ペプチド（ｖｉｒｉｐ）及びその使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1431678A (fr) * 1963-06-12 1966-03-18 Behringwerke Ag Procédé pour l'isolement de l'alpha1-antitrypsine
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
BR8101972A (pt) * 1980-06-06 1982-08-17 Biogen Nv Vetor, processo para sua producao, processo para produzir uma molecula recombinante de dna, e processo para produzir um polipeptideo
FR2526661B1 (fr) * 1982-05-13 1986-02-21 Transgene Sa Nouveaux vecteurs d'expression de la proteine antigenique de la rage et leur application a la preparation de vaccins
US4582800A (en) * 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression

Also Published As

Publication number Publication date
DE3482840D1 (de) 1990-09-06
DK450584D0 (da) 1984-09-20
EP0114777A2 (fr) 1984-08-01
EP0114777B1 (fr) 1990-08-01
CA1303530C (en) 1992-06-16
WO1984002918A1 (fr) 1984-08-02
EP0114777A3 (en) 1985-06-05

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