DK452088D0 - 4-amino-6,7-dimethoxy-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)quinolin-forbindelser, farmaceutiske praeparater indeholdende disse og deres anvendelse til fremstilling af antiarytmiske laegemidler samt n-(1-oe1,2,3,4-tetrahydroisozuinolin-2-ylaaethyliden)-2-cyan-4,5-dimethoxyanilin-forbindelser til anvendelse som udgangsmateriale ved deres fremstilling - Google Patents

4-amino-6,7-dimethoxy-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)quinolin-forbindelser, farmaceutiske praeparater indeholdende disse og deres anvendelse til fremstilling af antiarytmiske laegemidler samt n-(1-oe1,2,3,4-tetrahydroisozuinolin-2-ylaaethyliden)-2-cyan-4,5-dimethoxyanilin-forbindelser til anvendelse som udgangsmateriale ved deres fremstilling

Info

Publication number: DK452088D0
Authority: DK; Denmark
Prior art keywords: preparation; compounds; ylaaethylide; tetrahydroisozuinolin; ortemism
Prior art date: 1987-08-15

Application number

DK452088A

Other languages

English (en)

Other versions

DK452088A (da

DK171299B1 (da

Inventor

Nigel John Cussans

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-15

Filing date

1988-08-12

Publication date

1988-08-12

1988-08-12 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

1988-08-12 Publication of DK452088D0 publication Critical patent/DK452088D0/da

1989-02-16 Publication of DK452088A publication Critical patent/DK452088A/da

1996-08-26 Application granted granted Critical

1996-08-26 Publication of DK171299B1 publication Critical patent/DK171299B1/da

Links

238000002360 preparation method Methods 0.000 title 2
AIJHGSFCRNZQBV-UHFFFAOYSA-N 2-(3,4-dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxyquinolin-4-amine Chemical class NC1=CC(=NC2=CC(=C(C=C12)OC)OC)N1CC2=CC=CC=C2CC1 AIJHGSFCRNZQBV-UHFFFAOYSA-N 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
239000007858 starting material Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
239000003416 antiarrhythmic agent Substances 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

DK452088A 1987-08-15 1988-08-12 4-Amino-6,7-dimethoxy-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)quinolin-forbindelser, farmaceutiske præparater indeholdende disse og deres anvendelse til fremstilling af antiarytmiske lægemidler DK171299B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8719378		1987-08-15
GB878719378A GB8719378D0 (en)	1987-08-15	1987-08-15	Antiarrythmic agents

Publications (3)

Publication Number	Publication Date
DK452088D0 true DK452088D0 (da)	1988-08-12
DK452088A DK452088A (da)	1989-02-16
DK171299B1 DK171299B1 (da)	1996-08-26

Family

ID=10622374

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK452088A DK171299B1 (da)	1987-08-15	1988-08-12	4-Amino-6,7-dimethoxy-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)quinolin-forbindelser, farmaceutiske præparater indeholdende disse og deres anvendelse til fremstilling af antiarytmiske lægemidler

Country Status (13)

Country	Link
US (1)	US4965360A (da)
EP (1)	EP0308059B1 (da)
JP (1)	JP2800830B2 (da)
AT (1)	ATE80395T1 (da)
CA (1)	CA1332415C (da)
DE (1)	DE3874465T2 (da)
DK (1)	DK171299B1 (da)
ES (1)	ES2051856T3 (da)
FI (1)	FI90420C (da)
GB (1)	GB8719378D0 (da)
GR (1)	GR3005840T3 (da)
IE (1)	IE61749B1 (da)
PT (1)	PT88256B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9711650D0 (en) *	1997-06-05	1997-07-30	Pfizer Ltd	Compounds useful in therapy
GB0112061D0 (en) *	2001-05-18	2001-07-11	Pfizer Ltd	Process for the production of quinazolines
GB0118752D0 (en) *	2001-08-01	2001-09-26	Pfizer Ltd	Process for the production of quinazolines
KR100863692B1 (ko) *	2006-12-08	2008-10-15	울산대학교 산학협력단	퇴행성질환 및 염증질환에 대한 예방치료 효과를 갖는7-하이드록시-6-메톡시-1,2,3,4-테트라하이드로이소퀴놀린유도체
KR100870576B1 (ko) *	2008-08-27	2008-11-27	울산대학교 산학협력단	퇴행성질환 및 염증질환에 대한 예방치료 효과를 갖는 7-하이드록시-6-메톡시-1,2,3,4-테트라하이드로이소퀴놀린 유도체

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3855228A (en) *	1972-08-21	1974-12-17	Sterling Drug Inc	3,4-dihydro-1-or 3-(polyfluoroalkyl)-2(1h)-isoquinolinecarboxamidoximes
US4656174A (en) *	1982-07-24	1987-04-07	Pfizer Inc.	Quinoline therapeutic agents

1987
- 1987-08-15 GB GB878719378A patent/GB8719378D0/en active Pending
1988
- 1988-08-09 DE DE8888307351T patent/DE3874465T2/de not_active Expired - Fee Related
- 1988-08-09 ES ES88307351T patent/ES2051856T3/es not_active Expired - Lifetime
- 1988-08-09 EP EP88307351A patent/EP0308059B1/en not_active Expired - Lifetime
- 1988-08-09 AT AT88307351T patent/ATE80395T1/de not_active IP Right Cessation
- 1988-08-12 DK DK452088A patent/DK171299B1/da not_active IP Right Cessation
- 1988-08-12 CA CA000574572A patent/CA1332415C/en not_active Expired - Fee Related
- 1988-08-12 PT PT88256A patent/PT88256B/pt not_active IP Right Cessation
- 1988-08-12 FI FI883760A patent/FI90420C/fi not_active IP Right Cessation
- 1988-08-12 IE IE247488A patent/IE61749B1/en not_active IP Right Cessation
- 1988-08-15 JP JP63203058A patent/JP2800830B2/ja not_active Expired - Fee Related
1989
- 1989-08-23 US US07/397,605 patent/US4965360A/en not_active Expired - Fee Related
1992
- 1992-09-30 GR GR920402174T patent/GR3005840T3/el unknown

Also Published As

Publication number	Publication date
GB8719378D0 (en)	1987-09-23
FI90420B (fi)	1993-10-29
IE882474L (en)	1989-02-15
JP2800830B2 (ja)	1998-09-21
DE3874465T2 (de)	1993-02-25
ES2051856T3 (es)	1994-07-01
PT88256A (pt)	1989-06-30
JPH01110680A (ja)	1989-04-27
DK452088A (da)	1989-02-16
DE3874465D1 (de)	1992-10-15
IE61749B1 (en)	1994-11-30
US4965360A (en)	1990-10-23
FI883760A0 (fi)	1988-08-12
FI90420C (fi)	1994-02-10
GR3005840T3 (da)	1993-06-07
EP0308059A1 (en)	1989-03-22
EP0308059B1 (en)	1992-09-09
FI883760L (fi)	1989-02-16
ATE80395T1 (de)	1992-09-15
DK171299B1 (da)	1996-08-26
PT88256B (pt)	1995-03-01
CA1332415C (en)	1994-10-11

Similar Documents

Publication	Publication Date	Title
DK188288A (da)	1989-01-12	1-phenyl-3-naphthalenyloxypropanaminer, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske midler indeholdende disse
MA21502A1 (fr)	1989-10-01	4--phenyl-(-piperazinyl)phenols et procedes pour leur preparation .
DE69432611D1 (de)	2003-06-05	Herstellung einer substituierten 2,5-Diamino-3-hydroxyhexan
SE8601907L (sv)	1986-10-26	Antitrombogena och kardiotoniska imidazokinoliner
EP0077938A3 (en)	1983-08-24	N-(3-substituted aminophenyl) tetrahydrophthalimides and herbicidal composition
EP0353955A3 (en)	1991-08-14	Novel compounds
DK220386D0 (da)	1986-05-13	2-(4-benzoyl-1-piperidinyl)-alkanolderivater, fremgangsmaade til fremstilling af saadanne derivater og anvendelse af disse som laegemidler
FI906312A0 (fi)	1990-12-20	Menetelmä pikornaviruksia vastaan vaikuttavien pyridatsiiniamiinien valmistamiseksi ja menetelmässä käyttökelpoiset välituotteet
DK234388D0 (da)	1988-04-28	1,4-dihydropyridin-forbindelser, farmaceutiske praeparater indeholdende disse og deres anvendelse til deres fremstilling af laegemidler samt beskyttede derivater deraf til anvendelse som udgangsmateriale ved deres fremstilling
BR9503536A (pt)	1996-06-04	Composto processo para sua preparação seu uso e composição farmacêutica
DK39286A (da)	1986-07-29	Imidazolderivater, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende disse derivater
DK0549366T3 (da)	1999-03-08	Thiazolidinforbindelser indeholdende en quinolingruppe, deres fremstilling og deres terapeutiske anvendelser
DK411687A (da)	1988-04-28	1-(4-alkansulfonamidophenyl)-4-(4-alkansulfonamidophenylalkyl)piperazin-forbindelser og deres anvendelse som antiarytmiske midler samt forbindelser til anvendelse som udgangsmateriale ved deres fremstilling
ES2010284A6 (es)	1989-11-01	Procedimiento para preparar derivados de tiourea.
DK452088D0 (da)	1988-08-12	4-amino-6,7-dimethoxy-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)quinolin-forbindelser, farmaceutiske praeparater indeholdende disse og deres anvendelse til fremstilling af antiarytmiske laegemidler samt n-(1-oe1,2,3,4-tetrahydroisozuinolin-2-ylaaethyliden)-2-cyan-4,5-dimethoxyanilin-forbindelser til anvendelse som udgangsmateriale ved deres fremstilling
DK447284A (da)	1984-11-20	Aminoderivater af 2-(n-(2,2,5,5-tetramethyl-3-pyrrolin-3-carbonyl)),deres fremstilling og anvendelse
DK164908C (da)	1993-01-25	Phenoxyphthalidderivater, fremgangsmaade til deres fremstilling, samt herbicidt praeparat indeholdende disse
NO972943D0 (no)	1997-06-23	4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, fremgangsmåter for deres fremstilling, legemidler inneholdende disse forbindelsene og deres anvendelse
DE69017627D1 (de)	1995-04-13	Isochinolinderivate und ihre Salze als Proteasehemmer.
NZ510071A (en)	2003-06-30	Aryl alkanol and heteroaryl alkanol derivatives, pharmaceuticals thereof, and their use in the modulation of inflammatory and allergic conditions
DK158729C (da)	1990-11-19	N-(3-trifluormethylphenyl)-n'-propargylpiperazin, farmaceutiske praeparater, der indeholder det, dets anvendelse, samt en fremgangsmaade til fremstilling af et farmaceutisk praeparat
WO2000020399A3 (de)	2000-07-27	Verwendung von substituierten 5-hydroxypyrazolen, neue 5-hydroxypyrazole, verfahren zu deren herstellung, sowie sie enthaltende mittel
DK0586344T3 (da)	1999-06-07	Oxazolidinforbindelser og deres anvendelse som lægemidler
NO972942L (no)	1997-12-29	4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, fremgangsmåter for deres fremstilling, legemidler inneholdende disse forbindelsene og deres anvendelse
JPS55130961A (en)	1980-10-11	N-quinolyloxamic acid derivative and antiallergic remedy for asthma

Legal Events

Date	Code	Title	Description
1996-08-26	B1	Patent granted (law 1993)
2002-03-25	PBP	Patent lapsed