PT88256A - Processo para a preparacao de agentes antiarritmicos de 1,2,3,4-tetra-hidroisoquinolina - Google Patents

Processo para a preparacao de agentes antiarritmicos de 1,2,3,4-tetra-hidroisoquinolina

Info

Publication number: PT88256A
Authority: PT; Portugal
Prior art keywords: agents; antiryrymmic; tetrahydroisoquinoline; preparation; alkyl
Prior art date: 1987-08-15

Application number

PT88256A

Other languages

English (en)

Other versions

PT88256B (pt

Inventor

Nigel John Cussans

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-15

Filing date

1988-08-12

Publication date

1989-06-30

1988-08-12 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

1989-06-30 Publication of PT88256A publication Critical patent/PT88256A/pt

1995-03-01 Publication of PT88256B publication Critical patent/PT88256B/pt

Links

UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 title 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
239000003416 antiarrhythmic agent Substances 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

PT88256A 1987-08-15 1988-08-12 Processo para a preparacao de agentes antiarritmicos de 1,2,3,4-tetra-hidroisoquinolina PT88256B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878719378A GB8719378D0 (en)	1987-08-15	1987-08-15	Antiarrythmic agents

Publications (2)

Publication Number	Publication Date
PT88256A true PT88256A (pt)	1989-06-30
PT88256B PT88256B (pt)	1995-03-01

Family

ID=10622374

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT88256A PT88256B (pt)	1987-08-15	1988-08-12	Processo para a preparacao de agentes antiarritmicos de 1,2,3,4-tetra-hidroisoquinolina

Country Status (13)

Country	Link
US (1)	US4965360A (pt)
EP (1)	EP0308059B1 (pt)
JP (1)	JP2800830B2 (pt)
AT (1)	ATE80395T1 (pt)
CA (1)	CA1332415C (pt)
DE (1)	DE3874465T2 (pt)
DK (1)	DK171299B1 (pt)
ES (1)	ES2051856T3 (pt)
FI (1)	FI90420C (pt)
GB (1)	GB8719378D0 (pt)
GR (1)	GR3005840T3 (pt)
IE (1)	IE61749B1 (pt)
PT (1)	PT88256B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9711650D0 (en) *	1997-06-05	1997-07-30	Pfizer Ltd	Compounds useful in therapy
GB0112061D0 (en) *	2001-05-18	2001-07-11	Pfizer Ltd	Process for the production of quinazolines
GB0118752D0 (en) *	2001-08-01	2001-09-26	Pfizer Ltd	Process for the production of quinazolines
KR100863692B1 (ko) *	2006-12-08	2008-10-15	울산대학교 산학협력단	퇴행성질환 및 염증질환에 대한 예방치료 효과를 갖는7-하이드록시-6-메톡시-1,2,3,4-테트라하이드로이소퀴놀린유도체
KR100870576B1 (ko) *	2008-08-27	2008-11-27	울산대학교 산학협력단	퇴행성질환 및 염증질환에 대한 예방치료 효과를 갖는 7-하이드록시-6-메톡시-1,2,3,4-테트라하이드로이소퀴놀린 유도체

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3855228A (en) *	1972-08-21	1974-12-17	Sterling Drug Inc	3,4-dihydro-1-or 3-(polyfluoroalkyl)-2(1h)-isoquinolinecarboxamidoximes
GR79603B (pt) *	1982-07-24	1984-10-31	Pfizer

1987
- 1987-08-15 GB GB878719378A patent/GB8719378D0/en active Pending
1988
- 1988-08-09 EP EP88307351A patent/EP0308059B1/en not_active Expired - Lifetime
- 1988-08-09 ES ES88307351T patent/ES2051856T3/es not_active Expired - Lifetime
- 1988-08-09 DE DE8888307351T patent/DE3874465T2/de not_active Expired - Fee Related
- 1988-08-09 AT AT88307351T patent/ATE80395T1/de not_active IP Right Cessation
- 1988-08-12 DK DK452088A patent/DK171299B1/da not_active IP Right Cessation
- 1988-08-12 IE IE247488A patent/IE61749B1/en not_active IP Right Cessation
- 1988-08-12 FI FI883760A patent/FI90420C/fi not_active IP Right Cessation
- 1988-08-12 CA CA000574572A patent/CA1332415C/en not_active Expired - Fee Related
- 1988-08-12 PT PT88256A patent/PT88256B/pt not_active IP Right Cessation
- 1988-08-15 JP JP63203058A patent/JP2800830B2/ja not_active Expired - Fee Related
1989
- 1989-08-23 US US07/397,605 patent/US4965360A/en not_active Expired - Fee Related
1992
- 1992-09-30 GR GR920402174T patent/GR3005840T3/el unknown

Also Published As

Publication number	Publication date
GB8719378D0 (en)	1987-09-23
FI883760A0 (fi)	1988-08-12
ATE80395T1 (de)	1992-09-15
GR3005840T3 (pt)	1993-06-07
FI90420B (fi)	1993-10-29
ES2051856T3 (es)	1994-07-01
IE882474L (en)	1989-02-15
PT88256B (pt)	1995-03-01
DE3874465T2 (de)	1993-02-25
DE3874465D1 (de)	1992-10-15
US4965360A (en)	1990-10-23
DK171299B1 (da)	1996-08-26
DK452088A (da)	1989-02-16
CA1332415C (en)	1994-10-11
DK452088D0 (da)	1988-08-12
IE61749B1 (en)	1994-11-30
EP0308059B1 (en)	1992-09-09
EP0308059A1 (en)	1989-03-22
FI90420C (fi)	1994-02-10
JP2800830B2 (ja)	1998-09-21
FI883760L (fi)	1989-02-16
JPH01110680A (ja)	1989-04-27

Legal Events

Date

Code

Title

Description

1995-03-01

FG3A

Patent granted, date of granting

Effective date: 19940822

2002-06-28

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20020228

Publication	Publication Date	Title
ES533916A0 (es)	1985-12-01	Un metodo para producir acidos 1,4-dihidro-4-oxo-quinolin-3-carboxilico
PT82854B (pt)	1988-05-27	Processo para a preparacao de derivados do acido piridono-carboxilico
DK10086A (da)	1986-07-11	Guanidinderivater
PT81476B (pt)	1987-11-11	Processo para a preparacao de derivados do acido quinolono-carboxilico
FI904915A0 (fi)	1990-10-05	Kinolinderivat, deras framstaellning och anvaendning.
FI953710A0 (fi)	1995-08-03	Uusia pyrrolokarbatsoleja
ES2039221T3 (es)	1996-07-16	Procedimiento para producir derivados de piridazinona.
DE3766570D1 (de)	1991-01-17	Antiarrhythmische agenzien.
ES545936A0 (es)	1986-02-01	Un procedimiento para la preparacion de nuevos derivados de quinazolina e isoquinolina
EP0314429A3 (en)	1990-08-01	Fungicidal pyridyl cyclopropane carboxamidines
GR3005840T3 (pt)	1993-06-07
AU8866482A (en)	1983-03-31	Oxazolo- thiazolo- imidazolo (5,4-b) pyridines
GR3007089T3 (pt)	1993-07-30
EP0239064A3 (en)	1989-03-29	Herbicidal compounds, their production and use
FI863625A0 (fi)	1986-09-09	Difenyleterherbicider.
DK0412529T3 (da)	1994-04-05	Hidtil ukendte imidazolderivater, fremgangsmåde til fremstilling deraf og midler mod mavesår indeholdende disse
FI883507A0 (fi)	1988-07-26	Naftotiazepinderivat och deras framstaellning.
DK0401125T3 (da)	1994-09-19	Biphenylderivater, fremgangsmåde til fremstilling af disse samt mellemprodukter derfor
ATE17710T1 (de)	1986-02-15	Keten-0,0-acetale und verfahren zu ihrer herstellung.
ES2014041A6 (es)	1990-06-16	Un procedimiento para preparar un derivado de amina.