DK462376A - Fremgangsmade til fremstilling af 5-halogenpyrimidinderivater - Google Patents

Fremgangsmade til fremstilling af 5-halogenpyrimidinderivater

Info

Publication number
DK462376A
DK462376A DK462376A DK462376A DK462376A DK 462376 A DK462376 A DK 462376A DK 462376 A DK462376 A DK 462376A DK 462376 A DK462376 A DK 462376A DK 462376 A DK462376 A DK 462376A
Authority
DK
Denmark
Prior art keywords
halogenpyrimidine
derivatives
preparing
procedure
halogenpyrimidine derivatives
Prior art date
Application number
DK462376A
Other languages
English (en)
Other versions
DK144525C (da
DK144525B (da
Inventor
K Undheim
S G M Laland
M J Gacek
R Oftebro
Original Assignee
Nyegaard & Co As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard & Co As filed Critical Nyegaard & Co As
Publication of DK462376A publication Critical patent/DK462376A/da
Publication of DK144525B publication Critical patent/DK144525B/da
Application granted granted Critical
Publication of DK144525C publication Critical patent/DK144525C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK462376A 1975-10-16 1976-10-14 Analogifremgangsmaade til fremstilling af 5-halogenpyrimid-2-oner eller salte deraf DK144525C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4250975 1975-10-16
GB42509/75A GB1561290A (en) 1975-10-16 1975-10-16 Pyrimid - 2 - ones

Publications (3)

Publication Number Publication Date
DK462376A true DK462376A (da) 1977-04-17
DK144525B DK144525B (da) 1982-03-22
DK144525C DK144525C (da) 1982-10-18

Family

ID=10424751

Family Applications (1)

Application Number Title Priority Date Filing Date
DK462376A DK144525C (da) 1975-10-16 1976-10-14 Analogifremgangsmaade til fremstilling af 5-halogenpyrimid-2-oner eller salte deraf

Country Status (14)

Country Link
US (1) US4395406A (da)
JP (1) JPS5253869A (da)
BE (1) BE847234A (da)
CA (1) CA1086736A (da)
CH (3) CH634308A5 (da)
DE (1) DE2646676A1 (da)
DK (1) DK144525C (da)
FR (1) FR2327765A1 (da)
GB (1) GB1561290A (da)
IE (1) IE44431B1 (da)
LU (1) LU75994A1 (da)
NL (1) NL7611415A (da)
NO (1) NO151040C (da)
SE (1) SE439305B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DK330880A (da) * 1979-08-03 1981-02-04 Beecham Group Ltd Fremgangsmaade til fremstilling af clavulansyrederivater
ES498337A0 (es) * 1980-01-07 1982-06-01 Nyegaard & Co As Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas
ES8205782A1 (es) 1980-01-10 1982-08-01 Nyegaard & Co As Procedimiento para la preparacion de pirimidin-2-sulfuros y sus s-oxidos
CA1160226A (en) * 1980-07-15 1984-01-10 Gordon H. Phillipps Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor
CA1159830A (en) * 1980-07-15 1984-01-03 Gordon H. Phillipps Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor
EP0053893B1 (en) * 1980-12-09 1985-03-20 Beecham Group Plc Derivatives of clavulanic acid, their preparation and their use
NZ199200A (en) * 1980-12-23 1984-07-31 Beecham Group Ltd Clavulanic acid derivatives and pharmaceutical compositions
EP0056319B1 (en) * 1981-01-09 1986-04-16 NYEGAARD & CO. A/S Substituted pyrimidin-2-ones and the salts thereof
NO823075L (no) * 1981-09-11 1983-03-14 Nyegaard & Co As Fremgangsmaate for fremstilling av substituerte pyrimid-2-on-derivater
US4782142A (en) * 1982-01-05 1988-11-01 The Research Foundation Of State University Of New York Novel 5-substituted 2-pyrimidinone nucleosides and methods of use
JPS58159479A (ja) * 1982-02-24 1983-09-21 ニユエガ−ド・アンド・コンパニ−・アクシエ／セルカペト 置換されたピリミジン−２−オン化合物
NZ219299A (en) * 1986-03-14 1989-01-06 Squibb & Sons Inc Pyrimidine derivatives
GB8706176D0 (en) * 1987-03-16 1987-04-23 Wellcome Found Therapeutic nucleosides
KR900701763A (ko) * 1988-07-18 1990-12-04 하마구찌 미찌오 1-아미노-5-할로게노우라실, 그의 제조방법 및 이 화합물을 유효성분으로 함유하는 중추신경억제제
GB9026114D0 (en) * 1990-11-30 1991-01-16 Norsk Hydro As New compounds
WO1997014709A1 (en) * 1995-10-13 1997-04-24 F. Hoffmann-La Roche Ag Antisense oligomers
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
EP0882734B1 (en) * 1997-06-02 2009-08-26 F. Hoffmann-La Roche Ag 5'-Deoxy-cytidine derivatives
US6005098A (en) * 1998-02-06 1999-12-21 Hoffmann-La Roche Inc. 5'deoxycytidine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3317532A (en) * 1964-11-19 1967-05-02 Hoffmann La Roche Derivatives of pyrimidine
DE2032559A1 (de) * 1970-06-27 1972-01-13 Schering Ag Berlin Und Bergkamen, 1000 Berlin N-Substituierte Amide und Lactame
US3833586A (en) * 1971-03-25 1974-09-03 Morton Norwich Products Inc 1-(substituted benzyl)-2-(1h)pyrimidones and 1-(substituted benzyl)tetrahydro-2-(1h)pyrimidones
DE2440677A1 (de) * 1974-08-24 1976-03-04 Bayer Ag Pyrimidinylthionophosphonsaeureester, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
DE2450951A1 (de) * 1974-10-26 1976-05-06 Bayer Ag Pyrimidinyl(thiono)(thiol)phosphor (phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
US4003900A (en) * 1976-03-11 1977-01-18 Morton-Norwich Products, Inc. 1-Benzyl-5-chloro-2-(1H)-pyrimidone

Also Published As

Publication number Publication date
JPS5253869A (en) 1977-04-30
FR2327765A1 (fr) 1977-05-13
SE7611493L (sv) 1977-04-17
BE847234A (fr) 1977-04-13
IE44431B1 (en) 1981-12-02
NO151040B (no) 1984-10-22
NO763533L (da) 1977-04-19
SE439305B (sv) 1985-06-10
DE2646676A1 (de) 1977-04-28
LU75994A1 (da) 1977-05-11
CH634310A5 (de) 1983-01-31
DE2646676C2 (da) 1987-06-19
DK144525C (da) 1982-10-18
IE44431L (en) 1977-04-16
DK144525B (da) 1982-03-22
FR2327765B1 (da) 1981-11-20
NO151040C (no) 1985-01-30
CH634308A5 (de) 1983-01-31
GB1561290A (en) 1980-02-20
CA1086736A (en) 1980-09-30
US4395406A (en) 1983-07-26
NL7611415A (nl) 1977-04-19
CH634309A5 (de) 1983-01-31

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